EA200300201A1 - Композиция фентанила для интраназального введения - Google Patents

Композиция фентанила для интраназального введения

Info

Publication number
EA200300201A1
EA200300201A1 EA200300201A EA200300201A EA200300201A1 EA 200300201 A1 EA200300201 A1 EA 200300201A1 EA 200300201 A EA200300201 A EA 200300201A EA 200300201 A EA200300201 A EA 200300201A EA 200300201 A1 EA200300201 A1 EA 200300201A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fentanyl
administration
fentanila
composition
results
Prior art date
Application number
EA200300201A
Other languages
English (en)
Other versions
EA006384B1 (ru
Inventor
Йеспер Граруп
Ханне Вульфф Нильсен
Original Assignee
Нюкомед Данмарк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200300201(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Нюкомед Данмарк А/С filed Critical Нюкомед Данмарк А/С
Publication of EA200300201A1 publication Critical patent/EA200300201A1/ru
Publication of EA006384B1 publication Critical patent/EA006384B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Лечение острой боли достаточной дозой при интраназальном введении фентанила обеспечивает время наступления действия, сравнимое со временем при внутривенном введении, и значительно более быстрое наступление действия, чем при интраназальном введении фентанила методом "титрования". Интраназальное введение достаточного количества фентанила для облегчения боли приводит к более низким максимальным концентрациям в плазме по сравнению с концентрациями при внутривенном введении и обеспечивает меньшую степень нежелательных побочных эффектов, таких как респираторная депрессия, тошнота и рвота. Раскрыты также композиции для использования и способ использования.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200300201A 2000-07-31 2001-07-31 Композиция фентанила для интраназального введения EA006384B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001154 2000-07-31
PCT/DK2001/000521 WO2002009707A1 (en) 2000-07-31 2001-07-31 Fentanyl composition for nasal administration

Publications (2)

Publication Number Publication Date
EA200300201A1 true EA200300201A1 (ru) 2003-06-26
EA006384B1 EA006384B1 (ru) 2005-12-29

Family

ID=8159630

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300201A EA006384B1 (ru) 2000-07-31 2001-07-31 Композиция фентанила для интраназального введения

Country Status (24)

Country Link
US (3) US8017627B2 (ru)
EP (3) EP1307194B2 (ru)
JP (2) JP4898073B2 (ru)
KR (2) KR100888275B1 (ru)
CN (2) CN101181241A (ru)
AT (1) ATE388705T1 (ru)
AU (2) AU8174601A (ru)
CA (1) CA2417727C (ru)
CY (2) CY1107405T1 (ru)
DE (2) DE20122843U1 (ru)
DK (2) DK1307194T4 (ru)
EA (1) EA006384B1 (ru)
EE (1) EE05420B1 (ru)
ES (2) ES2302742T5 (ru)
HK (1) HK1089106A1 (ru)
IL (2) IL154041A0 (ru)
IS (1) IS2803B (ru)
NO (2) NO330565B1 (ru)
NZ (1) NZ524396A (ru)
PL (1) PL207845B1 (ru)
PT (2) PT1642578E (ru)
SI (2) SI1307194T2 (ru)
UA (2) UA77398C2 (ru)
WO (1) WO2002009707A1 (ru)

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WO2009070829A1 (en) 2007-12-05 2009-06-11 Krius Pty Ltd Non-aqueous oil-based fentanyl compositions for transmucosal administration

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EP1642578A3 (en) 2006-09-27
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AU2001281746C1 (en) 2010-09-09
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DK1307194T4 (da) 2011-07-18
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PT1307194E (pt) 2008-05-27
DK1307194T3 (da) 2008-07-14
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US20040034059A1 (en) 2004-02-19
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JP4898073B2 (ja) 2012-03-14
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WO2002009707A1 (en) 2002-02-07
EA006384B1 (ru) 2005-12-29
EP1642578A2 (en) 2006-04-05
CN100346788C (zh) 2007-11-07
JP2008044951A (ja) 2008-02-28
UA77398C2 (en) 2006-12-15
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SI1642578T2 (sl) 2022-01-31
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EP2255806A3 (en) 2011-06-29
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