EA200400182A1 - Фармацевтические композиции фибринолитического агента - Google Patents

Фармацевтические композиции фибринолитического агента

Info

Publication number
EA200400182A1
EA200400182A1 EA200400182A EA200400182A EA200400182A1 EA 200400182 A1 EA200400182 A1 EA 200400182A1 EA 200400182 A EA200400182 A EA 200400182A EA 200400182 A EA200400182 A EA 200400182A EA 200400182 A1 EA200400182 A1 EA 200400182A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compositions
fibrinolytic agent
lyophilized
composition
fibrinolytic
Prior art date
Application number
EA200400182A
Other languages
English (en)
Other versions
EA006600B1 (ru
Inventor
Брент С. Кендрик
Брайан Петерсон
Original Assignee
Амген Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA200400182A1 publication Critical patent/EA200400182A1/ru
Publication of EA006600B1 publication Critical patent/EA006600B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Описаны замороженная и лиофилизированная композиции металлопротеиназного фибринолитического агента (фибролазы или NAT), способ приготовления лиофилизированной композиции и набор и способ восстановления лиофилизированной композиции.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200400182A 1999-10-01 2000-09-29 Фармацевтические композиции фибринолитического агента EA006600B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/411,335 US6440414B1 (en) 1999-10-01 1999-10-01 Pharmaceutical compositions of fibrinolytic agent

Publications (2)

Publication Number Publication Date
EA200400182A1 true EA200400182A1 (ru) 2004-08-26
EA006600B1 EA006600B1 (ru) 2006-02-24

Family

ID=23628514

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200200396A EA004627B1 (ru) 1999-10-01 2000-09-29 Фармацевтические композиции фибринолитического агента
EA200400182A EA006600B1 (ru) 1999-10-01 2000-09-29 Фармацевтические композиции фибринолитического агента

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200200396A EA004627B1 (ru) 1999-10-01 2000-09-29 Фармацевтические композиции фибринолитического агента

Country Status (28)

Country Link
US (4) US6440414B1 (ru)
EP (2) EP1438967A3 (ru)
JP (1) JP2003510369A (ru)
KR (1) KR100717435B1 (ru)
CN (2) CN101209347A (ru)
AT (1) ATE262923T1 (ru)
AU (1) AU769313B2 (ru)
BG (1) BG106578A (ru)
BR (1) BR0014420A (ru)
CA (1) CA2385966A1 (ru)
CZ (1) CZ20021033A3 (ru)
DE (2) DE60009529T2 (ru)
DK (1) DK1220685T3 (ru)
EA (2) EA004627B1 (ru)
ES (2) ES2224917T1 (ru)
HK (1) HK1049112B (ru)
HU (1) HUP0202654A3 (ru)
IL (1) IL148842A0 (ru)
MX (1) MXPA02003197A (ru)
NO (1) NO20021500L (ru)
NZ (4) NZ540967A (ru)
PL (1) PL355016A1 (ru)
PT (1) PT1220685E (ru)
SG (1) SG148823A1 (ru)
SK (1) SK4242002A3 (ru)
WO (1) WO2001024817A2 (ru)
YU (1) YU23302A (ru)
ZA (1) ZA200202400B (ru)

