ES2165382T3 - Agentes antiateroescleroticos. - Google Patents

Agentes antiateroescleroticos.

Info

Publication number
ES2165382T3
ES2165382T3 ES94906461T ES94906461T ES2165382T3 ES 2165382 T3 ES2165382 T3 ES 2165382T3 ES 94906461 T ES94906461 T ES 94906461T ES 94906461 T ES94906461 T ES 94906461T ES 2165382 T3 ES2165382 T3 ES 2165382T3
Authority
ES
Spain
Prior art keywords
ester
dihydroequilin
alpha
sulfate
absence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94906461T
Other languages
English (en)
Inventor
Steven Jay Adelman
Kurt Edric Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/157,661 external-priority patent/US5482935A/en
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2165382T3 publication Critical patent/ES2165382T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

UN METODO PARA EL TRATAMIENTO DE LA ATEROESCLEROSIS QUE CONSISTE EN ADMINISTRAR A UN PACIENTE QUE NECESITE UN TRATAMIENTO ANTIATEROESCLEROTICO UNA CANTIDAD EFECTIVA DE 17 ALFADIHIDROEQUILINA, UN ESTER ALCANOILOXI C{SUB,2}-C{SUB,6} DE LA MISMA O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE SU ESTER DE SULFATO O FOSFATO, EN AUSENCIA DE LOS ESTEROIDES ESTROGENICOS QUE OCURREN DE FORMA NATURAL. UNA COMPOSICION FARMACEUTICA QUE CONTIENE 17 ALFA-DIHIDROEQUILINA, UN ESTER ALCANOILOXI C{SUB,2}C{SUB,6} DE LA MISMA O UNA SAL FARMACEUTICAMENTE ACEPTABLE DE SU ESTER DE SULFATO O FOSFATO, EN AUSENCIA DE LOS ESTEROIDES ESTROGENICOS QUE OCURREN DE FORMA NATURAL, Y UN PORTADOR FARMACEUTICAMENTE ACEPTABLE PARA LA MISMA.
ES94906461T 1993-01-05 1993-12-22 Agentes antiateroescleroticos. Expired - Lifetime ES2165382T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77793A 1993-01-05 1993-01-05
US08/157,661 US5482935A (en) 1993-01-05 1993-12-01 Anti-atherosclerotic use of 17 alpha-dihydroequilin
PCT/US1993/012559 WO1994015612A1 (en) 1993-01-05 1993-12-22 Anti-atherosclerotic agents

Publications (1)

Publication Number Publication Date
ES2165382T3 true ES2165382T3 (es) 2002-03-16

Family

ID=26668138

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94906461T Expired - Lifetime ES2165382T3 (es) 1993-01-05 1993-12-22 Agentes antiateroescleroticos.

Country Status (17)

Country Link
EP (1) EP0678027B1 (es)
JP (1) JP3344585B2 (es)
CN (1) CN1071573C (es)
AT (1) ATE209495T1 (es)
AU (1) AU6015794A (es)
CA (1) CA2152187A1 (es)
CY (1) CY2361B1 (es)
DE (1) DE69331237T2 (es)
DK (1) DK0678027T3 (es)
ES (1) ES2165382T3 (es)
HK (1) HK1011282A1 (es)
IL (1) IL108155A (es)
MX (1) MX9400254A (es)
PH (1) PH30474A (es)
PT (1) PT678027E (es)
SG (1) SG52359A1 (es)
WO (1) WO1994015612A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855703B1 (en) * 2000-03-10 2005-02-15 Endeavor Pharmaceuticals Pharmaceutical compositions of conjugated estrogens and methods of analyzing mixtures containing estrogenic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507889A (en) * 1968-06-11 1970-04-21 American Home Prod Process for the preparation of 17alpha-dihydroequilenin and related compounds
US3608075A (en) * 1969-07-28 1971-09-21 American Home Prod Compositions and methods of treating the menopausal syndrome
US4154820A (en) * 1976-02-23 1979-05-15 Akzona Incorporated Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers
US4379780A (en) * 1980-09-29 1983-04-12 American Home Products Corporation 17 α-Dihydroequilin hapten and assay method

Also Published As

Publication number Publication date
EP0678027B1 (en) 2001-11-28
IL108155A (en) 1999-08-17
MX9400254A (es) 1994-08-31
AU6015794A (en) 1994-08-15
SG52359A1 (en) 1998-09-28
JP3344585B2 (ja) 2002-11-11
CN1096443A (zh) 1994-12-21
DK0678027T3 (da) 2002-03-18
CN1071573C (zh) 2001-09-26
IL108155A0 (en) 1994-04-12
HK1011282A1 (en) 1999-07-09
JPH08505392A (ja) 1996-06-11
PH30474A (en) 1997-05-28
ATE209495T1 (de) 2001-12-15
PT678027E (pt) 2002-04-29
CY2361B1 (en) 2004-06-04
EP0678027A1 (en) 1995-10-25
DE69331237D1 (de) 2002-01-10
CA2152187A1 (en) 1994-07-21
WO1994015612A1 (en) 1994-07-21
DE69331237T2 (de) 2002-06-13

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