BR9609012A - "novos nor-pregnanos para indução de efeitos hipolalâmicos" - Google Patents
"novos nor-pregnanos para indução de efeitos hipolalâmicos"Info
- Publication number
- BR9609012A BR9609012A BR9609012-0A BR9609012A BR9609012A BR 9609012 A BR9609012 A BR 9609012A BR 9609012 A BR9609012 A BR 9609012A BR 9609012 A BR9609012 A BR 9609012A
- Authority
- BR
- Brazil
- Prior art keywords
- new
- effects
- vomeropherin
- hypolalamic
- pregnans
- Prior art date
Links
- 230000000694 effects Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 150000003431 steroids Chemical class 0.000 abstract 3
- 230000002267 hypothalamic effect Effects 0.000 abstract 2
- -1 19-nor-pregnane steroid Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Patente de Invenção:<B>"NOVOS NOR-PREGNANOS PARA INDUçãO DE EFEITOS HIPOTALâMICOS"<D>. A invenção se refere a um processo de alteração da função hipotalâmica em uma pessoa. O processo compreende a administração nasal a um ser humano de vomeroferina, por exemplo, um esteróide 19-nor-pregnano ou uma composição farmacêutica contendo uma vomeroferina, de modo que a vomeroferina se liga em um receptor neuroepitelial específico. O esteróide ou es esteróides é/são administrados na forma de uma composição farmacêutica contendo um ou mais veículo farmaceuticamente aceitáveis. Outras concretizações da invenção incluem composições farmacêuticas contendo os esteróides.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/485,615 US5792757A (en) | 1994-08-04 | 1995-06-07 | 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function |
PCT/US1996/009665 WO1996040727A1 (en) | 1995-06-07 | 1996-06-07 | Novel nor-pregnanes for inducing hypothalamic effects |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9609012A true BR9609012A (pt) | 1999-12-14 |
Family
ID=23928825
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9609012-0A BR9609012A (pt) | 1995-06-07 | 1996-06-07 | "novos nor-pregnanos para indução de efeitos hipolalâmicos" |
Country Status (17)
Country | Link |
---|---|
US (3) | US5792757A (pt) |
EP (1) | EP0830369B1 (pt) |
JP (1) | JPH11507360A (pt) |
KR (1) | KR19990022640A (pt) |
CN (1) | CN1191542A (pt) |
AT (1) | ATE240344T1 (pt) |
AU (1) | AU724787B2 (pt) |
BR (1) | BR9609012A (pt) |
CA (1) | CA2223397C (pt) |
CZ (1) | CZ391597A3 (pt) |
DE (1) | DE69628163T2 (pt) |
EA (1) | EA000965B1 (pt) |
ES (1) | ES2197949T3 (pt) |
HU (1) | HUP9900887A3 (pt) |
NO (1) | NO975709L (pt) |
NZ (1) | NZ312303A (pt) |
WO (1) | WO1996040727A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6057439A (en) * | 1994-08-04 | 2000-05-02 | Pherin Corporation | Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety |
US6066627A (en) * | 1994-08-04 | 2000-05-23 | Pherin Corporation | Steroids as neurochemical initiators of change in human blood levels of LH |
US6331534B1 (en) | 1994-08-04 | 2001-12-18 | Pherin Pharmaceuticals, Inc. | Steroids as neurochemical stimulators of the VNO to alleviate pain |
US6117860A (en) * | 1994-08-04 | 2000-09-12 | Pherin Pharmaceuticals, Inc. | Steroids as neurochemical stimulators of the VNO to treat paroxistic tachycardia |
US5922699A (en) * | 1996-06-07 | 1999-07-13 | Pherin Corporation | 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function |
BR9711812A (pt) * | 1996-07-23 | 1999-08-24 | Pherin Pharm Inc | EsterÄides como estimuladores neuroqu¡micos do ÄrgÆo vomeronasal para aliviar os sintomas de pms e ansiedade |
CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
CA2670236C (en) | 1999-09-30 | 2012-06-05 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
AUPQ342599A0 (en) * | 1999-10-14 | 1999-11-04 | University Of Melbourne, The | Conjugates and uses thereof |
US6555531B1 (en) * | 1999-12-30 | 2003-04-29 | Pherin Pharmaceuticals, Inc. | Weight promoting composition, method, and product |
US6413951B2 (en) * | 2000-06-27 | 2002-07-02 | Aventis Pharmaceuticals, Inc. | 20-fluoro-17(20)-vinyl steroids |
EP2135611A1 (en) | 2001-03-01 | 2009-12-23 | Hollis-Eden Pharmaceuticals Inc. | Pregn-5-en-20-yne-3,7,17-triol derivatives for use in therapy |
ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
EP2298315A1 (en) | 2002-08-28 | 2011-03-23 | Harbor BioSciences, Inc. | Therapeutic treatment methods |
CA2582231A1 (en) | 2004-09-29 | 2006-10-19 | Hollis-Eden Pharmaceuticals, Inc. | Steroid analogs and uses |
DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
EP1945240B1 (en) | 2005-09-16 | 2016-12-28 | Raptor Pharmaceutical Inc | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
EP2194962A2 (en) * | 2007-09-17 | 2010-06-16 | Human Pheromone Sciences, Inc. | Fragrance compositions and other compositions which contain naturally occurring substances found in corals |
MX2010011063A (es) | 2008-04-09 | 2010-11-22 | Pherin Pharm Inc | Tratamiento esteroidal para sofocos. |
ES2728225T3 (es) | 2009-02-20 | 2019-10-23 | 2 Bbb Medicines B V | Sistema de administración de fármacos a base de glutatión |
US8445002B2 (en) | 2009-05-06 | 2013-05-21 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
CN113527400A (zh) * | 2013-04-17 | 2021-10-22 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法 |
AU2015317652A1 (en) * | 2014-09-17 | 2017-04-06 | Prevacus, Inc. | C-20 steroid compounds, compositions and uses thereof to treat traumatic brain injury (TBI), including concussions |
DE102020204505A1 (de) | 2020-04-07 | 2021-10-07 | Henkel Ag & Co. Kgaa | Wasch-/Pflegeartikel umfassend Pheromone |
DE102020204509A1 (de) | 2020-04-07 | 2021-10-07 | Henkel Ag & Co. Kgaa | Waschmittel mit Pheromonen |
DE102020204506A1 (de) | 2020-04-07 | 2021-10-07 | Henkel Ag & Co. Kgaa | Weichspüler mit Pheromonen |
DE102020204507A1 (de) | 2020-04-07 | 2021-10-07 | Henkel Ag & Co. Kgaa | Weichspüler mit aphrodisierend wirkenden Duftstoffen |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL287863A (pt) | ||||
US2840582A (en) * | 1953-08-31 | 1958-06-24 | Searle & Co | Derivatives of 13-methyl-17-hydroxy-1, 2, 3, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16, 17-tetradecahydro-15h-cyclopenta[a]phenanthren-3-ones |
DE1297603B (de) | 1964-08-08 | 1969-06-19 | Schering Ag | Verfahren zur Herstellung von 3-Keto-delta 17(20)-pregnenen |
ES319318A1 (es) | 1964-11-13 | 1966-10-16 | American Cyanamid Co | Procedimiento para la preparaciën de una composiciën anticonceptiva |
US3385849A (en) * | 1965-07-01 | 1968-05-28 | Hoffmann La Roche | Process for the preparation of 17beta-pregnanes from 17-oxo-steroids |
US3492318A (en) * | 1968-01-22 | 1970-01-27 | Syntex Corp | Cyclopropenyl androstanes |
US3682983A (en) * | 1969-11-12 | 1972-08-08 | Klaus Prezewowsky | Preparation of {66 {11 {11 -17 ethinyl steroids |
FR2097045A1 (en) | 1970-07-30 | 1972-03-03 | Roussel Uclaf | 17-ethynylgon-4-en-3-ones - with progestomimetic activity useful as contraceptives and for gynaecological disorders |
