CY1118741T1 - Αναπνευστικος συγκυτιακος ιος με μια γονιδιωματικη ατελεια συμπληρωμενη in trans - Google Patents

Αναπνευστικος συγκυτιακος ιος με μια γονιδιωματικη ατελεια συμπληρωμενη in trans

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Publication number
CY1118741T1
CY1118741T1 CY20171100266T CY171100266T CY1118741T1 CY 1118741 T1 CY1118741 T1 CY 1118741T1 CY 20171100266 T CY20171100266 T CY 20171100266T CY 171100266 T CY171100266 T CY 171100266T CY 1118741 T1 CY1118741 T1 CY 1118741T1
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CY
Cyprus
Prior art keywords
virus
pulmonary
trans
viral
viruses
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CY20171100266T
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English (en)
Inventor
Willem Luytjes
Myra Noorely Widjojoatmodjo
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De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Volksgezondheid, Welzijn En Sport
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Application filed by De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Volksgezondheid, Welzijn En Sport filed Critical De Staat Der Nederlanden, Vertegenwoordigd Door De Minister Van Volksgezondheid, Welzijn En Sport
Publication of CY1118741T1 publication Critical patent/CY1118741T1/el

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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/08—RNA viruses
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/18011—Paramyxoviridae
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    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
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  • Health & Medical Sciences (AREA)
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  • Virology (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

Η παρούσα εφεύρεση αφορά πνευμονοϊικά βίρια, τα οποία αποτελούνται από ένα ιϊκό γονιδίωμα που έχει μια μετάλλαξη σε ένα γονίδιο που κωδικοποιεί για μια πρωτεΐνη, η οποία είναι ουσιώδης για μολυσματικότητα του πνευμονοϊού, όπου η μετάλλαξη αναγκάζει έναν ιό που παράγεται μόνο από το ιϊκό γονιδίωμα να στερείται μολυσματικότητας, και όπου το βίριο αποτελείται από την πρωτεΐνη σε μια μορφή και σε μια ποσότητα που απαιτείται για τη μολυσματικότητα του βιρίου. Η εφεύρεση αφορά μεθόδους για την παραγωγή των πνευμονοϊικών βιρίων και για τη χρήση των βιρίων στη θεραπευτική αγωγή ή πρόληψη πνευμονοϊικής λοίμωξης και ασθένειας. Ένα προτιμώμενο πνευμονοϊικό βίριο είναι ένα βίριο του Αναπνευστικού Συγκυτιακού Ιού, στο οποίο, κατά προτίμηση, το γονίδιο για την προσάρτηση πρωτεΐνης G απενεργοποιείται και συμπληρώνεται in trans.
CY20171100266T 2003-12-24 2017-02-28 Αναπνευστικος συγκυτιακος ιος με μια γονιδιωματικη ατελεια συμπληρωμενη in trans CY1118741T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL0300930 2003-12-24
PCT/NL2004/000911 WO2005061698A1 (en) 2003-12-24 2004-12-24 A respiratory syncytial virus with a genomic deficiency complemented in trans

Publications (1)

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CY1118741T1 true CY1118741T1 (el) 2017-07-12

