EE03975B1 - Keratinotsüüdi kasvufaktori analoogid - Google Patents

Keratinotsüüdi kasvufaktori analoogid

Info

Publication number
EE03975B1
EE03975B1 EE9700081A EE9700081A EE03975B1 EE 03975 B1 EE03975 B1 EE 03975B1 EE 9700081 A EE9700081 A EE 9700081A EE 9700081 A EE9700081 A EE 9700081A EE 03975 B1 EE03975 B1 EE 03975B1
Authority
EE
Estonia
Prior art keywords
growth factor
keratinocyte growth
factor analogues
analogues
keratinocyte
Prior art date
Application number
EE9700081A
Other languages
English (en)
Estonian (et)
Other versions
EE9700081A (et
Inventor
F. Morris Charles
C. Kenney William
Chen Bao-Lu
W. Hsu Eric
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of EE9700081A publication Critical patent/EE9700081A/xx
Publication of EE03975B1 publication Critical patent/EE03975B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EE9700081A 1994-10-13 1995-10-12 Keratinotsüüdi kasvufaktori analoogid EE03975B1 (et)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32347594A 1994-10-13 1994-10-13
US32334094A 1994-10-13 1994-10-13
US48782595A 1995-06-07 1995-06-07
PCT/IB1995/000971 WO1996011949A2 (en) 1994-10-13 1995-10-12 Analogs of keratinocyte growth factor

Publications (2)

Publication Number Publication Date
EE9700081A EE9700081A (et) 1997-10-15
EE03975B1 true EE03975B1 (et) 2003-02-17

Family

ID=27406268

Family Applications (2)

Application Number Title Priority Date Filing Date
EE9700081A EE03975B1 (et) 1994-10-13 1995-10-12 Keratinotsüüdi kasvufaktori analoogid
EE9700225A EE9700225A (et) 1994-10-13 1995-10-12 Meetod diabetes mellituse raviks, kasutades KKF

Family Applications After (1)

Application Number Title Priority Date Filing Date
EE9700225A EE9700225A (et) 1994-10-13 1995-10-12 Meetod diabetes mellituse raviks, kasutades KKF

Country Status (23)

Country Link
EP (2) EP0785948B1 (de)
JP (2) JP4216329B2 (de)
KR (1) KR100278597B1 (de)
CN (1) CN1168678A (de)
AT (2) ATE342278T1 (de)
AU (1) AU3707795A (de)
BG (2) BG101392A (de)
BR (2) BR9509269A (de)
CA (2) CA2202075C (de)
CZ (3) CZ297329B6 (de)
DE (2) DE69530403T2 (de)
DK (2) DK0804479T3 (de)
EE (2) EE03975B1 (de)
ES (2) ES2196082T3 (de)
FI (2) FI971420A0 (de)
HU (2) HUT78050A (de)
NO (2) NO971566L (de)
NZ (2) NZ505502A (de)
PL (2) PL182888B1 (de)
PT (2) PT785948E (de)
SI (2) SI0785948T1 (de)
SK (2) SK284534B6 (de)
WO (2) WO1996011949A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2153816T3 (es) 1989-01-31 2001-03-16 Jeffrey S Rubin Adn que codifica un factor de crecimiento especifico contra celulas epiteliales.
US7084119B2 (en) 1993-06-29 2006-08-01 Chiron Corporation Truncated keratinocyte growth factor (KGF) having increased biological activity
KR960703433A (ko) 1993-06-29 1996-08-17 로버트 피. 블랙버언 증가된 생물학적 활성을 갖는 끝이 잘린 케라틴세포성장인자(kgf) (a truncated keratinocyte growth factor(kgf) having increased biological activity)
IL115605A (en) * 1994-10-13 2003-06-24 Amgen Inc Method for purifying keratinocyte growth factors
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
DE69603269T3 (de) * 1995-04-27 2007-02-22 Coöperatie Cosun U.A. Derivate von inulin
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
DK0935652T3 (da) * 1996-10-15 2004-07-26 Amgen Inc Keratinocyt vækstfaktor-2 produkter
EP1473366A1 (de) * 1996-10-15 2004-11-03 Amgen Inc. Produkte des Keratinocyten-Wachstumsfaktors 2
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
ATE375363T1 (de) 1997-07-14 2007-10-15 Bolder Biotechnology Inc Derivate des wachstumshormons und verwandte proteine
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
WO1999032135A1 (en) 1997-12-22 1999-07-01 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6242666B1 (en) * 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
BR122013003013B8 (pt) * 1999-01-14 2021-07-06 Bolder Biotechnology Inc proteína isolada monopeguilada do hormônio do crescimento e método para sua obtenção
US6248725B1 (en) 1999-02-23 2001-06-19 Amgen, Inc. Combinations and methods for promoting in vivo liver cell proliferation and enhancing in vivo liver-directed gene transduction
CA2437270A1 (en) * 2001-02-06 2002-08-15 Merck Patent Gesellschaft Mit Beschraenkter Haftung Modified keratinocyte growth factor (kgf) with reduced immunogenicity
JP2005500390A (ja) 2001-08-21 2005-01-06 カイロン コーポレイション Ｋｇｆポリペプチド組成物
AU2007214362B2 (en) * 2001-08-21 2009-11-26 Novartis Vaccines And Diagnostics, Inc. KGF polypeptide compositions
US8304387B2 (en) 2004-12-15 2012-11-06 Swedish Orphan Biovitrum Ab (Publ) Therapeutic formulations of keratinocyte growth factor
CN102242124B (zh) * 2010-05-10 2013-05-22 齐鲁制药有限公司 改造的角化细胞生长因子基因及其在酵母中的表达
KR102440312B1 (ko) * 2020-08-28 2022-09-05 한국해양과학기술원 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
JPH01137994A (ja) * 1987-08-10 1989-05-30 Shionogi & Co Ltd ｒｅｇ蛋白質
US5145225A (en) * 1988-07-27 1992-09-08 Muller George M Carpet stretcher
ES2153816T3 (es) * 1989-01-31 2001-03-16 Jeffrey S Rubin Adn que codifica un factor de crecimiento especifico contra celulas epiteliales.
JP3303211B2 (ja) * 1991-04-26 2002-07-15 武田薬品工業株式会社 ｂＦＧＦムテインおよびその製造法
JP3578761B2 (ja) * 1993-03-26 2004-10-20 アムジエン・インコーポレーテツド 表皮ケラチン細胞成長因子の治療目的での使用
US5348563A (en) * 1993-06-29 1994-09-20 Honeywell Inc. Air purifying apparatus
KR960703433A (ko) * 1993-06-29 1996-08-17 로버트 피. 블랙버언 증가된 생물학적 활성을 갖는 끝이 잘린 케라틴세포성장인자(kgf) (a truncated keratinocyte growth factor(kgf) having increased biological activity)
GB9315501D0 (en) * 1993-07-27 1993-09-08 Ici Plc Surfactant compositions
AU7475694A (en) * 1993-08-02 1995-02-28 Prizm Pharmaceuticals, Inc. Monogenous preparations of cytotoxic conjugates

Also Published As

Publication number Publication date
SK43197A3 (en) 1999-03-12
CA2201940C (en) 2009-05-12
PL182888B1 (pl) 2002-03-29
FI971420A7 (fi) 1997-04-04
NO971566D0 (no) 1997-04-04
SK45597A3 (en) 1999-02-11
EP0785948A1 (de) 1997-07-30
JP4216329B2 (ja) 2009-01-28
FI971536L (fi) 1997-06-09
WO1996011949A3 (en) 1996-12-12
BG63167B1 (bg) 2001-05-31
CZ297328B6 (cs) 2006-11-15
AU681546B2 (en) 1997-08-28
FI971536A0 (fi) 1997-04-11
AU3708395A (en) 1996-05-06
DE69535264T2 (de) 2007-02-01
JPH10507080A (ja) 1998-07-14
FI120040B (fi) 2009-06-15
BR9509269A (pt) 1997-12-23
BR9509329A (pt) 1997-10-14
SI0785948T1 (en) 2003-08-31
NZ335109A (en) 2000-08-25
CZ297329B6 (cs) 2006-11-15
FI971420L (fi) 1997-04-04
EE9700081A (et) 1997-10-15
HUT78058A (hu) 1999-07-28
ATE237633T1 (de) 2003-05-15
CZ98197A3 (cs) 1998-11-11
NO971568D0 (no) 1997-04-04
CA2202075C (en) 2003-12-09
KR100278597B1 (ko) 2001-01-15
EP0785948B1 (de) 2003-04-16
DK0804479T3 (da) 2007-01-29
DE69530403T2 (de) 2003-10-30
WO1996011949A2 (en) 1996-04-25
PL319784A1 (en) 1997-08-18
EP0804479A1 (de) 1997-11-05
ES2196082T3 (es) 2003-12-16
EE9700225A (et) 1998-02-16
DK0785948T3 (da) 2003-08-04
HUT78050A (hu) 1999-07-28
HU226168B1 (en) 2008-05-28
JP4426646B2 (ja) 2010-03-03
CA2202075A1 (en) 1996-04-25
BG101408A (bg) 1997-12-30
EP0804479B1 (de) 2006-10-11
WO1996011950A1 (en) 1996-04-25
JPH10507193A (ja) 1998-07-14
DE69535264D1 (de) 2006-11-23
AU3707795A (en) 1996-05-06
ATE342278T1 (de) 2006-11-15
PT785948E (pt) 2003-09-30
SK284534B6 (sk) 2005-06-02
NO971568L (no) 1997-06-12
NO318761B1 (no) 2005-05-02
PT804479E (pt) 2007-02-28
FI971420A0 (fi) 1997-04-04
BG101392A (en) 1997-10-31
SI0804479T1 (sl) 2006-12-31
NO971566L (no) 1997-04-14
CA2201940A1 (en) 1996-04-25
ES2273338T3 (es) 2007-05-01
CZ105097A3 (cs) 1998-10-14
PL320484A1 (en) 1997-09-29
NZ505502A (en) 2005-01-28
DE69530403D1 (de) 2003-05-22
CN1168678A (zh) 1997-12-24

Similar Documents

Publication Publication Date Title
EE9700081A (et) Keratinotsüüdi kasvufaktori analoogid
FI973828A0 (fi) Yhdisteitä ja koostumuksia aktiivisten aineiden annostelemiseksi
BG45701A3 (bg) Метод за получаване на алфа-хетероциклично заместени толунитрили
DE69027865D1 (de) ZUSAMMENSETZUNGEN enthaltend omega Conotoxin Peptide Derivate und deren Verwendung ZUR BEHANDLUNG VON ISCHÄMIE-ARTIGEN NEURONALEN SCHÄDIGUNGEN
FI970522L (fi) Koostumukset ja menetelmät pidennetyn paikallisanestesian aikaansaamiseksi
TR200100922T2 (tr) Aktif maddelerin akciğerler yolu ile tatbik edilmesi.
ES2186783T3 (es) Derivados de la dolastatina, su preparacion y uso.
DE3484997D1 (de) Zellstimulierendes mittel.
MY117526A (en) N-(3-benzofuranyl)urea-derivatives
DK0460062T3 (da) Huperzin A-analoger
DE69111768D1 (de) Enzymatische Zusammensetzung zur Bestimmung von Äthanol.
ATE234614T1 (de) Verwendung von selegilin zur behandlung von gehörverlust bei säugetieren
BG100248A (bg) Инхибитори на скваленсинтетаза
UA37217C2 (uk) Аналоги 15-дезоксиспергуаліну, спосіб їх одержання, фармацевтична композиція та проміжні сполуки
DE69734349D1 (de) Behandlung von knochenleiden mit adrenomedullin
DE69824862D1 (de) Zusammenstellungen zur verbesserten wundheilung
ATE204286T1 (de) Modifizierte alpha-d-glcp-(1,2)-alpha-d-glcp-(1, 3)-alpha-d-glcp-analoge
NO984198D0 (no) Fremgangsmåte for behandling av aggresjon
UA43389C2 (uk) Спосіб зниження рівнів кальцію у сироватці
DK0741746T3 (da) Thymosin alpha 1-analoger
GR1001368B (el) Φαρμακευτικοί φορείς.
ECSP961819A (es) Nuevos inhibidores de farnesil-transferasa, su preparacion y las composiciones farmaceuticas que contienen (caso st 95042)
ES2059879T3 (es) Compuestos sn-198c fisiologicamente activos y metodo y bacterias para su produccion.

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

GB1A Change in the ownership or in the address of the owner
KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20111012