EA200601218A1 - Респираторно-синцитиальный вирус с перекрёстно компенсированным геномным дефицитом - Google Patents

Респираторно-синцитиальный вирус с перекрёстно компенсированным геномным дефицитом

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Publication number
EA200601218A1
EA200601218A1 EA200601218A EA200601218A EA200601218A1 EA 200601218 A1 EA200601218 A1 EA 200601218A1 EA 200601218 A EA200601218 A EA 200601218A EA 200601218 A EA200601218 A EA 200601218A EA 200601218 A1 EA200601218 A1 EA 200601218A1
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EA
Eurasian Patent Office
Prior art keywords
cross
pneumovirus
compensated
respiratory syncytial
syncytial virus
Prior art date
Application number
EA200601218A
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English (en)
Other versions
EA011878B1 (ru
Inventor
Виллем Люйтэйс
Мира Норели Видйойоатмодьо
Original Assignee
Де Стат Дер Недерланден, Вертегенвордигд Дор Де Министер Ван Волксгезондхейд, Велзейн Ен Спорт
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Application filed by Де Стат Дер Недерланден, Вертегенвордигд Дор Де Министер Ван Волксгезондхейд, Велзейн Ен Спорт filed Critical Де Стат Дер Недерланден, Вертегенвордигд Дор Де Министер Ван Волксгезондхейд, Велзейн Ен Спорт
Publication of EA200601218A1 publication Critical patent/EA200601218A1/ru
Publication of EA011878B1 publication Critical patent/EA011878B1/ru

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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
    • C07K14/135—Respiratory syncytial virus
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • C12N2760/18011—Paramyxoviridae
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    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18561—Methods of inactivation or attenuation
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
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  • Organic Chemistry (AREA)
  • Microbiology (AREA)
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  • Biophysics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Настоящее изобретение относится к пневмовирусным вирионам, содержащим вирусный геном, который имеет мутацию в гене, кодирующем белок, необходимый для инфекционности пневмовируса, при этом мутация приводит к тому, что вирус, продуцируемый только с вирусного генома, не имеет инфекционности, и при этом вирион включает в себя данный белок в форме и количестве, которое требуется для инфекционности вириона. Изобретение относится к способам продукции данных пневмовирусных вирионов и их применения при лечении и профилактике пневмовирусной инфекции и заболевания. Предпочтительный пневмовирусный вирион представляет собой вирион респираторно-синцитиального вируса, в котором предпочтительно инактивирован и перекрестно компенсирован ген белка прикрепления G.
EA200601218A 2003-12-24 2004-12-24 Респираторно-синцитиальный вирус с перекрестно компенсированным геномным дефицитом EA011878B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL0300930 2003-12-24
PCT/NL2004/000911 WO2005061698A1 (en) 2003-12-24 2004-12-24 A respiratory syncytial virus with a genomic deficiency complemented in trans

Publications (2)

Publication Number Publication Date
EA200601218A1 true EA200601218A1 (ru) 2006-12-29
EA011878B1 EA011878B1 (ru) 2009-06-30

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Family Applications (1)

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EA200601218A EA011878B1 (ru) 2003-12-24 2004-12-24 Респираторно-синцитиальный вирус с перекрестно компенсированным геномным дефицитом

Country Status (24)

Country Link
US (3) US9107939B2 (ru)
EP (2) EP1699919B1 (ru)
JP (1) JP4814799B2 (ru)
KR (1) KR101266715B1 (ru)
CN (1) CN1922309B (ru)
AU (1) AU2004303719B2 (ru)
BR (1) BRPI0418093A (ru)
CA (1) CA2551009C (ru)
CY (1) CY1118741T1 (ru)
DK (1) DK1699919T3 (ru)
EA (1) EA011878B1 (ru)
ES (2) ES2618523T3 (ru)
HK (1) HK1100494A1 (ru)
HU (1) HUE032898T2 (ru)
IL (1) IL176500A (ru)
LT (1) LT1699919T (ru)
NO (1) NO334756B1 (ru)
NZ (1) NZ548107A (ru)
PL (1) PL1699919T3 (ru)
PT (1) PT1699919T (ru)
SI (1) SI1699919T1 (ru)
TR (1) TR201808496T4 (ru)
WO (1) WO2005061698A1 (ru)
ZA (1) ZA200605218B (ru)

Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
GB201121210D0 (en) * 2011-12-09 2012-01-18 Health Prot Agency Respiratory infection assay
EP2822540B1 (en) 2012-03-05 2020-04-08 De Staat der Nederlanden, Vert. Door de Minister van VWS Methods and compositions for stabilizing dried biological materials
EP2970981B1 (en) 2013-03-14 2020-10-28 Emory University Recombinant rsv with silent mutations, vaccines, and methods related thereto
RS57864B1 (sr) 2013-06-17 2018-12-31 De Staat Der Nederlanden Vert Door De Minister Van Vws Ministerie Van Volksgezondheid Welzijn En Spo Postupci za sprečavanje agregacije virusnih komponenti
CA2951430A1 (en) 2014-06-13 2015-12-17 Glaxosmithkline Biologicals Sa Immunogenic combinations
US11235050B2 (en) 2015-10-29 2022-02-01 Emory University Chimeric RSV, immunogenic compositions, and methods of use
US10626126B2 (en) * 2016-04-08 2020-04-21 Pulmocide Limited Compounds
CN112746059A (zh) * 2020-09-15 2021-05-04 清华大学 基于病毒结构蛋白遗传互补的冠状病毒细胞模型
CN112501134B (zh) * 2020-12-09 2023-01-20 贵州医科大学附属医院 一种人呼吸道合胞病毒毒株及其应用
CN114990079B (zh) * 2022-04-29 2023-07-04 广州医科大学附属第一医院（广州呼吸中心） 治疗性缺陷干扰颗粒及其在制备用于防治rsv病毒感染的产品中的应用

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PT702085E (pt) 1994-07-18 2004-04-30 Karl Klaus Conzelmann Virus de arn de cadeia negativa nao segmentada infeccioso recombinante
WO1996010400A1 (en) * 1994-09-30 1996-04-11 The Uab Research Foundation Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses
JPH11512609A (ja) 1995-09-27 1999-11-02 アメリカ合衆国 クローン化されたヌクレオチド配列からの感染性ＲＳウイルス（ｒｅｓｐｉｒａｔｏｒｙ ｓｙｎｃｙｔｉａｌ ｖｉｒｕｓ）の生産
JP4413999B2 (ja) 1996-07-15 2010-02-10 アメリカ合衆国 クローニングされたヌクレオチド配列からの弱毒化呼吸シンシチウムウィルスワクチンの製造
EP1035205A1 (en) * 1999-03-08 2000-09-13 Stichting Dienst Landbouwkundig Onderzoek Non-spreading pestivirus
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WO2003029416A2 (en) 2001-10-01 2003-04-10 Uab Research Foundation Recombinant respiratory syncytial viruses with deleted surface glycoprotein genes and uses thereof

Also Published As

Publication number Publication date
NZ548107A (en) 2009-09-25
CY1118741T1 (el) 2017-07-12
ZA200605218B (en) 2007-05-30
NO20062967L (no) 2006-09-22
CA2551009A1 (en) 2005-07-07
PT1699919T (pt) 2017-04-03
US20180207211A1 (en) 2018-07-26
BRPI0418093A (pt) 2007-04-17
EA011878B1 (ru) 2009-06-30
NO334756B1 (no) 2014-05-19
EP2500419A1 (en) 2012-09-19
LT1699919T (lt) 2017-04-25
JP4814799B2 (ja) 2011-11-16
ES2670713T3 (es) 2018-05-31
EP1699919B1 (en) 2017-01-11
KR101266715B1 (ko) 2013-05-28
TR201808496T4 (tr) 2018-07-23
US10967014B2 (en) 2021-04-06
WO2005061698A1 (en) 2005-07-07
CA2551009C (en) 2017-01-17
IL176500A0 (en) 2006-10-05
EP1699919A1 (en) 2006-09-13
US9107939B2 (en) 2015-08-18
CN1922309B (zh) 2011-07-13
CN1922309A (zh) 2007-02-28
AU2004303719B2 (en) 2010-11-11
US20150329833A1 (en) 2015-11-19
IL176500A (en) 2015-02-26
AU2004303719A1 (en) 2005-07-07
HK1100494A1 (en) 2007-09-21
SI1699919T1 (sl) 2017-07-31
ES2618523T3 (es) 2017-06-21
JP2007516721A (ja) 2007-06-28
EP2500419B1 (en) 2018-03-21
KR20070022210A (ko) 2007-02-26
HUE032898T2 (hu) 2017-11-28
DK1699919T3 (en) 2017-03-20
US20100291035A1 (en) 2010-11-18
US9889168B2 (en) 2018-02-13
PL1699919T3 (pl) 2017-08-31

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Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU