EA200601469A1 - Способ отделения промежуточных соединений, который может быть использован для получения эсциталопрама - Google Patents
Способ отделения промежуточных соединений, который может быть использован для получения эсциталопрамаInfo
- Publication number
- EA200601469A1 EA200601469A1 EA200601469A EA200601469A EA200601469A1 EA 200601469 A1 EA200601469 A1 EA 200601469A1 EA 200601469 A EA200601469 A EA 200601469A EA 200601469 A EA200601469 A EA 200601469A EA 200601469 A1 EA200601469 A1 EA 200601469A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- separation
- escital
- prema
- receiving
- hydroxymethylbenzonitrile
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Abstract
Изобретение связано со способом разделения и выделения ацилированного производного 4-[(S)-4-диметиламино-1-(4-фторфенил)-1-гидроксибутил]-3-гидроксиметилбензонитрила посредством взаимодействия смеси 4-[ (S)-4-диметиламино-1-(4-фторфенил)-1-гидроксибутил]-3-гидроксиметилбензонитрила и его ацилированного производного с соединением, которое образует производное 4-[(S)-4-диметиламино-1-(4-фторфенил)-1-гидроксибутил]-3-гидроксиметилбензонитрила, содержащее группу карбоновой кислоты. Ацилированное производное, содержащее группу карбоновой кислоты, выпадает в осадок сразу же после его образования и может быть легко отделено от реакционной смеси.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54497004P | 2004-02-12 | 2004-02-12 | |
| DKPA200400217 | 2004-02-12 | ||
| PCT/DK2005/000075 WO2005077891A1 (en) | 2004-02-12 | 2005-02-02 | Method for the separation of intermediates which may be used for the preparation of escitalopram |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200601469A1 true EA200601469A1 (ru) | 2006-12-29 |
| EA012503B1 EA012503B1 (ru) | 2009-10-30 |
Family
ID=36603240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200601469A EA012503B1 (ru) | 2004-02-12 | 2005-02-02 | Способ отделения промежуточных соединений, который может быть использован для получения эсциталопрама |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7582780B2 (ru) |
| EP (1) | EP1716108B1 (ru) |
| JP (1) | JP4975450B2 (ru) |
| KR (1) | KR101156495B1 (ru) |
| CN (1) | CN1918112B (ru) |
| AR (1) | AR047522A1 (ru) |
| AT (1) | ATE411278T1 (ru) |
| AU (1) | AU2005212455A1 (ru) |
| BR (1) | BRPI0507580B8 (ru) |
| CA (1) | CA2555980C (ru) |
| DK (1) | DK1716108T3 (ru) |
| EA (1) | EA012503B1 (ru) |
| ES (1) | ES2315832T3 (ru) |
| HK (1) | HK1100922A1 (ru) |
| IL (1) | IL177365A0 (ru) |
| MY (1) | MY144749A (ru) |
| NZ (1) | NZ548441A (ru) |
| PE (1) | PE20051139A1 (ru) |
| PL (1) | PL1716108T3 (ru) |
| PT (1) | PT1716108E (ru) |
| RS (1) | RS50689B (ru) |
| SI (1) | SI1716108T1 (ru) |
| TW (1) | TWI339651B (ru) |
| UA (1) | UA86403C2 (ru) |
| UY (1) | UY28743A1 (ru) |
| WO (1) | WO2005077891A1 (ru) |
| ZA (1) | ZA200606639B (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100548974C (zh) * | 2007-10-11 | 2009-10-14 | 浙江大学 | 西酞普兰中间体的萃取分离方法 |
| CN108640856B (zh) * | 2018-06-11 | 2021-06-25 | 淮阴工学院 | 一种依地普仑中间体的不对称合成方法及其中间体 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8419963D0 (en) * | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| KR100411505B1 (ko) | 1998-10-20 | 2003-12-18 | 하. 룬트벡 아크티에 셀스카브 | 시탈로프람의 제조방법 |
| ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991581A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991486A1 (it) | 1999-07-06 | 2001-01-06 | Vis Farmaceutici S P A | Processo per la sintesi di citalopram |
| ES2229774T3 (es) | 1999-10-25 | 2005-04-16 | H. Lundbeck A/S | Metodo para la preparacion de citalopram. |
