EE03566B1 - Kondenseerunud tropaanderivaadid, nende valmistamine ja kasutamine - Google Patents

Kondenseerunud tropaanderivaadid, nende valmistamine ja kasutamine

Info

Publication number
EE03566B1
EE03566B1 EE9800100A EE9800100A EE03566B1 EE 03566 B1 EE03566 B1 EE 03566B1 EE 9800100 A EE9800100 A EE 9800100A EE 9800100 A EE9800100 A EE 9800100A EE 03566 B1 EE03566 B1 EE 03566B1
Authority
EE
Estonia
Prior art keywords
alkyl
alkynyl
alkenyl
aryl
arylalkyl
Prior art date
Application number
EE9800100A
Other languages
English (en)
Estonian (et)
Other versions
EE9800100A (et
Inventor
M. Olsen Gunnar
�stergaard Nielsen Elsebet
Hugo Dahl Bjarne
Helth Jensen Leif
Scheel-Kr�ger J�rgen
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of EE9800100A publication Critical patent/EE9800100A/xx
Publication of EE03566B1 publication Critical patent/EE03566B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Exhaust Gas After Treatment (AREA)
EE9800100A 1995-11-02 1996-11-04 Kondenseerunud tropaanderivaadid, nende valmistamine ja kasutamine EE03566B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK122395 1995-11-02
DK14696 1996-02-13
PCT/EP1996/004793 WO1997016451A1 (en) 1995-11-02 1996-11-04 Fused tropane-derivatives as neurotransmitter reuptake inhibitors

Publications (2)

Publication Number Publication Date
EE9800100A EE9800100A (et) 1998-10-15
EE03566B1 true EE03566B1 (et) 2001-12-17

Family

ID=26063395

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800100A EE03566B1 (et) 1995-11-02 1996-11-04 Kondenseerunud tropaanderivaadid, nende valmistamine ja kasutamine

Country Status (25)

Country Link
US (1) US5998405A (de)
EP (1) EP0858461B1 (de)
JP (1) JP3157839B2 (de)
KR (1) KR100277482B1 (de)
CN (1) CN1060775C (de)
AT (1) ATE224392T1 (de)
AU (1) AU702720B2 (de)
BR (1) BR9611300A (de)
CA (1) CA2236707C (de)
CZ (1) CZ285571B6 (de)
DE (1) DE69623799T2 (de)
DK (1) DK0858461T3 (de)
EE (1) EE03566B1 (de)
HK (1) HK1016984A1 (de)
HU (1) HUP9802534A3 (de)
IL (1) IL123898A (de)
IS (1) IS4708A (de)
NO (1) NO309569B1 (de)
NZ (1) NZ321970A (de)
PL (1) PL184843B1 (de)
RU (1) RU2162469C2 (de)
SK (1) SK282944B6 (de)
TR (1) TR199800780T2 (de)
UA (1) UA47442C2 (de)
WO (1) WO1997016451A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329520B1 (en) 1990-08-09 2001-12-11 Research Triangle Institute Cocaine receptor binding ligands
US6706880B2 (en) 1990-08-09 2004-03-16 Research Triangle Institute Cocaine receptor binding ligands
US6150376A (en) * 1998-08-05 2000-11-21 Georgetown University Bi- and tri-cyclic aza compounds and their uses
ES2191455T3 (es) 1998-08-18 2003-09-01 Ucb Sa Agonistas y antagonistas muscarinicos.
US6982271B1 (en) 1999-09-27 2006-01-03 Georgetown University Tropane analogs
US6479509B1 (en) 2000-05-22 2002-11-12 Research Triangle Institute Method of promoting smoking cessation
AU2001265820A1 (en) * 2000-07-04 2002-01-14 Neurosearch A/S Steric isomers of fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
MXPA03009185A (es) 2001-04-09 2004-02-17 Neurosearch As Antagonistas de receptor a2a de adenosina combinados con compuestos de actividad neurotrofica en el tratamiento de la enfermedad de parkinson.
WO2002094827A1 (en) * 2001-05-23 2002-11-28 Neurosearch A/S Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AR035898A1 (es) 2001-05-25 2004-07-21 Wyeth Corp Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
ATE345135T1 (de) * 2001-11-30 2006-12-15 Neurosearch As Tropan-derivate mit dopamin-wiederaufnahme-hemmer-wirkung für die behandlung von ischämischen erkrankungen
DK1594868T3 (da) 2003-02-12 2010-03-15 Neurosearch As 8-aza-bicyclo[3.2.1]octanderivater og anvendelse deraf som monoamin-neurotransmitter-genoptagelsesinhibitorer
NZ541248A (en) 2003-02-12 2008-04-30 Neurosearch As Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20090137625A1 (en) 2005-04-08 2009-05-28 Dan Peters Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
JP2008546826A (ja) * 2005-06-28 2008-12-25 ノイロサーチ アクティーゼルスカブ 新規な３，９−ジアザ−スピロ［５．５］ウンデカン誘導体及びモノアミン神経伝達物質再取り込み阻害剤としてのこれらの使用
ATE481386T1 (de) 2005-06-28 2010-10-15 Neurosearch As Neue 3-aza-spiroä5.5üundec-8-en derivate und deren verwendung als inhibitoren der wiederaufnahme von monoaminneurotransmittern
TW200800980A (en) 2006-02-17 2008-01-01 Neurosearch As Novel compounds
RU2011143972A (ru) 2009-05-15 2013-06-20 НьюроСёрч А/С Производные хромен-2-она и их применение в качестве ингибиторов обратного захвата моноаминовых нейромедиаторов
MX2011014019A (es) * 2009-06-19 2012-02-22 Abbott Lab Derivados de diazahomoadamantano y sus metodos de uso.
US20120220604A1 (en) 2009-09-21 2012-08-30 Neurosearch A/S Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20130040985A1 (en) 2010-01-29 2013-02-14 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en) 2010-03-25 2011-09-29 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
WO2012000881A1 (en) 2010-07-02 2012-01-05 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP6052524B1 (ja) * 2015-07-30 2016-12-27 秋夫 湯田 持ち運び設置が容易な手提げハンドルの付いた薪ストーブ。
TW202409027A (zh) 2022-07-08 2024-03-01 丹麥商創始人製藥股份有限公司 用於女性性功能障礙的治療之化合物
WO2024089247A1 (en) 2022-10-28 2024-05-02 Initiator Pharma A/S Compound for treatment of pain
WO2024146892A1 (en) 2023-01-03 2024-07-11 Initiator Pharma A/S Compound for treatment of erectile dysfunction

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
US5736556A (en) * 1994-04-19 1998-04-07 Neurosearch A/S Tropane-2-aldoxime derivatives as nevro transmitter reuptake inhibitors

Also Published As

Publication number Publication date
CN1201461A (zh) 1998-12-09
MX9803554A (es) 1998-09-30
EP0858461B1 (de) 2002-09-18
ATE224392T1 (de) 2002-10-15
PL184843B1 (pl) 2002-12-31
NO981609L (no) 1998-06-26
BR9611300A (pt) 1999-06-15
EE9800100A (et) 1998-10-15
DE69623799D1 (de) 2002-10-24
CA2236707A1 (en) 1997-05-09
CN1060775C (zh) 2001-01-17
US5998405A (en) 1999-12-07
JP3157839B2 (ja) 2001-04-16
HUP9802534A2 (hu) 1999-04-28
SK42298A3 (en) 1998-10-07
AU7563196A (en) 1997-05-22
KR19990064111A (ko) 1999-07-26
UA47442C2 (uk) 2002-07-15
CZ113898A3 (cs) 1998-07-15
IL123898A0 (en) 1998-10-30
WO1997016451A1 (en) 1997-05-09
EP0858461A1 (de) 1998-08-19
AU702720B2 (en) 1999-03-04
KR100277482B1 (ko) 2001-01-15
CZ285571B6 (cs) 1999-09-15
SK282944B6 (sk) 2003-01-09
CA2236707C (en) 2002-08-06
NO309569B1 (no) 2001-02-19
HUP9802534A3 (en) 1999-06-28
HK1016984A1 (en) 1999-11-12
TR199800780T2 (xx) 1998-07-21
IS4708A (is) 1998-03-31
DK0858461T3 (da) 2003-01-27
NO981609D0 (no) 1998-04-07
JPH11514638A (ja) 1999-12-14
DE69623799T2 (de) 2003-01-30
NZ321970A (en) 2000-02-28
IL123898A (en) 2001-08-08
RU2162469C2 (ru) 2001-01-27
PL326448A1 (en) 1998-09-28

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

MM4A Lapsed by not paying the annual fees

Effective date: 20031104