BRPI0413528A - isotiazol quinolonas e compostos afins como agentes antiinfecciosos - Google Patents

isotiazol quinolonas e compostos afins como agentes antiinfecciosos

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Publication number
BRPI0413528A
BRPI0413528A BRPI0413528-8A BRPI0413528A BRPI0413528A BR PI0413528 A BRPI0413528 A BR PI0413528A BR PI0413528 A BRPI0413528 A BR PI0413528A BR PI0413528 A BRPI0413528 A BR PI0413528A
Authority
BR
Brazil
Prior art keywords
formula
compounds
provides
quinolones
compositions
Prior art date
Application number
BRPI0413528-8A
Other languages
English (en)
Inventor
Barton James Bradbury
Milind Deshpande
Michael John Pucci
Quiping Wang
Jason Allan Wiles
Yongsheng Song
Akihiro Hashimoto
Edlaine Lucien
Original Assignee
Achillion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Publication of BRPI0413528A publication Critical patent/BRPI0413528A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"ISOTIAZOL QUINOLONAS E COMPOSTOS AFINS COMO AGENTES ANTIINFECCIOSOS". A invenção proporciona compostos e sais da Fórmula I e Fórmula II: os quais possuem atividade antimicrobiana. A invenção também proporciona novos intermediários sintéticos úteis na fabricação de compostos of Fórmula I e Fórmula II. As variáveis A~ 1~, R~ 2~, R~ 3~, R~ 5~, R~ 6~, R~ 7~, A~ 8~ e R~ 9~ são conforme definidas aqui. Determinados compostos da Fórmula I e Fórmula II divulgados aqui são inibidores potentes e seletivos da síntese de DNA bacteriano e replicação bacteriana. A invenção também proporciona composições antimicrobianas, incluindo composições farmacêuticas, contendo um ou mais compostos da Fórmula I ou da Fórmula II e um ou mais veículos, excipientes ou diluentes. Tais composições podem conter um composto da Fórmula I ou Fórmula II como o único agente ativo ou podem conter uma combinação de um composto da Fórmula I ou Fórmula II e um ou mais de outros agentes ativos. A invenção também proporciona métodos para o tratamento de infecções microbianas em animais.
BRPI0413528-8A 2003-08-12 2004-08-04 isotiazol quinolonas e compostos afins como agentes antiinfecciosos BRPI0413528A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49465503P 2003-08-12 2003-08-12
PCT/US2004/025365 WO2005019228A1 (en) 2003-08-12 2004-08-04 Isothiazoloquinolones and related compounds as anti-infective agents

Publications (1)

Publication Number Publication Date
BRPI0413528A true BRPI0413528A (pt) 2006-10-10

Family

ID=34215887

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413528-8A BRPI0413528A (pt) 2003-08-12 2004-08-04 isotiazol quinolonas e compostos afins como agentes antiinfecciosos

Country Status (14)

