MX9709693A - Novedosos nor-pregnanos, para inducir efectos hipotalamicos. - Google Patents

Novedosos nor-pregnanos, para inducir efectos hipotalamicos.

Info

Publication number
MX9709693A
MX9709693A MX9709693A MX9709693A MX9709693A MX 9709693 A MX9709693 A MX 9709693A MX 9709693 A MX9709693 A MX 9709693A MX 9709693 A MX9709693 A MX 9709693A MX 9709693 A MX9709693 A MX 9709693A
Authority
MX
Mexico
Prior art keywords
vomeropherin
pregnanes
novel
steroids
pharmaceutical composition
Prior art date
Application number
MX9709693A
Other languages
English (en)
Other versions
MXPA97009693A (es
Inventor
Clive L Jennings-White
David L Berliner
Nathan William Adams
Original Assignee
Pherin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pherin Pharm Inc filed Critical Pherin Pharm Inc
Publication of MX9709693A publication Critical patent/MX9709693A/es
Publication of MXPA97009693A publication Critical patent/MXPA97009693A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La invencion se refiere a un método para alterar la funcion hipotalámica en un individuo. Este método comprende administrar nasalmente una vomeroferina humana, por ejemplo un esteroide del 19-nor-pregnano, o una composicion farnacéutica que contenga una vomeroferina, de manera que esta vomeroferina se ligue a un receptor neuroepitelial específico. El esteride o los esterides se administran, preferiblemente, en la forma de una composicion farmacéutica que contiene, uno o más portadores aceptables farmacéutica que contiene estos esteroides.
MXPA/A/1997/009693A 1995-06-07 1997-12-05 Novedosos nor-pregnanos, para inducir efectos hipotalamicos MXPA97009693A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08485615 1995-06-07
US08/485,615 US5792757A (en) 1994-08-04 1995-06-07 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function

Publications (2)

Publication Number Publication Date
MX9709693A true MX9709693A (es) 1998-10-31
MXPA97009693A MXPA97009693A (es) 1999-01-11

Family

ID=

Also Published As

Publication number Publication date
KR19990022640A (ko) 1999-03-25
US5792757A (en) 1998-08-11
JPH11507360A (ja) 1999-06-29
EA199800052A1 (ru) 1998-08-27
ATE240344T1 (de) 2003-05-15
AU724787B2 (en) 2000-09-28
CA2223397C (en) 2007-07-31
EP0830369B1 (en) 2003-05-14
WO1996040727A1 (en) 1996-12-19
NO975709L (no) 1998-02-05
AU6380796A (en) 1996-12-30
CZ391597A3 (cs) 1998-06-17
DE69628163D1 (de) 2003-06-18
EA000965B1 (ru) 2000-08-28
US5962443A (en) 1999-10-05
ES2197949T3 (es) 2004-01-16
CA2223397A1 (en) 1996-12-19
EP0830369A4 (en) 1999-06-09
HUP9900887A2 (hu) 1999-08-30
BR9609012A (pt) 1999-12-14
NO975709D0 (no) 1997-12-05
EP0830369A1 (en) 1998-03-25
HUP9900887A3 (en) 1999-11-29
DE69628163T2 (de) 2004-04-01
NZ312303A (en) 2000-01-28
US6242619B1 (en) 2001-06-05
CN1191542A (zh) 1998-08-26

Similar Documents

Publication Publication Date Title
CA2223397A1 (en) Novel nor-pregnanes for inducing hypothalamic effects
ZA965607B (en) Drug delivery compositions for improved stability of steroids
MD1920F2 (ro) Compoziţie şi metodă de profilaxie sau frânare a debutului bolii Alzheimer
EP0711169A4 (en) ANDROSTANTEROIDS AS A NEUROCHEMICAL INITIATORS OF A CHANGE IN HUMAN HUMAN FUNCTION AND RELATED PHARMACEUTICAL PREPARATIONS AND METHODS
CA2258177A1 (en) 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function
HU9503579D0 (en) Estrene steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
AU3963797A (en) Steroids as neurochemical stimulators of the vno to alleviate symptoms of pms and anxiety
MX9702253A (es) Nuevos estrenos para inducir efectos hipotalamicos
MX9700881A (es) Pregnanos y colanos como indicadores neuroquimicos del cambio en la funcion hipotalamica.
MXPA94000705A (es) Esteroides de estreno como iniciadores neuroquimicos del cambio en la funcion hipotalamica humana ycomposiciones farmaceuticas y metodos relacionados.
CA2248841A1 (en) Sequential oestrogen/progesterone antagonist combination for hormone replacement therapy
BR9816142A (pt) Esteróides de 19-nor-colano como iniciadores neuroquìmicos de mudança na função hipotalâmica humana
TW289730B (en) Pharmaceutical composition for alleviating the symptoms of psychoses, depression or anxiety comprising androstene steroids
IL108155A0 (en) Pharmaceutical compositions containing 17 alphadihydroequilenin or an ester or salt thereof