EA202091160A1 - Композиции из фрагментов белков шелка и изделия, изготовленные из них - Google Patents

Композиции из фрагментов белков шелка и изделия, изготовленные из них

Info

Publication number
EA202091160A1
EA202091160A1 EA202091160A EA202091160A EA202091160A1 EA 202091160 A1 EA202091160 A1 EA 202091160A1 EA 202091160 A EA202091160 A EA 202091160A EA 202091160 A EA202091160 A EA 202091160A EA 202091160 A1 EA202091160 A1 EA 202091160A1
Authority
EA
Eurasian Patent Office
Prior art keywords
composition
fragments
compositions
products made
silk proteins
Prior art date
Application number
EA202091160A
Other languages
English (en)
Inventor
Грегори Х. Алтман
Ребекка Л. Хоран
Рейчел Ли Дау
Рейчел М. Линд
Дилан С. Хаас
Original Assignee
Силк Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Силк Терапьютикс, Инк. filed Critical Силк Терапьютикс, Инк.
Publication of EA202091160A1 publication Critical patent/EA202091160A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D33/00—Containers or accessories specially adapted for handling powdery toiletry or cosmetic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/70—Biological properties of the composition as a whole
    • A61K2800/72—Hypo-allergenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant

Abstract

Описана композиция, содержащая белковые фрагменты на основе чистого фиброина шелка, в основном свободные от серицина, где композиция обладает средней среднемассовой молекулярной массой в диапазоне от приблизительно 17 до приблизительно 38 кДа, где композиция обладает полидисперсностью между приблизительно 1,5 и приблизительно 3,0, где композиция является по существу гомогенной, где композиция содержит между 0 и приблизительно 500 м.д. неорганических остатков и где композиция содержит между 0 и приблизительно 500 м.д. органических остатков.
EA202091160A 2013-09-30 2014-09-30 Композиции из фрагментов белков шелка и изделия, изготовленные из них EA202091160A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361884820P 2013-09-30 2013-09-30
US201462000928P 2014-05-20 2014-05-20
US201462036450P 2014-08-12 2014-08-12
US14/503,076 US10166177B2 (en) 2013-09-30 2014-09-30 Silk protein fragment compositions and articles manufactured therefrom

Publications (1)

Publication Number Publication Date
EA202091160A1 true EA202091160A1 (ru) 2020-11-30

Family

ID=52740380

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202091160A EA202091160A1 (ru) 2013-09-30 2014-09-30 Композиции из фрагментов белков шелка и изделия, изготовленные из них
EA201690712A EA036027B1 (ru) 2013-09-30 2014-09-30 Композиция из фрагментов белков шелка (варианты) и изделия, изготовленные из них

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201690712A EA036027B1 (ru) 2013-09-30 2014-09-30 Композиция из фрагментов белков шелка (варианты) и изделия, изготовленные из них

Country Status (14)

