EE200200169A - Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid - Google Patents

Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid

Info

Publication number
EE200200169A
EE200200169A EEP200200169A EEP200200169A EE200200169A EE 200200169 A EE200200169 A EE 200200169A EE P200200169 A EEP200200169 A EE P200200169A EE P200200169 A EEP200200169 A EE P200200169A EE 200200169 A EE200200169 A EE 200200169A
Authority
EE
Estonia
Prior art keywords
indolyl
acid derivatives
glyoxylic acid
therapeutically valuable
valuable properties
Prior art date
Application number
EEP200200169A
Other languages
English (en)
Estonian (et)
Inventor
Nickel Bernd
Klenner Thomas
Bacher Gerald
Beckers Thomas
Emig Peter
Engel J�rgen
Bruyneel Erik
Kamp G�nter
Peters Kirsten
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19946301A external-priority patent/DE19946301A1/de
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of EE200200169A publication Critical patent/EE200200169A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EEP200200169A 1999-09-28 2000-09-26 Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid EE200200169A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19946301A DE19946301A1 (de) 1998-04-02 1999-09-28 Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
PCT/EP2000/009390 WO2001022954A2 (fr) 1999-09-28 2000-09-26 Derives d"acide indolyl-3-glyoxyle a bonnes proprietes therapeutiques

Publications (1)

Publication Number Publication Date
EE200200169A true EE200200169A (et) 2003-04-15

Family

ID=7923485

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200169A EE200200169A (et) 1999-09-28 2000-09-26 Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid

Country Status (32)

Country Link
EP (1) EP1218006B1 (fr)
JP (1) JP2003510274A (fr)
KR (1) KR100759242B1 (fr)
CN (1) CN1301712C (fr)
AR (1) AR025885A1 (fr)
AT (1) ATE459356T1 (fr)
AU (1) AU783436B2 (fr)
BG (1) BG106639A (fr)
BR (1) BR0014378A (fr)
CA (1) CA2386069C (fr)
CZ (1) CZ303246B6 (fr)
DE (1) DE50015879D1 (fr)
DZ (1) DZ3196A1 (fr)
EE (1) EE200200169A (fr)
ES (1) ES2342042T3 (fr)
GE (1) GEP20043250B (fr)
HK (1) HK1048941B (fr)
HR (1) HRP20020369A2 (fr)
HU (1) HUP0202788A3 (fr)
IL (2) IL148670A0 (fr)
IS (1) IS6319A (fr)
MX (1) MXPA02002824A (fr)
NO (1) NO322614B1 (fr)
NZ (1) NZ517988A (fr)
PL (1) PL199576B1 (fr)
RS (1) RS51302B (fr)
RU (1) RU2282444C2 (fr)
SK (1) SK287533B6 (fr)
TW (1) TWI269654B (fr)
UA (1) UA75872C2 (fr)
WO (1) WO2001022954A2 (fr)
ZA (1) ZA200202556B (fr)

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DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EP1484329A1 (fr) * 2003-06-06 2004-12-08 Zentaris GmbH Dérivés d'indole déstinés à l'induction d'apoptose
EP1595878A1 (fr) * 2004-05-15 2005-11-16 Zentaris GmbH Derives d'indole destines a l'induction d'apoptose
KR101132599B1 (ko) * 2003-06-05 2012-06-21 아에테르나 젠타리스 게엠베하 아폽토시스 유도 효과를 갖는 인돌 유도체
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
CA2567813C (fr) * 2004-05-23 2015-11-24 Gerard M. Housey Modulateurs de theramuteine
JP2008519036A (ja) * 2004-11-08 2008-06-05 バクスター・インターナショナル・インコーポレイテッド チューブリン阻害化合物のナノ粒子組成物
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
CA2605214C (fr) 2004-12-31 2016-07-12 Reddy Us Therapeutics, Inc. Nouveaux derives de benzylamine en tant qu'inhibiteurs de cetp
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
AU2007325797B2 (en) * 2006-11-28 2014-03-13 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
JP5964965B2 (ja) 2011-08-18 2016-08-03 ドクター レディズ ラボラトリーズ リミテッド コレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての置換複素環式アミン化合物
IN2014CN02290A (fr) 2011-09-27 2015-06-19 Reddys Lab Ltd Dr
WO2014089177A2 (fr) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Composés, conjugués et compositions d'épipolythiodicétopipérazines et de polythiodicétopipérazines
WO2014144715A1 (fr) 2013-03-15 2014-09-18 Memorial Sloan-Kettering Cancer Center Imagerie cardiaque à ciblage hsp90 et traitement associé
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
WO2018209239A1 (fr) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Dérivés d'agélastatine puissants en tant que modulateurs de l'invasion et de la métastase du cancer
CN109111501B (zh) * 2017-06-23 2022-04-22 首都医科大学 脂肪氨基酸修饰的吲哚乙醇衍生物, 其合成，活性和应用
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
WO2020247054A1 (fr) 2019-06-05 2020-12-10 Massachusetts Institute Of Technology Composés, conjugués et compositions d'épipolythiodicétopipérazines et de polythiodicétopipérazines et leurs utilisations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
JP3163631B2 (ja) * 1992-10-20 2001-05-08 東レ株式会社 好酸球浸潤抑制剤
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
WO1998045431A1 (fr) 1997-04-08 1998-10-15 Banyu Pharmaceutical Co., Ltd. Gene associe a la metastase cancereuse
WO1999043654A2 (fr) * 1998-02-25 1999-09-02 Genetics Institute, Inc. Inhibiteurs d'enzymes phospholipases
WO1999046237A1 (fr) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulateurs de proteine-tyrosine-phosphatases
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
ES2262072T3 (es) * 1998-04-28 2006-11-16 Elbion Ag Derivados de indol y su utilizacion como inhibidores de la fosfodiesterasa 4.
JP2000239252A (ja) * 1999-02-16 2000-09-05 Mitsubishi Chemicals Corp インドール誘導体
WO2000067802A1 (fr) * 1999-05-10 2000-11-16 Protarga, Inc. Compositions d'acides gras -n-substituted indol-3-glyoxyl-amide et leur utilisation

Also Published As

Publication number Publication date
PL364811A1 (en) 2004-12-13
CZ303246B6 (cs) 2012-06-20
CA2386069C (fr) 2012-08-14
WO2001022954A3 (fr) 2002-03-28
CN1376064A (zh) 2002-10-23
KR100759242B1 (ko) 2007-09-18
UA75872C2 (en) 2006-06-15
YU22702A (sh) 2004-12-31
ZA200202556B (en) 2003-08-27
GEP20043250B (en) 2004-06-25
BG106639A (bg) 2002-12-29
NO20021367L (no) 2002-05-22
IL148670A (en) 2009-09-01
SK4072002A3 (en) 2003-11-04
MXPA02002824A (es) 2003-07-21
CA2386069A1 (fr) 2001-04-05
PL199576B1 (pl) 2008-10-31
AR025885A1 (es) 2002-12-18
KR20030019295A (ko) 2003-03-06
DZ3196A1 (fr) 2001-04-05
IL148670A0 (en) 2002-09-12
AU7782900A (en) 2001-04-30
HUP0202788A3 (en) 2003-02-28
HK1048941B (zh) 2007-09-21
CZ20021005A3 (cs) 2004-01-14
NO20021367D0 (no) 2002-03-19
BR0014378A (pt) 2003-07-29
DE50015879D1 (de) 2010-04-15
NZ517988A (en) 2004-10-29
NO322614B1 (no) 2006-11-06
TWI269654B (en) 2007-01-01
HK1048941A1 (en) 2003-04-25
WO2001022954A2 (fr) 2001-04-05
CN1301712C (zh) 2007-02-28
IS6319A (is) 2002-03-21
AU783436B2 (en) 2005-10-27
RU2282444C2 (ru) 2006-08-27
ES2342042T3 (es) 2010-07-01
HRP20020369A2 (en) 2004-12-31
SK287533B6 (sk) 2011-01-04
EP1218006B1 (fr) 2010-03-03
RS51302B (sr) 2010-12-31
ATE459356T1 (de) 2010-03-15
EP1218006A2 (fr) 2002-07-03
JP2003510274A (ja) 2003-03-18
HUP0202788A2 (hu) 2003-01-28

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