EG17222A - Process for preparation bis-triazole derivatives as antifungal agents and pharmaceutical compositions containing them - Google Patents

Process for preparation bis-triazole derivatives as antifungal agents and pharmaceutical compositions containing them

Info

Publication number
EG17222A
EG17222A EG319/82A EG31982A EG17222A EG 17222 A EG17222 A EG 17222A EG 319/82 A EG319/82 A EG 319/82A EG 31982 A EG31982 A EG 31982A EG 17222 A EG17222 A EG 17222A
Authority
EG
Egypt
Prior art keywords
pharmaceutical compositions
compositions containing
antifungal agents
triazole derivatives
preparation bis
Prior art date
Application number
EG319/82A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27261198&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EG17222(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG17222A publication Critical patent/EG17222A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EG319/82A 1981-06-06 1982-06-05 Process for preparation bis-triazole derivatives as antifungal agents and pharmaceutical compositions containing them EG17222A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8117379 1981-06-06
GB8131370 1981-10-17
GB8206329 1982-03-04

Publications (1)

Publication Number Publication Date
EG17222A true EG17222A (en) 1991-03-30

Family

ID=27261198

Family Applications (1)

Application Number Title Priority Date Filing Date
EG319/82A EG17222A (en) 1981-06-06 1982-06-05 Process for preparation bis-triazole derivatives as antifungal agents and pharmaceutical compositions containing them

Country Status (27)

Country Link
US (1) US4404216A (fi)
EP (1) EP0069442B1 (fi)
KR (1) KR850001132B1 (fi)
AU (1) AU529987B2 (fi)
CA (1) CA1181076A (fi)
DE (1) DE3262386D1 (fi)
DK (1) DK149849C (fi)
EG (1) EG17222A (fi)
ES (2) ES8307794A1 (fi)
FI (1) FI71134C (fi)
GR (1) GR76491B (fi)
HK (1) HK8488A (fi)
HU (1) HU189143B (fi)
IE (1) IE53144B1 (fi)
IL (1) IL65963A (fi)
IN (1) IN158113B (fi)
LU (1) LU88329I2 (fi)
MX (1) MX7119E (fi)
MY (1) MY8800094A (fi)
NL (1) NL930061I2 (fi)
NO (2) NO156128C (fi)
NZ (1) NZ200864A (fi)
PH (1) PH18015A (fi)
PL (1) PL130909B1 (fi)
PT (1) PT75017B (fi)
SG (1) SG80887G (fi)
YU (1) YU42770B (fi)

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US4466974A (en) * 1982-11-16 1984-08-21 Pfizer Inc. Bistriazole antifungal agents
GB8302500D0 (en) * 1983-01-29 1983-03-02 Pfizer Ltd Antifungal agents
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GB8305377D0 (en) * 1983-02-25 1983-03-30 Pfizer Ltd Antifungal agents
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DE3307217A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Substituierte 1,3-diazolyl-2-propanole, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
DE3307216A1 (de) * 1983-03-02 1984-09-06 Bayer Ag, 5090 Leverkusen Fungizide mittel
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US4992454A (en) * 1983-03-16 1991-02-12 Pfizer Inc. Antifungal 1,3-bis (1H-1,2,4-triazol-1-yl)-2-aryl butan-2-ols and derivatives thereof
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DE4134125C2 (de) * 1991-10-15 1995-02-02 Mack Chem Pharm Triazol-Derivate enthaltende pharmazeutische Zusammensetzungen zur rektalen Applikation
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NZ270418A (en) 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
CA2139079C (en) * 1994-12-23 1996-05-28 K.S. Keshava Murthy Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof
CN1054853C (zh) * 1995-01-11 2000-07-26 上海三维制药公司 氟康唑中间体1－[2－(2,4－二氟苯基)2,3－环氧丙基]－1h－1,2,4－三氮唑及其甲磺酸盐的制备方法
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DE19617461A1 (de) * 1996-05-02 1997-11-06 Bayer Ag Acylmercapto-triazolyl-Derivate
DE19619544A1 (de) * 1996-05-15 1997-11-20 Bayer Ag Triazolyl-Disulfide
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US5710280A (en) * 1996-07-09 1998-01-20 Development Center For Biotechnology Preparation of fluconazole and pharmaceutically acceptable salts thereof
NZ328607A (en) * 1996-09-09 1999-08-30 Hoffmann La Roche Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions
KR100194945B1 (ko) * 1997-01-29 1999-06-15 서치영 플루코나졸의 제조방법
GR980100028A (el) * 1998-01-15 1999-09-30 Drug Research Hellas ����� Φαρμακευτικα προιοντα για τοπικη χρηση που περιεχουν φλουκοναζολη σε συγκεντρωσεις μεταξυ 0,2% και 5%
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CN111454227A (zh) * 2020-05-21 2020-07-28 湖南复瑞生物医药技术有限责任公司 一种西洛他唑中间体的制备方法
CN112137972A (zh) * 2020-09-16 2020-12-29 石家庄四药有限公司 一种氟康唑片剂组合物、片剂及制备方法
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2078719B (en) * 1980-06-02 1984-04-26 Ici Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
IN158113B (fi) 1986-09-06
FI71134B (fi) 1986-08-14
NZ200864A (en) 1985-07-12
CA1181076A (en) 1985-01-15
IL65963A0 (en) 1982-09-30
DK252282A (da) 1982-12-07
FI822005L (fi) 1982-12-07
KR840000528A (ko) 1984-02-25
YU42770B (en) 1988-12-31
PL236740A1 (en) 1983-04-25
HK8488A (en) 1988-02-05
YU119582A (en) 1984-12-31
AU8448482A (en) 1982-12-23
PT75017B (en) 1985-01-07
NL930061I2 (nl) 1993-10-01
ES512882A0 (es) 1983-08-01
PH18015A (en) 1985-02-28
NO156128B (no) 1987-04-21
ES8404348A1 (es) 1984-05-01
NL930061I1 (nl) 1993-09-01
DK149849C (da) 1987-04-27
MY8800094A (en) 1988-12-31
EP0069442A1 (en) 1983-01-12
GR76491B (fi) 1984-08-10
HU189143B (en) 1986-06-30
IL65963A (en) 1985-02-28
DK149849B (da) 1986-10-13
FI822005A0 (fi) 1982-06-04
NO1994019I1 (no) 1994-11-02
ES8307794A1 (es) 1983-08-01
NO156128C (no) 1987-07-29
IE53144B1 (en) 1988-07-20
LU88329I2 (fr) 1994-05-04
PT75017A (en) 1982-07-01
PL130909B1 (en) 1984-09-29
EP0069442B1 (en) 1985-02-20
DE3262386D1 (en) 1985-03-28
US4404216A (en) 1983-09-13
KR850001132B1 (ko) 1985-08-09
SG80887G (en) 1988-09-16
ES520794A0 (es) 1984-05-01
IE821285L (en) 1982-12-06
NO821886L (no) 1982-12-07
FI71134C (fi) 1986-11-24
AU529987B2 (en) 1983-06-30
MX7119E (es) 1987-06-29

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