RU99120072A - Способ и композиция для профилактики и задержки начала болезни Альцгеймера - Google Patents
Способ и композиция для профилактики и задержки начала болезни АльцгеймераInfo
- Publication number
- RU99120072A RU99120072A RU99120072/14A RU99120072A RU99120072A RU 99120072 A RU99120072 A RU 99120072A RU 99120072/14 A RU99120072/14 A RU 99120072/14A RU 99120072 A RU99120072 A RU 99120072A RU 99120072 A RU99120072 A RU 99120072A
- Authority
- RU
- Russia
- Prior art keywords
- campesterol
- stigmastanol
- composition
- alzheimer
- disease
- Prior art date
Links
- 206010001897 Alzheimer's disease Diseases 0.000 title claims 3
- SGNBVLSWZMBQTH-PODYLUTMSA-N Campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 claims 9
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 claims 9
- LGJMUZUPVCAVPU-JFBKYFIKSA-N Sitostanol Natural products O[C@@H]1C[C@H]2[C@@](C)([C@@H]3[C@@H]([C@H]4[C@@](C)([C@@H]([C@@H](CC[C@H](C(C)C)CC)C)CC4)CC3)CC2)CC1 LGJMUZUPVCAVPU-JFBKYFIKSA-N 0.000 claims 9
- LGJMUZUPVCAVPU-HRJGVYIJSA-N Stigmastanol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]2(C)CC1 LGJMUZUPVCAVPU-HRJGVYIJSA-N 0.000 claims 9
- 229940076810 beta Sitosterol Drugs 0.000 claims 9
- 235000000431 campesterol Nutrition 0.000 claims 9
- 229950005143 sitosterol Drugs 0.000 claims 9
- KZJWDPNRJALLNS-VJSFXXLFSA-N β-Sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims 9
- ARYTXMNEANMLMU-ATEDBJNTSA-N Campestanol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]2(C)CC1 ARYTXMNEANMLMU-ATEDBJNTSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 1
Claims (10)
1. Способ профилактики или задержки начала болезни Альцгеймера у животного, который включает введение животному фитостериновой композиции.
2. Способ по п.1, в котором животное представляет собой человека.
3. Способ по п.1, в котором композиция включает бетаситостерин, кампестерин и стигмастанол.
4. Способ по п.1, в котором композиция включает бетаситостерин, кампестерин и стигмастанол, и в которой кампестерин и стигмастанол вместе составляют, по меньшей мере, 50% концентрации бета-ситостерина.
5. Способ по п.1, в котором композиция включает бетаситостерин, кампестерин и стигмастанол, и в которой композиция включает от 10 до 25% кампестерина, от 10 до 40% стигмастанола и от 45 до 75% бета-ситостерина.
6. Способ по п.1, в котором композиция включает бетаситостерин, кампестерин, стигмастанол и кампестанол.
7. Терапевтически эффективный продукт для предотвращения болезни Альцгеймера, включающий бета-ситостерин, кампестерин и стигмастанол.
8. Продукт по п.7, в котором кампестерин и стигмастанол вместе составляют, по меньшей мере, 50% концентрации бета-ситостерина.
9. Продукт по п.7, включающий от 10 до 25% кампестерина, от 10 до 40% стигмастанола и от 45 до 75% бета-ситостерина.
10. Продукт по п.1, дополнительно включающий кампестанол.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/993,901 | 1997-12-18 | ||
| US08/993,901 US5985936A (en) | 1997-12-18 | 1997-12-18 | Method of preventing and delaying onset of Alzheimer's disease and composition therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2173151C2 RU2173151C2 (ru) | 2001-09-10 |
| RU99120072A true RU99120072A (ru) | 2003-07-20 |
Family
ID=25540052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99120072/14A RU2173151C2 (ru) | 1997-12-18 | 1998-12-18 | Способ и композиция для профилактики и задержки начала болезни альцгеймера |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5985936A (ru) |
| EP (1) | EP0967982A2 (ru) |
| CN (1) | CN1252724A (ru) |
| AU (1) | AU1656099A (ru) |
| BG (1) | BG103740A (ru) |
| BR (1) | BR9807577A (ru) |
| CA (1) | CA2281710A1 (ru) |
| EE (1) | EE9900354A (ru) |
| GE (1) | GEP20022783B (ru) |
| HU (1) | HUP0100737A3 (ru) |
| LT (1) | LT4801B (ru) |
| LV (1) | LV12438B (ru) |
| MD (1) | MD1920F2 (ru) |
| NO (1) | NO993979L (ru) |
| PL (1) | PL335421A1 (ru) |
| RU (1) | RU2173151C2 (ru) |
| SK (1) | SK112999A3 (ru) |
| WO (1) | WO1999032097A2 (ru) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8679534B2 (en) * | 1997-12-12 | 2014-03-25 | Andrx Labs, Llc | HMG-CoA reductase inhibitor extended release formulation |
| US20020107173A1 (en) * | 1999-11-04 | 2002-08-08 | Lawrence Friedhoff | Method of treating amyloid beta precursor disorders |
| EP1225880A2 (en) * | 1999-11-04 | 2002-07-31 | Andrx Corporation | Use of a hmg-coa reductase inhibitor for treating amyloid beta precursor disorders |
| AU2001253294A1 (en) | 2000-04-14 | 2001-10-30 | Mars, Incorporated | Compositions and methods for improving vascular health |
| US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US20030013692A1 (en) * | 2001-01-19 | 2003-01-16 | Gullans Steven R. | Methods of treating neurological disorders |
| US6399310B1 (en) | 2001-02-12 | 2002-06-04 | Akzo Nobel N.V. | Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4 |
| US20030105082A1 (en) * | 2001-12-03 | 2003-06-05 | Murphy Greer Marechal | Methods for improving the therapeutic response of humans having major depression and carrying the gene for apolipoprotein E4 |
| WO2002064735A2 (en) * | 2001-02-12 | 2002-08-22 | Akzo Nobel N.V. | Methods for improving the treatment of major depression by genotyping for the gene for apolipoproteine e4 |
| DE10154221A1 (de) * | 2001-11-07 | 2003-05-15 | Max Delbrueck Centrum | Mittel zur Behandlung von Läsionen des Nervensystems |
| FR2848452B1 (fr) * | 2002-12-12 | 2007-04-06 | Aventis Pharma Sa | Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer |
| CA2517573C (en) * | 2003-03-07 | 2011-12-06 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| US7235543B2 (en) | 2003-03-07 | 2007-06-26 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| US20080182801A1 (en) * | 2003-12-22 | 2008-07-31 | Btg International Limited | Core 2 glcnac-t inhibitors |
| GB0513881D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors III |
| GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
| WO2005072151A2 (en) * | 2004-01-22 | 2005-08-11 | Genaissance Pharmaceuticals, Inc. | Apoe genetic markers associated with age of onset of alzheimer's disease |
| CA2587985C (en) * | 2004-11-24 | 2016-05-10 | Neopro Labs, Llc | Peptides for use in treatment in fever or pain |
| GB0512726D0 (en) * | 2005-06-22 | 2005-07-27 | Btg Int Ltd | Multiple sclerosis therapy and diagnosis |
| GB0513883D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Diagnosis of Atherosclerosis |
| GB0513888D0 (en) * | 2005-07-06 | 2005-08-10 | Btg Int Ltd | Core 2 GLCNAC-T Inhibitors II |
| NZ588698A (en) * | 2008-03-27 | 2012-06-29 | Evotec Neurosciences Gmbh | Methods for treating disorders using nmda nr2b-subtype selective antagonist |
| WO2010104375A1 (en) * | 2009-03-12 | 2010-09-16 | N.V. Nutricia | Stigmasterol for the treatment of alzheimer's disease |