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JP5149470B2 (ja) 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド 新規のアルブミンを含有していない第ｖｉｉｉ因子処方物
US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US7033776B2 (en) 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
DE10149030A1 (de) * 2001-10-05 2003-04-10 Viscum Ag Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin
US20050239746A1 (en) * 2002-02-01 2005-10-27 Penkler Lawrence J Pharmaceutical composition
WO2003068805A2 (en) * 2002-02-14 2003-08-21 Bayer Pharmaceuticals Corporation Formulation strategies in stabilizing peptides in organic solvents and in dried states
US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
JP5201992B2 (ja) * 2004-12-15 2013-06-05 バイオビトラム・アクテイエボラーグ（パブリツク） ケラチノサイト増殖因子の治療用製剤
KR20080076907A (ko) * 2005-11-18 2008-08-20 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 유도체의 제조 방법
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
KR100807692B1 (ko) * 2006-11-08 2008-02-28 신라대학교 산학협력단 혈전용해성 메탈로프로테아제 및 이를 포함하는 조성물
EP1958618A1 (de) 2007-02-15 2008-08-20 Octapharma AG Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren
CA2742328C (en) 2008-11-07 2019-02-26 Baxter International Inc. Factor viii formulations
KR20120050442A (ko) * 2009-07-10 2012-05-18 쓰롬보제닉스 엔.브이. 플라스미노겐 및 플라스민의 변이체
CN102000022A (zh) * 2010-11-23 2011-04-06 郑州大学 注射用重组双功能纤溶酶冻干制剂及其制备方法
CA2823491A1 (en) 2011-01-05 2012-07-12 Thrombogenics Nv Plasminogen and plasmin variants
US9644196B2 (en) 2011-08-12 2017-05-09 Thrombogenics Nv Plasminogen and plasmin variants
US20140212405A1 (en) 2013-01-28 2014-07-31 2294719 Ontario Limited Fibrinolytic/Proteolytic Treatment of Myofacial and Neuropathic Pain and Related Conditions
US11137409B2 (en) * 2014-11-06 2021-10-05 The Regents Of The University Of Colorado, A Body Corporate Identification of novel disease states using viscoelastic analysis in the presence of a thrombolytic agent
CN113382714A (zh) * 2019-01-06 2021-09-10 恩多全球美学有限公司 胶原酶制剂及其制备方法

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Also Published As

Publication number Publication date
HUP0202654A3 (en) 2003-11-28
EP1220685A2 (en) 2002-07-10
EP1220685B1 (en) 2004-03-31
EP1438967A3 (en) 2005-01-26
ES2224917T1 (es) 2005-03-16
NZ518007A (en) 2004-03-26
JP2003510369A (ja) 2003-03-18
EA004627B1 (ru) 2004-06-24
CA2385966A1 (en) 2001-04-12
US20060246053A1 (en) 2006-11-02
CZ20021033A3 (cs) 2003-06-18
US6440414B1 (en) 2002-08-27
KR20020053065A (ko) 2002-07-04
HUP0202654A2 (hu) 2002-12-28
EA006600B1 (ru) 2006-02-24
AU769313B2 (en) 2004-01-22
HK1049112A1 (en) 2003-05-02
BG106578A (bg) 2003-04-30
CN100353999C (zh) 2007-12-12
HK1049112B (zh) 2005-01-21
ATE262923T1 (de) 2004-04-15
DE04007657T1 (de) 2005-01-13
AU7743000A (en) 2001-05-10
CN1402641A (zh) 2003-03-12
BR0014420A (pt) 2002-06-11
IL148842A0 (en) 2002-09-12
NO20021500D0 (no) 2002-03-26
US7244426B2 (en) 2007-07-17
NZ540967A (en) 2007-02-23
DE60009529D1 (de) 2004-05-06
SG148823A1 (en) 2009-01-29
US7138114B2 (en) 2006-11-21
ZA200202400B (en) 2003-05-28
DK1220685T3 (da) 2004-08-02
US7311908B2 (en) 2007-12-25
NZ530959A (en) 2005-08-26
US20020192207A1 (en) 2002-12-19
WO2001024817A2 (en) 2001-04-12
YU23302A (sh) 2005-06-10
EA200200396A1 (ru) 2002-10-31
US20060263347A1 (en) 2006-11-23
MXPA02003197A (es) 2002-09-30
EP1438967A2 (en) 2004-07-21
NZ550200A (en) 2008-04-30
DE60009529T2 (de) 2005-04-14
PT1220685E (pt) 2004-08-31
CN101209347A (zh) 2008-07-02
SK4242002A3 (en) 2003-08-05
WO2001024817A3 (en) 2001-10-18
NO20021500L (no) 2002-05-27
PL355016A1 (en) 2004-03-22
ES2218228T3 (es) 2004-11-16
KR100717435B1 (ko) 2007-05-14

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