BR112018072247A2 - formas cristalinas de n-[2-(3-hidróxi-3-metilbutil)-6-(2-hidróxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)piridina-2-carboxamida - Google Patents
formas cristalinas de n-[2-(3-hidróxi-3-metilbutil)-6-(2-hidróxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)piridina-2-carboxamidaInfo
- Publication number
- BR112018072247A2 BR112018072247A2 BR112018072247-2A BR112018072247A BR112018072247A2 BR 112018072247 A2 BR112018072247 A2 BR 112018072247A2 BR 112018072247 A BR112018072247 A BR 112018072247A BR 112018072247 A2 BR112018072247 A2 BR 112018072247A2
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxypropan
- indazol
- methylbutyl
- trifluoromethyl
- pyridine
- Prior art date
Links
- NWFPCWIBSBZRGV-UHFFFAOYSA-N N-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide Chemical compound OC(CCN1N=C2C=C(C(=CC2=C1)NC(=O)C1=NC(=CC=C1)C(F)(F)F)C(C)(C)O)(C)C NWFPCWIBSBZRGV-UHFFFAOYSA-N 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
formas cristalinas de n-[2-(3-hidróxi-3-metilbutil)-6-(2-hidróxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)piridina-2-carboxamida. a presente invenção se refere a formas cristalinas de n-[2-(3-hidróxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)piridina-2-carboxamida, a processos para sua preparação, a composições farmacêuticas que as constitui e a seu uso no controle de doenças.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16167650 | 2016-04-29 | ||
EP16167649 | 2016-04-29 | ||
EP16167649.9 | 2016-04-29 | ||
EP16167650.7 | 2016-04-29 | ||
PCT/EP2017/059764 WO2017186700A1 (en) | 2016-04-29 | 2017-04-25 | Crystalline forms of n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018072247A2 true BR112018072247A2 (pt) | 2019-02-12 |
Family
ID=58579196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018072247-2A BR112018072247A2 (pt) | 2016-04-29 | 2017-04-25 | formas cristalinas de n-[2-(3-hidróxi-3-metilbutil)-6-(2-hidróxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)piridina-2-carboxamida |
Country Status (37)
Country | Link |
---|---|
US (2) | US10633365B2 (pt) |
EP (2) | EP3448847A1 (pt) |
JP (2) | JP6916207B2 (pt) |
KR (2) | KR102379948B1 (pt) |
CN (3) | CN109071491B (pt) |
AU (2) | AU2017257208B2 (pt) |
BR (1) | BR112018072247A2 (pt) |
CA (2) | CA3022327A1 (pt) |
CL (2) | CL2018003085A1 (pt) |
CO (2) | CO2018011607A2 (pt) |
CU (1) | CU24593B1 (pt) |
DK (1) | DK3448849T3 (pt) |
DO (1) | DOP2018000236A (pt) |
EA (1) | EA038103B1 (pt) |
EC (1) | ECSP18081451A (pt) |
ES (1) | ES2801800T3 (pt) |
GE (1) | GEP20217230B (pt) |
HU (1) | HUE049331T2 (pt) |
IL (2) | IL262391B (pt) |
JO (2) | JOP20170102B1 (pt) |
LT (1) | LT3448849T (pt) |
MA (1) | MA44758A (pt) |
MX (2) | MX2018013227A (pt) |
NI (1) | NI201800111A (pt) |
PE (2) | PE20190172A1 (pt) |
PH (1) | PH12018502288A1 (pt) |
PL (1) | PL3448849T3 (pt) |
PT (1) | PT3448849T (pt) |
RS (1) | RS60419B1 (pt) |
SG (2) | SG11201808686VA (pt) |
SI (1) | SI3448849T1 (pt) |
SV (1) | SV2018005776A (pt) |
TN (1) | TN2018000359A1 (pt) |
TW (3) | TWI671291B (pt) |
UA (2) | UA122882C2 (pt) |
UY (2) | UY37217A (pt) |
WO (2) | WO2017186700A1 (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
CA3016364A1 (en) | 2016-03-03 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | New 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
