SG11201808804TA - A method to enhance wound healing using silk-derived protein - Google Patents

A method to enhance wound healing using silk-derived protein

Info

Publication number
SG11201808804TA
SG11201808804TA SG11201808804TA SG11201808804TA SG11201808804TA SG 11201808804T A SG11201808804T A SG 11201808804TA SG 11201808804T A SG11201808804T A SG 11201808804TA SG 11201808804T A SG11201808804T A SG 11201808804TA SG 11201808804T A SG11201808804T A SG 11201808804TA
Authority
SG
Singapore
Prior art keywords
suite
international
silk
solution
sdp
Prior art date
Application number
SG11201808804TA
Inventor
Waleed Abdel-Naby
Mark Rosenblatt
Brian Lawrence
David Infanger
Original Assignee
Univ Cornell
Silk Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cornell, Silk Technologies Ltd filed Critical Univ Cornell
Publication of SG11201808804TA publication Critical patent/SG11201808804TA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111011101010111110101111 1 001010111011011011011101111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/200659 A2 23 November 2017 (23.11.2017) WIPO I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: Not classified International Application Number: PCT/US2017/026656 International Filing Date: 07 April 2017 (07.04.2017) English Publication Language: English Priority Data: 62/320,177 08 April 2016 (08.04.2016) US Applicants: CORNELL UNIVERSITY [US/US]; Cen- ter for Technology Licensing (CTL), 395 Pine Tree Road, Suite 310, Ithaca, New York 14850 (US). SILK TECH- NOLOGIES, LTD. [US/US]; 3700 Annapolis Lane North, Suite 105, Plymouth, Minnesota 55447 (US). Inventors: ABDEL-NABY, Waleed; 208 Bay 22nd Street, Apt. C2, Brooklyn, New York 11214 (US). ROSEN- BLATT, Mark; c/o Cornell University, CTL, 395 Pine Tree Road, Suite 310, Ithaca, New York 14850 (US). LAWRENCE, Brian; 3700 Annapolis Lane North, Suite 105, Plymouth, Minnesota 55447 (US). INFANGER, David; 3700 Annapolis Lane North, Suite 105, Plymouth, Minnesota 55411 (US). (74) Agent: EWING, James F. et al.; Foley & Lardner LLP, 3000 K. Street N.W., Suite 600, Washington, District of Co- lumbia 20007 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, _ = = = (54) Title: A : burns, and skin ulcers, weight 0 incisions, METHOD TO ENHANCE WOUND HEALING USING SILK-DERIVED PROTEIN Also described are compositions SDP S ution Prtaductiof , Pro e s = = = = = = tract fitroil Pan COMMIS Dtasolve Main in IRS-solution Antockeve Min/RA/Br solution Av Fibroin Solution Ditlyth Li& Seft NMI solution Ftff-4183i mg/Iota:1 anis coma m Ilatats SOP aft ic product = = — = Pri Silk Production. !Aiwa Liar NW 'nom solution Process Mr-out ;9regAto aa 3taTrinilte8 = = — = Martin rare cocoons Dissolve Malin wail Ilk solution Prior at Wk Rama * Vlitliert . product = Fig. 1 enhancing wound healing using silk -derived proteins (SDP), including low molecular for the treatment fragments, including low molecular wight SDP fragments. ei c:r irl ,tD 0 0 ei .---- (57) IN ei SDP fragments. Described herein are methods of comprising SDP of wounds, including corneal wounds, skin wounds, surgical o [Continued on next page] WO 2017/200659 A2 MIDEDIM01101 DIVIIMMEM00101011101111111111111011111011110111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to upon receipt of that report (Rule 48.2(g)) be republished
SG11201808804TA 2016-04-08 2017-04-07 A method to enhance wound healing using silk-derived protein SG11201808804TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662320177P 2016-04-08 2016-04-08
PCT/US2017/026656 WO2017200659A2 (en) 2016-04-08 2017-04-07 A method to enhance wound healing using silk-derived protein

Publications (1)

Publication Number Publication Date
SG11201808804TA true SG11201808804TA (en) 2018-11-29

Family

ID=60325550

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201808804TA SG11201808804TA (en) 2016-04-08 2017-04-07 A method to enhance wound healing using silk-derived protein

Country Status (8)

Country Link
US (1) US10953132B2 (en)
JP (1) JP2019519596A (en)
KR (1) KR20190008210A (en)
CN (1) CN109640694A (en)
AU (1) AU2017267370B2 (en)
CA (1) CA3020342A1 (en)
SG (1) SG11201808804TA (en)
WO (1) WO2017200659A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019519596A (en) 2016-04-08 2019-07-11 コーネル・ユニバーシティーCornell University Methods of promoting wound healing using silk derived proteins
KR102275012B1 (en) * 2016-08-12 2021-07-07 실크 테크놀로지스 리미티드 Silk-derived protein for the treatment of inflammation
US20210236644A1 (en) 2017-11-10 2021-08-05 Cocoon Biotech Inc. Ocular applications of silk-based products
CN111330067A (en) * 2018-12-18 2020-06-26 生命之星国际股份有限公司 Double-layer fibroin dressing and manufacturing method thereof
JP7458619B2 (en) 2019-01-31 2024-04-01 Ｓｐｉｂｅｒ株式会社 Fibroin fiber manufacturing method and fibroin solution
CN110051623B (en) * 2019-04-30 2022-07-05 广州暨南生物医药研究开发基地有限公司 Anti-herpes virus gel and preparation method thereof
CA3142608A1 (en) 2019-06-04 2020-12-10 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
JPWO2021015153A1 (en) * 2019-07-19 2021-01-28
US20220411482A1 (en) * 2019-11-15 2022-12-29 Silk Technologies, Ltd. Stable formulations of silk-derived protein
KR102365211B1 (en) * 2020-03-27 2022-02-18 (주)네이처앤트리 Hair coating agent using silk fibroin protein having stability in water-soluble phase
KR102295015B1 (en) * 2020-03-27 2021-08-27 주식회사 바이오스탠다드 Silk fibroin aqueous solution with extreme stability in aqueous phase

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5931520B2 (en) 1979-03-22 1984-08-02 カネボウ株式会社 Method for producing silk fibroin peptide aqueous solution
CA2125060C (en) 1993-07-02 1999-03-30 Henry P. Dabrowski Ophthalmic solution for artificial tears
JPH0767686A (en) 1993-09-06 1995-03-14 Shinano Kenshi Co Ltd Production of silk fibroin peptide having low molecular weight
US5760004A (en) 1994-11-21 1998-06-02 Protein Polymer Technologies, Inc. Chemical modification of repetitive polymers to enhance water solubility
US5895645A (en) 1995-01-31 1999-04-20 Bausch & Lomb Incorporated Opthalmic solution for artificial tears
JPH08295697A (en) 1995-04-26 1996-11-12 Kanebo Ltd Production of aqueous solution of silk fibroin at high concentration
AU2022599A (en) 1997-12-31 1999-07-19 Kimberly-Clark Worldwide, Inc. Method of reducing molecular weights and polydispersity indices of polymers of ethylene oxide
FR2774588B1 (en) 1998-02-11 2000-05-05 Oreal COSMETIC OR DERMATOLOGICAL COMPOSITION CONTAINING AT LEAST ONE NATURAL, RECOMBINANT ARACHNID SILK PROTEIN OR THE LIKE
JP2000143472A (en) 1998-11-10 2000-05-23 Hiroshi Akai Cosmetic having ultraviolet light-absorbing function
US20030206897A1 (en) 2000-09-13 2003-11-06 The Procter & Gamble Company Cosmetic compositions
WO2003045336A1 (en) 2001-11-29 2003-06-05 National Institute Of Agrobiological Sciences Emulsifier and process for producing the same
US7842780B2 (en) 2003-01-07 2010-11-30 Trustees Of Tufts College Silk fibroin materials and use thereof
US7060260B2 (en) 2003-02-20 2006-06-13 E.I. Du Pont De Nemours And Company Water-soluble silk proteins in compositions for skin care, hair care or hair coloring
KR20040077553A (en) 2003-02-28 2004-09-04 독립행정법인농업생물자원연구소 Extraction and utilization of cell growth promoting peptides from silk protein
US7115388B2 (en) 2003-03-14 2006-10-03 National Institute Of Agrobiological Sciences Production of functional polypeptides originating from silk protein and use thereof
US20050196370A1 (en) 2003-03-18 2005-09-08 Zhi-Jian Yu Stable ophthalmic oil-in-water emulsions with sodium hyaluronate for alleviating dry eye
EP3231846A1 (en) 2003-04-10 2017-10-18 Tufts University Concentrated aqueous silk fibroin solution and use thereof
WO2005058380A1 (en) * 2003-12-19 2005-06-30 Keratec Limited Wound care products containing keratin
US20050202097A1 (en) 2004-03-12 2005-09-15 Melbj Holdings, Llc, Florida Lubricant for the ocular surface
EP1609801A1 (en) 2004-06-25 2005-12-28 Technische Universität München Proteins of natural origin and materials made therefrom
US10010574B2 (en) 2004-07-31 2018-07-03 Brainguard Co., Ltd. Silk peptide for improving neuroprotective and neurofunctional effects and a method of its preparation
US8569367B2 (en) 2004-11-16 2013-10-29 Allergan, Inc. Ophthalmic compositions and methods for treating eyes
EP2395014A3 (en) 2005-10-05 2012-07-11 Commonwealth Scientific and Industrial Research Organization Silk proteins
EP2035015A4 (en) 2006-05-01 2009-11-11 Riolan Technologies Inc Compositions, methods, and kits for treating dry eye
US20080219938A1 (en) 2007-03-07 2008-09-11 Grune Guerry L SPF compositions
CN101194666A (en) 2007-11-28 2008-06-11 吴江市方霞企业信息咨询有限公司 Silkworm chrysalis fibroin protein functional foods
WO2009088119A1 (en) 2008-01-07 2009-07-16 Bioleaders Corporation Composition for preventing or treating dry eye syndrome comprising poly-gamma-glutamic acid
US20120052124A1 (en) 2009-03-04 2012-03-01 Trustees Of Tufts College Silk fibroin systems for antibiotic delivery
US20110008437A1 (en) 2009-04-20 2011-01-13 Altman Gregory H Silk Fibroin Hydrogels and Uses Thereof
NZ596932A (en) 2009-06-05 2014-04-30 Allergan Inc Artificial tears and therapeutic uses
EP2453931A4 (en) 2009-07-14 2014-04-30 Tufts College Electrospun silk material systems for wound healing
WO2011109691A2 (en) 2010-03-05 2011-09-09 Trustees Of Tufts College Silk-based ionomeric compositions
CA2839719A1 (en) 2010-06-17 2011-12-22 Tufts University / Trustees Of Tufts College Silk optical particles and uses thereof
US20140193466A1 (en) * 2011-06-07 2014-07-10 Cornell University Silk compositions and methods of using same
CN102860969A (en) 2011-07-07 2013-01-09 刘畅 Soybean eye cream
CA2865132A1 (en) 2012-02-22 2013-08-29 Trustees Of Tufts College Compositions and methods for ocular delivery of a therapeutic agent
US9056063B2 (en) 2012-03-13 2015-06-16 James E. Hanson Natural sunscreen composition
US20150079012A1 (en) 2012-04-20 2015-03-19 Trustees Of Tufts College Silk fibroin-based personal care compositions
WO2014127007A1 (en) 2013-02-12 2014-08-21 Seryx Biomedical, Inc. Ophthalmic formulation derived from silk protein
CA2898717C (en) * 2013-02-14 2019-01-08 Helix Biomedix, Inc. Short bio-active peptides for promoting wound healing
JP6457482B2 (en) 2013-03-15 2019-01-23 トラスティーズ オブ タフツ カレッジ Low molecular weight silk composition and stabilization of silk composition
CA2905365C (en) 2013-03-15 2021-03-23 Banner Life Sciences Llc Silk-based capsules
CN103239707A (en) 2013-05-22 2013-08-14 江苏紫石化工科技有限公司 Eye drop for treating myopia
CA3137437A1 (en) 2013-09-30 2015-04-02 Evolved By Nature, Inc. Silk protein fragment compositions and articles manufactured therefrom
US9968708B2 (en) * 2013-11-19 2018-05-15 Cornell University Tissue scaffold materials for tissue regeneration and methods of making
SG11201704010UA (en) * 2014-08-20 2017-06-29 Silk Tech Ltd Fibroin-derived protein composition
JP2019519596A (en) 2016-04-08 2019-07-11 コーネル・ユニバーシティーCornell University Methods of promoting wound healing using silk derived proteins

Also Published As

Publication number Publication date
CN109640694A (en) 2019-04-16
JP2019519596A (en) 2019-07-11
WO2017200659A2 (en) 2017-11-23
US20190117834A1 (en) 2019-04-25
AU2017267370B2 (en) 2021-07-08
CA3020342A1 (en) 2017-11-23
US10953132B2 (en) 2021-03-23
WO2017200659A3 (en) 2018-02-08
AU2017267370A1 (en) 2018-11-22
KR20190008210A (en) 2019-01-23

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