EA200800444A1 - 8-МЕТОКСИ-9Н-ИЗОТИАЗОЛО[5,4-b]ХИНОЛИН-3,4-ДИОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ПРОТИВОИНФЕКЦИОННЫХ СРЕДСТВ - Google Patents

8-МЕТОКСИ-9Н-ИЗОТИАЗОЛО[5,4-b]ХИНОЛИН-3,4-ДИОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ПРОТИВОИНФЕКЦИОННЫХ СРЕДСТВ

Info

Publication number
EA200800444A1
EA200800444A1 EA200800444A EA200800444A EA200800444A1 EA 200800444 A1 EA200800444 A1 EA 200800444A1 EA 200800444 A EA200800444 A EA 200800444A EA 200800444 A EA200800444 A EA 200800444A EA 200800444 A1 EA200800444 A1 EA 200800444A1
Authority
EA
Eurasian Patent Office
Prior art keywords
formula
compounds
compound
isothiaosolo
diona
Prior art date
Application number
EA200800444A
Other languages
English (en)
Other versions
EA013244B1 (ru
Inventor
Бартон Джеймс Брэдбери
Джейсон Аллан Уайлс
Циупинг Ванг
Акихиро Хасимото
Эдлэйн Лусиен
Годвин Клэренс Гилрой Пейс
Майлинд Дешпенде
Майкл Джон Пуччи
Ха Юнг Ким
Original Assignee
Ачиллион Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ачиллион Фармасьютикалз, Инк. filed Critical Ачиллион Фармасьютикалз, Инк.
Publication of EA200800444A1 publication Critical patent/EA200800444A1/ru
Publication of EA013244B1 publication Critical patent/EA013244B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Изобретение относится к соединению и солям формулы (I) и (II), описанным здесь, которые включают соединения формулы (А) и формулы (В), такие соединения обладают полезной антимикробной активностью. Варьируемые заместители R, R, R, R, Rи R, показанные в формулах А и В определены здесь. Некоторые соединения формулы (I) и формулы (II), описанные здесь, являются сильными и/или селективными ингибиторами бактериального синтеза ДНК и бактериальной репликации. Изобретение также относится к противомикробным композициям, включающим фармацевтические композиции, содержащие одно или несколько соединений формулы (I) или формулы (II) и один или несколько носителей, эксципиентов или разбавителей. Такие композиции могут содержать соединение формулы (I) или формулы (II) в качестве единственного активного вещества или комбинацию соединения формулы I или формулы II и одно или несколько других активных веществ. Изобретение относится к способам лечения микробных инфекций у животных.
EA200800444A 2005-07-27 2006-07-27 8-МЕТОКСИ-9Н-ИЗОТИАЗОЛО[5,4-b]ХИНОЛИН-3,4-ДИОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ПРОТИВОИНФЕКЦИОННЫХ СРЕДСТВ EA013244B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70281105P 2005-07-27 2005-07-27
PCT/US2006/029302 WO2007014308A1 (en) 2005-07-27 2006-07-27 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents

Publications (2)

Publication Number Publication Date
EA200800444A1 true EA200800444A1 (ru) 2008-06-30
EA013244B1 EA013244B1 (ru) 2010-04-30

Family

ID=37106335

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800444A EA013244B1 (ru) 2005-07-27 2006-07-27 8-МЕТОКСИ-9Н-ИЗОТИАЗОЛО[5,4-b]ХИНОЛИН-3,4-ДИОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ПРОТИВОИНФЕКЦИОННЫХ СРЕДСТВ

Country Status (20)

Country Link
US (2) US8044204B2 (ru)
EP (1) EP1913004B1 (ru)
JP (1) JP5143000B2 (ru)
KR (1) KR101272263B1 (ru)
CN (1) CN101263146B (ru)
AT (1) ATE482219T1 (ru)
AU (1) AU2006272571B2 (ru)
BR (1) BRPI0614456B8 (ru)
CA (1) CA2616768C (ru)
DE (1) DE602006017082D1 (ru)
DK (1) DK1913004T3 (ru)
EA (1) EA013244B1 (ru)
ES (1) ES2352799T3 (ru)
HK (1) HK1122024A1 (ru)
IL (1) IL189017A (ru)
NO (1) NO343376B1 (ru)
NZ (1) NZ566209A (ru)
PL (1) PL1913004T3 (ru)
PT (1) PT1913004E (ru)
WO (1) WO2007014308A1 (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7902365B2 (en) 2006-08-16 2011-03-08 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones
US8173636B2 (en) * 2009-04-03 2012-05-08 Achillion Pharmaceuticals, Inc. Hydroxylthienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
CN104628729B (zh) * 2009-10-16 2018-11-06 梅琳塔治疗公司 抗微生物化合物和其制备和使用方法
CN102725274A (zh) 2009-10-16 2012-10-10 Rib-X制药公司 抗微生物化合物和其制备和使用方法
MX359743B (es) 2009-10-16 2018-10-08 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos para fabricar y utilizar los mismos.
TN2010000566A1 (en) * 2010-12-03 2012-05-24 Rekik Raouf Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
KR20160070066A (ko) 2013-09-09 2016-06-17 멜린타 테라퓨틱스, 인크. 항균 화합물, 및 이의 제조 방법 및 이용 방법
MX2016003046A (es) 2013-09-09 2016-09-08 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
WO2015114317A1 (en) * 2014-01-28 2015-08-06 Redx Pharma Plc 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds
BR112017019349A2 (pt) 2015-03-11 2018-06-05 Melinta Therapeutics Inc compostos antimicrobianos e métodos de fabricação e uso dos mesmos
EP3455218A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
JPH01160985A (ja) 1987-12-17 1989-06-23 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JPH01193275A (ja) 1988-01-28 1989-08-03 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
JP2681190B2 (ja) 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
JPH02174784A (ja) 1988-12-27 1990-07-06 Hokuriku Seiyaku Co Ltd イソチアゾロキノリン誘導体
JPH02243692A (ja) 1989-03-16 1990-09-27 Dainippon Pharmaceut Co Ltd 三環式化合物
JPH02255687A (ja) 1989-03-27 1990-10-16 Dainippon Pharmaceut Co Ltd 三環式化合物
FR2645862B1 (fr) * 1989-04-18 1991-07-12 Esteve Labor Dr Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments
JP2787713B2 (ja) 1989-07-28 1998-08-20 富山化学工業株式会社 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩
US5071848A (en) * 1989-10-23 1991-12-10 Abbott Laboratories Tricyclic quinoline antineoplastic agents
JP2939280B2 (ja) 1990-01-10 1999-08-25 三共株式会社 フッ素置換メトキシキノロンカルボン酸誘導体
US5580872A (en) * 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
CZ238698A3 (cs) 1996-01-31 1998-12-16 Sankyo Company, Limited Prostředky pro léčení a prevenci AIDS
JP3616454B2 (ja) 1996-04-19 2005-02-02 栄研化学株式会社 生体成分測定用試薬
JPH10130149A (ja) 1996-07-12 1998-05-19 Sankyo Co Ltd Ｔｎｆ産生抑制剤
DE19652219A1 (de) * 1996-12-16 1998-06-18 Bayer Ag Verwendung von 7-(1-Aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-chinolon- und naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
WO2002048138A1 (en) * 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial quinolones
NZ545157A (en) * 2003-08-12 2009-03-31 Achillion Pharmaceuticals Inc Isothiazoloquinolones and related compounds as anti-infective agents
KR20070085791A (ko) * 2004-11-11 2007-08-27 아칠리온 파르마세우티칼스 인코포레이티드 항감염성 제제로서8ａ,9-디히드로-4ａ-ｈ-이소티아졸로［5,4-ｂ］퀴놀린-3,4-디온 및 관련 화합물
DE602006018866D1 (de) * 2005-02-16 2011-01-27 Achillion Pharmaceuticals Inc Neue isothiazolochinolone und verwandte verbindungen als infektionsschutzmittel
US8173636B2 (en) 2009-04-03 2012-05-08 Achillion Pharmaceuticals, Inc. Hydroxylthienoquinolones and related compounds as anti-infective agents

Also Published As

Publication number Publication date
JP5143000B2 (ja) 2013-02-13
CA2616768A1 (en) 2007-02-01
CA2616768C (en) 2014-05-06
IL189017A (en) 2014-01-30
BRPI0614456B8 (pt) 2021-05-25
IL189017A0 (en) 2008-08-07
ES2352799T3 (es) 2011-02-23
HK1122024A1 (en) 2009-05-08
US20070049586A1 (en) 2007-03-01
PT1913004E (pt) 2010-12-09
BRPI0614456A2 (pt) 2011-03-29
US20120040959A1 (en) 2012-02-16
PL1913004T3 (pl) 2011-03-31
CN101263146B (zh) 2012-12-05
CN101263146A (zh) 2008-09-10
ATE482219T1 (de) 2010-10-15
WO2007014308A1 (en) 2007-02-01
DK1913004T3 (da) 2011-01-10
JP2009502953A (ja) 2009-01-29
US8044204B2 (en) 2011-10-25
AU2006272571A1 (en) 2007-02-01
DE602006017082D1 (de) 2010-11-04
NO20081005L (no) 2008-04-09
US8946422B2 (en) 2015-02-03
NZ566209A (en) 2011-03-31
NO343376B1 (no) 2019-02-11
EP1913004A1 (en) 2008-04-23
KR20080035661A (ko) 2008-04-23
EA013244B1 (ru) 2010-04-30
KR101272263B1 (ko) 2013-06-13
EP1913004B1 (en) 2010-09-22
AU2006272571B2 (en) 2012-03-08
BRPI0614456B1 (pt) 2019-08-27

Similar Documents

Publication Publication Date Title
EA200800444A1 (ru) 8-МЕТОКСИ-9Н-ИЗОТИАЗОЛО[5,4-b]ХИНОЛИН-3,4-ДИОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ПРОТИВОИНФЕКЦИОННЫХ СРЕДСТВ
NO20060653L (no) Isotiazolokinoloner og beslektede forbindelser som anti-infektive midler
EA200701734A1 (ru) Новые изотиазолохинолоны и родственные им соединения как антиинфекционные средства
NO20083207L (no) Inhibitorer av IAP
ATE420639T1 (de) Antimykotische mittel
RS20090249A (en) Spiroketone acetyl-coa carboxylase inhibotors
ATE433447T1 (de) Pyrimiidinverbindungen
ECSP066886A (es) Compuestos y métodos para el tratamiento de dislipidemia
UA94901C2 (ru) Антибактериальные производные пиперидина
MXPA05009352A (es) Metodos y composiciones para tratamiento y prevencion de staphylococcus y otras infecciones bacterianas.
WO2006120563A3 (en) Antibacterial agents
DE602008004540D1 (de) 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydroindolizin-3-yl)acetamidderivate und verwandte verbindungen als antipilzmittel
TW200510317A (en) Caspase inhibitors and uses thereof
NO20064351L (no) Caspaseinhibitorer og anvendelser derav
WO2010115184A3 (en) Hydroxythienoquinolones and related compounds as anti-infective agents
ZA200704913B (en) 3-[2-(3-acylamino-2-oxo-2H-pyridin-1-YL)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors
AP2003002942A0 (en) New derivatives of oxazolidinones as bacterial agents
DE602004008959D1 (de) Benzoäbüä1,4üdioxepinderivate
MXPA05009688A (es) Derivados de naftiridina como agentes antibacterianos.
IL183153A0 (en) 8a, 9-DIHYDRO-4a-H-ISOTHIAZOLO[5,4-b]QUINOLINE-3,4-DIONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS
WO2008036420A3 (en) 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
BR0307468A (pt) Derivados tiadiazinona antimicrobianos úteis no tratamento de infecções bacterianas
TH87141A (th) อนุพันธ์ควิโนลีนเป็นสารต้านแบคทีเรีย
TH87141B (th) อนุพันธ์ควิโนลีนเป็นสารต้านแบคเทีเรีย