EA200900065A1 - Ингибиторы глицинового переносчика-1 - Google Patents

Ингибиторы глицинового переносчика-1

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Publication number
EA200900065A1
EA200900065A1 EA200900065A EA200900065A EA200900065A1 EA 200900065 A1 EA200900065 A1 EA 200900065A1 EA 200900065 A EA200900065 A EA 200900065A EA 200900065 A EA200900065 A EA 200900065A EA 200900065 A1 EA200900065 A1 EA 200900065A1
Authority
EA
Eurasian Patent Office
Prior art keywords
inhibitors
compounds
glyt
glycine transfer
glycine
Prior art date
Application number
EA200900065A
Other languages
English (en)
Other versions
EA014959B1 (ru
EA014959B3 (ru
Inventor
Стивен Хичкок
Альберт Эмагадзи
Вэньюань Цян
Сяоян Ся
Скотт С. Хэррид
Original Assignee
Амген Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38565553&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200900065(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA200900065A1 publication Critical patent/EA200900065A1/ru
Publication of EA014959B1 publication Critical patent/EA014959B1/ru
Publication of EA014959B3 publication Critical patent/EA014959B3/ru

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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
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  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Anesthesiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Данное изобретение предусматривает соединения, которые являются ингибиторами глицинового переносчика-1 (далее обозначаемого GlyT-1) и, следовательно, пригодны для лечения болезней, которые излечиваются при ингибировании GlyT-1, таких как нарушение познавательных функций, связанных с шизофренией, ADMD (дефицит внимания с гиперактивностью), MCI (умеренное ухудшение познавательных способностей) и т.п. Предложены также фармацевтические композиции, содержащие такие соединения, и способы получения этих соединений.
EA200900065A 2006-06-28 2007-06-26 Ингибиторы глицинового переносчика-1 EA014959B3 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81693606P 2006-06-28 2006-06-28
US85002706P 2006-10-06 2006-10-06
PCT/US2007/014842 WO2008002583A1 (en) 2006-06-28 2007-06-26 Glycine transporter-1 inhibitors

Publications (3)

Publication Number Publication Date
EA200900065A1 true EA200900065A1 (ru) 2009-06-30
EA014959B1 EA014959B1 (ru) 2011-04-29
EA014959B3 EA014959B3 (ru) 2014-10-30

Family

ID=38565553

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900065A EA014959B3 (ru) 2006-06-28 2007-06-26 Ингибиторы глицинового переносчика-1

Country Status (29)

Country Link
US (4) US7538114B2 (ru)
EP (3) EP2041088B1 (ru)
JP (1) JP5179486B2 (ru)
KR (2) KR101288781B1 (ru)
AR (1) AR077156A1 (ru)
AU (1) AU2007265467C1 (ru)
BR (1) BRPI0713381A2 (ru)
CA (1) CA2655159C (ru)
CR (1) CR10570A (ru)
CY (1) CY1115119T1 (ru)
DK (1) DK2041088T3 (ru)
EA (1) EA014959B3 (ru)
ES (1) ES2452822T3 (ru)
HK (1) HK1126205A1 (ru)
HR (1) HRP20140336T1 (ru)
IL (1) IL195473A (ru)
MX (1) MX2008015448A (ru)
MY (1) MY153714A (ru)
NO (1) NO20090402L (ru)
NZ (1) NZ573129A (ru)
PE (2) PE20120223A1 (ru)
PL (1) PL2041088T3 (ru)
PT (1) PT2041088E (ru)
RS (1) RS53277B (ru)
SG (1) SG172685A1 (ru)
SI (1) SI2041088T1 (ru)
TW (1) TWI429631B (ru)
WO (1) WO2008002583A1 (ru)
ZA (1) ZA201004216B (ru)

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NZ573129A (en) 2006-06-28 2011-06-30 Amgen Inc Piperazine acetic acid glycine transporter-1 inhibitors
JP2011506441A (ja) * 2007-12-12 2011-03-03 アムジエン・インコーポレーテツド グリシン輸送体−１阻害薬
CA2801074A1 (en) 2010-06-04 2011-12-08 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
US9012489B2 (en) 2011-08-03 2015-04-21 Boehringer Ingelheim International Gmbh Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
JOP20130213B1 (ar) 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
WO2015164520A1 (en) 2014-04-24 2015-10-29 Dart Neuroscience, Llc Substituted 2,4,5,6-tetrahydropyrrolo[3,4-c] pyrazole and 4,5,6,7-tetrahydro-2h-pyrazolo [4,3-c] pyridine compounds as glyt1 inhibitors
HUE055175T2 (hu) 2014-09-29 2021-11-29 Takeda Pharmaceuticals Co Az 1-(1-metil-1H-pirazol-4-il)-N-((1R,5S,7S)-9-metil-3-oxa-9-azabiciklo[3.3.1] nonan-7-il)-1H-indol-3-karboxamid kristályos formája
WO2016073420A1 (en) 2014-11-05 2016-05-12 Dart Neuroscience, Llc Substituted azetidinyl compounds as glyt1 inhibitors
KR101753617B1 (ko) 2016-05-10 2017-07-11 주식회사 뉴로벤티 피페라진-1-카복사미딘 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 자폐 범주성 장애 예방 및 치료용 약학적 조성물

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