BR112015028551A2 - derivados de pirimidin-4-il)óxi)-1h-indol-1-carboxamida e usos dos mesmos - Google Patents

derivados de pirimidin-4-il)óxi)-1h-indol-1-carboxamida e usos dos mesmos

Info

Publication number
BR112015028551A2
BR112015028551A2 BR112015028551A BR112015028551A BR112015028551A2 BR 112015028551 A2 BR112015028551 A2 BR 112015028551A2 BR 112015028551 A BR112015028551 A BR 112015028551A BR 112015028551 A BR112015028551 A BR 112015028551A BR 112015028551 A2 BR112015028551 A2 BR 112015028551A2
Authority
BR
Brazil
Prior art keywords
pyrimidin
oxy
indol
methyl
relates
Prior art date
Application number
BR112015028551A
Other languages
English (en)
Inventor
Nufer Robert
Glaenzel Ulrike
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112015028551A2 publication Critical patent/BR112015028551A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

a b s t r a c t this invention relates to certain metabolites of n-(1-methyl-5-(trifluoromethyl)-1h-pyrazol-3-yl)-5-((6-((methylamino)methyl)pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide in particular, the present invention relates to pharmaceutical compositions comprising these metabolites, as well as processes for their preparation and their use in the treatment of diseases. tradução do resumo resumo patente de invenção: "derivados de pirimidin-4-il)óxi)-1h-indol-1-carboxamida e usos dos mesmos". a presente invenção refere-se a certos metabolitos de n-(1-metil-5-(trifluorometil)-1h-pirazol-3-il)-5-((6-((metilamino)metil)pirimidin-4-yl)oxy)-1h-indol-1-carboxamida. em particular, a presente invenção refere-se a composições farmacêuticas compreendendo estes metabolitos, bem como processos para a sua preparação e ao seu uso no tratamento de doenças.
BR112015028551A 2013-05-17 2014-05-16 derivados de pirimidin-4-il)óxi)-1h-indol-1-carboxamida e usos dos mesmos BR112015028551A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824464P 2013-05-17 2013-05-17
PCT/IB2014/061484 WO2014184778A1 (en) 2013-05-17 2014-05-16 Pyrimidin-4-yl)oxy)-1h-indole-1-carboxamide derivatives and use thereof

Publications (1)

Publication Number Publication Date
BR112015028551A2 true BR112015028551A2 (pt) 2017-07-25

Family

ID=50896374

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015028551A BR112015028551A2 (pt) 2013-05-17 2014-05-16 derivados de pirimidin-4-il)óxi)-1h-indol-1-carboxamida e usos dos mesmos

Country Status (13)

Country Link
US (2) US20150018376A1 (pt)
EP (1) EP2997022B1 (pt)
JP (1) JP2016518443A (pt)
KR (1) KR20160010522A (pt)
CN (1) CN105452241B (pt)
AR (1) AR096322A1 (pt)
AU (1) AU2014266867B2 (pt)
BR (1) BR112015028551A2 (pt)
CA (1) CA2912130A1 (pt)
EA (1) EA201592190A1 (pt)
ES (1) ES2699776T3 (pt)
MX (1) MX2015015845A (pt)
WO (1) WO2014184778A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101973074B1 (ko) * 2018-11-30 2019-04-26 주식회사 티움바이오 퓨로피리미딘 화합물의 염 및 결정형, 및 이를 포함하는 약학적 조성물

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Also Published As

Publication number Publication date
US20150018376A1 (en) 2015-01-15
CN105452241A (zh) 2016-03-30
EA201592190A1 (ru) 2016-04-29
AU2014266867B2 (en) 2017-07-13
WO2014184778A1 (en) 2014-11-20
CA2912130A1 (en) 2014-11-20
EP2997022B1 (en) 2018-08-29
MX2015015845A (es) 2016-06-29
US9604969B2 (en) 2017-03-28
US20160115156A1 (en) 2016-04-28
CN105452241B (zh) 2018-01-05
JP2016518443A (ja) 2016-06-23
EP2997022A1 (en) 2016-03-23
AU2014266867A1 (en) 2015-12-03
KR20160010522A (ko) 2016-01-27
AR096322A1 (es) 2015-12-23
ES2699776T3 (es) 2019-02-12

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2514 DE 12-03-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]