SG11201901137UA - Silk-derived protein for treating inflammation - Google Patents
Silk-derived protein for treating inflammationInfo
- Publication number
- SG11201901137UA SG11201901137UA SG11201901137UA SG11201901137UA SG11201901137UA SG 11201901137U A SG11201901137U A SG 11201901137UA SG 11201901137U A SG11201901137U A SG 11201901137UA SG 11201901137U A SG11201901137U A SG 11201901137UA SG 11201901137U A SG11201901137U A SG 11201901137UA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- silk
- sdp
- minnesota
- rule
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Insects & Arthropods (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property --11` . 1#11101111 0 11101 HOE 3E1 0 0111E011H MO Ell 0011110 1111 OEN Organization International Bureau (10) International Publication Number (43) International Publication Date ..../.- WO 2018/031973 Al 15 February 2018 (15.02.2018) WIPOIPCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61F 2/14 (2006.01) A61K 47/42 (2017.01) kind of national protection available): AE, AG, AL, AM, A61K 38/17 (2006.01) CO7K 14/435 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, PCT/US2017/046659 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (22) International Filing Date: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 12 August 2017 (12.08.2017) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (26) Publication Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/374,532 12 August 2016 (12.08.2016) US kind of regional protection available): ARIPO (BW, GH, 62/407,863 13 October 2016 (13.10.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 62/467,697 06 March 2017 (06.03.2017) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (71) Applicant: SILK TECHNOLOGIES, LTD. [US/US]; EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 3700 Annapolis Ln N, Ste 105, Plymouth, Minnesota 55447 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (72) Inventors: LAWRENCE, Brian D.; 51 Sandpiper Road, KM, ML, MR, NE, SN, TD, TG). _ Tampa, Florida 33609 (US). INFANGER, David W.; 6236 = Troy Lane North, Maple Grove, Minnesota 55311 (US). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) = (74) Agent: HAUKAAS, Michael H.; 5100 Eden Avenue, Suite _ 303, Edina, Minnesota 55436 (US). (54) Title: SILK-DERIVED PROTEIN FOR TREATING INFLAMMATION = 1 . 5 — A e.v '••••••4 •••4 ee4v e••••0 .••• 4 1.0 = c*:•:1 ... 4 :::::::: NAN% ,:o ' ::o .:.:4 ox *4 0:4 4 , , H202 SIGNAL X: M 1......„ I I • • • (FOLD CONTROL) 0:+:; :* 1 .*x M 4:o 0 t i m, *:* 0.•40 = 4...0 SW4 I 1 = g C + • :: e••••0 • :•N • •• •4 C.:4•4 1,••11 + :4 W9 ......v ow : • A k x.:4 . A 4444 M _ 1-1 '• M IN CT - - 1 4.) M © -- -- GC (57) : Described herein are methods for reducing proteins (SDP) or a fraction thereof to a subject having 0 conditions and wounds, including corneal wounds, comprising N described herein. ;;;$ an 0.5% P A S F inflammation inflammatory condition. the topical a Fig. by administration 1 . 0 % SDP 5 administration The methods a of 5.0% SDP-4 of an effective amount of silk-derived include the treatment of inflammatory an effective amount of SDP material as C [Continued on next page] WO 2018/031973 Al MIDEDIMOHNOBEIERIMIDEMEIERVON Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662374532P | 2016-08-12 | 2016-08-12 | |
US201662407863P | 2016-10-13 | 2016-10-13 | |
US201762467697P | 2017-03-06 | 2017-03-06 | |
PCT/US2017/046659 WO2018031973A1 (en) | 2016-08-12 | 2017-08-12 | Silk-derived protein for treating inflammation |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201901137UA true SG11201901137UA (en) | 2019-03-28 |
Family