Country Link
US (17) US10166177B2 (ru)
EP (1) EP3052203A4 (ru)
JP (4) JP6775751B2 (ru)
KR (3) KR102379848B1 (ru)
CN (2) CN113274307B (ru)
AU (3) AU2014324412B2 (ru)
BR (1) BR112016006898A8 (ru)
CA (2) CA2925820C (ru)
EA (2) EA202091160A1 (ru)
IL (3) IL300992A (ru)
MX (1) MX2016003961A (ru)
NZ (1) NZ719165A (ru)
SG (2) SG10201907426UA (ru)
WO (1) WO2015048805A1 (ru)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016006898A8 (pt) 2013-09-30 2020-02-18 Silk Therapeutics Inc composição, filmes, método de redução de linhas finas e rugas, géis, método de suavização e rejuvenescimento da pele humana, soro, método de hidratação da pele humana, composição de descamação da pele e método para a preparação de uma solução
EP3182985B1 (en) 2014-08-20 2020-01-08 Silk Technologies Ltd. Fibroin-derived protein composition
EP3226835A4 (en) 2014-12-02 2018-09-26 Silk Therapeutics, Inc. Silk performance apparel and products and methods of preparing the same
US11260012B2 (en) * 2015-01-12 2022-03-01 Evolved By Nature, Inc. Preserved silk protein fragment compositions and articles manufactured therefrom
JP7290912B2 (ja) * 2015-04-29 2023-06-14 エボルブド バイ ネイチャー， インコーポレイテッド 絹ベース湿潤剤組成物、及びその方法
EP3322434A4 (en) 2015-07-14 2019-01-09 Silk Therapeutics Inc. SILK FUNCTIONAL CLOTHING AND PRODUCTS AND METHOD OF MANUFACTURING THEM
CN109640694A (zh) 2016-04-08 2019-04-16 康奈尔大学 使用丝衍生蛋白质增强伤口愈合的方法
SG11201901137UA (en) 2016-08-12 2019-03-28 Silk Technologies Ltd Silk-derived protein for treating inflammation
WO2018081815A2 (en) 2016-10-31 2018-05-03 Sofregen Medical, Inc. Compositions comprising silk fibroin particles and uses thereof
SG11201913229PA (en) 2017-06-26 2020-01-30 Evolved By Nature Inc Silk-hyaluronic acid based tissue fillers and methods of using the same
US20230190997A1 (en) 2017-06-26 2023-06-22 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same
CN107417471A (zh) * 2017-09-06 2017-12-01 汪建利 肥料省一半、作物不减产的土壤肥力激活剂及其制备方法
CN111712514A (zh) 2017-09-27 2020-09-25 自然进化公司 丝涂布织物和产品及其制备方法
WO2019094702A1 (en) 2017-11-10 2019-05-16 Cocoon Biotech Inc. Ocular applications of silk-based products
CN108546290B (zh) * 2018-03-27 2021-07-27 宜州市壮之都丝绸家纺有限公司 一种蚕丝的提取方法
AU2019307930A1 (en) 2018-07-18 2021-02-25 Evolved By Nature, Inc. Silk coated leather and products and methods of preparing the same
TWI691531B (zh) * 2019-02-11 2020-04-21 南臺學校財團法人南臺科技大學 蠶絲蛋白膜的製造方法
US20220401335A1 (en) * 2019-04-16 2022-12-22 Evolved By Nature, Inc. Silk hair care compositions
EP3968906A4 (en) * 2019-05-13 2022-12-07 E. Aubrey Woodroof IMPROVED SURFACE ADHESION, EXTENSIBILITY AND RELIABILITY FOR SURFACE
CA3140673A1 (en) * 2019-06-06 2020-12-10 Evolved By Nature, Inc. Silk stimulated collagen production and methods of use thereof
WO2021035087A1 (en) * 2019-08-20 2021-02-25 Evolved By Nature, Inc. Silk personal care compositions
US11707497B2 (en) 2019-10-09 2023-07-25 Brain Health Holding Llc Methods and compositions with purified Bombyx mori cocoon silk peptide fiber and refined Buglossoides arvensis seed oil providing anti-inflammatory effects and neuroprotection for disease states
CA3153891A1 (en) 2019-10-09 2021-04-15 Gregory CUMBERFORD Compositions with purified bombyx mori cocoon silk peptide fiber and refined buglossoides arvensis seed oil, and related methods
WO2021076798A1 (en) 2019-10-15 2021-04-22 Sofregen Medical, Inc. Delivery devices for delivering and methods of delivering compositions
CN114213517A (zh) * 2021-02-08 2022-03-22 复向丝泰医疗科技(苏州)有限公司 利用切向流超滤技术制备可控高浓度丝素蛋白溶液的方法
WO2022197871A1 (en) * 2021-03-16 2022-09-22 Evolved By Nature, Inc. Silk coated synthetic fabrics
US11585016B2 (en) 2021-05-21 2023-02-21 Cambridge Crops, Inc. Systems and methods for manufacturing a silk fibroin solution and powders containing silk fibroin
US11864569B2 (en) 2021-08-16 2024-01-09 Cambridge Crops, Inc. Systems and methods for improving the performance of cereal using a silk fibroin solution and powders containing silk fibroin
WO2023081711A1 (en) 2021-11-02 2023-05-11 Bolt Threads, Inc. Cosmetic and personal care compositions comprising recombinant silk
WO2023215264A1 (en) * 2022-05-02 2023-11-09 Cocoon Biotech Inc. Methods for reducing impurities in silk fibroin preparations

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US445875A (en) 1891-02-03 Burial apparatus
US64499A (en) 1867-05-07 Improved apparatus foe extracting oil from herbs, and for other purposes
US26501A (en) 1859-12-20 Gbaving-dock
US687221A (en) 1901-09-25 1901-11-26 Thomas T Gaff Grits and the art or process of making same.
KR940011689B1 (ko) * 1992-07-02 1994-12-23 재단법인 한국전자통신연구소 온도보상용 유전체 자기 조성물
JPH0767686A (ja) * 1993-09-06 1995-03-14 Shinano Kenshi Co Ltd 低分子量の絹フィブロインペプチドの製造方法
AU2022599A (en) 1997-12-31 1999-07-19 Kimberly-Clark Worldwide, Inc. Method of reducing molecular weights and polydispersity indices of polymers of ethylene oxide
US5902932A (en) 1998-01-09 1999-05-11 Granville-Phillips Company Force balancing capacitance manometer
US7410489B2 (en) 1998-09-28 2008-08-12 Daos Limited Internal cord fixation device
JP2000143472A (ja) * 1998-11-10 2000-05-23 Hiroshi Akai 紫外線吸収機能を有する化粧剤
JP2001163899A (ja) 1999-12-09 2001-06-19 Natl Inst Of Sericultural & Entomological Science 機能性絹フィブロインの製造方法とその利用
JP3256210B2 (ja) * 2000-01-18 2002-02-12 百樹 中川 繊維処理剤及び繊維の処理方法
WO2001066018A1 (en) 2000-03-03 2001-09-13 C. R. Bard, Inc. Endoscopic tissue apposition device with multiple suction ports
US20030220646A1 (en) 2002-05-23 2003-11-27 Thelen Sarah L. Method and apparatus for reducing femoral fractures
US6712830B2 (en) 2000-03-15 2004-03-30 Esplin Medical Inventions, L.L.C. Soft tissue anchor
EP1294414B1 (en) 2000-06-29 2006-03-15 Biosyntech Canada Inc. Composition and method for the repair and regeneration of cartilage and other tissues
US20030206897A1 (en) * 2000-09-13 2003-11-06 The Procter & Gamble Company Cosmetic compositions
US6565564B2 (en) 2000-12-14 2003-05-20 Synthes U.S.A. Multi-pin clamp and rod attachment
US6558344B2 (en) 2001-02-09 2003-05-06 Westmed, Inc. Wound irrigation device
US7713306B2 (en) 2001-02-23 2010-05-11 Biomet Manufacturing Corp. Method and apparatus for acetabular reconstruction
US7597715B2 (en) 2005-04-21 2009-10-06 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
CA2405850A1 (en) * 2001-03-14 2002-10-10 Tetsuo Asakura Method for producing fiber and film of silk and silk-like material
US20050177237A1 (en) 2001-04-12 2005-08-11 Ben Shappley Spinal cage insert, filler piece and method of manufacturing
US8317871B2 (en) 2001-07-27 2012-11-27 Biomet Manufacturing Corp. Modular humeral head resurfacing system
US7235091B2 (en) 2002-06-20 2007-06-26 Brian Thornes Apparatus and method for fixation of ankle syndesmosis
ITVR20010098A1 (it) 2001-09-11 2003-03-11 Consorzio Per Gli Studi Uni Procedimento per l'ottenimento di idrogeli di fibroina di seta.
US7727542B2 (en) * 2001-10-25 2010-06-01 University Of Connecticut Bioactive materials, methods of making bioactive materials and method of use thereof
US6902932B2 (en) 2001-11-16 2005-06-07 Tissue Regeneration, Inc. Helically organized silk fibroin fiber bundles for matrices in tissue engineering
JP4480936B2 (ja) 2001-11-26 2010-06-16 オリンパス株式会社 組織穿刺用システム
WO2003045336A1 (fr) * 2001-11-29 2003-06-05 National Institute Of Agrobiological Sciences Emulsifiant et procede d'elaboration correspondant
DE50200594D1 (de) 2002-02-08 2004-08-12 Storz Karl Gmbh & Co Kg Ankerelement zum Verankern eines Ligamenttransplantates
US7416556B2 (en) 2002-06-06 2008-08-26 Abbott Laboratories Stop-cock suture clamping system
JP3772207B2 (ja) 2002-06-19 2006-05-10 独立行政法人農業生物資源研究所 生分解性生体高分子材料、その製造方法、およびこの高分子材料からなる機能性素材
EP3351376B1 (en) 2002-06-24 2023-04-12 Tufts University Silk biomaterials and methods of use thereof