Country Link
US (2) US20050075363A1 (pt)
EP (1) EP1664062B1 (pt)
JP (1) JP5147237B2 (pt)
KR (1) KR20060069836A (pt)
CN (1) CN1867570A (pt)
AU (1) AU2004267052B2 (pt)
BR (1) BRPI0413528A (pt)
CA (1) CA2535370C (pt)
IL (1) IL173492A0 (pt)
MX (1) MXPA06001645A (pt)
NO (1) NO20060653L (pt)
NZ (1) NZ545157A (pt)
UA (1) UA84879C2 (pt)
WO (1) WO2005019228A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006214234B2 (en) * 2003-08-12 2012-04-12 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
MX2007005731A (es) * 2004-11-11 2007-07-19 Achillion Pharmaceuticals Inc 8a, 9-dihidro-4a-h-isotiazolo [5,4-b] quinolina-3, 4-diomas y compuestos relacionados como agentes anti-infeccion.
US7659399B2 (en) 2005-01-05 2010-02-09 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents
ATE482219T1 (de) 2005-07-27 2010-10-15 Achillion Pharmaceuticals Inc 8-methoxy-9h-isothiazoloä5,4-büchinolin-3,4-dio e und verwandte verbindungen als antiinfektive mittel
US7902365B2 (en) 2006-08-16 2011-03-08 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones
WO2008036420A2 (en) * 2006-09-21 2008-03-27 Achillion Pharmaceuticals, Inc. 9-(heteroaryl)-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
EA201101451A1 (ru) * 2009-04-03 2012-03-30 Ачиллион Фармасьютикалз, Инк. Гидрокситиенохинолоны и родственные соединения как противоинфекционные средства
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
CN102725274A (zh) 2009-10-16 2012-10-10 Rib-X制药公司 抗微生物化合物和其制备和使用方法
WO2011047320A2 (en) * 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
TW201726630A (zh) * 2009-10-16 2017-08-01 梅林塔療法公司 抗微生物性化合物及其製造與使用方法
CN102866153B (zh) * 2012-09-29 2014-08-13 郑州安图生物工程股份有限公司 前列腺炎联合检测试剂盒
AU2014315050A1 (en) 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compunds and methods of making and using the same
JP2016529325A (ja) 2013-09-09 2016-09-23 メリンタ セラピューティクス，インコーポレイテッド 抗微生物化合物ならびにそれの製造方法および使用方法
CN104530034B (zh) * 2014-12-31 2017-02-22 西南大学 喹诺酮噻唑类化合物及其制备方法和应用
MX2017011616A (es) 2015-03-11 2018-04-11 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos para hacerlos y usarlos.
US11098047B2 (en) 2016-05-06 2021-08-24 BioVersys AG Antimicrobials and methods of making and using same
KR101891315B1 (ko) 2017-08-01 2018-08-24 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
KR101915550B1 (ko) 2016-10-20 2018-11-07 한국화학연구원 퀴놀린 4-온 유도체 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 폐렴의 예방 또는 치료용 약학적 조성물
TW202107762A (zh) 2019-05-31 2021-02-16 日商傑士湯淺國際股份有限公司 鉛蓄電池
WO2021129799A1 (zh) * 2019-12-27 2021-07-01 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62187472A (ja) * 1985-12-23 1987-08-15 アボツト　ラボラトリ−ズ イソオキサゾロ−ナフチリジン、イソオキサゾロキノリン、イソチアゾロ−ナフチリジン及びイソチアゾロ−キノリン誘導体
US4767762A (en) * 1985-12-23 1988-08-30 Abbott Laboratories Tricyclic quinoline and naphthyride antibacterials
JP2681190B2 (ja) * 1988-04-13 1997-11-26 塩野義製薬株式会社 ピリドン系抗菌剤
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
US4945160A (en) * 1988-11-22 1990-07-31 Warner-Lambert Company Preparation of certain 7-substituted quinolones
JP2787713B2 (ja) * 1989-07-28 1998-08-20 富山化学工業株式会社 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩
US5646163A (en) * 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
US20020103115A1 (en) * 2000-09-19 2002-08-01 Karl Guegler Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
AU2006214234B2 (en) * 2003-08-12 2012-04-12 Achillion Pharmaceuticals, Inc. New isothiazoloquinolones and related compounds as anti-infective agents
US7678235B2 (en) * 2005-10-19 2010-03-16 Sylvan Source, Inc. Water purification system

Also Published As

Publication number Publication date
JP2007502275A (ja) 2007-02-08
NO20060653L (no) 2006-03-13
AU2004267052B2 (en) 2009-02-05
JP5147237B2 (ja) 2013-02-20
EP1664062A1 (en) 2006-06-07
KR20060069836A (ko) 2006-06-22
MXPA06001645A (es) 2006-05-12
EP1664062B1 (en) 2013-03-13
CN1867570A (zh) 2006-11-22
IL173492A0 (en) 2006-06-11
AU2004267052A1 (en) 2005-03-03
US20050075363A1 (en) 2005-04-07
UA84879C2 (ru) 2008-12-10
CA2535370A1 (en) 2005-03-03
NZ545157A (en) 2009-03-31
US20110223132A1 (en) 2011-09-15
WO2005019228A1 (en) 2005-03-03
CA2535370C (en) 2011-01-25

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