EA201490711A8 - Фармацевтическая композиция, содержащая фитоканнабиноиды каннабидиварин (cbdv) и каннабидиол (cbd) - Google Patents

Фармацевтическая композиция, содержащая фитоканнабиноиды каннабидиварин (cbdv) и каннабидиол (cbd)

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Publication number
EA201490711A8
EA201490711A8 EA201490711A EA201490711A EA201490711A8 EA 201490711 A8 EA201490711 A8 EA 201490711A8 EA 201490711 A EA201490711 A EA 201490711A EA 201490711 A EA201490711 A EA 201490711A EA 201490711 A8 EA201490711 A8 EA 201490711A8
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EA
Eurasian Patent Office
Prior art keywords
cbdv
cbd
composition
cannabichromen
cannabidiol
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EA201490711A
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English (en)
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EA029697B1 (ru
EA201490711A1 (ru
Inventor
Бенджамин Уэлли
Клэр Уилльямс
Гэри Стефенс
Томас ХИЛЛ
Original Assignee
ДжиДаблЮ ФАРМА ЛИМИТЕД
Оцука Фармасьютикал Ко., Лимитед
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Application filed by ДжиДаблЮ ФАРМА ЛИМИТЕД, Оцука Фармасьютикал Ко., Лимитед filed Critical ДжиДаблЮ ФАРМА ЛИМИТЕД
Publication of EA201490711A1 publication Critical patent/EA201490711A1/ru
Publication of EA201490711A8 publication Critical patent/EA201490711A8/ru
Publication of EA029697B1 publication Critical patent/EA029697B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Изобретение относится к фармацевтической композиции, содержащей или состоящей, по существу, из фитоканнабиноидов каннабидиварина (CBDV) и каннабидиола (CBD). Данная композиция в высокой степени безопасна и эффективна при применении для лечения неврологических состояний, характеризующихся повышенной возбудимостью центральной нервной системы, судорогами или припадками, такими как случаются при эпилепсии. Предпочтительно CBDV и CBD присутствуют, по меньшей мере, с одним неканнабиноидным компонентом конопли, таким как один или более терпен или фракция терпенов. Более конкретно, данная композиция также содержит одно или более соединение типа каннабихромена. В частности, пропиловый вариант каннабихромена (CBCV) и/или каннабихромен (СВС). Более конкретно, данная композиция также не содержит или практически не содержит других каннабиноидов, включая, в частности, тетрагидроканнабинол (ТНС) и тетрагидроканнабиварин (THCV), которые обычно содержатся в значительных количествах в хемотипах конопли, выведенных для получения значительного количества CBDV и/или CBD.
EA201490711A 2011-09-29 2012-09-14 Фармацевтическая композиция, содержащая фитоканнабиноиды каннабидиварин (cbdv) и каннабидиол (cbd) EA029697B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1116789.7A GB2495118B (en) 2011-09-29 2011-09-29 A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD)
PCT/GB2012/052284 WO2013045891A1 (en) 2011-09-29 2012-09-14 A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (cbdv) and cannabidiol (cbd)

Publications (3)

Publication Number Publication Date
EA201490711A1 EA201490711A1 (ru) 2014-09-30
EA201490711A8 true EA201490711A8 (ru) 2018-02-28
EA029697B1 EA029697B1 (ru) 2018-05-31

Family

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EA201490711A EA029697B1 (ru) 2011-09-29 2012-09-14 Фармацевтическая композиция, содержащая фитоканнабиноиды каннабидиварин (cbdv) и каннабидиол (cbd)

Country Status (18)

Country Link
US (3) US10729665B2 (ru)
EP (2) EP2760440A1 (ru)
JP (1) JP6326695B2 (ru)
KR (1) KR102107715B1 (ru)
CN (2) CN103826621A (ru)
AR (1) AR088047A1 (ru)
AU (1) AU2012314129B2 (ru)
BR (1) BR112014007519A8 (ru)
CA (1) CA2845677C (ru)
CO (1) CO6900149A2 (ru)
EA (1) EA029697B1 (ru)
GB (2) GB2495118B (ru)
IL (2) IL231701B (ru)
MX (1) MX367758B (ru)
MY (1) MY171310A (ru)
SG (3) SG10202103035YA (ru)
TW (1) TWI577373B (ru)
WO (1) WO2013045891A1 (ru)

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