| US9011937B2 (en) * | 2010-11-22 | 2015-04-21 | Phoenix Biotechnology, Inc. | Method of treating neurological conditions with extract of Nerium species or Thevetia species |
| US10383886B2 (en) | 2010-01-11 | 2019-08-20 | Phoenix Biotechnology, Inc. | Method of treating neurological conditions with oleandrin |
| US10307450B2 (en) | 2010-01-11 | 2019-06-04 | Phoenix Biotechnology, Inc. | Method of treating neurological conditions with extract of Nerium species or Thevetia species |
| US9376481B2 (en) | 2011-04-26 | 2016-06-28 | The Regents Of The University Of California | Methods of promoting CNS neuronal repair by inhibiting LRP-1 |
| CN102813659A (zh) * | 2012-08-21 | 2012-12-12 | 贵阳中医学院 | 20α-二甲胺基- 2α-羟基-3β-惕洛酰胺基-5α-孕甾烷的用途 |
| WO2015123618A1 (en) * | 2014-02-14 | 2015-08-20 | Arizona Board Of Regents For The University Of Arizona | Method for increasing bcl2 gene expression |
| US10596186B2 (en) | 2016-09-14 | 2020-03-24 | Phoenix Biotechnology, Inc. | Method and compositions for treating viral infections |
| US10702567B2 (en) | 2016-09-14 | 2020-07-07 | Phoenix Biotechnology, Inc. | Method and compositions for treating viral infection |
| US11331291B2 (en) | 2017-09-14 | 2022-05-17 | Phoenix Biotechnology, Inc. | Method of and improved composition for treating triterpene-responsive conditions, diseases or disorders |
| KR20200083969A (ko) | 2017-09-14 | 2020-07-09 | 피닉스 바이오테크놀러지 인코포레이티드. | 신경학적 상태를 치료하기 위한 방법 및 개선된 신경보호 조성물 |
| EP4081198A1 (en) | 2019-12-24 | 2022-11-02 | Folium Biosciences Europe B.V. | Food supplement for alzheimer |
| EP3842039A1 (en) * | 2019-12-24 | 2021-06-30 | Folium Biosciences Europe B.V. | Food supplement comprising cannbinoids and phytosterols for alzheimer |
| US11806359B2 (en) | 2020-03-31 | 2023-11-07 | Phoenix Biotechnology, Inc. | Method and compositions for treating Coronavirus infection |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1203515B (it) * | 1987-02-26 | 1989-02-15 | Indena Spa | Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono |
| WO1994018994A1 (en) * | 1993-02-23 | 1994-09-01 | Pharmakon Usa, Inc. | Therapeutic herbal composition |
| US5589182A (en) * | 1993-12-06 | 1996-12-31 | Tashiro; Renki | Compositions and method of treating cardio-, cerebro-vascular and alzheimer's diseases and depression |
| MD1721C2 (ru) * | 1994-09-29 | 2002-01-31 | The University Of British Columbia | Способ выделения композиции фитостеролов из мыла в виде пульпы, композиции понижающие холестерин и терапевтический продукт |
| CN1179903A (zh) * | 1996-10-09 | 1998-04-29 | 李辉 | 营养丝米粉 |
| EP1019044B1 (en) * | 1997-05-15 | 2007-04-11 | University of Washington | Composition and methods for treating alzheimer's disease and other amyloidoses |
-
1997
- 1997-12-18 US US08/993,901 patent/US5985936A/en not_active Expired - Fee Related
-
1998
- 1998-12-18 EP EP98960959A patent/EP0967982A2/en not_active Ceased
- 1998-12-18 MD MD99-0262A patent/MD1920F2/ru unknown
- 1998-12-18 SK SK1129-99A patent/SK112999A3/sk unknown
- 1998-12-18 PL PL98335421A patent/PL335421A1/xx unknown
- 1998-12-18 BR BR9807577-2A patent/BR9807577A/pt not_active IP Right Cessation
- 1998-12-18 GE GEAP19984990A patent/GEP20022783B/en unknown
- 1998-12-18 EE EEP199900354A patent/EE9900354A/xx unknown
- 1998-12-18 WO PCT/CA1998/001147 patent/WO1999032097A2/en not_active Application Discontinuation
- 1998-12-18 AU AU16560/99A patent/AU1656099A/en not_active Abandoned
- 1998-12-18 CA CA002281710A patent/CA2281710A1/en not_active Abandoned
- 1998-12-18 RU RU99120072/14A patent/RU2173151C2/ru not_active IP Right Cessation
- 1998-12-18 CN CN98804259A patent/CN1252724A/zh active Pending
- 1998-12-18 HU HU0100737A patent/HUP0100737A3/hu unknown
-
1999
- 1999-08-18 NO NO993979A patent/NO993979L/no not_active Application Discontinuation
- 1999-09-16 LT LT1999114A patent/LT4801B/lt not_active IP Right Cessation
- 1999-09-17 BG BG103740A patent/BG103740A/xx unknown
- 1999-09-17 LV LVP-99-134A patent/LV12438B/en unknown
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