ID=61163249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201901137UA SG11201901137UA (en) | 2016-08-12 | 2017-08-12 | Silk-derived protein for treating inflammation |
Country Status (10)
Country | Link |
---|---|
US (2) | US11242367B2 (en) |
EP (1) | EP3496662A4 (en) |
JP (1) | JP2019531334A (en) |
KR (1) | KR102275012B1 (en) |
CN (1) | CN109862851A (en) |
AU (1) | AU2017310520A1 (en) |
CA (1) | CA3033507A1 (en) |
MX (1) | MX2019001633A (en) |
SG (1) | SG11201901137UA (en) |
WO (1) | WO2018031973A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2781114T3 (en) * | 2014-08-20 | 2020-08-28 | Silk Tech Ltd | Protein composition derived from fibroin |
WO2019094702A1 (en) | 2017-11-10 | 2019-05-16 | Cocoon Biotech Inc. | Ocular applications of silk-based products |
AU2020288624A1 (en) | 2019-06-04 | 2022-02-03 | Cocoon Biotech Inc. | Silk-based products, formulations, and methods of use |
KR102374291B1 (en) * | 2019-09-10 | 2022-03-14 | 강릉원주대학교산학협력단 | Feed additive composition containing natural pozzolan |
JP2023502591A (en) * | 2019-11-15 | 2023-01-25 | シルク テクノロジーズ、リミテッド | Stable formulation of silk-derived proteins |
KR102194995B1 (en) * | 2020-09-16 | 2020-12-28 | 장혜란 | stabilization compoation of improved dried humoral diagnosis and its opplication method |
CN114685825B (en) * | 2022-03-22 | 2023-02-28 | 浙江大学 | Preparation method of fibroin eutectic gel, product and application thereof |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5931520B2 (en) | 1979-03-22 | 1984-08-02 | カネボウ株式会社 | Method for producing silk fibroin peptide aqueous solution |
IL101850A (en) | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | 11-(4-Piperidinyl)-imidazo (2,1-b) (3) benzazepine derivatives their preparation and pharmaceutical compositions containing them |
CA2125060C (en) | 1993-07-02 | 1999-03-30 | Henry P. Dabrowski | Ophthalmic solution for artificial tears |
JPH0767686A (en) | 1993-09-06 | 1995-03-14 | Shinano Kenshi Co Ltd | Production of silk fibroin peptide having low molecular weight |
US5760004A (en) | 1994-11-21 | 1998-06-02 | Protein Polymer Technologies, Inc. | Chemical modification of repetitive polymers to enhance water solubility |
JP3449658B2 (en) | 1994-12-21 | 2003-09-22 | 杏林製薬株式会社 | 8-Alkoxyquinolonecarboxylic acid hydrate excellent in stability and method for producing the same |
US5895645A (en) | 1995-01-31 | 1999-04-20 | Bausch & Lomb Incorporated | Opthalmic solution for artificial tears |
JPH08295697A (en) | 1995-04-26 | 1996-11-12 | Kanebo Ltd | Production of aqueous solution of silk fibroin at high concentration |
WO1999033899A1 (en) | 1997-12-31 | 1999-07-08 | Kimberly-Clark Worlwide, Inc. | Method of reducing molecular weights and polydispersity indices of polymers of ethylene oxide |
FR2774588B1 (en) | 1998-02-11 | 2000-05-05 | Oreal | COSMETIC OR DERMATOLOGICAL COMPOSITION CONTAINING AT LEAST ONE NATURAL, RECOMBINANT ARACHNID SILK PROTEIN OR THE LIKE |
AU761040B2 (en) | 1998-08-21 | 2003-05-29 | Kyorin Pharmaceutical Co. Ltd. | Aqueous liquid preparations |
JP2000143472A (en) | 1998-11-10 | 2000-05-23 | Hiroshi Akai | Cosmetic having ultraviolet light-absorbing function |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
BR0109317A (en) | 2000-07-14 | 2003-06-17 | Allergan Inc | Compositions containing alpha-2-adrenergic agonist components |
BR0112461A (en) | 2000-07-14 | 2003-07-22 | Allergan Inc | Compositions containing therapeutically active components having increased solubility |
US8858961B2 (en) | 2000-07-14 | 2014-10-14 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
US20030206897A1 (en) | 2000-09-13 | 2003-11-06 | The Procter & Gamble Company | Cosmetic compositions |
IT1316885B1 (en) | 2000-10-02 | 2003-05-13 | Consorzio Per Gli Studi Uni | PROCEDURE FOR THE PREPARATION OF A NON-WOVEN FABRIC IN SILK FIBER. |
ATE420671T1 (en) | 2001-10-25 | 2009-01-15 | Univ Connecticut | FIBROIN COMPOSITIONS AND METHODS FOR THE PRODUCTION THEREOF |
EP1459728A4 (en) | 2001-11-29 | 2005-04-20 | Nat Inst Of Agrobio Sciences | Emulsifier and process for producing the same |
US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
US7030149B2 (en) | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
US7642258B2 (en) | 2002-04-19 | 2010-01-05 | Allergan, Inc. | Combination of brimonidine and timolol for topical ophthalmic use |
WO2004062697A2 (en) | 2003-01-07 | 2004-07-29 | Tufts University | Silk fibroin materials and use thereof |
US7060260B2 (en) | 2003-02-20 | 2006-06-13 | E.I. Du Pont De Nemours And Company | Water-soluble silk proteins in compositions for skin care, hair care or hair coloring |
US7193038B2 (en) | 2003-02-28 | 2007-03-20 | National Institute Of Agrobiological Sciences | Extraction and utilization of cell growth-promoting peptides from silk protein |
US7115388B2 (en) | 2003-03-14 | 2006-10-03 | National Institute Of Agrobiological Sciences | Production of functional polypeptides originating from silk protein and use thereof |
US20050196370A1 (en) | 2003-03-18 | 2005-09-08 | Zhi-Jian Yu | Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye |
WO2005012606A2 (en) | 2003-04-10 | 2005-02-10 | Tufts University | Concentrated aqueous silk fibroin solution and use thereof |
US8008338B2 (en) | 2003-06-03 | 2011-08-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating or preventing ocular pain |
PL1654002T5 (en) | 2003-08-07 | 2014-06-30 | Allergan Inc | Compositions for delivery of therapeutics into the eyes |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
ES2383525T3 (en) | 2003-11-05 | 2012-06-21 | Sarcode Bioscience Inc. | Cell adhesion modulators |
US20050202097A1 (en) | 2004-03-12 | 2005-09-15 | Melbj Holdings, Llc, Florida | Lubricant for the ocular surface |
EP1609801A1 (en) | 2004-06-25 | 2005-12-28 | Technische Universität München | Proteins of natural origin and materials made therefrom |
JP4896017B2 (en) | 2004-07-31 | 2012-03-14 | バイオグランド シーオー エル ティー ディー | Composition for improving brain disease or brain function |
US8569367B2 (en) | 2004-11-16 | 2013-10-29 | Allergan, Inc. | Ophthalmic compositions and methods for treating eyes |
WO2010102078A1 (en) | 2009-03-04 | 2010-09-10 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
US7851504B2 (en) | 2005-03-16 | 2010-12-14 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
PT1881823E (en) | 2005-05-17 | 2015-03-02 | Sarcode Bioscience Inc | Compositions and methods for treatment of eye disorders |
CA2624667C (en) | 2005-10-05 | 2018-01-09 | Commonwealth Scientific And Industrial Research Organisation | Silk proteins containing coiled coil region |
ES2752823T3 (en) | 2006-03-31 | 2020-04-06 | Vistakon Pharmaceuticals Llc | Eye allergy treatment |
WO2007130364A2 (en) | 2006-05-01 | 2007-11-15 | Riolan Technologies, Inc. | Compositions, methods, and kits for treating dry eye |
WO2008109138A1 (en) | 2007-03-07 | 2008-09-12 | Grune Guerry L | Spf compositions |
KR20100029217A (en) | 2007-05-29 | 2010-03-16 | 트러스티즈 오브 터프츠 칼리지 | Method for silk fibroin gelation using sonication |
CN101194666A (en) | 2007-11-28 | 2008-06-11 | 吴江市方霞企业信息咨询有限公司 | Silkworm chrysalis fibroin protein functional foods |
WO2009088119A1 (en) | 2008-01-07 | 2009-07-16 | Bioleaders Corporation | Composition for preventing or treating dry eye syndrome comprising poly-gamma-glutamic acid |
US7842714B2 (en) | 2008-03-03 | 2010-11-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating ocular pain |
WO2009139817A2 (en) | 2008-04-15 | 2009-11-19 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
US8569730B2 (en) | 2008-07-08 | 2013-10-29 | Sandisk 3D Llc | Carbon-based interface layer for a memory device and methods of forming the same |
EP2403551A4 (en) | 2009-03-04 | 2014-02-26 | Tufts College | Silk fibroin systems for antibiotic delivery |
WO2010123947A2 (en) | 2009-04-20 | 2010-10-28 | Allergan, Inc. | Silk fibroin hydrogels and uses thereof |
NZ596932A (en) | 2009-06-05 | 2014-04-30 | Allergan Inc | Artificial tears and therapeutic uses |
WO2011008842A2 (en) | 2009-07-14 | 2011-01-20 | Trustees Of Tufts College | Electrospun silk material systems for wound healing |
WO2011050175A1 (en) | 2009-10-21 | 2011-04-28 | Sarcode Corporation | Crystalline pharmaceutical and methods of preparation and use thereof |
US9603971B2 (en) | 2010-03-05 | 2017-03-28 | Trustees Of Tufts College | Silk-based ionomeric compositions |
US8309689B2 (en) | 2010-05-20 | 2012-11-13 | Taipei Medical University | High yield dialysis-free process for producing organosoluble regenerated silk fibroin |
EP2582360A4 (en) | 2010-06-17 | 2014-01-22 | Tufts University Trustees Of Tufts College | Silk optical particles and uses thereof |
WO2012170655A1 (en) | 2011-06-07 | 2012-12-13 | Cornell University | Silk compositions and methods of using same |
CN102860969A (en) | 2011-07-07 | 2013-01-09 | 刘畅 | Soybean eye cream |
WO2013126799A1 (en) | 2012-02-22 | 2013-08-29 | Trustees Of Tufts College | Compositions and methods for ocular delivery of a therapeutic agent |
US9056063B2 (en) | 2012-03-13 | 2015-06-16 | James E. Hanson | Natural sunscreen composition |
US20150079012A1 (en) | 2012-04-20 | 2015-03-19 | Trustees Of Tufts College | Silk fibroin-based personal care compositions |
EP3715345B8 (en) | 2012-07-25 | 2024-05-29 | Bausch + Lomb Ireland Limited | Preparation of lfa-1 inhibitor |
US20140235554A1 (en) | 2013-02-12 | 2014-08-21 | Brian Lawrence | Ophthalmic formulation derived from silk protein |
KR20230021768A (en) * | 2013-03-15 | 2023-02-14 | 트러스티즈 오브 터프츠 칼리지 | Low molecular weight silk compositions and stabilizing silk compositions |
AU2014240170B2 (en) | 2013-03-15 | 2018-05-17 | Patheon Softgels Inc. | Silk-based capsules |
CN103239707A (en) | 2013-05-22 | 2013-08-14 | 江苏紫石化工科技有限公司 | Eye drop for treating myopia |
JP6775751B2 (en) | 2013-09-30 | 2020-10-28 | エボルブド バイ ネイチャー, インコーポレイテッド | Silk protein fragment composition and articles produced from it |
AU2014353110B2 (en) | 2013-11-19 | 2018-05-10 | Cornell University | Tissue scaffold materials for tissue regeneration and methods of making |
ES2781114T3 (en) * | 2014-08-20 | 2020-08-28 | Silk Tech Ltd | Protein composition derived from fibroin |
US10758645B2 (en) * | 2014-12-17 | 2020-09-01 | Tufts University | Injectable, flexible hydroxyapatite-silk foams for osteochondral and dental repair |
CA3020342A1 (en) | 2016-04-08 | 2017-11-23 | Cornell University | A method to enhance wound healing using silk-derived protein |
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2017
- 2017-08-12 US US16/324,844 patent/US11242367B2/en active Active
- 2017-08-12 CN CN201780062299.5A patent/CN109862851A/en active Pending
- 2017-08-12 CA CA3033507A patent/CA3033507A1/en active Pending
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US20220332773A1 (en) | 2022-10-20 |
EP3496662A1 (en) | 2019-06-19 |
CA3033507A1 (en) | 2018-02-15 |
CN109862851A (en) | 2019-06-07 |
US11242367B2 (en) | 2022-02-08 |
MX2019001633A (en) | 2019-09-18 |
KR20190042608A (en) | 2019-04-24 |
KR102275012B1 (en) | 2021-07-07 |
JP2019531334A (en) | 2019-10-31 |
AU2017310520A1 (en) | 2019-03-21 |
US20190169243A1 (en) | 2019-06-06 |
EP3496662A4 (en) | 2019-10-30 |
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