EA201590601A1 - Применение pedf-производных полипептидов для лечения остеоартрита - Google Patents

Применение pedf-производных полипептидов для лечения остеоартрита

Info

Publication number
EA201590601A1
EA201590601A1 EA201590601A EA201590601A EA201590601A1 EA 201590601 A1 EA201590601 A1 EA 201590601A1 EA 201590601 A EA201590601 A EA 201590601A EA 201590601 A EA201590601 A EA 201590601A EA 201590601 A1 EA201590601 A1 EA 201590601A1
Authority
EA
Eurasian Patent Office
Prior art keywords
osteoarthritis
treatment
amino acid
synthetic peptide
pedf
Prior art date
Application number
EA201590601A
Other languages
English (en)
Other versions
EA030022B1 (ru
Inventor
Йеоу-Пин Цао
Цунь-Чуань Хо
Original Assignee
Маккей Мемориал Хоспитал
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Маккей Мемориал Хоспитал filed Critical Маккей Мемориал Хоспитал
Publication of EA201590601A1 publication Critical patent/EA201590601A1/ru
Publication of EA030022B1 publication Critical patent/EA030022B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/12—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Раскрыт синтетический пептид, который имеет аминокислотную последовательность, которая имеет 20-39 аминокислотных остатков. Синтетический пептид имеет по меньшей мере 80% идентичности аминокислотной последовательности с SEQ ID NO:1 и включает по меньшей мере 20 последовательных остатков, которые имеют по меньшей мере 90% идентичности аминокислотной последовательности с остатками 11-30 SEQ ID NO:1. Также раскрыты фармацевтические композиции, содержащие синтетический пептид, и их применение. В соответствии с различными вариантами осуществления настоящего раскрытия синтетический пептид пригоден в лечении остеоартрита у пациента.
EA201590601A 2012-09-20 2012-09-20 Применение pedf-производных полипептидов для лечения остеоартрита EA030022B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2012/081659 WO2014043871A1 (en) 2012-09-20 2012-09-20 Use of pedf-derived polypeptides for treating osteoarthritis

Publications (2)

Publication Number Publication Date
EA201590601A1 true EA201590601A1 (ru) 2015-08-31
EA030022B1 EA030022B1 (ru) 2018-06-29

Family

ID=50340531

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590601A EA030022B1 (ru) 2012-09-20 2012-09-20 Применение pedf-производных полипептидов для лечения остеоартрита

Country Status (9)

Country Link
US (1) US9777048B2 (ru)
EP (1) EP2897974B1 (ru)
JP (1) JP6208763B2 (ru)
KR (1) KR101770252B1 (ru)
CN (1) CN104903344B (ru)
AU (1) AU2012390210B2 (ru)
EA (1) EA030022B1 (ru)
IL (1) IL237835B (ru)
WO (1) WO2014043871A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2895502B1 (en) 2012-09-17 2018-09-05 Mackay Memorial Hospital Use of pedf-derived polypeptides for treating alopecia and/or hair depigmentation
KR101830926B1 (ko) 2012-09-19 2018-02-22 맥케이 메모리얼 호스피탈 피부 노화를 방지 및/또는 개선하기 위해 사용되는 pedf-유도 폴리펩티드의 용도
WO2016014786A2 (en) 2014-07-24 2016-01-28 Yale University Pigment epithelium-derived factor (pedf) and peptide derivatives thereof for use in osteoblast differentiation and bone growth
CN110312732A (zh) * 2016-10-07 2019-10-08 全福生物科技股份有限公司 包含pedf-衍生的短肽的组合物及其用途
CN106581666A (zh) * 2016-11-23 2017-04-26 新乡医学院 Pedf在制备治疗糖尿病骨组织并发症药物中的应用
KR20200140843A (ko) * 2018-04-08 2020-12-16 브림 바이오테크놀로지, 인코퍼레이티드 Pedf-유래 짧은 펩타이드의 골관절염의 치료에의 적용
CN115151243A (zh) * 2019-10-06 2022-10-04 全福生物科技股份有限公司 包含pedf-衍生短肽(pdsp)的组合物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005041887A2 (en) * 2003-10-29 2005-05-12 The Johns Hopkins University Pigment epithelium-derived factor, novel biological activity and methods of use
US8173591B2 (en) 2004-11-16 2012-05-08 Yeda Research And Development Co. Variants of pigment epithelium derived factor and uses thereof
EP1986676A4 (en) 2006-02-15 2009-11-04 Univ Yale Inc COMPOSITIONS AND METHODS USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) PEPTIDE FRAGMENTS
ITPD20060219A1 (it) 2006-05-31 2007-12-01 Fidia Farmaceutici Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi
AU2008296733B2 (en) * 2007-08-08 2013-07-11 The Board Of Regents Of The University Of Texas System VEGFR-1/NRP-1 targeting peptides
EP2508196B1 (en) 2011-03-23 2018-09-26 Mackay Memorial Hospital Use of PEDF-derived polypeptides for promoting stem cells proliferation and wound healing
EP2882772B1 (en) 2012-08-09 2017-12-20 Mackay Memorial Hospital Use of pedf-derived polypeptides for promoting muscle or tendon regeneration or arteriogenesis
EP2895502B1 (en) 2012-09-17 2018-09-05 Mackay Memorial Hospital Use of pedf-derived polypeptides for treating alopecia and/or hair depigmentation
KR101830926B1 (ko) 2012-09-19 2018-02-22 맥케이 메모리얼 호스피탈 피부 노화를 방지 및/또는 개선하기 위해 사용되는 pedf-유도 폴리펩티드의 용도

Also Published As

Publication number Publication date
EP2897974B1 (en) 2018-03-28
EA030022B1 (ru) 2018-06-29
IL237835B (en) 2020-04-30
KR20150058365A (ko) 2015-05-28
JP6208763B2 (ja) 2017-10-11
US9777048B2 (en) 2017-10-03
KR101770252B1 (ko) 2017-08-22
EP2897974A1 (en) 2015-07-29
EP2897974A4 (en) 2016-05-18
IL237835A0 (en) 2015-05-31
AU2012390210A1 (en) 2015-04-09
JP2015530392A (ja) 2015-10-15
CN104903344A (zh) 2015-09-09
AU2012390210B2 (en) 2017-06-29
US20150239942A1 (en) 2015-08-27
CN104903344B (zh) 2018-09-04
WO2014043871A1 (en) 2014-03-27

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