EA201000210A1 - Агонисты пиридон gpr119, сопряженного с g-белком рецептора - Google Patents

Агонисты пиридон gpr119, сопряженного с g-белком рецептора

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Publication number
EA201000210A1
EA201000210A1 EA201000210A EA201000210A EA201000210A1 EA 201000210 A1 EA201000210 A1 EA 201000210A1 EA 201000210 A EA201000210 A EA 201000210A EA 201000210 A EA201000210 A EA 201000210A EA 201000210 A1 EA201000210 A1 EA 201000210A1
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EA
Eurasian Patent Office
Prior art keywords
pyridon
protein receptor
protein
gpr119 agonists
gpr119 receptor
Prior art date
Application number
EA201000210A
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English (en)
Other versions
EA018709B1 (ru
Inventor
Дин А. Уокер
Карен А. Росси
Инг Ван
Original Assignee
Бристол-Маерс Сквибб Компани
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Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA201000210A1 publication Critical patent/EA201000210A1/ru
Publication of EA018709B1 publication Critical patent/EA018709B1/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

Обеспечены новые соединения, которые являются модуляторами рецептора GPR119, сопряженного с G-белком. Модуляторы рецептора GPR119, сопряженного с G-белком, применимы в лечении, профилактике или замедлении прогрессирования заболеваний, отвечающих за терапию модулятором рецептора GPR119, сопряженного с G-белком. Эти новые соединения имеют структуру с формулой I или формулой IA.
EA201000210A 2007-07-17 2008-07-16 Пиридоновые агонисты сопряженного с g-белком рецептора gpr119 EA018709B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95016207P 2007-07-17 2007-07-17
PCT/US2008/070101 WO2009012275A1 (en) 2007-07-17 2008-07-16 Pyridone gpr119 g protein-coupled receptor agonists

Publications (2)

Publication Number Publication Date
EA201000210A1 true EA201000210A1 (ru) 2010-06-30
EA018709B1 EA018709B1 (ru) 2013-10-30

Family

ID=39864683

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201000210A EA018709B1 (ru) 2007-07-17 2008-07-16 Пиридоновые агонисты сопряженного с g-белком рецептора gpr119
EA201000211A EA016595B1 (ru) 2007-07-17 2008-07-16 Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA201000211A EA016595B1 (ru) 2007-07-17 2008-07-16 Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения

Country Status (27)

Country Link
US (6) US7928230B2 (ru)
EP (2) EP2173737B1 (ru)
JP (3) JP5318867B2 (ru)
KR (2) KR20100045471A (ru)
CN (3) CN101801957A (ru)
AR (2) AR067569A1 (ru)
AT (2) ATE540945T1 (ru)
AU (2) AU2008276055B2 (ru)
BR (2) BRPI0814428A2 (ru)
CA (2) CA2693439A1 (ru)
CL (2) CL2008002111A1 (ru)
CO (1) CO6160315A2 (ru)
CY (2) CY1112151T1 (ru)
DK (2) DK2170864T3 (ru)
EA (2) EA018709B1 (ru)
ES (2) ES2378914T3 (ru)
HK (2) HK1136298A1 (ru)
HR (2) HRP20110806T1 (ru)
IL (1) IL228120A0 (ru)
NZ (2) NZ582664A (ru)
PE (2) PE20090888A1 (ru)
PL (2) PL2173737T3 (ru)
PT (2) PT2173737E (ru)
SI (2) SI2173737T1 (ru)
TW (2) TW200904440A (ru)
WO (2) WO2009012277A1 (ru)
ZA (2) ZA201000151B (ru)

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