MD1920F2 - Compoziţie şi metodă de profilaxie sau frânare a debutului bolii Alzheimer - Google Patents

Compoziţie şi metodă de profilaxie sau frânare a debutului bolii Alzheimer

Info

Publication number
MD1920F2
MD1920F2 MD99-0262A MD990262A MD1920F2 MD 1920 F2 MD1920 F2 MD 1920F2 MD 990262 A MD990262 A MD 990262A MD 1920 F2 MD1920 F2 MD 1920F2
Authority
MD
Moldova
Prior art keywords
composititon
alzheimer
prevention
delay
disease origin
Prior art date
Application number
MD99-0262A
Other languages
English (en)
Russian (ru)
Other versions
MD990262A (ro
Inventor
Егон НОВАК
Original Assignee
Форбес-Тек Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Форбес-Тек Инк. filed Critical Форбес-Тек Инк.
Publication of MD990262A publication Critical patent/MD990262A/ro
Publication of MD1920F2 publication Critical patent/MD1920F2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Invenţia se referă la domeniul medicinei, în special la neurologie şi psihiatrie.Esenţa invenţiei constă în aceea că compoziţia conţine beta-sitosterol, campesterol şi stigmastanol şi suplimentar poate include campestanol, iar metoda se caracterizează prin aceea că mamiferului i se administrează o cantitate terapeutic eficientă de această compoziţie de fitosteroli.
MD99-0262A 1997-12-18 1998-12-18 Compoziţie şi metodă de profilaxie sau frânare a debutului bolii Alzheimer MD1920F2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/993,901 US5985936A (en) 1997-12-18 1997-12-18 Method of preventing and delaying onset of Alzheimer's disease and composition therefor
PCT/CA1998/001147 WO1999032097A2 (en) 1997-12-18 1998-12-18 Phytosterol composition for preventing alzheimer's disease

Publications (2)

Publication Number Publication Date
MD990262A MD990262A (ro) 2000-06-30
MD1920F2 true MD1920F2 (ro) 2002-05-31

Family

ID=25540052

Family Applications (1)

Application Number Title Priority Date Filing Date
MD99-0262A MD1920F2 (ro) 1997-12-18 1998-12-18 Compoziţie şi metodă de profilaxie sau frânare a debutului bolii Alzheimer

Country Status (18)

Country Link
US (1) US5985936A (ro)
EP (1) EP0967982A2 (ro)
CN (1) CN1252724A (ro)
AU (1) AU1656099A (ro)
BG (1) BG103740A (ro)
BR (1) BR9807577A (ro)
CA (1) CA2281710A1 (ro)
EE (1) EE9900354A (ro)
GE (1) GEP20022783B (ro)
HU (1) HUP0100737A3 (ro)
LT (1) LT4801B (ro)
LV (1) LV12438B (ro)
MD (1) MD1920F2 (ro)
NO (1) NO993979L (ro)
PL (1) PL335421A1 (ro)
RU (1) RU2173151C2 (ro)
SK (1) SK112999A3 (ro)
WO (1) WO1999032097A2 (ro)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8679534B2 (en) * 1997-12-12 2014-03-25 Andrx Labs, Llc HMG-CoA reductase inhibitor extended release formulation
US20020107173A1 (en) * 1999-11-04 2002-08-08 Lawrence Friedhoff Method of treating amyloid beta precursor disorders
WO2001032161A2 (en) * 1999-11-04 2001-05-10 Andrx Corporation Use of a hmg-coa reductase inhibitor for treating amyloid beta precursor disorders
US6610320B2 (en) 2000-04-14 2003-08-26 Mars, Incorporated Compositions and methods for improving vascular health
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US20030013692A1 (en) * 2001-01-19 2003-01-16 Gullans Steven R. Methods of treating neurological disorders
US6399310B1 (en) 2001-02-12 2002-06-04 Akzo Nobel N.V. Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
ES2296893T3 (es) * 2001-02-12 2008-05-01 N.V. Organon Uso de mirtazapina para el tratamiento de la depresion severa en un paciente humano y portador del gen de la apolipoproteina e4.
US20030105082A1 (en) * 2001-12-03 2003-06-05 Murphy Greer Marechal Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
DE10154221A1 (de) * 2001-11-07 2003-05-15 Max Delbrueck Centrum Mittel zur Behandlung von Läsionen des Nervensystems
FR2848452B1 (fr) * 2002-12-12 2007-04-06 Aventis Pharma Sa Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
WO2004081002A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN1756755A (zh) * 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
GB0513881D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
US20050277129A1 (en) * 2004-01-22 2005-12-15 Genaissance Pharmaceuticals APOE genetic markers associated with age of onset of Alzheimer's disease
CN101291683B (zh) * 2004-11-24 2011-08-17 纽普罗研究有限公司 治疗疾病的方法和组合物
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513888D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
GB0513883D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
BRPI0909378A2 (pt) * 2008-03-27 2015-10-06 Evotec Neurosciences Gmbh métodos para tratar distúrbios usando antagonista seletivo de nmda subtipo nr2b
WO2010104375A1 (en) * 2009-03-12 2010-09-16 N.V. Nutricia Stigmasterol for the treatment of alzheimer's disease
US10307450B2 (en) 2010-01-11 2019-06-04 Phoenix Biotechnology, Inc. Method of treating neurological conditions with extract of Nerium species or Thevetia species
US10383886B2 (en) 2010-01-11 2019-08-20 Phoenix Biotechnology, Inc. Method of treating neurological conditions with oleandrin
US9011937B2 (en) * 2010-11-22 2015-04-21 Phoenix Biotechnology, Inc. Method of treating neurological conditions with extract of Nerium species or Thevetia species
WO2012149111A1 (en) * 2011-04-26 2012-11-01 The Regents Of The University Of California Methods of promoting cns neuronal repair by inhibiting lrp-1
CN102813659A (zh) * 2012-08-21 2012-12-12 贵阳中医学院 20α-二甲胺基- 2α-羟基-3β-惕洛酰胺基-5α-孕甾烷的用途
WO2015123617A1 (en) * 2014-02-14 2015-08-20 Arizona Board Of Regents For The University Of Arizona Method for reducing bcl2 gene expression
US10596186B2 (en) 2016-09-14 2020-03-24 Phoenix Biotechnology, Inc. Method and compositions for treating viral infections
US10702567B2 (en) 2016-09-14 2020-07-07 Phoenix Biotechnology, Inc. Method and compositions for treating viral infection
US11331291B2 (en) 2017-09-14 2022-05-17 Phoenix Biotechnology, Inc. Method of and improved composition for treating triterpene-responsive conditions, diseases or disorders
JP7370966B2 (ja) 2017-09-14 2023-10-30 フェニックス・バイオテクノロジー・インコーポレイテッド 神経学的状態を治療するための方法および改善された神経保護組成物
WO2021130002A1 (en) 2019-12-24 2021-07-01 Folium Biosciences Europe B.V. Food supplement for alzheimer
EP3842039A1 (en) * 2019-12-24 2021-06-30 Folium Biosciences Europe B.V. Food supplement comprising cannbinoids and phytosterols for alzheimer
US11806359B2 (en) 2020-03-31 2023-11-07 Phoenix Biotechnology, Inc. Method and compositions for treating Coronavirus infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010033A1 (en) * 1994-09-29 1996-04-04 The University Of British Columbia Sterol compositions from pulping soap

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1203515B (it) * 1987-02-26 1989-02-15 Indena Spa Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
AU6274394A (en) * 1993-02-23 1994-09-14 Pharmakon Usa, Inc. Therapeutic herbal composition
US5589182A (en) * 1993-12-06 1996-12-31 Tashiro; Renki Compositions and method of treating cardio-, cerebro-vascular and alzheimer's diseases and depression
CN1179903A (zh) * 1996-10-09 1998-04-29 李辉 营养丝米粉
DE69837551T2 (de) * 1997-05-15 2007-12-20 University Of Washington, Seattle Zusammensetzung und verfahren zur behandlung der alzheimer'schen krankheit und anderen amyloidosen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010033A1 (en) * 1994-09-29 1996-04-04 The University Of British Columbia Sterol compositions from pulping soap
MD1721C2 (ro) * 1994-09-29 2002-01-31 The University Of British Columbia Procedeu de separare a compoziţiei de fitosteroli din săpun de pulpă, compoziţie de reducere a nivelului de colesterol şi produs terapeutic

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WEISGRABER et al. Lipoproteins, neurobiology, and Alzheimer(s disease: Structure and function of apolipoprotein-E. Curr. Opin. Struct. Biol. 1994, 4, p. 507-515 *

Also Published As

Publication number Publication date
WO1999032097A2 (en) 1999-07-01
HUP0100737A3 (en) 2002-07-29
CN1252724A (zh) 2000-05-10
NO993979L (no) 1999-10-13
RU2173151C2 (ru) 2001-09-10
US5985936A (en) 1999-11-16
WO1999032097A3 (en) 1999-09-02
LV12438A (en) 2000-03-20
PL335421A1 (en) 2000-04-25
AU1656099A (en) 1999-07-12
LV12438B (en) 2000-09-20
HUP0100737A2 (hu) 2001-09-28
GEP20022783B (en) 2002-09-25
CA2281710A1 (en) 1999-07-01
MD990262A (ro) 2000-06-30
EP0967982A2 (en) 2000-01-05
EE9900354A (et) 2000-02-15
NO993979D0 (no) 1999-08-18
BR9807577A (pt) 2001-08-07
SK112999A3 (en) 2001-11-06
BG103740A (en) 2000-05-31
LT99114A (lt) 2001-01-25
LT4801B (lt) 2001-06-25

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