EA199800052A1 - Новые норпрегнаны для стимуляции гипоталамических эффектов - Google Patents

Новые норпрегнаны для стимуляции гипоталамических эффектов

Info

Publication number
EA199800052A1
EA199800052A1 EA199800052A EA199800052A EA199800052A1 EA 199800052 A1 EA199800052 A1 EA 199800052A1 EA 199800052 A EA199800052 A EA 199800052A EA 199800052 A EA199800052 A EA 199800052A EA 199800052 A1 EA199800052 A1 EA 199800052A1
Authority
EA
Eurasian Patent Office
Prior art keywords
norpregnans
hypotalamic
stimulating
effects
new
Prior art date
Application number
EA199800052A
Other languages
English (en)
Other versions
EA000965B1 (ru
Inventor
Клив Л. Дженнингс-Уайт
Дэвид Л. Берлинер
Натан Уильям Адамс
Original Assignee
Ферин Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ферин Корпорейшн filed Critical Ферин Корпорейшн
Publication of EA199800052A1 publication Critical patent/EA199800052A1/ru
Publication of EA000965B1 publication Critical patent/EA000965B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение касается способа изменения функции гипоталамуса у индивидуума. Способ включает назально вводимый вомероферин, т.е. 19-норпрегнановый стероид, или сложную фармацевтическую форму, включающую вомероферин, так что вомероферин связывается со специфическим нейроэпителиальным рецептором. Стероид или стероиды предпочтительно вводится/вводятся в виде сложной фармацевтической формы, содержащей один или более фармацевтически приемлемый носитель. Другие формы реализации изобретения включают сложные фармацевтические формы, содержащие стероиды.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800052A 1995-06-07 1996-06-07 Новые норпрегнаны для стимуляции гипоталамических эффектов EA000965B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/485,615 US5792757A (en) 1994-08-04 1995-06-07 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function
PCT/US1996/009665 WO1996040727A1 (en) 1995-06-07 1996-06-07 Novel nor-pregnanes for inducing hypothalamic effects

Publications (2)

Publication Number Publication Date
EA199800052A1 true EA199800052A1 (ru) 1998-08-27
EA000965B1 EA000965B1 (ru) 2000-08-28

Family

ID=23928825

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800052A EA000965B1 (ru) 1995-06-07 1996-06-07 Новые норпрегнаны для стимуляции гипоталамических эффектов

Country Status (17)

Country Link
US (3) US5792757A (ru)
EP (1) EP0830369B1 (ru)
JP (1) JPH11507360A (ru)
KR (1) KR19990022640A (ru)
CN (1) CN1191542A (ru)
AT (1) ATE240344T1 (ru)
AU (1) AU724787B2 (ru)
BR (1) BR9609012A (ru)
CA (1) CA2223397C (ru)
CZ (1) CZ391597A3 (ru)
DE (1) DE69628163T2 (ru)
EA (1) EA000965B1 (ru)
ES (1) ES2197949T3 (ru)
HU (1) HUP9900887A3 (ru)
NO (1) NO975709L (ru)
NZ (1) NZ312303A (ru)
WO (1) WO1996040727A1 (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066627A (en) * 1994-08-04 2000-05-23 Pherin Corporation Steroids as neurochemical initiators of change in human blood levels of LH
US6117860A (en) * 1994-08-04 2000-09-12 Pherin Pharmaceuticals, Inc. Steroids as neurochemical stimulators of the VNO to treat paroxistic tachycardia
US6331534B1 (en) 1994-08-04 2001-12-18 Pherin Pharmaceuticals, Inc. Steroids as neurochemical stimulators of the VNO to alleviate pain
US6057439A (en) * 1994-08-04 2000-05-02 Pherin Corporation Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety
US5922699A (en) 1996-06-07 1999-07-13 Pherin Corporation 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function
JP4450435B2 (ja) * 1996-07-23 2010-04-14 フィーリン・ファーマシューティカルズ・インコーポレイテッド Ｐｍｓおよび不安の症状を緩和する、ｖｎｏにおける神経化学刺激物質としてのステロイド
DE69942578D1 (de) 1998-05-22 2010-08-26 Univ R Bifunktionelle moleküle sowie darauf basierende therapien.
DK1955700T3 (da) 1999-09-30 2011-05-23 Harbor Biosciences Inc Terapeutisk behandling af androgenreceptor-betingede lidelser
AUPQ342599A0 (en) * 1999-10-14 1999-11-04 University Of Melbourne, The Conjugates and uses thereof
US6555531B1 (en) * 1999-12-30 2003-04-29 Pherin Pharmaceuticals, Inc. Weight promoting composition, method, and product
US6413951B2 (en) * 2000-06-27 2002-07-02 Aventis Pharmaceuticals, Inc. 20-fluoro-17(20)-vinyl steroids
AU2002244247B2 (en) 2001-03-01 2007-12-13 Harbor Biosciences, Inc. Use of certain steroids for treatment of blood cell deficiencies
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP2298316A1 (en) 2002-08-28 2011-03-23 Harbor BioSciences, Inc. Therapeutic treatment methods
EP2471536A1 (en) 2004-09-29 2012-07-04 Harbor BioSciences, Inc. Steroid analogs and characterization and treatment methods
CA2789097C (en) 2005-04-28 2017-02-21 Proteus Digital Health, Inc. Pharma-informatics system
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
CA2698903A1 (en) * 2007-09-17 2009-03-26 Human Pheromone Sciences, Inc. Fragrance compositions and other compositions which contain naturally occurring substances found in corals
US20090258040A1 (en) * 2008-04-09 2009-10-15 Pherin Pharmaceuticals, Inc. Steroid treatment for hot flashes
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
MX362543B (es) * 2013-04-17 2019-01-24 Sage Therapeutics Inc Esteroides c21-n-pirazolilo 19-nor c3,3- disustituidos y metodos de uso de los mismos.
WO2016044559A1 (en) * 2014-09-17 2016-03-24 Prevacus, Inc. C-20 steroid compounds, compositions and uses thereof to treat traumatic brain injury (tbi), including concussions
DE102020204505A1 (de) 2020-04-07 2021-10-07 Henkel Ag & Co. Kgaa Wasch-/Pflegeartikel umfassend Pheromone
DE102020204509A1 (de) 2020-04-07 2021-10-07 Henkel Ag & Co. Kgaa Waschmittel mit Pheromonen
DE102020204507A1 (de) 2020-04-07 2021-10-07 Henkel Ag & Co. Kgaa Weichspüler mit aphrodisierend wirkenden Duftstoffen
DE102020204506A1 (de) 2020-04-07 2021-10-07 Henkel Ag & Co. Kgaa Weichspüler mit Pheromonen

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL287863A (ru)
US2840582A (en) * 1953-08-31 1958-06-24 Searle & Co Derivatives of 13-methyl-17-hydroxy-1, 2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17-tetradecahydro-15h-cyclopenta[a]phenanthren-3-ones
DE1297603B (de) 1964-08-08 1969-06-19 Schering Ag Verfahren zur Herstellung von 3-Keto-delta 17(20)-pregnenen
ES319318A1 (es) 1964-11-13 1966-10-16 American Cyanamid Co Procedimiento para la preparaciën de una composiciën anticonceptiva
US3385849A (en) * 1965-07-01 1968-05-28 Hoffmann La Roche Process for the preparation of 17beta-pregnanes from 17-oxo-steroids
US3492318A (en) * 1968-01-22 1970-01-27 Syntex Corp Cyclopropenyl androstanes
US3682983A (en) * 1969-11-12 1972-08-08 Klaus Prezewowsky Preparation of {66 {11 {11 -17 ethinyl steroids
FR2097045A1 (en) 1970-07-30 1972-03-03 Roussel Uclaf 17-ethynylgon-4-en-3-ones - with progestomimetic activity useful as contraceptives and for gynaecological disorders
US3681410A (en) * 1970-08-07 1972-08-01 Syntex Corp Process for preparing 17{60 -hydroxy-20-keto and 17{60 ,21-dihydroxy-20-keto pregnanes and derivatives and intermediates thereof
US3946052A (en) * 1975-06-16 1976-03-23 Stanford Research Institute 19-Norpregna- 1,3,5(10)-trien-3-ol and loweralkyl homologs thereof having postcoital antifertility activity
US5155045A (en) 1985-01-25 1992-10-13 Trustees Of The University Of Penn. Use of male essence to alter female endocrine response
US5108995A (en) 1987-09-24 1992-04-28 Jencap Research Ltd. Hormone preparation and method
JP2578369B2 (ja) * 1989-05-09 1997-02-05 ポーラ化成工業株式会社 芳香組成物
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
US5272134A (en) * 1992-03-24 1993-12-21 Erox Corporation Fragrance compositions and other compositions which contain human pheromones
US5278141A (en) * 1992-03-24 1994-01-11 Erox Corporation Fragrance compositions containing human pheromones

Also Published As

Publication number Publication date
DE69628163D1 (de) 2003-06-18
MX9709693A (es) 1998-10-31
EP0830369B1 (en) 2003-05-14
CZ391597A3 (cs) 1998-06-17
CN1191542A (zh) 1998-08-26
EP0830369A1 (en) 1998-03-25
EA000965B1 (ru) 2000-08-28
CA2223397A1 (en) 1996-12-19
US5962443A (en) 1999-10-05
NO975709D0 (no) 1997-12-05
AU724787B2 (en) 2000-09-28
CA2223397C (en) 2007-07-31
DE69628163T2 (de) 2004-04-01
EP0830369A4 (en) 1999-06-09
ATE240344T1 (de) 2003-05-15
KR19990022640A (ko) 1999-03-25
HUP9900887A2 (hu) 1999-08-30
AU6380796A (en) 1996-12-30
JPH11507360A (ja) 1999-06-29
NZ312303A (en) 2000-01-28
US6242619B1 (en) 2001-06-05
HUP9900887A3 (en) 1999-11-29
WO1996040727A1 (en) 1996-12-19
NO975709L (no) 1998-02-05
US5792757A (en) 1998-08-11
ES2197949T3 (es) 2004-01-16
BR9609012A (pt) 1999-12-14

Similar Documents

Publication Publication Date Title
EA199800052A1 (ru) Новые норпрегнаны для стимуляции гипоталамических эффектов
NO20003552D0 (no) Progesteron-agonistforbindelser, farmasøytiske sammensetninger inneholdende disse og anvendelsen av forbindelsen, samt en fremgangsmÕte for bestemmelse av tilstedeværelse av steroidreseptorer, ligand-steroidreseptorkomplekser og en fremgangsmÕte
SE9301667D0 (sv) New use
DE69330754D1 (de) 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINE ALS NMDA REZEPTOR ANTAGONISTEN
BR9307867A (pt) Esteroides de androstano como iniciadores neuroquimicos de alteraçao na funçao hipotalamica humana e composiçoes e métodos farmaceuticos relacionados
NO990498L (no) 19-nor-cholansteroider som neurokjemiske initiatorer av forandring i human, hypotalamisk funksjon
NO955084D0 (no) Estrensteroider som nevrokjemiske initiatorer for forandring i menneskets hypotalamiske funksjon og beslektede farmasöytiske blandinger og metoder
NO990305D0 (no) Steroider som neurokjemiske stimulatorer av VNO for Õ lindre symptomer av PMS og angst
MX9702253A (es) Nuevos estrenos para inducir efectos hipotalamicos
WO1995016709A3 (en) Anti-mullerian hormone receptor polypeptides and antibodies thereto
DE69631770D1 (de) Pharmazeutische zusammensetzungen von steroiden zur förderung der immunantwort
MX9700881A (es) Pregnanos y colanos como indicadores neuroquimicos del cambio en la funcion hipotalamica.
NO308583B1 (no) Anvendelse av steroider for fremstilling av et medikament for behandling av forstyrrelser indusert av østrogenmangel, steroidene samt farmasøytisk blanding
MXPA94000705A (es) Esteroides de estreno como iniciadores neuroquimicos del cambio en la funcion hipotalamica humana ycomposiciones farmaceuticas y metodos relacionados.
BR9816142A (pt) Esteróides de 19-nor-colano como iniciadores neuroquìmicos de mudança na função hipotalâmica humana
ES2165382T3 (es) Agentes antiateroescleroticos.

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU