EA201600478A1 - Новые индазолкарбоксамиды, способы их получения, содержащие их фармацевтические препараты и их применение для изготовления лекарственных средств - Google Patents
Новые индазолкарбоксамиды, способы их получения, содержащие их фармацевтические препараты и их применение для изготовления лекарственных средствInfo
- Publication number
- EA201600478A1 EA201600478A1 EA201600478A EA201600478A EA201600478A1 EA 201600478 A1 EA201600478 A1 EA 201600478A1 EA 201600478 A EA201600478 A EA 201600478A EA 201600478 A EA201600478 A EA 201600478A EA 201600478 A1 EA201600478 A1 EA 201600478A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- production
- medicines
- new
- methods
- indazolkarboxamides
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 230000006806 disease prevention Effects 0.000 abstract 2
- -1 6-substituted indazoles Chemical class 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000002780 macular degeneration Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Immunology (AREA)
- Epidemiology (AREA)
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- Reproductive Health (AREA)
- Hematology (AREA)
- Obesity (AREA)
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- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Настоящая заявка относится к новым 6-замещенным индазолам, содержащим карбоксамидную боковую цепь, к способам их получения, к их применению отдельно или в комбинации для лечения и/или профилактики заболеваний и к их применению для изготовления лекарственных средств для лечения и/или профилактики заболеваний, в частности для лечения и/или профилактики эндометриоза, лимфом, дегенерации желтого пятна, ХОЗЛ и псориаза.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13198463 | 2013-12-19 | ||
EP14189216 | 2014-10-16 | ||
PCT/EP2014/077877 WO2015091426A1 (de) | 2013-12-19 | 2014-12-16 | Neue indazolcarboxamide, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201600478A1 true EA201600478A1 (ru) | 2016-11-30 |
EA032621B1 EA032621B1 (ru) | 2019-06-28 |
Family
ID=52292884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201600478A EA032621B1 (ru) | 2013-12-19 | 2014-12-16 | Индазолкарбоксамиды, способы их получения, содержащие их фармацевтические препараты и их применение для изготовления лекарственных средств |
Country Status (34)
Country | Link |
---|---|
US (1) | US9951086B2 (ru) |
EP (1) | EP3083586B1 (ru) |
JP (1) | JP6530406B2 (ru) |
KR (1) | KR20160094381A (ru) |
CN (1) | CN106170486B (ru) |
AP (1) | AP2016009273A0 (ru) |
AU (1) | AU2014364744B2 (ru) |
BR (1) | BR112016013632B1 (ru) |
CA (1) | CA2934137C (ru) |
CL (1) | CL2016001579A1 (ru) |
CR (1) | CR20160278A (ru) |
CU (1) | CU20160087A7 (ru) |
CY (1) | CY1120437T1 (ru) |
DK (1) | DK3083586T3 (ru) |
DO (1) | DOP2016000150A (ru) |
EA (1) | EA032621B1 (ru) |
ES (1) | ES2677996T3 (ru) |
HR (1) | HRP20181107T1 (ru) |
HU (1) | HUE038367T2 (ru) |
IL (1) | IL246032B (ru) |
JO (1) | JO3460B1 (ru) |
LT (1) | LT3083586T (ru) |
MX (1) | MX368413B (ru) |
PE (1) | PE20160900A1 (ru) |
PH (1) | PH12016501188A1 (ru) |
PL (1) | PL3083586T3 (ru) |
PT (1) | PT3083586T (ru) |
RS (1) | RS57423B1 (ru) |
SG (1) | SG11201604685RA (ru) |
SI (1) | SI3083586T1 (ru) |
TW (1) | TWI667233B (ru) |
UA (1) | UA117392C2 (ru) |
UY (1) | UY35907A (ru) |
WO (1) | WO2015091426A1 (ru) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017505337A (ja) | 2014-01-10 | 2017-02-16 | アウリジーン ディスカバリー テクノロジーズ リミテッド | Irak4阻害剤としてのインダゾール化合物 |
EP3805233B1 (en) | 2014-01-13 | 2024-03-06 | Aurigene Oncology Limited | (r) and (s) enantiomers of n-(5-(3-hydroxypyrrolidin-1-yl)-2-morpholinooxazolo[4,5-b]pyridin-6-yl)-2-(2-methylpyridin-4-yl)oxazole-carboxamide as irak4 inhibitors for the treatment of cancer |
JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
EP3195865A1 (de) | 2016-01-25 | 2017-07-26 | Bayer Pharma Aktiengesellschaft | Kombinationen von irak4 inhibitoren und btk inhibitoren |
JP6847855B2 (ja) | 2015-04-30 | 2021-03-24 | バイエル ファーマ アクチエンゲゼルシャフト | Irak4の阻害剤とbtkの阻害剤の組み合わせ |
DK3331879T3 (da) * | 2015-08-04 | 2020-08-10 | Rigel Pharmaceuticals Inc | Benzazolforbindelser og fremgangsmåder til fremstilling og anvendelse af forbindelserne |
WO2017108744A1 (de) * | 2015-12-22 | 2017-06-29 | Bayer Pharma Aktiengesellschaft | Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
WO2017148902A1 (de) | 2016-03-03 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | Neue 2-substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
EP3219329A1 (en) * | 2016-03-17 | 2017-09-20 | Bayer Pharma Aktiengesellschaft | Combinations of copanlisib |
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HUE064389T2 (hu) * | 2016-04-29 | 2024-03-28 | Bayer Pharma AG | Az N-{6-(2-hidroxipropán-2-il)-2-[2-(metilszulfonil)etil]-2h-indazol-5-il}-6- (trifluormetil)piridin-2-karboxamid polimorf formája |
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