MX2015015845A - Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos. - Google Patents

Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos.

Info

Publication number
MX2015015845A
MX2015015845A MX2015015845A MX2015015845A MX2015015845A MX 2015015845 A MX2015015845 A MX 2015015845A MX 2015015845 A MX2015015845 A MX 2015015845A MX 2015015845 A MX2015015845 A MX 2015015845A MX 2015015845 A MX2015015845 A MX 2015015845A
Authority
MX
Mexico
Prior art keywords
pyrimidin
indole
oxy
carboxamide derivatives
methyl
Prior art date
Application number
MX2015015845A
Other languages
English (en)
Inventor
Ulrike Glaenzel
Robert Nufer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2015015845A publication Critical patent/MX2015015845A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a ciertos metabolitos de la N-(1-metil-5-(trifluoro-metil)-1H-pirazol-3-il)-5-((6-((metil-ami no)-metil)-pirimidin-4-il)-oxi)-1H-indol-1-carboxamida; en particular, la presente invención se refiere a composiciones farmacéuticas que comprenden estos metabolitos, así como a los procesos para su preparación, y a su uso en el tratamiento de enfermedades.
MX2015015845A 2013-05-17 2014-05-16 Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos. MX2015015845A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824464P 2013-05-17 2013-05-17
PCT/IB2014/061484 WO2014184778A1 (en) 2013-05-17 2014-05-16 Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof

Publications (1)

Publication Number Publication Date
MX2015015845A true MX2015015845A (es) 2016-06-29

Family

ID=50896374

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015845A MX2015015845A (es) 2013-05-17 2014-05-16 Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos.

Country Status (13)

Country Link
US (2) US20150018376A1 (es)
EP (1) EP2997022B1 (es)
JP (1) JP2016518443A (es)
KR (1) KR20160010522A (es)
CN (1) CN105452241B (es)
AR (1) AR096322A1 (es)
AU (1) AU2014266867B2 (es)
BR (1) BR112015028551A2 (es)
CA (1) CA2912130A1 (es)
EA (1) EA201592190A1 (es)
ES (1) ES2699776T3 (es)
MX (1) MX2015015845A (es)
WO (1) WO2014184778A1 (es)

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524747A (en) 1976-05-11 1978-09-13 Ici Ltd Polypeptide
PT72878B (en) 1980-04-24 1983-03-29 Merck & Co Inc Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents
DE3372965D1 (en) 1982-07-23 1987-09-17 Ici Plc Amide derivatives
GB8327256D0 (en) 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
US5093330A (en) 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
US5010099A (en) 1989-08-11 1991-04-23 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and method of preparation and use
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
TW225528B (es) 1992-04-03 1994-06-21 Ciba Geigy Ag
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
CA2216796C (en) 1995-03-30 2003-09-02 Pfizer Inc. Quinazoline derivatives
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5843901A (en) 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
SK398A3 (en) 1995-07-06 1998-07-08 Novartis Ag Pyrrolopyrimidines and processes for the preparation thereof
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
RO121900B1 (ro) 1996-04-12 2008-07-30 Warner-Lambert Company Compuşi inhibitori, ireversibili, ai tirozin kinazelor, compoziţie farmaceutică care îi conţine şi utilizarea acestora
CA2258548C (en) 1996-06-24 2005-07-26 Pfizer Inc. Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
EP0923583A1 (de) 1996-08-30 1999-06-23 Novartis AG Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens
WO1998010121A1 (en) 1996-09-06 1998-03-12 Obducat Ab Method for anisotropic etching of structures in conducting materials
EP0954315A2 (en) 1996-09-13 1999-11-10 Sugen, Inc. Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
EP0837063A1 (en) 1996-10-17 1998-04-22 Pfizer Inc. 4-Aminoquinazoline derivatives
HU229833B1 (en) 1996-11-18 2014-09-29 Biotechnolog Forschung Gmbh Epothilone d production process, and its use as cytostatic as well as phytosanitary agents
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE69927790T2 (de) 1998-02-25 2006-07-20 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen
ATE459616T1 (de) 1998-08-11 2010-03-15 Novartis Ag Isochinoline derivate mit angiogenesis-hemmender wirkung
KR100716272B1 (ko) 1998-11-20 2007-05-09 코산 바이오사이언시즈, 인코포레이티드 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질
PE20010306A1 (es) * 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
KR100371449B1 (ko) 1999-07-20 2003-02-07 주식회사 아이디어파크 무선 이어폰/마이크를 갖는 착탈형 무선전환장치
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
AR035885A1 (es) 2001-05-14 2004-07-21 Novartis Ag Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
GB0119249D0 (en) 2001-08-07 2001-10-03 Novartis Ag Organic compounds
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
JO3265B1 (ar) * 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض

Also Published As

Publication number Publication date
US20150018376A1 (en) 2015-01-15
KR20160010522A (ko) 2016-01-27
EP2997022B1 (en) 2018-08-29
EP2997022A1 (en) 2016-03-23
EA201592190A1 (ru) 2016-04-29
AU2014266867A1 (en) 2015-12-03
CN105452241A (zh) 2016-03-30
ES2699776T3 (es) 2019-02-12
CA2912130A1 (en) 2014-11-20
AU2014266867B2 (en) 2017-07-13
BR112015028551A2 (pt) 2017-07-25
CN105452241B (zh) 2018-01-05
AR096322A1 (es) 2015-12-23
WO2014184778A1 (en) 2014-11-20
US20160115156A1 (en) 2016-04-28
JP2016518443A (ja) 2016-06-23
US9604969B2 (en) 2017-03-28

Similar Documents

Publication Publication Date Title
PH12018500284A1 (en) 5-bromo-2,6-di-(1h-pyrazol-1-yl)pyrimidin-4-amine for use in the treatment of cancer
PH12015501648B1 (en) 2-aminopyrimidine derivatives for the treatment of viral infections
MX2020010412A (es) Inhibidores de tirosina quinasa de bruton.
PH12015500983A1 (en) Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
MD20170070A2 (ro) Derivaţi de chinazolină utilizaţi în tratamentul HIV
PH12015500274A1 (en) Alkylpyrimidine derivatives for the treatment of viral infections and further diseases
PH12015502261A1 (en) Macrocyclic deaza-purinones for the treatment of viral infections
SG10201804306VA (en) THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
PH12014501738A1 (en) Piperidino-pyrimidine derivatives for the treatment of viral infections
PH12015500713A1 (en) Acylaminopyrimidine derivatives for the treatment of viral infections and further diseases
MX2021011906A (es) Composiciones de liberacion retardada de linaclotida.
EA032271B9 (ru) Вещества, фармацевтическая композиция и методы применения при лечении воспалительных заболеваний
PH12015502564A1 (en) Pyridone derivatives for the treatment of viral infections and further diseases
PH12015501555A1 (en) Topical aqueous ophthalmic compositions containing a 1h-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease
PH12017500323A1 (en) P38 map kinase inhibiting indanyl urea compounds
MX2015015845A (es) Derivados de pirimidin-4-il)-oxi)-1h-indol-1-carboxamida y uso de los mismos.
UA110910C2 (uk) Карбоксамідні похідні піразолу як інгібітори тирозинкінази брутона, фармацевтична композиція на їх основі та спосіб лікування захворювань (варіанти)