NO20081005L - 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents - Google Patents
8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agentsInfo
- Publication number
- NO20081005L NO20081005L NO20081005A NO20081005A NO20081005L NO 20081005 L NO20081005 L NO 20081005L NO 20081005 A NO20081005 A NO 20081005A NO 20081005 A NO20081005 A NO 20081005A NO 20081005 L NO20081005 L NO 20081005L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compounds
- compound
- isothiazolo
- dione
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Oppfinnelsen tilveiebringer forbindelse og salter med Formel I og II, beskrevet her, som innbefatter forbindelser med Formel A og Formel B: Slike forbindelser har anvendelig antimikrobiell aktivitet. Variablene R2, R3, R5, R6, R7 og R9 vist i Formel A og B er definert her. Visse forbindelser med Formel I og Formel II som er beskrevet her, er kraftige og/eller selektive inhibitorer av bakteriell DNA-syntese og bakteriell replikasjon. Oppfinnelsen tilveiebringer også antimikrobielle preparater, som omfatter farmasøytiske preparater, inneholdende én eller flere forbindelser med Formel I eller Formel II og én eller flere bærere, tilsetningsmidler eller fortynningsmidler. Slike preparater kan inneholde en forbindelse med Formel I eller Formel II som eneste aktive middel eller kan inneholde en kombinasjon av en forbindelse med Formel I eller Formel II og én eller flere andre aktive midler. Oppfinnelsen tilveiebringer også metoder for behandling av mikrobielle infeksjoner i dyr. Formel A Fo rmel B
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70281105P | 2005-07-27 | 2005-07-27 | |
PCT/US2006/029302 WO2007014308A1 (en) | 2005-07-27 | 2006-07-27 | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20081005L true NO20081005L (no) | 2008-04-09 |
NO343376B1 NO343376B1 (no) | 2019-02-11 |
Family
ID=37106335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20081005A NO343376B1 (no) | 2005-07-27 | 2008-02-27 | 8-metoksy-9H-isotiazolo[5,4-b]kinolin-3,4-dioner, farmasøytisk preparater omfattende slike samt slike forbindelser og preparater for anvendelse ved behandling eller forhindring av infeksjoner |
Country Status (20)
Country | Link |
---|---|
US (2) | US8044204B2 (no) |
EP (1) | EP1913004B1 (no) |
JP (1) | JP5143000B2 (no) |
KR (1) | KR101272263B1 (no) |
CN (1) | CN101263146B (no) |
AT (1) | ATE482219T1 (no) |
AU (1) | AU2006272571B2 (no) |
BR (1) | BRPI0614456B8 (no) |
CA (1) | CA2616768C (no) |
DE (1) | DE602006017082D1 (no) |
DK (1) | DK1913004T3 (no) |
EA (1) | EA013244B1 (no) |
ES (1) | ES2352799T3 (no) |
HK (1) | HK1122024A1 (no) |
IL (1) | IL189017A (no) |
NO (1) | NO343376B1 (no) |
NZ (1) | NZ566209A (no) |
PL (1) | PL1913004T3 (no) |
PT (1) | PT1913004E (no) |
WO (1) | WO2007014308A1 (no) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7902365B2 (en) | 2006-08-16 | 2011-03-08 | Achillion Pharmaceuticals, Inc. | Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones |
US8173636B2 (en) * | 2009-04-03 | 2012-05-08 | Achillion Pharmaceuticals, Inc. | Hydroxylthienoquinolones and related compounds as anti-infective agents |
WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
CN104628729B (zh) * | 2009-10-16 | 2018-11-06 | 梅琳塔治疗公司 | 抗微生物化合物和其制备和使用方法 |
CN102725274A (zh) | 2009-10-16 | 2012-10-10 | Rib-X制药公司 | 抗微生物化合物和其制备和使用方法 |
MX359743B (es) | 2009-10-16 | 2018-10-08 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos para fabricar y utilizar los mismos. |
TN2010000566A1 (en) * | 2010-12-03 | 2012-05-24 | Rekik Raouf | Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs |
CN103819401B (zh) * | 2012-11-19 | 2016-04-13 | 浙江中欣氟材股份有限公司 | 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法 |
KR20160070066A (ko) | 2013-09-09 | 2016-06-17 | 멜린타 테라퓨틱스, 인크. | 항균 화합물, 및 이의 제조 방법 및 이용 방법 |
MX2016003046A (es) | 2013-09-09 | 2016-09-08 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos. |
WO2015114317A1 (en) * | 2014-01-28 | 2015-08-06 | Redx Pharma Plc | 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds |
BR112017019349A2 (pt) | 2015-03-11 | 2018-06-05 | Melinta Therapeutics Inc | compostos antimicrobianos e métodos de fabricação e uso dos mesmos |
EP3455218A4 (en) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | C3 CARBON-BASED GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
WO2017197036A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
Family Cites Families (25)
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US4767762A (en) * | 1985-12-23 | 1988-08-30 | Abbott Laboratories | Tricyclic quinoline and naphthyride antibacterials |
JPH01160985A (ja) | 1987-12-17 | 1989-06-23 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
JPH01193275A (ja) | 1988-01-28 | 1989-08-03 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
JP2681190B2 (ja) | 1988-04-13 | 1997-11-26 | 塩野義製薬株式会社 | ピリドン系抗菌剤 |
US5328908A (en) * | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
CA2001203C (en) * | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Novel antimicrobial dithiocarbamoyl quinolones |
JPH02174784A (ja) | 1988-12-27 | 1990-07-06 | Hokuriku Seiyaku Co Ltd | イソチアゾロキノリン誘導体 |
JPH02243692A (ja) | 1989-03-16 | 1990-09-27 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
JPH02255687A (ja) | 1989-03-27 | 1990-10-16 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
FR2645862B1 (fr) * | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments |
JP2787713B2 (ja) | 1989-07-28 | 1998-08-20 | 富山化学工業株式会社 | 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩 |
US5071848A (en) * | 1989-10-23 | 1991-12-10 | Abbott Laboratories | Tricyclic quinoline antineoplastic agents |
JP2939280B2 (ja) | 1990-01-10 | 1999-08-25 | 三共株式会社 | フッ素置換メトキシキノロンカルボン酸誘導体 |
US5580872A (en) * | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
US5646163A (en) * | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
CZ238698A3 (cs) | 1996-01-31 | 1998-12-16 | Sankyo Company, Limited | Prostředky pro léčení a prevenci AIDS |
JP3616454B2 (ja) | 1996-04-19 | 2005-02-02 | 栄研化学株式会社 | 生体成分測定用試薬 |
JPH10130149A (ja) | 1996-07-12 | 1998-05-19 | Sankyo Co Ltd | Tnf産生抑制剤 |
DE19652219A1 (de) * | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(1-Aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-chinolon- und naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
WO2002048138A1 (en) * | 2000-12-14 | 2002-06-20 | The Procter & Gamble Company | Antimicrobial quinolones |
NZ545157A (en) * | 2003-08-12 | 2009-03-31 | Achillion Pharmaceuticals Inc | Isothiazoloquinolones and related compounds as anti-infective agents |
KR20070085791A (ko) * | 2004-11-11 | 2007-08-27 | 아칠리온 파르마세우티칼스 인코포레이티드 | 항감염성 제제로서8a,9-디히드로-4a-h-이소티아졸로[5,4-b]퀴놀린-3,4-디온 및 관련 화합물 |
DE602006018866D1 (de) * | 2005-02-16 | 2011-01-27 | Achillion Pharmaceuticals Inc | Neue isothiazolochinolone und verwandte verbindungen als infektionsschutzmittel |
US8173636B2 (en) | 2009-04-03 | 2012-05-08 | Achillion Pharmaceuticals, Inc. | Hydroxylthienoquinolones and related compounds as anti-infective agents |
-
2006
- 2006-07-27 WO PCT/US2006/029302 patent/WO2007014308A1/en active Application Filing
- 2006-07-27 PL PL06800428T patent/PL1913004T3/pl unknown
- 2006-07-27 EP EP06800428A patent/EP1913004B1/en active Active
- 2006-07-27 AU AU2006272571A patent/AU2006272571B2/en not_active Ceased
- 2006-07-27 ES ES06800428T patent/ES2352799T3/es active Active
- 2006-07-27 CN CN200680033548XA patent/CN101263146B/zh active Active
- 2006-07-27 US US11/494,205 patent/US8044204B2/en active Active
- 2006-07-27 BR BRPI0614456A patent/BRPI0614456B8/pt active IP Right Grant
- 2006-07-27 DK DK06800428.2T patent/DK1913004T3/da active
- 2006-07-27 JP JP2008524168A patent/JP5143000B2/ja active Active
- 2006-07-27 PT PT06800428T patent/PT1913004E/pt unknown
- 2006-07-27 NZ NZ566209A patent/NZ566209A/en unknown
- 2006-07-27 CA CA2616768A patent/CA2616768C/en not_active Expired - Fee Related
- 2006-07-27 DE DE602006017082T patent/DE602006017082D1/de active Active
- 2006-07-27 KR KR1020087004769A patent/KR101272263B1/ko active IP Right Grant
- 2006-07-27 AT AT06800428T patent/ATE482219T1/de active
- 2006-07-27 EA EA200800444A patent/EA013244B1/ru unknown
-
2008
- 2008-01-24 IL IL189017A patent/IL189017A/en active IP Right Grant
- 2008-02-27 NO NO20081005A patent/NO343376B1/no unknown
-
2009
- 2009-03-06 HK HK09102201.2A patent/HK1122024A1/xx unknown
-
2011
- 2011-10-24 US US13/279,852 patent/US8946422B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP5143000B2 (ja) | 2013-02-13 |
CA2616768A1 (en) | 2007-02-01 |
CA2616768C (en) | 2014-05-06 |
IL189017A (en) | 2014-01-30 |
BRPI0614456B8 (pt) | 2021-05-25 |
EA200800444A1 (ru) | 2008-06-30 |
IL189017A0 (en) | 2008-08-07 |
ES2352799T3 (es) | 2011-02-23 |
HK1122024A1 (en) | 2009-05-08 |
US20070049586A1 (en) | 2007-03-01 |
PT1913004E (pt) | 2010-12-09 |
BRPI0614456A2 (pt) | 2011-03-29 |
US20120040959A1 (en) | 2012-02-16 |
PL1913004T3 (pl) | 2011-03-31 |
CN101263146B (zh) | 2012-12-05 |
CN101263146A (zh) | 2008-09-10 |
ATE482219T1 (de) | 2010-10-15 |
WO2007014308A1 (en) | 2007-02-01 |
DK1913004T3 (da) | 2011-01-10 |
JP2009502953A (ja) | 2009-01-29 |
US8044204B2 (en) | 2011-10-25 |
AU2006272571A1 (en) | 2007-02-01 |
DE602006017082D1 (de) | 2010-11-04 |
US8946422B2 (en) | 2015-02-03 |
NZ566209A (en) | 2011-03-31 |
NO343376B1 (no) | 2019-02-11 |
EP1913004A1 (en) | 2008-04-23 |
KR20080035661A (ko) | 2008-04-23 |
EA013244B1 (ru) | 2010-04-30 |
KR101272263B1 (ko) | 2013-06-13 |
EP1913004B1 (en) | 2010-09-22 |
AU2006272571B2 (en) | 2012-03-08 |
BRPI0614456B1 (pt) | 2019-08-27 |
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