EA202190046A1 - N-замещенные производные тетрагидротиенопиридина и их применение - Google Patents
N-замещенные производные тетрагидротиенопиридина и их применениеInfo
- Publication number
- EA202190046A1 EA202190046A1 EA202190046A EA202190046A EA202190046A1 EA 202190046 A1 EA202190046 A1 EA 202190046A1 EA 202190046 A EA202190046 A EA 202190046A EA 202190046 A EA202190046 A EA 202190046A EA 202190046 A1 EA202190046 A1 EA 202190046A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- application
- substituted
- tetrahydrothienopyridine derivatives
- derivatives
- substituted tetrahydrothienopyridine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862687068P | 2018-06-19 | 2018-06-19 | |
| PCT/IB2019/055121 WO2019244047A1 (en) | 2018-06-19 | 2019-06-18 | N-substituted tetrahydrothienopyridine derivatives and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202190046A1 true EA202190046A1 (ru) | 2021-03-24 |
Family
ID=67841114
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202190046A EA202190046A1 (ru) | 2018-06-19 | 2019-06-18 | N-замещенные производные тетрагидротиенопиридина и их применение |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US12012417B2 (enExample) |
| EP (2) | EP4169925B1 (enExample) |
| JP (1) | JP7328260B2 (enExample) |
| KR (1) | KR102835904B1 (enExample) |
| CN (1) | CN112313237A (enExample) |
| AU (1) | AU2019291488B2 (enExample) |
| BR (1) | BR112020025696A2 (enExample) |
| CA (1) | CA3100957A1 (enExample) |
| CL (1) | CL2020003248A1 (enExample) |
| CR (1) | CR20200618A (enExample) |
| CU (1) | CU20200100A7 (enExample) |
| EA (1) | EA202190046A1 (enExample) |
| EC (1) | ECSP20080995A (enExample) |
| ES (2) | ES3062606T3 (enExample) |
| IL (1) | IL279441B2 (enExample) |
| JO (1) | JOP20200326A1 (enExample) |
| MA (1) | MA52976A (enExample) |
| MX (1) | MX2020013852A (enExample) |
| MY (1) | MY201990A (enExample) |
| PE (1) | PE20210097A1 (enExample) |
| PH (1) | PH12020552185A1 (enExample) |
| SA (1) | SA520420809B1 (enExample) |
| SG (1) | SG11202012625PA (enExample) |
| WO (1) | WO2019244047A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110945002B (zh) * | 2017-08-01 | 2021-12-24 | 正大天晴药业集团股份有限公司 | 作为RORγ抑制剂的双环化合物 |
| AU2019291488B2 (en) | 2018-06-19 | 2022-02-24 | Novartis Ag | N-substituted tetrahydrothienopyridine derivatives and uses thereof |
| USD1006154S1 (en) * | 2023-06-27 | 2023-11-28 | Qiongfang Mao | Cable crossover attachment |
| WO2025238553A1 (en) | 2024-05-14 | 2025-11-20 | Novartis Ag | Dosing regimens for n-(3-cyano-5-(cyclohexylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)-2-(4-sulfamoylphenyl)acetamide for use in treating or preventing a dengue virus disease or disorder |
| WO2025253267A1 (en) | 2024-06-06 | 2025-12-11 | Janssen Pharmaceuticals, Inc. | Combination of mosnodenvir and close analogs with nitd-688 for use in the treatment and prevention of dengue disease |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5807A (en) | 1848-09-26 | Brake fob cabs | ||
| US4656A (en) | 1846-07-24 | Improvement in potato-plows | ||
| US6344A (en) | 1849-04-17 | Driving-bobbin | ||
| US54472A (en) | 1866-05-01 | Improved blacking-brush | ||
| US498178A (en) | 1893-05-23 | William valentine leonard | ||
| US8766A (en) | 1852-02-24 | Appabatus for lightening vessels | ||
| US5807876A (en) | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| US6054472A (en) | 1996-04-23 | 2000-04-25 | Vertex Pharmaceuticals, Incorporated | Inhibitors of IMPDH enzyme |
| HUP0004421A3 (en) | 1996-04-23 | 2002-10-28 | Vertex Pharmaceuticals Inc Cam | Urea derivatives and pharmaceutical compositions containing them, use thereof for the treatment of deseases mediated by impdh enzyme |
| EP0966465B1 (en) | 1997-03-14 | 2003-07-09 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
| AP1498A (en) | 1999-03-19 | 2005-11-21 | Vertex Pharma | Inhibitors of impdh enzyme. |
| GB0114185D0 (en) | 2001-06-12 | 2001-08-01 | Protherics Molecular Design Lt | Compounds |
| CN1288974C (zh) | 2001-05-21 | 2006-12-13 | 孟山都技术公司 | 含有醚胺表面活性剂的农药浓缩物 |
| US20030232994A1 (en) | 2001-10-04 | 2003-12-18 | Shao-Po Lu | Bicyclic thiophene derivatives and combinatorial libraries thereof |
| CA2498399A1 (en) | 2002-09-12 | 2004-03-25 | Merck & Co., Inc. | Method of treating diabetes and related conditions |
| US7138529B2 (en) * | 2003-04-16 | 2006-11-21 | Hoffmann-La Roche Inc. | Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists |
| GB0324653D0 (en) | 2003-10-22 | 2003-11-26 | Syngenta Participations Ag | Fungicides |