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US (3) US9107939B2 (el)
EP (2) EP2500419B1 (el)
JP (1) JP4814799B2 (el)
KR (1) KR101266715B1 (el)
CN (1) CN1922309B (el)
AU (1) AU2004303719B2 (el)
BR (1) BRPI0418093A (el)
CA (1) CA2551009C (el)
CY (1) CY1118741T1 (el)
DK (1) DK1699919T3 (el)
EA (1) EA011878B1 (el)
ES (2) ES2618523T3 (el)
HK (1) HK1100494A1 (el)
HU (1) HUE032898T2 (el)
IL (1) IL176500A (el)
LT (1) LT1699919T (el)
NO (1) NO334756B1 (el)
NZ (1) NZ548107A (el)
PL (1) PL1699919T3 (el)
PT (1) PT1699919T (el)
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GB201121210D0 (en) * 2011-12-09 2012-01-18 Health Prot Agency Respiratory infection assay
JP6253161B2 (ja) 2012-03-05 2017-12-27 デ スタート デル ネーデルランデン， ヴェルト． ドール デ ミニステル ヴァン ヴイダブリューエス ミニステリー ヴァン ボルクスゲツォントヘイト， ベルジーン エン シュポルトＤｅ Ｓｔａａｔ Ｄｅｒ Ｎｅｄｅｒｌａｎｄｅｎ， Ｖｅｒｔ． Ｄｏｏｒ Ｄｅ Ｍｉｎｉｓｔｅｒ Ｖａｎ Ｖｗｓ Ｍｉｎｉｓｔｅｒｉｅ Ｖａｎ Ｖｏｌｋｓｇｅｚｏｎｄｈｅｉｄ， Ｗｅｌｚｉｊｎ Ｅｎ Ｓｐｏｒｔ 乾燥された生物学的材料を安定化するための方法及び組成物
AU2014239583B2 (en) 2013-03-14 2020-07-02 Children's Healthcare Of Atlanta, Inc. Recombinant RSV with silent mutations, vaccines, and methods related thereto
KR102219672B1 (ko) 2013-06-17 2021-02-25 드 슈타트 데르 네덜란덴, 베르테겐부어디그트 두어 드 미니스터 반 베이웨이에스, 미니스테리 반 폭스겐트존하이트, 벨지인 엔 스포츠 바이러스 성분의 어그리게이션을 저해하는 방법
US11571472B2 (en) 2014-06-13 2023-02-07 Glaxosmithkline Biologicals Sa Immunogenic combinations
EP3368547A4 (en) 2015-10-29 2019-06-05 Emory University RSV CHIMERIC VIRUSES, IMMUNOGENIC COMPOSITIONS AND METHODS OF USE
WO2017175000A1 (en) * 2016-04-08 2017-10-12 Pulmocide Limited Compounds
CN112746059A (zh) * 2020-09-15 2021-05-04 清华大学 基于病毒结构蛋白遗传互补的冠状病毒细胞模型
CN112501134B (zh) * 2020-12-09 2023-01-20 贵州医科大学附属医院 一种人呼吸道合胞病毒毒株及其应用
CN114990079B (zh) * 2022-04-29 2023-07-04 广州医科大学附属第一医院（广州呼吸中心） 治疗性缺陷干扰颗粒及其在制备用于防治rsv病毒感染的产品中的应用

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BR9710363A (pt) 1996-07-15 2000-01-11 Us Gov Health & Human Serv "vìrus sincicial respirátorio recombinante infeccioso isolado, partìcula do mesmo, processos para estimular o sistema imunológico de um indivìduo para induzir proteção contra o vìrus sincicial respiratório e para produzir uma partìcula de vìrus sincicial respiratório recombinante, vacina para induzir proteção contra o vìrus sincicial respiratório recombinante composição e ceta de vìrus sincicial respiratório recombinante"
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TR201808496T4 (tr) 2018-07-23
HUE032898T2 (hu) 2017-11-28
ZA200605218B (en) 2007-05-30
US9107939B2 (en) 2015-08-18
KR101266715B1 (ko) 2013-05-28
EP1699919A1 (en) 2006-09-13
SI1699919T1 (sl) 2017-07-31
DK1699919T3 (en) 2017-03-20
WO2005061698A1 (en) 2005-07-07
IL176500A0 (en) 2006-10-05
EP2500419B1 (en) 2018-03-21
EP2500419A1 (en) 2012-09-19
CA2551009C (en) 2017-01-17
BRPI0418093A (pt) 2007-04-17
JP2007516721A (ja) 2007-06-28
CN1922309A (zh) 2007-02-28
JP4814799B2 (ja) 2011-11-16
AU2004303719B2 (en) 2010-11-11
US9889168B2 (en) 2018-02-13
CN1922309B (zh) 2011-07-13
ES2618523T3 (es) 2017-06-21
IL176500A (en) 2015-02-26
LT1699919T (lt) 2017-04-25
AU2004303719A1 (en) 2005-07-07
KR20070022210A (ko) 2007-02-26
CA2551009A1 (en) 2005-07-07
HK1100494A1 (en) 2007-09-21
EA011878B1 (ru) 2009-06-30
NO334756B1 (no) 2014-05-19
EP1699919B1 (en) 2017-01-11
US20180207211A1 (en) 2018-07-26
EA200601218A1 (ru) 2006-12-29
NZ548107A (en) 2009-09-25
ES2670713T3 (es) 2018-05-31
US20150329833A1 (en) 2015-11-19
PT1699919T (pt) 2017-04-03
US10967014B2 (en) 2021-04-06
PL1699919T3 (pl) 2017-08-31
US20100291035A1 (en) 2010-11-18
NO20062967L (no) 2006-09-22

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