ECSP003508A - Formas polimorfas de un citrato de azobiciclo [2.2.2] octan-3-amina y sus composiciones farmaceuticas - Google Patents

Formas polimorfas de un citrato de azobiciclo [2.2.2] octan-3-amina y sus composiciones farmaceuticas

Info

Publication number
ECSP003508A
ECSP003508A EC2000003508A ECSP003508A ECSP003508A EC SP003508 A ECSP003508 A EC SP003508A EC 2000003508 A EC2000003508 A EC 2000003508A EC SP003508 A ECSP003508 A EC SP003508A EC SP003508 A ECSP003508 A EC SP003508A
Authority
EC
Ecuador
Prior art keywords
citrate
octan
azobiciclo
amina
pharmaceutical compositions
Prior art date
Application number
EC2000003508A
Other languages
English (en)
Inventor
George Joseph Quallich
Lewin Theophilus Wint
Michael James Castaldi
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ECSP003508A publication Critical patent/ECSP003508A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Una forma polimorfa cristalina individual del citrato de (2S,3S) -(metoxi-5-t-buti!fenilmetil-2-difenilmetil-I-azobiciclo[2,2,2) octan-3-amina (citrato monohidrato) y su composición farmacéutica. La composición farmacéutica de la forma polimorfa si el citrato monohidrato tiene la estabilidad necesaria para una formulación para tratar la emesis. La administración de esta composición farmacéutica es una forma de dosificación oral de liberación inmediata, preferiblemente en forma de comprimido o cápsula, o intravenosa.
EC2000003508A 1999-06-01 2000-06-01 Formas polimorfas de un citrato de azobiciclo [2.2.2] octan-3-amina y sus composiciones farmaceuticas ECSP003508A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13699299P 1999-06-01 1999-06-01

Publications (1)

Publication Number Publication Date
ECSP003508A true ECSP003508A (es) 2002-02-25

Family

ID=22475338

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2000003508A ECSP003508A (es) 1999-06-01 2000-06-01 Formas polimorfas de un citrato de azobiciclo [2.2.2] octan-3-amina y sus composiciones farmaceuticas

Country Status (48)

Country Link
US (1) US6255320B1 (es)
EP (1) EP1181290B1 (es)
JP (1) JP3830816B2 (es)
KR (1) KR100476606B1 (es)
CN (1) CN1146565C (es)
AP (1) AP2001002349A0 (es)
AR (1) AR033331A1 (es)
AT (1) ATE244239T1 (es)
AU (1) AU767334B2 (es)
BG (1) BG65240B1 (es)
BR (1) BR0011094A (es)
CA (1) CA2372238C (es)
CO (1) CO5170463A1 (es)
CY (1) CY2007011I2 (es)
CZ (1) CZ295819B6 (es)
DE (1) DE60003679T2 (es)
DK (1) DK1181290T3 (es)
DZ (1) DZ3050A1 (es)
EA (1) EA003731B1 (es)
EC (1) ECSP003508A (es)
EE (1) EE200100656A (es)
ES (1) ES2199825T3 (es)
GT (1) GT200000087A (es)
HN (1) HN2000000077A (es)
HR (1) HRP20010904A2 (es)
HU (1) HUP0201301A3 (es)
IL (1) IL146406A0 (es)
MA (1) MA26742A1 (es)
MX (1) MXPA01012325A (es)
MY (1) MY133508A (es)
NO (1) NO20015848L (es)
NZ (1) NZ515349A (es)
OA (1) OA11956A (es)
PA (1) PA8496101A1 (es)
PE (1) PE20010209A1 (es)
PL (1) PL196046B1 (es)
PT (1) PT1181290E (es)
SI (1) SI1181290T1 (es)
SK (1) SK285820B6 (es)
SV (1) SV2001000093A (es)
TN (1) TNSN00120A1 (es)
TR (1) TR200103473T2 (es)
TW (1) TWI285204B (es)
UA (1) UA66925C2 (es)
UY (1) UY26176A1 (es)
WO (1) WO2000073304A1 (es)
YU (1) YU81101A (es)
ZA (1) ZA200109775B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2554823A1 (en) 2004-01-30 2005-09-09 Pfizer Products Inc. Nk-1 receptor antagonists to improve anesthesia recovery
EP1713506A1 (en) * 2004-01-30 2006-10-25 Pfizer Products Incorporated Pharmaceutical compositions of neurokinin receptor antagonists and cyclodextrin and methods for improved injection site toleration
LT1713504T (lt) * 2004-01-30 2017-09-11 Zoetis Services Llc Antimikrobinis konservantas, skirtas multi-dozinėms kompozicijoms, panaudojant beta-ciklodekstrinus, skirtas skystoms vaisto formoms
SI1713801T1 (sl) * 2004-02-02 2008-04-30 Pfizer Prod Inc Postopek priprave 1-(2S,3S)-2-benzhidril-N-(5-terc-butil-2-metoksibenzil)kinuklidin-3- amina
KR102391332B1 (ko) * 2013-03-15 2022-04-26 펄 테라퓨틱스 인코포레이티드 미립자 결정질 재료를 컨디셔닝하는 방법 및 시스템
CN110577522B (zh) * 2018-06-07 2022-12-27 东莞市东阳光动物保健药品有限公司 马罗匹坦柠檬酸盐新晶型及其制备方法
CN112979639B (zh) * 2019-12-16 2025-08-08 凯默斯医药科技(上海)有限公司 一种马罗皮坦新晶型及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU657552B2 (en) * 1991-05-31 1995-03-16 Pfizer Inc. Quinuclidine as substance P antagonists
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
US5576317A (en) * 1994-12-09 1996-11-19 Pfizer Inc. NK-1 receptor antagonists and 5HT3 receptor antagonists for the treatment of emesis

