PE20051139A1 - Metodo para la separacion de los intermediarios que puede ser utilizado para la preparacion de escitalopram - Google Patents

Metodo para la separacion de los intermediarios que puede ser utilizado para la preparacion de escitalopram

Info

Publication number
PE20051139A1
PE20051139A1 PE2005000157A PE2005000157A PE20051139A1 PE 20051139 A1 PE20051139 A1 PE 20051139A1 PE 2005000157 A PE2005000157 A PE 2005000157A PE 2005000157 A PE2005000157 A PE 2005000157A PE 20051139 A1 PE20051139 A1 PE 20051139A1
Authority
PE
Peru
Prior art keywords
separation
preparation
alkyl
escitalopram
intermediaries
Prior art date
Application number
PE2005000157A
Other languages
English (en)
Inventor
Lars Ole Lyngso
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36603240&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20051139(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of PE20051139A1 publication Critical patent/PE20051139A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)

Abstract

REFERIDA A UN METODO PARA EL AISLAMIENTO Y PURIFICACION DEL COMPUESTO DE FORMULA (IV) DONDE R ES CIANO O UN GRUPO CONVERTIBLE EN CIANO; --- ES UN ENLACE SIMPLE O DOBLE; Hal ES HALOGENO, Z ES DIMETILAMINOMETILO O UN GRUPO CONVERTIBLE EN ESTE; W ES O, S; Y ES ENLACE, O, S, NH; R1 ES ALQUILO C1-C10, ALQUENILO C2-C10, ALQUINILO C2-C10, ENTRE OTROS. TAMBIEN REFERIDA A LA SEPARACION Y AISLAMIENTO DE UN DERIVADO ACILADO DE 4-[(S)-4-DIMETILAMINO-1-(4-FLUOROFENIL)-1- HIDROXIBUTIL]-3-HIDROXIMETILBENZONOTRILO Y A UN METODO DE ELABORACION DE ESCITALOPRAM
PE2005000157A 2004-02-12 2005-02-10 Metodo para la separacion de los intermediarios que puede ser utilizado para la preparacion de escitalopram PE20051139A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200400217 2004-02-12

Publications (1)

Publication Number Publication Date
PE20051139A1 true PE20051139A1 (es) 2006-01-28

Family

ID=36603240

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005000157A PE20051139A1 (es) 2004-02-12 2005-02-10 Metodo para la separacion de los intermediarios que puede ser utilizado para la preparacion de escitalopram

Country Status (27)

Country Link
US (1) US7582780B2 (es)
EP (1) EP1716108B1 (es)
JP (1) JP4975450B2 (es)
KR (1) KR101156495B1 (es)
CN (1) CN1918112B (es)
AR (1) AR047522A1 (es)
AT (1) ATE411278T1 (es)
AU (1) AU2005212455A1 (es)
BR (1) BRPI0507580B8 (es)
CA (1) CA2555980C (es)
DK (1) DK1716108T3 (es)
EA (1) EA012503B1 (es)
ES (1) ES2315832T3 (es)
HK (1) HK1100922A1 (es)
IL (1) IL177365A0 (es)
MY (1) MY144749A (es)
NZ (1) NZ548441A (es)
PE (1) PE20051139A1 (es)
PL (1) PL1716108T3 (es)
PT (1) PT1716108E (es)
RS (1) RS50689B (es)
SI (1) SI1716108T1 (es)
TW (1) TWI339651B (es)
UA (1) UA86403C2 (es)
UY (1) UY28743A1 (es)
WO (1) WO2005077891A1 (es)
ZA (1) ZA200606639B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100548974C (zh) * 2007-10-11 2009-10-14 浙江大学 西酞普兰中间体的萃取分离方法
CN108640856B (zh) * 2018-06-11 2021-06-25 淮阴工学院 一种依地普仑中间体的不对称合成方法及其中间体

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
PL199423B1 (pl) 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
GB2360281B (en) * 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CA2402553A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
BR0109176A (pt) 2000-03-13 2003-04-22 Lundbeck & Co As H Método para preparação de citalopram e composto da fórmula
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
EP1274699A1 (en) 2000-03-16 2003-01-15 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
DE60217932T2 (de) * 2001-07-31 2007-08-30 H. Lundbeck A/S, Valby Kristalline Zusammensetzung enthaltend Escitalopram
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
CA2381341A1 (en) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Process and intermediates for preparing escitalopram
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
EP1581483B1 (en) * 2002-12-23 2012-06-06 H. Lundbeck A/S A PROCESS FOR THE PREPARATION OF RACEMIC CITALOPRAM DIOL AND/OR i S- /i OR i R- /i CITALOPRAM DIOLS AND THE USE OF SUCH DIOLS FOR THE PREPARATION OF RACEMIC CITALOPRAM, i R- /i CITALOPRAM AND/OR i S- /i CITALOPRAM

Also Published As

Publication number Publication date
BRPI0507580B8 (pt) 2021-05-25
KR101156495B1 (ko) 2012-07-06
ES2315832T3 (es) 2009-04-01
NZ548441A (en) 2009-12-24
JP4975450B2 (ja) 2012-07-11
DK1716108T3 (da) 2009-01-19
SI1716108T1 (sl) 2009-02-28
PT1716108E (pt) 2008-12-31
PL1716108T3 (pl) 2009-04-30
UA86403C2 (uk) 2009-04-27
TWI339651B (en) 2011-04-01
AU2005212455A1 (en) 2005-08-25
JP2007524678A (ja) 2007-08-30
CN1918112B (zh) 2011-11-23
AR047522A1 (es) 2006-01-25
WO2005077891A1 (en) 2005-08-25
CA2555980A1 (en) 2005-08-25
IL177365A0 (en) 2006-12-10
EP1716108A1 (en) 2006-11-02
BRPI0507580B1 (pt) 2018-01-09
MY144749A (en) 2011-10-31
UY28743A1 (es) 2005-09-30
ZA200606639B (en) 2007-12-27
US7582780B2 (en) 2009-09-01
HK1100922A1 (en) 2007-10-05
RS50689B (sr) 2010-06-30
CA2555980C (en) 2010-08-03
KR20060116222A (ko) 2006-11-14
TW200530210A (en) 2005-09-16
EA200601469A1 (ru) 2006-12-29
BRPI0507580A (pt) 2007-07-31
EA012503B1 (ru) 2009-10-30
CN1918112A (zh) 2007-02-21
EP1716108B1 (en) 2008-10-15
US20070190624A1 (en) 2007-08-16
ATE411278T1 (de) 2008-10-15

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