IL148842A0 - Pharmaceutical compositions of fibrinolytic agent - Google Patents

Pharmaceutical compositions of fibrinolytic agent

Info

Publication number
IL148842A0
IL148842A0 IL14884200A IL14884200A IL148842A0 IL 148842 A0 IL148842 A0 IL 148842A0 IL 14884200 A IL14884200 A IL 14884200A IL 14884200 A IL14884200 A IL 14884200A IL 148842 A0 IL148842 A0 IL 148842A0
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
fibrinolytic agent
lyophilized
agent
lyophilized composition
Prior art date
Application number
IL14884200A
Other languages
English (en)
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of IL148842A0 publication Critical patent/IL148842A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL14884200A 1999-10-01 2000-09-29 Pharmaceutical compositions of fibrinolytic agent IL148842A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/411,335 US6440414B1 (en) 1999-10-01 1999-10-01 Pharmaceutical compositions of fibrinolytic agent
PCT/US2000/027022 WO2001024817A2 (en) 1999-10-01 2000-09-29 Pharmaceutical compositions of fibrinolytic agent

Publications (1)

Publication Number Publication Date
IL148842A0 true IL148842A0 (en) 2002-09-12

Family

ID=23628514

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14884200A IL148842A0 (en) 1999-10-01 2000-09-29 Pharmaceutical compositions of fibrinolytic agent

Country Status (28)

Country Link
US (4) US6440414B1 (xx)
EP (2) EP1438967A3 (xx)
JP (1) JP2003510369A (xx)
KR (1) KR100717435B1 (xx)
CN (2) CN101209347A (xx)
AT (1) ATE262923T1 (xx)
AU (1) AU769313B2 (xx)
BG (1) BG106578A (xx)
BR (1) BR0014420A (xx)
CA (1) CA2385966A1 (xx)
CZ (1) CZ20021033A3 (xx)
DE (2) DE60009529T2 (xx)
DK (1) DK1220685T3 (xx)
EA (2) EA006600B1 (xx)
ES (2) ES2224917T1 (xx)
HK (1) HK1049112B (xx)
HU (1) HUP0202654A3 (xx)
IL (1) IL148842A0 (xx)
MX (1) MXPA02003197A (xx)
NO (1) NO20021500L (xx)
NZ (4) NZ540967A (xx)
PL (1) PL355016A1 (xx)
PT (1) PT1220685E (xx)
SG (1) SG148823A1 (xx)
SK (1) SK4242002A3 (xx)
WO (1) WO2001024817A2 (xx)
YU (1) YU23302A (xx)
ZA (1) ZA200202400B (xx)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2193809T3 (en) 1999-02-22 2015-05-26 Univ Connecticut The albumin-free Factor VIII formulation
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US7033776B2 (en) 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
DE10149030A1 (de) * 2001-10-05 2003-04-10 Viscum Ag Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin
EP1469886B8 (en) * 2002-02-01 2008-01-09 Shimoda Biotech (PTY) LTD Lyophilized pharmaceutical composition of propofol
AU2003219787A1 (en) * 2002-02-14 2003-09-04 Bayer Pharmaceuticals Corporation Formulation strategies in stabilizing peptides in organic solvents and in dried states
US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
PL1827483T3 (pl) * 2004-12-15 2014-12-31 Swedish Orphan Biovitrum Ab Publ Formulacje terapeutyczne czynnika wzrostu keratynocytów
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
US20090270623A1 (en) * 2005-11-18 2009-10-29 Naoyuki Shimomura Process for production of cinnamide derivative
KR100807692B1 (ko) * 2006-11-08 2008-02-28 신라대학교 산학협력단 혈전용해성 메탈로프로테아제 및 이를 포함하는 조성물
EP1958618A1 (de) 2007-02-15 2008-08-20 Octapharma AG Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren
MX339060B (es) 2008-11-07 2016-05-09 Baxter Int Formulaciones del factor viii.
CN102482338B (zh) * 2009-07-10 2016-09-28 斯路姆基因公司 纤溶酶原和纤溶酶的变体
CN102000022A (zh) * 2010-11-23 2011-04-06 郑州大学 注射用重组双功能纤溶酶冻干制剂及其制备方法
MX337248B (es) 2011-01-05 2016-02-19 Thrombogenics Nv Variantes de plasminogeno y plasmina.
WO2013024074A1 (en) 2011-08-12 2013-02-21 Thrombogenics N.V. Plasminogen and plasmin variants
US20140212405A1 (en) 2013-01-28 2014-07-31 2294719 Ontario Limited Fibrinolytic/Proteolytic Treatment of Myofacial and Neuropathic Pain and Related Conditions
JP6877340B2 (ja) * 2014-11-06 2021-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ 血栓溶解剤の存在下における粘弾性解析を用いた新規病態の確認
US20220305094A1 (en) * 2019-01-06 2022-09-29 Endo Global Aesthetics Limited Collagenase formulations and methods of producing the same

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FR2310133A2 (fr) 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne
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US4447236A (en) * 1982-02-05 1984-05-08 Cordis Corporation Infusion catheter system
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CA1237482A (en) * 1984-03-09 1988-05-31 Frank B. Stiles Catheter for effecting removal of obstructions from a biological duct
US4755167A (en) * 1984-04-10 1988-07-05 Research Corporation In vivo method for distribution and stirring of therapeutic agents
US4837148A (en) * 1984-10-30 1989-06-06 Phillips Petroleum Company Autonomous replication sequences for yeast strains of the genus pichia
US4855231A (en) * 1984-10-30 1989-08-08 Phillips Petroleum Company Regulatory region for heterologous gene expression in yeast
US4885242A (en) * 1984-10-30 1989-12-05 Phillips Petroleum Company Genes from pichia histidine pathway and uses thereof
US4818700A (en) * 1985-10-25 1989-04-04 Phillips Petroleum Company Pichia pastoris argininosuccinate lyase gene and uses thereof
US4812405A (en) * 1986-02-18 1989-03-14 Phillips Petroleum Company Double auxotrophic mutants of Pichia pastoris and methods for preparation
US5000185A (en) * 1986-02-28 1991-03-19 Cardiovascular Imaging Systems, Inc. Method for intravascular two-dimensional ultrasonography and recanalization
US4848700A (en) * 1987-04-16 1989-07-18 Lockheed John A Canard control system for aircraft
ZA889415B (en) 1987-12-18 1989-09-27 Chiron Corp Compositions and method for recombinant production of crotalidus venum fibrolase
WO1990007352A1 (en) 1989-01-04 1990-07-12 Boston Scientific Corporation Angioplasty catheter
US5222941A (en) * 1990-01-12 1993-06-29 Don Michael T Anthony Method of dissolving an obstruction in a vessel
ES2180528T3 (es) 1990-01-16 2003-02-16 Ct Ingenieria Genetica Biotech Metodo de expresion de genes heterologos en la levadura pichia pastoris, vectores de expresion y microorganismos transformados.
US5709676A (en) * 1990-02-14 1998-01-20 Alt; Eckhard Synergistic treatment of stenosed blood vessels using shock waves and dissolving medication
US5250034A (en) * 1990-09-17 1993-10-05 E-Z-Em, Inc. Pressure responsive valve catheter
US5167628A (en) * 1991-05-02 1992-12-01 Boyles Paul W Aortic balloon catheter assembly for indirect infusion of the coronary arteries
US5380273A (en) * 1992-05-19 1995-01-10 Dubrul; Will R. Vibrating catheter
EP0624642B1 (en) 1993-05-12 1999-01-20 Indian Council For Medical Research Novel thrombolytic agent, process for preparing same and its use for the preparation of a thrombi dissolving medicament
US5370653A (en) * 1993-07-22 1994-12-06 Micro Therapeutics, Inc. Thrombectomy method and apparatus
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US6020181A (en) * 1995-05-17 2000-02-01 New York Blood, Inc. Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase
US5830468A (en) * 1995-05-17 1998-11-03 The New York Blood Center, Inc. Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase
US5741779A (en) * 1996-05-10 1998-04-21 Xoma Corporation Antithrombotic materials and methods
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US5951981A (en) * 1996-12-02 1999-09-14 Diatide, Inc. Thrombolytic agents with antithrombotic activity
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US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
WO2002012283A2 (en) 2000-08-03 2002-02-14 Zymogenetics, Inc. Disintegrin homologs, zsnk10, zsnk11, and zsnk12

Also Published As

Publication number Publication date
EA200400182A1 (ru) 2004-08-26
MXPA02003197A (es) 2002-09-30
CN101209347A (zh) 2008-07-02
CZ20021033A3 (cs) 2003-06-18
KR100717435B1 (ko) 2007-05-14
NZ518007A (en) 2004-03-26
HUP0202654A2 (hu) 2002-12-28
DK1220685T3 (da) 2004-08-02
AU7743000A (en) 2001-05-10
EA004627B1 (ru) 2004-06-24
HK1049112B (zh) 2005-01-21
US7244426B2 (en) 2007-07-17
US20020192207A1 (en) 2002-12-19
EP1220685B1 (en) 2004-03-31
HK1049112A1 (en) 2003-05-02
ES2224917T1 (es) 2005-03-16
ATE262923T1 (de) 2004-04-15
EP1438967A3 (en) 2005-01-26
BG106578A (bg) 2003-04-30
AU769313B2 (en) 2004-01-22
EA006600B1 (ru) 2006-02-24
ES2218228T3 (es) 2004-11-16
WO2001024817A3 (en) 2001-10-18
DE60009529D1 (de) 2004-05-06
PT1220685E (pt) 2004-08-31
SK4242002A3 (en) 2003-08-05
DE04007657T1 (de) 2005-01-13
ZA200202400B (en) 2003-05-28
US7311908B2 (en) 2007-12-25
YU23302A (sh) 2005-06-10
BR0014420A (pt) 2002-06-11
NZ530959A (en) 2005-08-26
US20060246053A1 (en) 2006-11-02
US7138114B2 (en) 2006-11-21
EP1220685A2 (en) 2002-07-10
DE60009529T2 (de) 2005-04-14
PL355016A1 (en) 2004-03-22
EA200200396A1 (ru) 2002-10-31
JP2003510369A (ja) 2003-03-18
CA2385966A1 (en) 2001-04-12
NO20021500D0 (no) 2002-03-26
US6440414B1 (en) 2002-08-27
WO2001024817A2 (en) 2001-04-12
NZ550200A (en) 2008-04-30
CN1402641A (zh) 2003-03-12
KR20020053065A (ko) 2002-07-04
NZ540967A (en) 2007-02-23
HUP0202654A3 (en) 2003-11-28
NO20021500L (no) 2002-05-27
EP1438967A2 (en) 2004-07-21
CN100353999C (zh) 2007-12-12
US20060263347A1 (en) 2006-11-23
SG148823A1 (en) 2009-01-29

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