CU24593B1 - Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)- piridin-2-carboxamida - Google Patents

Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)- piridin-2-carboxamida

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Publication number
CU24593B1
CU24593B1 CU2018000130A CU20180130A CU24593B1 CU 24593 B1 CU24593 B1 CU 24593B1 CU 2018000130 A CU2018000130 A CU 2018000130A CU 20180130 A CU20180130 A CU 20180130A CU 24593 B1 CU24593 B1 CU 24593B1
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Prior art keywords
hydroxypropan
indazol
methylbutyl
carboxamide
pyridine
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CU2018000130A
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English (en)
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CU20180130A7 (es
Inventor
Dr Nicolas Guimond
Dr Johannes Platzek
Dr Tobias Thaler
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Bayer Pharma AG
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Publication date
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Publication of CU20180130A7 publication Critical patent/CU20180130A7/es
Publication of CU24593B1 publication Critical patent/CU24593B1/es

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

<p>La presente invención se refiere a formas cristalinas de N-[2-(3-Hidroxi-3-metilbutil)-6-(2hidroxipropan-2-ii)-2H-indazol-5-il]-6-(trifluorometil)piridin-2-carboxamida, particularmente el hidrato, que es activo como inhibidor de IRAK4 y por lo tanto útil para el tratamiento o la prevención de linfoma, psoriasis, lupus eritematoso, esclerosis múltiple y EPOC, entre otras afecciones.</p>
CU2018000130A 2016-04-29 2017-04-25 Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)- piridin-2-carboxamida CU24593B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16167649 2016-04-29
EP16167650 2016-04-29
PCT/EP2017/059764 WO2017186700A1 (en) 2016-04-29 2017-04-25 Crystalline forms of n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide

Publications (2)

Publication Number Publication Date
CU20180130A7 CU20180130A7 (es) 2019-06-04
CU24593B1 true CU24593B1 (es) 2022-05-11

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CU2018000130A CU24593B1 (es) 2016-04-29 2017-04-25 Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)- piridin-2-carboxamida

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US (2) US10501437B2 (es)
EP (2) EP3448847A1 (es)
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CN (4) CN118184628A (es)
AU (2) AU2017256659B2 (es)
BR (1) BR112018072247A2 (es)
CA (2) CA3022329A1 (es)
CL (2) CL2018003085A1 (es)
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GEP20217230B (en) 2016-04-29 2021-03-10 Bayer Pharma AG Crystalline forms of n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
SG10202011653WA (en) 2016-06-01 2020-12-30 Bayer Pharma AG Use of 2-substituted indazoles for the treatment and prophylaxis of autoimmune diseases
RU2743170C2 (ru) 2016-06-01 2021-02-15 Байер Энимал Хелс Гмбх Замещенные индазолы, пригодные для лечения и предупреждения аллергических и/или воспалительных заболеваний у животных

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EP3448849A1 (en) 2019-03-06
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PL3448849T3 (pl) 2020-12-14
JP2019514924A (ja) 2019-06-06
CN109071491B (zh) 2020-08-21
SG11201809172WA (en) 2018-11-29
MX2018013232A (es) 2019-02-13
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IL262413A (en) 2018-12-31
IL262413B (en) 2021-05-31
UA123550C2 (uk) 2021-04-21
KR20180137498A (ko) 2018-12-27
JOP20170101B1 (ar) 2022-03-14
KR102409105B1 (ko) 2022-06-16
GEP20217230B (en) 2021-03-10
UA122882C2 (uk) 2021-01-13
EA201892407A1 (ru) 2019-05-31
JP2019514921A (ja) 2019-06-06
CA3022327A1 (en) 2017-11-02
DK3448849T3 (da) 2020-06-29
CN112898269A (zh) 2021-06-04
SG11201808686VA (en) 2018-11-29
TW201738233A (zh) 2017-11-01
UY37217A (es) 2017-11-30
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PT3448849T (pt) 2020-06-30
CN118184628A (zh) 2024-06-14

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