MX2018013235A (es) | 2016-04-29 | 2019-02-13 | Bayer Pharma AG | Forma polimorfa de n-{6-(2-hidroxipropan-2-il)-2-[2-(metilsulfonil )etil]-2h-indazol-5-il}-6-(trifluorometil)piridin-2-carboxamida. |
CN109071491B (zh) | 2016-04-29 | 2020-08-21 | 拜耳医药股份有限公司 | 吲唑的合成 |
BR112018074919A2 (pt) | 2016-06-01 | 2020-11-03 | Bayer Pharma Aktiengesellschaft | uso de indazóis 2-substituídos para tratamento e profilaxia de doenças autoimunes. |
KR102547834B1 (ko) * | 2016-06-01 | 2023-06-26 | 바이엘 애니멀 헬스 게엠베하 | 동물에서의 알레르기성 및/또는 염증성 질환의 치료 및 예방에 유용한 치환된 인다졸 |
KR20210024543A (ko) | 2018-06-25 | 2021-03-05 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | IRAK4 억제제로서의 이소티아졸로[5,4-d]피리미딘 화합물 |
KR102392788B1 (ko) | 2019-01-08 | 2022-04-28 | 주식회사 엘지에너지솔루션 | 폴더블 사이드 플레이트를 구비하는 배터리 모듈 및 그 제조 방법 |
CN111499612B (zh) * | 2019-01-30 | 2022-12-30 | 上海美悦生物科技发展有限公司 | 一种作为irak抑制剂的化合物及其制备方法和用途 |
CN113521079A (zh) * | 2020-04-20 | 2021-10-22 | 上海领泰生物医药科技有限公司 | Irak4抑制剂在治疗ali/ards中的应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US20100048660A1 (en) | 2006-02-10 | 2010-02-25 | Graham Michael Wynne | Treatment of duchenne muscular dystrophy |
JP5258563B2 (ja) | 2006-06-29 | 2013-08-07 | 日産化学工業株式会社 | αアミノ酸誘導体及びそれを有効成分として含む医薬 |
CA2663100A1 (en) | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | Indazole derivatives as modulators of interleukin-1 receptor-associated kinase |
US20120196824A1 (en) | 2009-10-09 | 2012-08-02 | Mitsubishi Tanabe Pharma Corporation | Therapeutic agent for cerebral infarction |
WO2011153588A1 (en) | 2010-06-10 | 2011-12-15 | Biota Scientific Management Pty Ltd | Viral polymerase inhibitors |
US9073892B2 (en) | 2010-12-20 | 2015-07-07 | Merck Serono S.A. | Indazolyl triazol derivatives |
WO2013106254A1 (en) | 2012-01-11 | 2013-07-18 | Dow Agrosciences Llc | Pesticidal compositions and processes related thereto |
EP2928886B1 (en) | 2012-12-07 | 2016-11-02 | Boehringer Ingelheim International GmbH | New indanyloxydihydrobenzofuranylacetic acids |
US9126984B2 (en) * | 2013-11-08 | 2015-09-08 | Iteos Therapeutics | 4-(indol-3-yl)-pyrazole derivatives, pharmaceutical compositions and methods for use |
TWI667233B (zh) * | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
SG11201605408RA (en) * | 2014-01-10 | 2016-07-28 | Aurigene Discovery Tech Ltd | Indazole compounds as irak4 inhibitors |
JO3705B1 (ar) * | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
WO2016174183A1 (en) | 2015-04-30 | 2016-11-03 | Bayer Pharma Aktiengesellschaft | Combinations of inhibitors of irak4 with inhibitors of btk |
BR112018000624A2 (pt) | 2015-07-15 | 2018-09-18 | Aurigene Discovery Technologies Limited | compostos de indazol e azaindazol como inibidores de irak-4 |
CA3016364A1 (en) | 2016-03-03 | 2017-09-08 | Bayer Pharma Aktiengesellschaft | New 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs |
EP3219329A1 (en) * | 2016-03-17 | 2017-09-20 | Bayer Pharma Aktiengesellschaft | Combinations of copanlisib |
CN109071491B (zh) | 2016-04-29 | 2020-08-21 | 拜耳医药股份有限公司 | 吲唑的合成 |
MX2018013235A (es) | 2016-04-29 | 2019-02-13 | Bayer Pharma AG | Forma polimorfa de n-{6-(2-hidroxipropan-2-il)-2-[2-(metilsulfonil )etil]-2h-indazol-5-il}-6-(trifluorometil)piridin-2-carboxamida. |
KR102547834B1 (ko) | 2016-06-01 | 2023-06-26 | 바이엘 애니멀 헬스 게엠베하 | 동물에서의 알레르기성 및/또는 염증성 질환의 치료 및 예방에 유용한 치환된 인다졸 |