| NL1017415C1 (nl) | 2000-02-24 | 2001-05-18 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
| IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| CN1429219A (zh) | 2000-03-13 | 2003-07-09 | H·隆德贝克有限公司 | 制备西酞普兰的方法 |
| CA2402553A1 (en) | 2000-03-13 | 2001-09-20 | H. Lundbeck A/S | Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
| ATE257832T1 (de) | 2000-03-14 | 2004-01-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
| TR200202168T2 (tr) | 2000-03-16 | 2002-12-23 | H. Lundbeck A/S | 5-Siyano-1-(4-Florofenil)-1,3-Dihidroizobenzofuranların preparasyon metodu |
| AR034612A1 (es) | 2001-06-25 | 2004-03-03 | Lundbeck & Co As H | Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram |
| AR034759A1 (es) * | 2001-07-13 | 2004-03-17 | Lundbeck & Co As H | Metodo para la preparacion de escitalopram |
| EA006213B1 (ru) * | 2001-07-31 | 2005-10-27 | Х. Лундбекк А/С | Кристаллическая композиция, содержащая эсциталопрам |
| IS7239A (is) * | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
| ES2194597B2 (es) * | 2002-01-25 | 2004-08-01 | Esteve Quimica, S.A. | Procedimiento para la obtencion de citalopram. |
| GB0204607D0 (en) * | 2002-02-27 | 2002-04-10 | Matrix Lab Ltd | Process |
| CA2381341A1 (en) * | 2002-04-09 | 2003-10-09 | Torcan Chemical Ltd. | Process and intermediates for preparing escitalopram |
| TWI306846B (en) * | 2002-08-12 | 2009-03-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| EP2363389A1 (en) * | 2002-12-23 | 2011-09-07 | H. Lundbeck A/S | A process for the preparation of racemic citalopram diol and/or S- or R-citalopram diols and the use of such diols for the preparation of racemic citalopram, R-citalopram and/or S-citalopram |
-
2005
- 2005-01-24 TW TW094102002A patent/TWI339651B/zh active
- 2005-01-31 AR ARP050100350A patent/AR047522A1/es active IP Right Grant
- 2005-02-02 RS RSP-2008/0564A patent/RS50689B/sr unknown
- 2005-02-02 JP JP2006552461A patent/JP4975450B2/ja active Active
- 2005-02-02 CN CN2005800045942A patent/CN1918112B/zh active Active
- 2005-02-02 UA UAA200609731A patent/UA86403C2/ru unknown
- 2005-02-02 DK DK05700625T patent/DK1716108T3/da active
- 2005-02-02 PL PL05700625T patent/PL1716108T3/pl unknown
- 2005-02-02 ES ES05700625T patent/ES2315832T3/es active Active
- 2005-02-02 US US10/597,836 patent/US7582780B2/en active Active
- 2005-02-02 AT AT05700625T patent/ATE411278T1/de active
- 2005-02-02 PT PT05700625T patent/PT1716108E/pt unknown
- 2005-02-02 KR KR1020067016151A patent/KR101156495B1/ko active IP Right Grant
- 2005-02-02 CA CA2555980A patent/CA2555980C/en not_active Expired - Fee Related
- 2005-02-02 SI SI200530512T patent/SI1716108T1/sl unknown
- 2005-02-02 BR BRPI0507580A patent/BRPI0507580B8/pt active IP Right Grant
- 2005-02-02 EA EA200601469A patent/EA012503B1/ru unknown
- 2005-02-02 NZ NZ548441A patent/NZ548441A/en unknown
- 2005-02-02 ZA ZA200606639A patent/ZA200606639B/xx unknown
- 2005-02-02 WO PCT/DK2005/000075 patent/WO2005077891A1/en active Application Filing
- 2005-02-02 EP EP05700625A patent/EP1716108B1/en active Active
- 2005-02-02 AU AU2005212455A patent/AU2005212455A1/en not_active Abandoned
- 2005-02-03 MY MYPI20050416A patent/MY144749A/en unknown
- 2005-02-10 PE PE2005000157A patent/PE20051139A1/es not_active Application Discontinuation
- 2005-02-10 UY UY28743A patent/UY28743A1/es not_active Application Discontinuation
-
2006
- 2006-08-08 IL IL177365A patent/IL177365A0/en unknown
-
2007
- 2007-08-09 HK HK07108652.5A patent/HK1100922A1/xx unknown
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