US7056308B2 (en) 2002-10-04 2006-06-06 Dsu Medical Corporation Medical device with elastomeric penetrable wall and inner seal
FR2848417B1 (fr) * 2002-12-13 2006-06-16 Oreal Composition cosmetique ou dermatologique comprenant un copolymere a gradient et procede cosmetique de maquillage ou de soin employant ledit copolymere
US7632873B2 (en) 2002-12-13 2009-12-15 L'oreal S.A. Cosmetic dermatological composition comprising at least one gradient copolymer, makeup comprising the cosmetic or dermatological composition and cosmetic method using the composition
JP3738255B2 (ja) 2003-02-21 2006-01-25 株式会社オードレマン 非結晶性絹フィブロインを含有する化粧料
JP3906927B2 (ja) * 2003-03-14 2007-04-18 独立行政法人農業生物資源研究所 絹タンパク由来機能性ポリペプチドの製造と利用
US7115388B2 (en) * 2003-03-14 2006-10-03 National Institute Of Agrobiological Sciences Production of functional polypeptides originating from silk protein and use thereof
JP4698596B2 (ja) 2003-04-10 2011-06-08 タフツ ユニバーシティー 濃縮された水性シルクフィブロイン溶液およびそれらの使用
JP4850709B2 (ja) * 2003-05-14 2012-01-11 ダニスコ・ユーエス・インコーポレーテッド 反復配列タンパク質ポリマーを使用する、活性剤の制御放出
US20040267317A1 (en) 2003-06-26 2004-12-30 Laurence Higgins Methods for attaching tissue to bone
CA2531623A1 (en) 2003-07-09 2005-01-20 Sdgi Holdings, Inc. Isolation of bone marrow fraction rich in connective tissue growth components and the use thereof to promote connective tissue formation
US20050049598A1 (en) 2003-08-29 2005-03-03 West Hugh S. Suture pulley for use with graft tensioning device
DE10349953B4 (de) 2003-10-24 2006-06-01 Karl Storz Gmbh & Co. Kg Vorrichtung zum Fixieren und Spannen zumindest eines Zugfadens für das Anlegen einer Neovagina
US20050090827A1 (en) 2003-10-28 2005-04-28 Tewodros Gedebou Comprehensive tissue attachment system
US7357810B2 (en) 2003-12-18 2008-04-15 Ethicon, Inc. High strength suture with absorbable core and suture anchor combination
US20050171604A1 (en) 2004-01-20 2005-08-04 Alexander Michalow Unicondylar knee implant
US7455683B2 (en) 2004-02-26 2008-11-25 Depuy Mitek, Inc. Methods and devices for repairing triangular fibrocartilage complex tears
US8062272B2 (en) 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
JP4700384B2 (ja) 2004-04-07 2011-06-15 オリンパス株式会社 医療用結紮縫合装置及び医療用結紮縫合システム
US8257394B2 (en) 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
MXPA06014064A (es) 2004-06-02 2007-07-13 Kfx Medical Corp Sistema y metodo para unir tejido blando al hueso.
AU2004322006B2 (en) * 2004-07-31 2012-05-24 Brainguard Co., Ltd. Silk peptide improving neuroprotective and neurofunctional effects and a method of its preparation
US7754243B2 (en) 2004-08-03 2010-07-13 Clemson University Research Foundation Aqueous suspension of nanoscale drug particles from supercritical fluid processing
US9173647B2 (en) 2004-10-26 2015-11-03 P Tech, Llc Tissue fixation system
US8628534B2 (en) 2005-02-02 2014-01-14 DePuy Synthes Products, LLC Ultrasonic cutting device
US7825083B2 (en) 2005-02-10 2010-11-02 Spine Wave, Inc. Synovial fluid barrier
US8292967B2 (en) 2005-04-21 2012-10-23 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
KR100841742B1 (ko) 2006-12-14 2008-06-27 화인코주식회사 하이드로겔 마스크 팩, 이의 제조 방법 및 이의 제조에이용되는 조성물
CN1985791B (zh) * 2006-12-27 2010-05-19 浙江大学 护肤丝素凝胶霜膏的制备方法
JP2008169171A (ja) * 2007-01-15 2008-07-24 Luc Sangyo Kk 絹フィブロイン含有組成物及びその製造法
SI2211876T1 (sl) 2007-05-29 2015-06-30 Trustees Of Tufts College Postopek za geliranje fibriona svile z uporabo ultrazvoka
WO2009023615A1 (en) 2007-08-10 2009-02-19 Trustees Of Tufts College Tubular silk compositions and methods of use thereof