BR112018074919A2 (pt) | 2016-06-01 | 2020-11-03 | Bayer Pharma Aktiengesellschaft | uso de indazóis 2-substituídos para tratamento e profilaxia de doenças autoimunes. |
-
2017
- 2017-04-25 CN CN201780026606.4A patent/CN109071491B/zh active Active
- 2017-04-25 WO PCT/EP2017/059764 patent/WO2017186700A1/en active Application Filing
- 2017-04-25 MA MA044758A patent/MA44758A/fr unknown
- 2017-04-25 GE GEAP201714932A patent/GEP20217230B/en unknown
- 2017-04-25 PE PE2018002240A patent/PE20190172A1/es unknown
- 2017-04-25 EA EA201892407A patent/EA038103B1/ru unknown
- 2017-04-25 HU HUE17719256A patent/HUE049331T2/hu unknown
- 2017-04-25 RS RS20200749A patent/RS60419B1/sr unknown
- 2017-04-25 SG SG11201808686VA patent/SG11201808686VA/en unknown
- 2017-04-25 DK DK17719256.4T patent/DK3448849T3/da active
- 2017-04-25 PE PE2023003161A patent/PE20240651A1/es unknown
- 2017-04-25 AU AU2017257208A patent/AU2017257208B2/en active Active
- 2017-04-25 PT PT177192564T patent/PT3448849T/pt unknown
- 2017-04-25 CN CN201780040907.2A patent/CN109415339A/zh active Pending
- 2017-04-25 TN TNP/2018/000359A patent/TN2018000359A1/en unknown
- 2017-04-25 CU CU2018000130A patent/CU24593B1/es unknown
- 2017-04-25 SG SG11201809172WA patent/SG11201809172WA/en unknown
- 2017-04-25 PL PL17719256T patent/PL3448849T3/pl unknown
- 2017-04-25 MX MX2018013227A patent/MX2018013227A/es unknown
- 2017-04-25 SI SI201730292T patent/SI3448849T1/sl unknown
- 2017-04-25 JP JP2018556406A patent/JP6916207B2/ja active Active
- 2017-04-25 EP EP17718559.2A patent/EP3448847A1/en active Pending
- 2017-04-25 US US16/097,463 patent/US10633365B2/en active Active
- 2017-04-25 US US16/097,506 patent/US10501437B2/en active Active
- 2017-04-25 AU AU2017256659A patent/AU2017256659B2/en active Active
- 2017-04-25 WO PCT/EP2017/059748 patent/WO2017186693A1/en active Application Filing
- 2017-04-25 EP EP17719256.4A patent/EP3448849B1/en active Active
- 2017-04-25 BR BR112018072247-2A patent/BR112018072247A2/pt active Search and Examination
- 2017-04-25 KR KR1020187030703A patent/KR102379948B1/ko active IP Right Grant
- 2017-04-25 ES ES17719256T patent/ES2801800T3/es active Active
- 2017-04-25 CA CA3022327A patent/CA3022327A1/en active Pending
- 2017-04-25 KR KR1020187030702A patent/KR102409105B1/ko active IP Right Grant
- 2017-04-25 MX MX2018013232A patent/MX2018013232A/es unknown
- 2017-04-25 UA UAA201811328A patent/UA122882C2/uk unknown
- 2017-04-25 CN CN202110078561.3A patent/CN112898269A/zh active Pending
- 2017-04-25 JP JP2018556410A patent/JP6821701B2/ja active Active
- 2017-04-25 CA CA3022329A patent/CA3022329A1/en active Pending
- 2017-04-25 LT LTEP17719256.4T patent/LT3448849T/lt unknown
- 2017-04-25 UA UAA201811327A patent/UA123550C2/uk unknown
- 2017-04-27 JO JOP/2017/0102A patent/JOP20170102B1/ar active
- 2017-04-27 JO JOP/2017/0101A patent/JOP20170101B1/ar active
- 2017-04-28 TW TW106114179A patent/TWI671291B/zh active
- 2017-04-28 TW TW106114181A patent/TWI651316B/zh active
- 2017-04-28 UY UY0001037217A patent/UY37217A/es active IP Right Grant
- 2017-04-28 UY UY0001037214A patent/UY37214A/es not_active Application Discontinuation
- 2017-04-28 TW TW108120349A patent/TW201936599A/zh unknown
-
2018
- 2018-10-15 IL IL262391A patent/IL262391B/en unknown
- 2018-10-16 IL IL262413A patent/IL262413B/en active IP Right Grant
- 2018-10-26 PH PH12018502288A patent/PH12018502288A1/en unknown
- 2018-10-29 NI NI201800111A patent/NI201800111A/es unknown
- 2018-10-29 CO CONC2018/0011607A patent/CO2018011607A2/es unknown
- 2018-10-29 CL CL2018003085A patent/CL2018003085A1/es unknown
- 2018-10-29 SV SV2018005776A patent/SV2018005776A/es unknown
- 2018-10-29 CO CONC2018/0011655A patent/CO2018011655A2/es unknown
- 2018-10-29 EC ECSENADI201881451A patent/ECSP18081451A/es unknown
- 2018-10-29 DO DO2018000236A patent/DOP2018000236A/es unknown
- 2018-10-29 CL CL2018003097A patent/CL2018003097A1/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112018072247A2 (pt) | formas cristalinas de n-[2-(3-hidróxi-3-metilbutil)-6-(2-hidróxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)piridina-2-carboxamida | |
BR112018072242A2 (pt) | forma polimórfica de n-{6-(2-hidróxipropan-2-il)-2-[2-(metilsulfonil)etil]-2h-indazol-5-il}-6-(trifluorometil)piridina-2-carboxamida | |
CY1124726T1 (el) | Παραγωγα κιναζολινης που χρησιμοποιουνται για την αντιμετωπιση του hiv | |
BR112018006243A2 (pt) | formas de cristal de mononucleotídeo de beta-nicotinamida | |
CO2018000113A2 (es) | Compuestos derivados de 2-(4-fenil-2-oxopiridin-1-(2h)-il)alcanoilamina | |
BR112017013491A2 (pt) | compostos de pirimidina fundida para o tratamento de hiv | |
BR112018005497A2 (pt) | compostos heterocíclicos e usos dos mesmos | |
BR112015020118A2 (pt) | derivados de 2-aminopirimidina para o tratamento de infecções virais | |
EA201692301A1 (ru) | Производные бороновой кислоты и их терапевтическое применение | |
CL2017000979A1 (es) | Formas cristalinas de 5-cloro-n4-[2-(dimetilfosforil)fenil]-n2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidina-2,4-diamina | |
BR112015011036A2 (pt) | derivados de 2-amino-quinazolina substituídos heterocíclicos para o tratamento de infecções virais | |
DOP2016000333A (es) | Sales cristalinas de (s)-6-((1-acetilpiperidin-4-il)amino)-n-(3-(3,4-dihidroisoquinolin-2(1h)-il)-2-hidroxipropil)pirimidino-4-carboxamida | |
CR20170425A (es) | Nuevas proteínas específicas para pioverdina y pioquelina | |
CL2017000715A1 (es) | Compuestos de 1-alquil-6-oxo-1,6-dihidropiridin-3-ilo | |
BR112017010402A2 (pt) | carboxamida substituída à base de tiazol e oxazol e derivados de ureia como ligantes de receptor vanilóide ii | |
BR112016028037A2 (pt) | Novos compostos | |
EA201790275A1 (ru) | Кристаллические формы 6-((6,7-диметоксихиназолин-4-ил)окси)-n,2-диметилбензофуран-3-карбоксамида | |
CY1123877T1 (el) | Μορφες στερεας καταστασης αλατων νιλοτινιμπης | |
CL2015003431A1 (es) | Derivados de piridona para el tratamiento de infecciones virales y enfermedades adicionales | |
EA201691231A1 (ru) | Фармацевтические лекарственные формы | |
BR112015032379A2 (pt) | inibidores virais de replicação, seu processo de preparação e suas utilizações terapêuticas | |
TR201908937T4 (tr) | P38 MAP kinazı inhibe eden indanil üre bileşikleri. | |
BR112017019816A2 (pt) | compostos, composição farmacêutica, método para o tratamento profilático ou terapêutico de doença dos rins e/ou fígado em um sujeito, e uso de um composto | |
BR112019004458A2 (pt) | formulações contendo fluopirame para o controle de nematódeos. | |
MX2015015845A (es) | Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS. |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2631 DE 08/06/2021 POR TER SIDO INDEVIDA. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |