NO20060653L - Isotiazolokinoloner og beslektede forbindelser som anti-infektive midler - Google Patents

Isotiazolokinoloner og beslektede forbindelser som anti-infektive midler

Info

Publication number
NO20060653L
NO20060653L NO20060653A NO20060653A NO20060653L NO 20060653 L NO20060653 L NO 20060653L NO 20060653 A NO20060653 A NO 20060653A NO 20060653 A NO20060653 A NO 20060653A NO 20060653 L NO20060653 L NO 20060653L
Authority
NO
Norway
Prior art keywords
formula
compounds
provides
isothiazoloquinolones
contain
Prior art date
Application number
NO20060653A
Other languages
English (en)
Inventor
Barton James Bradbury
Millind Deshphande
Michael John Pucci
Quiping Wang
Jason Allan Wiles
Monishing Song
Akihiro Hashimoto
Edlaine Lucien
Original Assignee
Achillion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Publication of NO20060653L publication Critical patent/NO20060653L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicinal Preparation (AREA)

Abstract

Oppfinnelsen tilveiebringer forbindelser og salter med Formel I og Formel II: som har antimikrobielle aktivitet. Oppfinnelsen tilveiebringer også nye syntetiske mellomprodukter anvendelige i syntesen av forbindelsene med Formel I og Formel II Variablene A1, R2, R3, R5, R6, R7, A8 og R9 er definert her. Visse forbindelser med Formel I og Formel II beskrevet her er kraftig og selektive inhibitorer av bakterielle DNA-syntese og bakterielle replikasjon. Oppfinnelsen tilveiebringer også antimikrobielle preparater, omfattende farmasøytiske preparater, inneholdende en eller flere forbindelser med Formel I eller Formel II og en eller flere bærere, tilsetningsmidler eller fortynningsmidler. Slike preparater kan inneholde en forbindelse med Formel I eller Formel II som eneste aktiv middel eller kan inneholde en kombinasjon av en forbindelse med Formel I eller Formel II og en eller flere andre aktive midler. Oppfinnelsen tilveiebringer også metoder for behandling av mikrobielle infeksjoner i dyr.
NO20060653A 2003-08-12 2006-02-09 Isotiazolokinoloner og beslektede forbindelser som anti-infektive midler NO20060653L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49465503P 2003-08-12 2003-08-12
PCT/US2004/025365 WO2005019228A1 (en) 2003-08-12 2004-08-04 Isothiazoloquinolones and related compounds as anti-infective agents

Publications (1)

Publication Number Publication Date
NO20060653L true NO20060653L (no) 2006-03-13

Family

ID=34215887

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20060653A NO20060653L (no) 2003-08-12 2006-02-09 Isotiazolokinoloner og beslektede forbindelser som anti-infektive midler

Country Status (14)

Country Link
US (2) US20050075363A1 (no)
EP (1) EP1664062B1 (no)
JP (1) JP5147237B2 (no)
KR (1) KR20060069836A (no)
CN (1) CN1867570A (no)
AU (1) AU2004267052B2 (no)
BR (1) BRPI0413528A (no)
CA (1) CA2535370C (no)
IL (1) IL173492A0 (no)
MX (1) MXPA06001645A (no)
NO (1) NO20060653L (no)
NZ (1) NZ545157A (no)
UA (1) UA84879C2 (no)
WO (1) WO2005019228A1 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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AU2005331275A1 (en) * 2004-11-11 2006-11-09 Achillion Pharmaceuticals, Inc. 8a, 9-dihydro-4a-H-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents
US7659399B2 (en) 2005-01-05 2010-02-09 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents
ATE491713T1 (de) 2005-02-16 2011-01-15 Achillion Pharmaceuticals Inc Neue isothiazolochinolone und verwandte verbindungen als infektionsschutzmittel
PT1913004E (pt) 2005-07-27 2010-12-09 Achillion Pharmaceuticals Inc 8-metoxi-9h-isotiazolo[5,4-b]quinolina-3,4-dionas e compostos relacionados como agentes anti-infecciosos
WO2008021491A2 (en) 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2008036420A2 (en) * 2006-09-21 2008-03-27 Achillion Pharmaceuticals, Inc. 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
AU2010232388A1 (en) * 2009-04-03 2011-10-27 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
TWI618707B (zh) * 2009-10-16 2018-03-21 梅林塔療法公司 抗微生物性化合物，及製法及其用途
MX358697B (es) 2009-10-16 2018-08-31 Melinta Therapeutics Inc Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
JP6274723B2 (ja) 2009-10-16 2018-02-07 メリンタ セラピューティクス，インコーポレイテッド 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
CN102866153B (zh) * 2012-09-29 2014-08-13 郑州安图生物工程股份有限公司 前列腺炎联合检测试剂盒
WO2015035426A1 (en) 2013-09-09 2015-03-12 Melinta Therapeutics, Inc. Antimicrobial compunds and methods of making and using the same
MX2016003046A (es) 2013-09-09 2016-09-08 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
CN104530034B (zh) * 2014-12-31 2017-02-22 西南大学 喹诺酮噻唑类化合物及其制备方法和应用
JP2018507881A (ja) 2015-03-11 2018-03-22 メリンタ セラピューティクス，インコーポレイテッド 抗微生物化合物ならびにこれらを作製および使用する方法
KR101891315B1 (ko) 2017-08-01 2018-08-24 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
KR101915550B1 (ko) 2016-10-20 2018-11-07 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
TW202107762A (zh) 2019-05-31 2021-02-16 日商傑士湯淺國際股份有限公司 鉛蓄電池
CN113045589A (zh) * 2019-12-27 2021-06-29 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途

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ATE491713T1 (de) * 2005-02-16 2011-01-15 Achillion Pharmaceuticals Inc Neue isothiazolochinolone und verwandte verbindungen als infektionsschutzmittel

Also Published As

Publication number Publication date
KR20060069836A (ko) 2006-06-22
IL173492A0 (en) 2006-06-11
AU2004267052B2 (en) 2009-02-05
BRPI0413528A (pt) 2006-10-10
EP1664062A1 (en) 2006-06-07
UA84879C2 (ru) 2008-12-10
US20050075363A1 (en) 2005-04-07
NZ545157A (en) 2009-03-31
EP1664062B1 (en) 2013-03-13
CA2535370A1 (en) 2005-03-03
JP2007502275A (ja) 2007-02-08
MXPA06001645A (es) 2006-05-12
AU2004267052A1 (en) 2005-03-03
WO2005019228A1 (en) 2005-03-03
JP5147237B2 (ja) 2013-02-20
US20110223132A1 (en) 2011-09-15
CN1867570A (zh) 2006-11-22
CA2535370C (en) 2011-01-25

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