EE9800377A - Ret-i ligand (RetL) närvi- ja neerukasvu stimuleerimiseks - Google Patents

Ret-i ligand (RetL) närvi- ja neerukasvu stimuleerimiseks

Info

Publication number
EE9800377A
EE9800377A EE9800377A EE9800377A EE9800377A EE 9800377 A EE9800377 A EE 9800377A EE 9800377 A EE9800377 A EE 9800377A EE 9800377 A EE9800377 A EE 9800377A EE 9800377 A EE9800377 A EE 9800377A
Authority
EE
Estonia
Prior art keywords
seq
retl
human
cdna
retl3
Prior art date
Application number
EE9800377A
Other languages
English (en)
Estonian (et)
Inventor
Sanicola-Nadel Michelle
A. Hession Catherine
L. Cate Richard
Original Assignee
Biogen, Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen, Incorporated filed Critical Biogen, Incorporated
Publication of EE9800377A publication Critical patent/EE9800377A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EE9800377A 1996-05-08 1997-05-07 Ret-i ligand (RetL) närvi- ja neerukasvu stimuleerimiseks EE9800377A (et)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1742796P 1996-05-08 1996-05-08
US1930096P 1996-06-07 1996-06-07
US2185996P 1996-07-16 1996-07-16
US4353397P 1997-04-11 1997-04-11
PCT/US1997/007726 WO1997044356A2 (fr) 1996-05-08 1997-05-07 Test diagnostique de detection de la schizophrenie faisant appel a de la miacine

Publications (1)

Publication Number Publication Date
EE9800377A true EE9800377A (et) 1999-04-15

Family

ID=27360789

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800377A EE9800377A (et) 1996-05-08 1997-05-07 Ret-i ligand (RetL) närvi- ja neerukasvu stimuleerimiseks

Country Status (24)

Country Link
EP (2) EP1757617A1 (fr)
JP (1) JP2002515743A (fr)
KR (2) KR100587556B1 (fr)
CN (2) CN1163509C (fr)
AT (1) ATE335003T1 (fr)
AU (1) AU732392B2 (fr)
BG (2) BG64907B1 (fr)
BR (1) BR9710665A (fr)
CA (1) CA2253871C (fr)
CZ (1) CZ296516B6 (fr)
DE (1) DE69736428T2 (fr)
DK (1) DK0914339T3 (fr)
EA (1) EA002544B1 (fr)
EE (1) EE9800377A (fr)
ES (1) ES2270465T3 (fr)
IL (1) IL126918A (fr)
IS (1) IS2361B (fr)
NO (2) NO323612B1 (fr)
NZ (1) NZ332706A (fr)
PT (1) PT914339E (fr)
RO (1) RO120343B1 (fr)
SK (1) SK286115B6 (fr)
TR (2) TR199802252T2 (fr)
WO (1) WO1997044356A2 (fr)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
US6696259B1 (en) 1995-11-13 2004-02-24 Licentia Ltd. Assays using glial cell line-derived neurotrophic factor receptors
EP0846764A3 (fr) * 1996-11-27 1998-09-30 Smithkline Beecham Plc Famille de facteurs alpha neurotrophiques des cellules gliales
AU5516498A (en) * 1996-12-06 1998-06-29 Genetics Institute Inc. Secreted proteins and polynucleotides encoding them
US6372453B1 (en) 1997-02-18 2002-04-16 Genetech, Inc. Neurturin receptor
DE69832797T2 (de) * 1997-02-18 2006-08-17 Genentech, Inc., South San Francisco Neurturin-rezeptor
US6025157A (en) 1997-02-18 2000-02-15 Genentech, Inc. Neurturin receptor
US6777196B2 (en) 1997-02-18 2004-08-17 Genentech, Inc. Neurturin receptor
NZ501423A (en) * 1997-04-17 2002-02-01 Univ Washington Receptors for TGF-beta-related neurotrophic factors and use for treating disease
AU7583898A (en) * 1997-05-20 1998-12-11 Human Genome Sciences, Inc. Gdnf receptors
EP1007072A4 (fr) * 1997-05-22 2002-06-26 Cephalon Inc Recepteurs du facteur neurotrophique derive de lignes de cellules gliales
JP2002505576A (ja) * 1997-05-30 2002-02-19 アムジエン・インコーポレーテツド 神経栄養因子レセプター
US7026138B1 (en) 1998-03-23 2006-04-11 Genentech, Inc. Polynucleotides encoding GFRα3
JP4469935B2 (ja) * 1998-03-23 2010-06-02 ジェネンテック， インコーポレイテッド ＧＦＲα３およびその使用
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
US20020055467A1 (en) 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
WO2001016169A2 (fr) * 1999-09-01 2001-03-08 Biogen, Inc. COMPOSITIONS A BASE DE LIGAND 5 (RetL5) ET SES UTILISATIONS
DK2246362T3 (en) 2003-01-31 2014-03-10 Biogen Idec Inc Polymer conjugates of mutated neublastin
SG10201506591TA (en) 2010-05-20 2015-09-29 Array Biopharma Inc Macrocyclic compounds as trk kinase inhibitors
US10023855B2 (en) 2011-10-31 2018-07-17 Macrogen, Inc. Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker
WO2014017491A1 (fr) * 2012-07-26 2014-01-30 独立行政法人国立がん研究センター Gène de fusion formé par le gène cep55 et le gène ret
EP3457138A3 (fr) 2013-04-30 2019-06-19 Université de Montréal Nouveaux biomarqueurs pour la leucémie myéloïde aiguë
BR112018000808A2 (pt) 2015-07-16 2018-09-04 Array Biopharma Inc compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
WO2018136663A1 (fr) 2017-01-18 2018-07-26 Array Biopharma, Inc. Inhibiteurs de ret
CN110267960B (zh) 2017-01-18 2022-04-26 阿雷生物药品公司 作为RET激酶抑制剂的取代的吡唑并[1,5-a]吡嗪化合物
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
TW202410896A (zh) 2017-10-10 2024-03-16 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
US11603374B2 (en) 2018-01-18 2023-03-14 Array Biopharma Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
CN111615514B (zh) 2018-01-18 2022-10-11 奥瑞生物药品公司 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物
US11524963B2 (en) 2018-01-18 2022-12-13 Array Biopharma Inc. Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors
US11964988B2 (en) 2018-09-10 2024-04-23 Array Biopharma Inc. Fused heterocyclic compounds as RET kinase inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169637A (en) 1983-03-24 1992-12-08 The Liposome Company, Inc. Stable plurilamellar vesicles
CA1237671A (fr) 1983-08-01 1988-06-07 Michael W. Fountain Augmentation de l'activite pharmaceutique
US4762915A (en) 1985-01-18 1988-08-09 Liposome Technology, Inc. Protein-liposome conjugates
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4956288A (en) 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
US5185154A (en) 1989-02-02 1993-02-09 Liposome Technology, Inc. Method for instant preparation of a drug containing large unilamellar vesicles
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
JP3021800B2 (ja) 1990-07-24 2000-03-15 セイコーエプソン株式会社 半導体装置及びその製造方法
US5219990A (en) 1991-01-28 1993-06-15 Biogen, Inc. Papillomavirus e2 trans-activation repressors
FR2693107B1 (fr) 1992-07-01 1994-09-23 Chauvin Laboratoire Moyens pour la prévention de la cataracte secondaire.
WO1995016709A2 (fr) * 1993-12-13 1995-06-22 Biogen, Inc. Recepteur de l'hormone antimullerienne et polypeptides et anticorps s'y rapportant
EP0879247A4 (fr) * 1995-11-13 2002-01-30 Carlos Ibanez Recepteurs du facteur neurotrophique derive de lignees de cellules gliales
AU719482B2 (en) * 1996-03-14 2000-05-11 Genentech Inc. Uses of GDNF and GDNF receptor
US6455277B1 (en) * 1996-04-22 2002-09-24 Amgen Inc. Polynucleotides encoding human glial cell line-derived neurotrophic factor receptor polypeptides

Also Published As

Publication number Publication date
CA2253871A1 (fr) 1997-11-27
IL126918A (en) 2007-06-03
AU3472997A (en) 1997-12-09
KR20060024843A (ko) 2006-03-17
JP2002515743A (ja) 2002-05-28
EA199800990A1 (ru) 1999-06-24
CZ296516B6 (cs) 2006-04-12
ATE335003T1 (de) 2006-08-15
BG102973A (en) 1999-08-31
BR9710665A (pt) 1999-08-17
NZ332706A (en) 1999-10-28
CA2253871C (fr) 2005-04-26
IS2361B (is) 2008-05-15
WO1997044356A2 (fr) 1997-11-27
KR100587556B1 (ko) 2006-06-08
CN1232469A (zh) 1999-10-20
IS4884A (is) 1998-11-06
DE69736428T2 (de) 2007-08-30
BG64907B1 (bg) 2006-08-31
NO985231D0 (no) 1998-11-09
AU732392B2 (en) 2001-04-26
KR20050056275A (ko) 2005-06-14
CZ361598A3 (cs) 1999-03-17
DK0914339T3 (da) 2006-12-04
TR199802252T2 (xx) 1999-02-22
DE69736428D1 (de) 2006-09-14
SK286115B6 (sk) 2008-03-05
EP1757617A1 (fr) 2007-02-28
NO985231L (no) 1999-01-08
CN1163509C (zh) 2004-08-25
RO120343B1 (ro) 2005-12-30
NO20065528L (no) 1999-01-08
ES2270465T3 (es) 2007-04-01
BG109433A (en) 2007-08-31
CN1624126A (zh) 2005-06-08
WO1997044356A3 (fr) 1998-02-19
TR200103297T2 (tr) 2002-06-21
EA002544B1 (ru) 2002-06-27
EP0914339A2 (fr) 1999-05-12
SK152498A3 (en) 1999-08-06
PT914339E (pt) 2006-12-29
EP0914339B1 (fr) 2006-08-02
NO323612B1 (no) 2007-06-18
IL126918A0 (en) 1999-09-22
NO324957B1 (no) 2008-01-14

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