| DK1753512T3 (da) | 2004-05-28 | 2008-11-17 | 4Sc Ag | Tetrahydropyridothiophener |
| AU2005272646A1 (en) | 2004-08-12 | 2006-02-23 | Wyeth | Combination therapy for diabetes, obesity, and cardiovascular diseases using GDF-8 inhibitors |
| AU2006212224A1 (en) | 2005-02-09 | 2006-08-17 | 4Sc Ag | Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer |
| AU2006212179A1 (en) | 2005-02-11 | 2006-08-17 | 4Sc Ag | Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer |
| WO2006119646A1 (en) | 2005-05-13 | 2006-11-16 | Virochem Pharma Inc. | Compounds and methods for the treatment or prevention of flavivirus infections |
| CA2609003A1 (en) | 2005-05-25 | 2006-11-30 | Nycomed Gmbh | Tetrahydropyridothiophenes for use in the treatment of cancer |
| EP1893618A2 (en) | 2005-05-25 | 2008-03-05 | Nycomed GmbH | Tetrahydropyridothiophenes for use in the treatment of cancer |
| US7932391B2 (en) | 2005-09-08 | 2011-04-26 | Zhejiang Hauhai Pharmaceutical Co., Ltd. | Method for the preparation of clopidogrel and its analogues of methyl-tetrahydrothieno[3,2-C]pyridine acetate |
| WO2008020045A1 (en) | 2006-08-16 | 2008-02-21 | 4Sc Ag | Tetrahydrobenzothiophene derivatives |
| JP2010500395A (ja) | 2006-08-16 | 2010-01-07 | ４エスツェー アクチェンゲゼルシャフト | 癌治療のためのテトラヒドロピリドチオフェン誘導体 |
| AU2007325315A1 (en) | 2006-11-28 | 2008-06-05 | Kalypsys Inc | Heterocyclic modulators of TGR5 |
| WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| CN104856991A (zh) * | 2009-02-27 | 2015-08-26 | 西佳技术公司 | 用于治疗和预防登革热病毒感染的噻吩并吡啶衍生物 |
| US20130129677A1 (en) * | 2009-02-27 | 2013-05-23 | Siga Technologies, Inc. | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections |
| JP5701655B2 (ja) * | 2011-03-29 | 2015-04-15 | 奈良県 | 植物精油中のトロポロン類及び／又はフェノール類の金属錯体化方法 |
| JP2014528412A (ja) | 2011-09-30 | 2014-10-27 | キネタ・インコーポレイテツド | 抗ウイルス化合物 |
| CA3030582A1 (en) | 2015-07-22 | 2017-01-26 | The Royal Institution For The Advancement Of Learning/Mcgill University | Compounds and uses thereof in the treatment of cancers and other medical conditions |
| CN108689987A (zh) | 2017-04-05 | 2018-10-23 | 浙江海正药业股份有限公司 | 一种磺胺类衍生物及其制备方法和用途 |
| UA125970C2 (uk) | 2017-05-22 | 2022-07-20 | Янссен Фармасьютікалз, Інк. | Заміщені похідні індоліну як інгібітори реплікації вірусів денге |
| CN110945002B (zh) | 2017-08-01 | 2021-12-24 | 正大天晴药业集团股份有限公司 | 作为RORγ抑制剂的双环化合物 |
| CN108191885B (zh) | 2018-01-29 | 2020-08-04 | 华东师范大学 | 一类哌啶并噻吩类小分子有机化合物及其应用 |
| AU2019291488B2 (en) | 2018-06-19 | 2022-02-24 | Novartis Ag | N-substituted tetrahydrothienopyridine derivatives and uses thereof |
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2019
- 2019-06-18 AU AU2019291488A patent/AU2019291488B2/en active Active
- 2019-06-18 ES ES22207844T patent/ES3062606T3/es active Active
- 2019-06-18 KR KR1020217001077A patent/KR102835904B1/ko active Active
- 2019-06-18 MA MA052976A patent/MA52976A/fr unknown
- 2019-06-18 MX MX2020013852A patent/MX2020013852A/es unknown
- 2019-06-18 CN CN201980040348.4A patent/CN112313237A/zh active Pending
- 2019-06-18 EP EP22207844.6A patent/EP4169925B1/en active Active
- 2019-06-18 JO JOP/2020/0326A patent/JOP20200326A1/ar unknown
- 2019-06-18 CA CA3100957A patent/CA3100957A1/en active Pending
- 2019-06-18 CR CR20200618A patent/CR20200618A/es unknown
- 2019-06-18 PE PE2020002060A patent/PE20210097A1/es unknown
- 2019-06-18 EP EP19762467.9A patent/EP3810613B1/en active Active
- 2019-06-18 JP JP2020570065A patent/JP7328260B2/ja active Active
- 2019-06-18 ES ES19762467T patent/ES2941946T3/es active Active
- 2019-06-18 WO PCT/IB2019/055121 patent/WO2019244047A1/en not_active Ceased
- 2019-06-18 CU CU2020000100A patent/CU20200100A7/es unknown
- 2019-06-18 IL IL279441A patent/IL279441B2/en unknown
- 2019-06-18 EA EA202190046A patent/EA202190046A1/ru unknown
- 2019-06-18 BR BR112020025696-0A patent/BR112020025696A2/pt unknown
- 2019-06-18 MY MYPI2020006010A patent/MY201990A/en unknown
- 2019-06-18 SG SG11202012625PA patent/SG11202012625PA/en unknown
- 2019-06-18 US US17/253,755 patent/US12012417B2/en active Active
-
2020
- 2020-12-15 SA SA520420809A patent/SA520420809B1/ar unknown
- 2020-12-15 CL CL2020003248A patent/CL2020003248A1/es unknown
- 2020-12-15 EC ECSENADI202080995A patent/ECSP20080995A/es unknown
- 2020-12-16 PH PH12020552185A patent/PH12020552185A1/en unknown
-
2024
- 2024-05-07 US US18/657,123 patent/US12331060B2/en active Active
-
2025
- 2025-05-09 US US19/204,147 patent/US20260070920A1/en active Pending
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