US3681410A (en) * | 1970-08-07 | 1972-08-01 | Syntex Corp | Process for preparing 17{60 -hydroxy-20-keto and 17{60 ,21-dihydroxy-20-keto pregnanes and derivatives and intermediates thereof |
US3946052A (en) * | 1975-06-16 | 1976-03-23 | Stanford Research Institute | 19-Norpregna- 1,3,5(10)-trien-3-ol and loweralkyl homologs thereof having postcoital antifertility activity |
US5155045A (en) | 1985-01-25 | 1992-10-13 | Trustees Of The University Of Penn. | Use of male essence to alter female endocrine response |
US5108995A (en) | 1987-09-24 | 1992-04-28 | Jencap Research Ltd. | Hormone preparation and method |
JP2578369B2 (ja) * | 1989-05-09 | 1997-02-05 | ポーラ化成工業株式会社 | 芳香組成物 |
GB8912043D0 (en) * | 1989-05-25 | 1989-07-12 | Beecham Group Plc | Novel compounds |
US5272134A (en) * | 1992-03-24 | 1993-12-21 | Erox Corporation | Fragrance compositions and other compositions which contain human pheromones |
US5278141A (en) * | 1992-03-24 | 1994-01-11 | Erox Corporation | Fragrance compositions containing human pheromones |
-
1995
- 1995-06-07 US US08/485,615 patent/US5792757A/en not_active Expired - Lifetime
-
1996
- 1996-06-07 US US08/660,297 patent/US5962443A/en not_active Expired - Lifetime
- 1996-06-07 AT AT96923241T patent/ATE240344T1/de not_active IP Right Cessation
- 1996-06-07 DE DE69628163T patent/DE69628163T2/de not_active Expired - Lifetime
- 1996-06-07 BR BR9609012-0A patent/BR9609012A/pt unknown
- 1996-06-07 ES ES96923241T patent/ES2197949T3/es not_active Expired - Lifetime
- 1996-06-07 NZ NZ312303A patent/NZ312303A/xx unknown
- 1996-06-07 CZ CZ973915A patent/CZ391597A3/cs unknown
- 1996-06-07 EA EA199800052A patent/EA000965B1/ru not_active IP Right Cessation
- 1996-06-07 CN CN96195782A patent/CN1191542A/zh active Pending
- 1996-06-07 KR KR1019970709215A patent/KR19990022640A/ko not_active Application Discontinuation
- 1996-06-07 JP JP9501937A patent/JPH11507360A/ja active Pending
- 1996-06-07 AU AU63807/96A patent/AU724787B2/en not_active Ceased
- 1996-06-07 HU HU9900887A patent/HUP9900887A3/hu unknown
- 1996-06-07 CA CA002223397A patent/CA2223397C/en not_active Expired - Fee Related
- 1996-06-07 EP EP96923241A patent/EP0830369B1/en not_active Expired - Lifetime
- 1996-06-07 WO PCT/US1996/009665 patent/WO1996040727A1/en not_active Application Discontinuation
-
1997
- 1997-12-05 NO NO975709A patent/NO975709L/no not_active Application Discontinuation
-
1998
- 1998-08-11 US US09/131,998 patent/US6242619B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CZ391597A3 (cs) | 1998-06-17 |
NO975709L (no) | 1998-02-05 |
MX9709693A (es) | 1998-10-31 |
AU724787B2 (en) | 2000-09-28 |
CA2223397C (en) | 2007-07-31 |
EP0830369B1 (en) | 2003-05-14 |
US5962443A (en) | 1999-10-05 |
CA2223397A1 (en) | 1996-12-19 |
EP0830369A4 (en) | 1999-06-09 |
NO975709D0 (no) | 1997-12-05 |
DE69628163D1 (de) | 2003-06-18 |
US5792757A (en) | 1998-08-11 |
NZ312303A (en) | 2000-01-28 |
US6242619B1 (en) | 2001-06-05 |
EA199800052A1 (ru) | 1998-08-27 |
KR19990022640A (ko) | 1999-03-25 |
DE69628163T2 (de) | 2004-04-01 |
HUP9900887A2 (hu) | 1999-08-30 |
HUP9900887A3 (en) | 1999-11-29 |
EA000965B1 (ru) | 2000-08-28 |
ATE240344T1 (de) | 2003-05-15 |
AU6380796A (en) | 1996-12-30 |
ES2197949T3 (es) | 2004-01-16 |
EP0830369A1 (en) | 1998-03-25 |
CN1191542A (zh) | 1998-08-26 |
WO1996040727A1 (en) | 1996-12-19 |
JPH11507360A (ja) | 1999-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A,8A E 9A ANUIDADES. |