EA201171131A1 - Усовершенствованное определение экспрессии генов - Google Patents

Усовершенствованное определение экспрессии генов

Info

Publication number
EA201171131A1
EA201171131A1 EA201171131A EA201171131A EA201171131A1 EA 201171131 A1 EA201171131 A1 EA 201171131A1 EA 201171131 A EA201171131 A EA 201171131A EA 201171131 A EA201171131 A EA 201171131A EA 201171131 A1 EA201171131 A1 EA 201171131A1
Authority
EA
Eurasian Patent Office
Prior art keywords
gene expression
improved determination
oligonucleotide
primer
probe
Prior art date
Application number
EA201171131A
Other languages
English (en)
Other versions
EA021100B1 (ru
Inventor
Гаэтан Отто
Кэтрин Бови
Original Assignee
МДхХЭЛС СА
Глаксосмитклайн Байлоджикалс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by МДхХЭЛС СА, Глаксосмитклайн Байлоджикалс С.А. filed Critical МДхХЭЛС СА
Publication of EA201171131A1 publication Critical patent/EA201171131A1/ru
Publication of EA021100B1 publication Critical patent/EA021100B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

К охране предложены олигонуклеотид, праймер или зонд, содержащие нуклеотидную последовательность, указанную в любой из SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 44, 61, 62 или 63. Олигонуклеотид, праймер или зонд применимы для определения статуса метилирования гена. Олигонуклеотиды могут быть использованы для диагностики или лечения рака.
EA201171131A 2009-03-17 2010-03-17 Усовершенствованное определение экспрессии генов EA021100B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16093509P 2009-03-17 2009-03-17
PCT/EP2010/001674 WO2010105815A2 (en) 2009-03-17 2010-03-17 Improved detection of gene expression

Publications (2)

Publication Number Publication Date
EA201171131A1 true EA201171131A1 (ru) 2012-03-30
EA021100B1 EA021100B1 (ru) 2015-04-30

Family

ID=42224406

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171131A EA021100B1 (ru) 2009-03-17 2010-03-17 Усовершенствованное определение экспрессии генов

Country Status (14)

Country Link
US (1) US20120039993A1 (ru)
EP (1) EP2408933A2 (ru)
JP (1) JP2012520663A (ru)
KR (1) KR20120002534A (ru)
CN (1) CN102575284A (ru)
AU (1) AU2010225125A1 (ru)
BR (1) BRPI1009873A2 (ru)
CA (1) CA2755734A1 (ru)
EA (1) EA021100B1 (ru)
IL (1) IL215182A0 (ru)
MX (1) MX2011009597A (ru)
SG (1) SG174877A1 (ru)
WO (1) WO2010105815A2 (ru)
ZA (1) ZA201107175B (ru)

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US20180187267A1 (en) * 2017-01-05 2018-07-05 Michael J. Powell Method for conducting early detection of colon cancer and/or of colon cancer precursor cells and for monitoring colon cancer recurrence
EP3164508B1 (en) 2014-07-02 2023-06-07 Myriad myPath, LLC Genes and gene signatures for diagnosis and treatment of melanoma
CN104611453B (zh) * 2015-02-28 2016-08-24 基因科技（上海）有限公司 诊断基因甲基化的探针组及其应用
WO2016208466A1 (ja) * 2015-06-22 2016-12-29 ウシオ電機株式会社 検出対象物質の検出方法
DE102016005947B3 (de) 2016-05-16 2017-06-08 Dimo Dietrich Verfahren zur Abschätzung der Prognose und zur Prädiktion des Ansprechens auf eine Immuntherapie von Patienten mit malignen Erkrankungen
US11685955B2 (en) 2016-05-16 2023-06-27 Dimo Dietrich Method for predicting response of patients with malignant diseases to immunotherapy
CN109400697B (zh) * 2017-08-17 2021-04-23 香雪生命科学技术（广东）有限公司 一种识别prame抗原短肽的tcr及其相关组合物
US11441182B2 (en) * 2018-08-08 2022-09-13 Virginia Commonwealth University Multiplexed and recyclable single-molecule sensors for quantitative analysis of nucleic-acid biomarkers
JP7216995B2 (ja) * 2018-12-05 2023-02-02 学校法人関西医科大学 胸腺癌バイオマーカー及び胸腺腫瘍の予後予測マーカー
CN110387421A (zh) * 2019-08-28 2019-10-29 深圳市新合生物医疗科技有限公司 用于肺癌检测的DNA甲基化qPCR试剂盒及使用方法
RU2760573C1 (ru) * 2021-01-20 2021-11-29 Общество с ограниченной ответственностью "Эс Джи" Набор олигонуклеотидных праймеров и флуоресцентно-меченых зондов для выявления эпигенетических маркеров рака шейки матки

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Also Published As

Publication number Publication date
CA2755734A1 (en) 2010-09-23
US20120039993A1 (en) 2012-02-16
KR20120002534A (ko) 2012-01-05
MX2011009597A (es) 2012-05-29
EA021100B1 (ru) 2015-04-30
ZA201107175B (en) 2012-06-27
IL215182A0 (en) 2011-12-29
AU2010225125A1 (en) 2011-10-20
BRPI1009873A2 (pt) 2016-03-08
CN102575284A (zh) 2012-07-11
WO2010105815A2 (en) 2010-09-23
JP2012520663A (ja) 2012-09-10
WO2010105815A3 (en) 2010-11-25
EP2408933A2 (en) 2012-01-25
SG174877A1 (en) 2011-11-28

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU