EA201591832A1 - Коэкспрессия фактора viii и фактора фон виллебранда - Google Patents

Коэкспрессия фактора viii и фактора фон виллебранда

Info

Publication number
EA201591832A1
EA201591832A1 EA201591832A EA201591832A EA201591832A1 EA 201591832 A1 EA201591832 A1 EA 201591832A1 EA 201591832 A EA201591832 A EA 201591832A EA 201591832 A EA201591832 A EA 201591832A EA 201591832 A1 EA201591832 A1 EA 201591832A1
Authority
EA
Eurasian Patent Office
Prior art keywords
factor
expression
villebrand
von
factor viii
Prior art date
Application number
EA201591832A
Other languages
English (en)
Other versions
EA038034B1 (ru
Inventor
Джон Хендерсон Маквей
Иэн Гарнер
Адель Дейл
Брюс Вернон
Original Assignee
Профактор Фарма Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Профактор Фарма Лтд. filed Critical Профактор Фарма Лтд.
Publication of EA201591832A1 publication Critical patent/EA201591832A1/ru
Publication of EA038034B1 publication Critical patent/EA038034B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретение относится к функциональной экспрессии рекомбинантного фактора VIII (rFVIII) в клетках и, конкретно, к его стабильной экспрессии и секреции из клеток в in vitro и/или in vivo применениях.
EA201591832A 2013-03-19 2014-03-18 Коэкспрессия фактора viii и фактора фон виллебранда EA038034B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1304973.9A GB201304973D0 (en) 2013-03-19 2013-03-19 Recombinant protein
PCT/GB2014/050850 WO2014147386A1 (en) 2013-03-19 2014-03-18 Co-expression of factor viii and von willebrand factor

Publications (2)

Publication Number Publication Date
EA201591832A1 true EA201591832A1 (ru) 2016-08-31
EA038034B1 EA038034B1 (ru) 2021-06-25

Family

ID=48226639

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591832A EA038034B1 (ru) 2013-03-19 2014-03-18 Коэкспрессия фактора viii и фактора фон виллебранда

Country Status (7)

Country Link
EP (1) EP2976422B1 (ru)
CN (1) CN105229143B (ru)
EA (1) EA038034B1 (ru)
GB (1) GB201304973D0 (ru)
LT (1) LT2976422T (ru)
WO (1) WO2014147386A1 (ru)
ZA (1) ZA201507754B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3205665A1 (en) * 2016-02-11 2017-08-16 Octapharma AG Method of separating factor viii from blood products
US10654911B1 (en) * 2019-04-02 2020-05-19 Beijing Neoletix Biological Technology Co., Ltd. Vector co-expressing truncated von Willebrand factor and factor VIII
GB2628173A (en) * 2023-03-17 2024-09-18 Thermo Fisher Scient Geneart Gmbh Methods of producing modified nucleic acid sequences for eliminating adverse splicing events

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198349A (en) 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
EP2499165B1 (en) * 2009-11-13 2016-09-14 Grifols Therapeutics Inc. Von willebrand factor (vwf)-containing preparations, and methods, kits, and uses related thereto

Also Published As

Publication number Publication date
CN105229143A (zh) 2016-01-06
EA038034B1 (ru) 2021-06-25
GB201304973D0 (en) 2013-05-01
CN105229143B (zh) 2019-08-09
ZA201507754B (en) 2019-08-28
LT2976422T (lt) 2018-04-25
WO2014147386A1 (en) 2014-09-25
EP2976422B1 (en) 2017-12-13
EP2976422A1 (en) 2016-01-27

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