US20100254961A1 (en) 2007-09-05 2010-10-07 Taiyokagaku Co., Ltd. Water-soluble electrospun sheet
WO2009126689A2 (en) 2008-04-08 2009-10-15 Trustees Of Tufts College System and method for making biomaterial structures
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
CN102271724B (zh) 2008-10-09 2015-10-14 塔夫茨大学信托人 含有甘油的改性丝膜
WO2010057142A2 (en) 2008-11-17 2010-05-20 Trustees Of Tufts College Surface modification of silk fibroin matrices with poly(ethylene glycol) useful as anti adhesion barriers and anti thrombotic materials
ES2414879T4 (es) * 2009-04-20 2013-10-30 Allergan, Inc. Hidrogeles de fibroína de seda y usos de éstos
US20110189292A1 (en) 2009-04-20 2011-08-04 Allergan, Inc. Dermal fillers comprising silk fibroin hydrogels and uses thereof
WO2011005381A2 (en) 2009-06-01 2011-01-13 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
JP2013506058A (ja) 2009-09-28 2013-02-21 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ 延伸したシルクｅｇｅｌ繊維およびその製造方法
CA2774643A1 (en) 2009-09-29 2011-04-07 Trustees Of Tufts College Silk nanospheres and microspheres and methods of making same
WO2011130335A2 (en) * 2010-04-12 2011-10-20 Tufts University Silk electronic components
JP5827790B2 (ja) * 2010-04-28 2015-12-02 東レ・ダウコーニング株式会社 高級アルコール変性シリコーンを含有してなる化粧料および皮膚外用剤
US20130243693A1 (en) * 2010-06-17 2013-09-19 Tufts University Silk optical particles and uses thereof
US8894992B2 (en) 2010-08-19 2014-11-25 Allergan, Inc. Compositions and soft tissue replacement methods
US8900571B2 (en) 2010-08-19 2014-12-02 Allergan, Inc. Compositions and soft tissue replacement methods
US8741281B2 (en) 2010-08-19 2014-06-03 Allergan, Inc. Compositions and soft tissue replacement methods
US8926963B2 (en) 2010-08-19 2015-01-06 Allergan, Inc. Compositions and soft tissue replacement methods
JP6081358B2 (ja) * 2010-09-01 2017-02-15 トラスティーズ・オブ・タフツ・カレッジＴｒｕｓｔｅｅｓ Ｏｆ Ｔｕｆｔｓ Ｃｏｌｌｅｇｅ 絹フィブロインおよびポリエチレングリコールをベースとする生体材料
JP5985795B2 (ja) * 2011-02-09 2016-09-06 八藤　眞 セリシンペプチドの製造方法
US8972214B2 (en) * 2011-04-21 2015-03-03 Microchip Technology Incorporated Touch sense determined by characterizing impedance changes in a transmission line
AU2012245198B2 (en) * 2011-04-21 2017-07-13 Trustees Of Tufts College Compositions and methods for stabilization of active agents
US8551538B2 (en) * 2011-08-18 2013-10-08 Golden Pearl Investment LLC Skin formulation, preparation and uses thereof
WO2013070907A1 (en) 2011-11-08 2013-05-16 Tufts University A silk-based scaffold platform for engineering tissue constructs
KR20130053494A (ko) 2011-11-14 2013-05-24 강용구 당뇨, 고콜레스테롤증 및 고지혈증 개선의 복합 기능을 가지는 실크 펩타이드의 제조방법
KR20130052910A (ko) 2011-11-14 2013-05-23 강용구 고콜레스테롤증 및 고지혈증 개선의 복합 기능을 가지는 실크 펩타이드 조성물
KR20130052878A (ko) 2011-11-14 2013-05-23 강용구 당뇨 개선 기능을 가지는 실크 펩타이드 조성물
WO2013159101A1 (en) 2012-04-20 2013-10-24 Trustees Of Tufts College Silk fibroin-based personal care compositions
CN104254341B (zh) * 2012-04-25 2018-04-13 日立化成株式会社 药剂缓释载体
WO2014011644A1 (en) 2012-07-09 2014-01-16 Trustees Of Tufts College High molecular weight silk fibroin and uses thereof
US20140222152A1 (en) 2013-02-06 2014-08-07 Tufts University Implantable intervertebral disc devices and uses thereof
KR20210149207A (ko) 2013-03-15 2021-12-08 트러스티즈 오브 터프츠 칼리지 저분자량 실크 조성물 및 안정화 실크 조성물
BR112016006898A8 (pt) 2013-09-30 2020-02-18 Silk Therapeutics Inc composição, filmes, método de redução de linhas finas e rugas, géis, método de suavização e rejuvenescimento da pele humana, soro, método de hidratação da pele humana, composição de descamação da pele e método para a preparação de uma solução

Also Published As

Publication number Publication date
US20150094269A1 (en) 2015-04-02
EA201690712A1 (ru) 2016-08-31
CN113274307B (zh) 2023-10-03
US9511012B2 (en) 2016-12-06
JP6775751B2 (ja) 2020-10-28
US11298310B2 (en) 2022-04-12
BR112016006898A2 (pt) 2017-08-01
CN106029176A (zh) 2016-10-12
AU2020203045B2 (en) 2022-06-02
US20160022560A1 (en) 2016-01-28
US9522108B2 (en) 2016-12-20
KR20210153142A (ko) 2021-12-16
AU2014324412B2 (en) 2020-02-20
US20190380944A1 (en) 2019-12-19
US20220226223A1 (en) 2022-07-21
EP3052203A1 (en) 2016-08-10
AU2022221406A1 (en) 2022-09-15
CN113274307A (zh) 2021-08-20
CN106029176B (zh) 2021-03-12
AU2020203045A1 (en) 2020-05-28
JP2021001198A (ja) 2021-01-07
WO2015048805A1 (en) 2015-04-02
SG11201602416RA (en) 2016-04-28
US11857663B2 (en) 2024-01-02
US20150093340A1 (en) 2015-04-02
JP2016531943A (ja) 2016-10-13
US20160193130A1 (en) 2016-07-07
WO2015048805A8 (en) 2016-05-12
US10987294B2 (en) 2021-04-27
CA2925820A1 (en) 2015-04-02
KR20240025711A (ko) 2024-02-27
SG10201907426UA (en) 2019-09-27
JP2024050635A (ja) 2024-04-10
US20160022562A1 (en) 2016-01-28
US20200188269A1 (en) 2020-06-18
IL292426A (en) 2022-06-01
KR20160062152A (ko) 2016-06-01
US9522107B2 (en) 2016-12-20
US9517191B2 (en) 2016-12-13
MX2016003961A (es) 2018-02-19
JP2022116179A (ja) 2022-08-09
IL244713A0 (en) 2016-04-21
NZ719165A (en) 2024-02-23
IL300992A (en) 2023-04-01
US10610478B2 (en) 2020-04-07
US20230085841A1 (en) 2023-03-23
US20190070089A1 (en) 2019-03-07
US11298311B2 (en) 2022-04-12
US20190070088A1 (en) 2019-03-07
US10166177B2 (en) 2019-01-01
CA2925820C (en) 2021-11-30
JP7263298B2 (ja) 2023-04-24
US20160022563A1 (en) 2016-01-28
US11857664B2 (en) 2024-01-02
US20160022561A1 (en) 2016-01-28
IL244713B (en) 2022-06-01
KR102379848B1 (ko) 2022-03-28
JP7423688B2 (ja) 2024-01-29
CA3137437A1 (en) 2015-04-02
US20190336431A1 (en) 2019-11-07
US10588843B2 (en) 2020-03-17
BR112016006898A8 (pt) 2020-02-18
US9187538B2 (en) 2015-11-17
EP3052203A4 (en) 2017-08-23
US9545369B2 (en) 2017-01-17
US20160022559A1 (en) 2016-01-28
EA036027B1 (ru) 2020-09-15
US20200188268A1 (en) 2020-06-18
US20230212234A1 (en) 2023-07-06

