MD1920F2 - Compoziţie şi metodă de profilaxie sau frânare a debutului bolii Alzheimer - Google Patents

Compoziţie şi metodă de profilaxie sau frânare a debutului bolii Alzheimer Download PDF

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Publication number
MD1920F2
MD1920F2 MD99-0262A MD990262A MD1920F2 MD 1920 F2 MD1920 F2 MD 1920F2 MD 990262 A MD990262 A MD 990262A MD 1920 F2 MD1920 F2 MD 1920F2
Authority
MD
Moldova
Prior art keywords
composititon
alzheimer
prevention
delay
disease origin
Prior art date
Application number
MD99-0262A
Other languages
English (en)
Russian (ru)
Other versions
MD990262A (ro
Inventor
Егон НОВАК
Original Assignee
Форбес-Тек Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Форбес-Тек Инк. filed Critical Форбес-Тек Инк.
Publication of MD990262A publication Critical patent/MD990262A/ro
Publication of MD1920F2 publication Critical patent/MD1920F2/ro

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Invenţia se referă la domeniul medicinei, în special la neurologie şi psihiatrie.Esenţa invenţiei constă în aceea că compoziţia conţine beta-sitosterol, campesterol şi stigmastanol şi suplimentar poate include campestanol, iar metoda se caracterizează prin aceea că mamiferului i se administrează o cantitate terapeutic eficientă de această compoziţie de fitosteroli.
MD99-0262A 1997-12-18 1998-12-18 Compoziţie şi metodă de profilaxie sau frânare a debutului bolii Alzheimer MD1920F2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/993,901 US5985936A (en) 1997-12-18 1997-12-18 Method of preventing and delaying onset of Alzheimer's disease and composition therefor
PCT/CA1998/001147 WO1999032097A2 (en) 1997-12-18 1998-12-18 Phytosterol composition for preventing alzheimer's disease

Publications (2)

Publication Number Publication Date
MD990262A MD990262A (ro) 2000-06-30
MD1920F2 true MD1920F2 (ro) 2002-05-31

Family

ID=25540052

Family Applications (1)

Application Number Title Priority Date Filing Date
MD99-0262A MD1920F2 (ro) 1997-12-18 1998-12-18 Compoziţie şi metodă de profilaxie sau frânare a debutului bolii Alzheimer

Country Status (18)

Country Link
US (1) US5985936A (ro)
EP (1) EP0967982A2 (ro)
CN (1) CN1252724A (ro)
AU (1) AU1656099A (ro)
BG (1) BG103740A (ro)
BR (1) BR9807577A (ro)
CA (1) CA2281710A1 (ro)
EE (1) EE9900354A (ro)
GE (1) GEP20022783B (ro)
HU (1) HUP0100737A3 (ro)
LT (1) LT4801B (ro)
LV (1) LV12438B (ro)
MD (1) MD1920F2 (ro)
NO (1) NO993979L (ro)
PL (1) PL335421A1 (ro)
RU (1) RU2173151C2 (ro)
SK (1) SK112999A3 (ro)
WO (1) WO1999032097A2 (ro)

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US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US20030013692A1 (en) * 2001-01-19 2003-01-16 Gullans Steven R. Methods of treating neurological disorders
BRPI0206641B8 (pt) 2001-01-26 2021-05-25 Merck Sharp & Dohme uso de um inibidor da absorção de esteróis
SK288217B6 (sk) 2001-01-26 2014-08-05 Merck Sharp & Dohme Corp. Zmes, terapeutická kombinácia, farmaceutický prostriedok a ich použitie
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US6399310B1 (en) 2001-02-12 2002-06-04 Akzo Nobel N.V. Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
DE60224078T2 (de) * 2001-02-12 2008-12-04 N.V. Organon Verwendung von Mirtazapin zur Verbesserung der Behandlung von Menschen mit starken Depressionen, welche Träger des Gens für Apolipoprotein E4 sind.
US20030105082A1 (en) * 2001-12-03 2003-06-05 Murphy Greer Marechal Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
DE60216300T2 (de) 2001-09-21 2007-06-28 Schering Corp. Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
DE10154221A1 (de) * 2001-11-07 2003-05-15 Max Delbrueck Centrum Mittel zur Behandlung von Läsionen des Nervensystems
AU2003291719A1 (en) 2002-11-06 2004-06-03 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
FR2848452B1 (fr) * 2002-12-12 2007-04-06 Aventis Pharma Sa Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
PL378571A1 (pl) * 2003-02-01 2006-05-02 Neuralab Limited Czynna immunizacja dla wytworzenia przeciwciał przeciw rozpuszczalnemu A-ß
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2517573C (en) * 2003-03-07 2011-12-06 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
ES2311806T3 (es) 2003-03-07 2009-02-16 Schering Corporation Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
CN1756756A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
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JP2007526764A (ja) * 2004-01-22 2007-09-20 ジェネッサンス ファーマシューティカルズ，インコーポレイティド アルツハイマー病の発症年齢に関連するａｐｏｅ遺伝子マーカー
CN101291683B (zh) * 2004-11-24 2011-08-17 纽普罗研究有限公司 治疗疾病的方法和组合物
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
GB0513883D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
KR20100135847A (ko) * 2008-03-27 2010-12-27 에보텍 뉴로사이언시즈 게엠베하 Ｎｍｄａ ｎｒ２ｂ―서브타입 선택적 길항제를 사용한 질병 치료 방법
WO2010104375A1 (en) * 2009-03-12 2010-09-16 N.V. Nutricia Stigmasterol for the treatment of alzheimer's disease
US9011937B2 (en) * 2010-11-22 2015-04-21 Phoenix Biotechnology, Inc. Method of treating neurological conditions with extract of Nerium species or Thevetia species
US10383886B2 (en) 2010-01-11 2019-08-20 Phoenix Biotechnology, Inc. Method of treating neurological conditions with oleandrin
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WO2015123618A1 (en) * 2014-02-14 2015-08-20 Arizona Board Of Regents For The University Of Arizona Method for increasing bcl2 gene expression
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US11331291B2 (en) 2017-09-14 2022-05-17 Phoenix Biotechnology, Inc. Method of and improved composition for treating triterpene-responsive conditions, diseases or disorders
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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
LT99114A (lt) 2001-01-25
GEP20022783B (en) 2002-09-25
NO993979D0 (no) 1999-08-18
SK112999A3 (en) 2001-11-06
HUP0100737A3 (en) 2002-07-29
PL335421A1 (en) 2000-04-25
BR9807577A (pt) 2001-08-07
LV12438B (en) 2000-09-20
AU1656099A (en) 1999-07-12
US5985936A (en) 1999-11-16
LV12438A (en) 2000-03-20
EP0967982A2 (en) 2000-01-05
HUP0100737A2 (hu) 2001-09-28
WO1999032097A3 (en) 1999-09-02
EE9900354A (et) 2000-02-15
CA2281710A1 (en) 1999-07-01
LT4801B (lt) 2001-06-25
MD990262A (ro) 2000-06-30
NO993979L (no) 1999-10-13
CN1252724A (zh) 2000-05-10
WO1999032097A2 (en) 1999-07-01
BG103740A (en) 2000-05-31
RU2173151C2 (ru) 2001-09-10

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