Also Published As

Publication number Publication date
AP2001002349A0 (en) 2001-12-31
KR20020010688A (ko) 2002-02-04
PE20010209A1 (es) 2001-03-01
AR033331A1 (es) 2003-12-17
EA200101108A1 (ru) 2002-04-25
JP3830816B2 (ja) 2006-10-11
EP1181290B1 (en) 2003-07-02
MA26742A1 (fr) 2004-12-20
PT1181290E (pt) 2003-09-30
AU767334B2 (en) 2003-11-06
NO20015848L (no) 2001-12-18
UY26176A1 (es) 2000-12-29
CZ295819B6 (cs) 2005-11-16
MXPA01012325A (es) 2002-07-22
PL196046B1 (pl) 2007-11-30
NO20015848D0 (no) 2001-11-30
HN2000000077A (es) 2001-02-02
NZ515349A (en) 2004-03-26
CN1353711A (zh) 2002-06-12
HUP0201301A2 (en) 2002-08-28
EE200100656A (et) 2003-02-17
HK1046284A1 (en) 2003-01-03
KR100476606B1 (ko) 2005-03-18
DZ3050A1 (fr) 2004-03-27
BG65240B1 (bg) 2007-09-28
CZ20014269A3 (cs) 2002-04-17
PL352716A1 (en) 2003-09-08
ZA200109775B (en) 2002-11-28
DE60003679T2 (de) 2004-05-27
UA66925C2 (uk) 2004-06-15
SK285820B6 (sk) 2007-09-06
EA003731B1 (ru) 2003-08-28
SI1181290T1 (en) 2003-12-31
ATE244239T1 (de) 2003-07-15
OA11956A (en) 2006-04-13
PA8496101A1 (es) 2002-07-30
IL146406A0 (en) 2002-07-25
ES2199825T3 (es) 2004-03-01
TR200103473T2 (tr) 2002-04-22
TNSN00120A1 (fr) 2005-11-10
CY2007011I1 (el) 2010-07-28
HRP20010904A2 (en) 2003-02-28
DK1181290T3 (da) 2003-09-29
MY133508A (en) 2007-11-30
BR0011094A (pt) 2002-03-19
SV2001000093A (es) 2001-11-08
WO2000073304A1 (en) 2000-12-07
TWI285204B (en) 2007-08-11
YU81101A (sh) 2004-07-15
CN1146565C (zh) 2004-04-21
CA2372238A1 (en) 2000-12-07
GT200000087A (es) 2001-11-22
DE60003679D1 (de) 2003-08-07
EP1181290A1 (en) 2002-02-27
SK17332001A3 (sk) 2002-07-02
US6255320B1 (en) 2001-07-03
CA2372238C (en) 2006-12-19
AU4424800A (en) 2000-12-18
CY2007011I2 (el) 2010-07-28
JP2003501354A (ja) 2003-01-14
CO5170463A1 (es) 2002-06-27
HUP0201301A3 (en) 2002-10-28
BG106204A (en) 2002-07-31

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