Similar Documents

Publication Publication Date Title
EA202091160A1 (ru) Композиции из фрагментов белков шелка и изделия, изготовленные из них
CY1120729T1 (el) Πεπτιδια και συνθεσεις για τη θεραπεια τραυματισμου των αρθρωσεων
EA201892123A1 (ru) 6-гидрокси-4-оксо-1,4-дигидропиримидин-5-карбоксамиды в качестве агонистов apj
EA201791460A1 (ru) N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения
EA201591643A1 (ru) Варианты пертузумаба и их аналитическая характеристика
WO2016115159A8 (en) Preserved silk protein fragment compositions and articles manufactured therefrom
EA201491644A1 (ru) Фармацевтические композиции
BR112017010177A2 (pt) composição para tratamento de tecido
EA201692552A1 (ru) МОДИФИЦИРОВАННЫЕ МЕНИНГОКОККОВЫЕ ПОЛИПЕПТИДЫ fHbp
CY1119036T1 (el) Νεοι αγωνιστες του υποδοχεα τυπου 2 της αγγειοτενσινης (ατ2) και χρησεις τους
PE20151978A1 (es) Composiciones nutricionales que contienen un componente peptidico con propiedades antinflamatorias y usos del mismo
MX344635B (es) Composiciones y usos de materiales antimicrobianos con propiedades compatibles con el tejido.
BR112017002836A2 (pt) composições de terpolímero com clareza e brilho aprimorados
EA201690859A1 (ru) Предотвращение инфекций, вызываемых staphylococcus aureus, гликопротеиновыми вакцинами, синтезированными в escherichia coli
EA202092464A1 (ru) Способы получения стабильных композиций на основе белков
EA201790349A1 (ru) Производные 6-алкинил-пиридина в качестве миметиков белка smac
EA201590601A1 (ru) Применение pedf-производных полипептидов для лечения остеоартрита
BR112014014572A2 (pt) composição bioativa
PE20151999A1 (es) Composiciones nutricionales que contienen un componente peptidico y usos del mismo
EA202191515A1 (ru) Фармацевтическая композиция, содержащая апиксабан
GB201118201D0 (en) Novel peptides
EA201992288A1 (ru) Мягкая полипропиленовая композиция с улучшенными свойствами
EA201591832A1 (ru) Коэкспрессия фактора viii и фактора фон виллебранда
TR201819920T4 (tr) Kuru göz sendromunun tedavisinde kullanım için oftalmik bileşimler.
EA202090971A1 (ru) Способы применения и композиции, содержащие дулаглутид