EA199700123A1 - Таблетки валацикловира, содержащие коллоидный диоксид кремния - Google Patents

Таблетки валацикловира, содержащие коллоидный диоксид кремния

Info

Publication number
EA199700123A1
EA199700123A1 EA199700123A EA199700123A EA199700123A1 EA 199700123 A1 EA199700123 A1 EA 199700123A1 EA 199700123 A EA199700123 A EA 199700123A EA 199700123 A EA199700123 A EA 199700123A EA 199700123 A1 EA199700123 A1 EA 199700123A1
Authority
EA
Eurasian Patent Office
Prior art keywords
silicon dioxide
tablets containing
containing colloid
colloid silicon
valacyclovir
Prior art date
Application number
EA199700123A
Other languages
English (en)
Other versions
EA000276B1 (ru
Inventor
Бэрри Хауард Картер
Ллойд Гэри Тиллмен
Original Assignee
Де Веллкам Фаундейшн Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10768317&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199700123(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Де Веллкам Фаундейшн Лимитед filed Critical Де Веллкам Фаундейшн Лимитед
Publication of EA199700123A1 publication Critical patent/EA199700123A1/ru
Publication of EA000276B1 publication Critical patent/EA000276B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Предлагается таблетка, содержащая по меньшей мере 50% (мас./мас.) валацикловира и 0,05-3,0% (мас./мас.) коллоидного диоксида кремния, обладающая превосходными параметрами твердости и хрупкости, сохраняющая при этом хороший показатель смазываемости гранул таблетки.
EA199700123A 1995-01-20 1996-01-19 Таблетки валацикловира, содержащие коллоидный диоксид кремния EA000276B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9501127.6A GB9501127D0 (en) 1995-01-20 1995-01-20 Tablet
PCT/GB1996/000111 WO1996022082A1 (en) 1995-01-20 1996-01-19 Valaciclovir tablets containing colloidal silicon dioxide

Publications (2)

Publication Number Publication Date
EA199700123A1 true EA199700123A1 (ru) 1997-12-30
EA000276B1 EA000276B1 (ru) 1999-02-25

Family

ID=10768317

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700123A EA000276B1 (ru) 1995-01-20 1996-01-19 Таблетки валацикловира, содержащие коллоидный диоксид кремния

Country Status (39)

Country Link
US (1) US5879706A (ru)
EP (1) EP0806943B1 (ru)
JP (1) JP3350055B2 (ru)
KR (1) KR100412298B1 (ru)
CN (2) CN1131026C (ru)
AP (1) AP666A (ru)
AT (1) ATE190483T1 (ru)
AU (1) AU710823B2 (ru)
BG (1) BG63187B1 (ru)
BR (1) BR9606769A (ru)
CA (1) CA2210891C (ru)
CY (1) CY2182B1 (ru)
CZ (1) CZ296514B6 (ru)
DE (1) DE69607146T2 (ru)
DK (1) DK0806943T3 (ru)
EA (1) EA000276B1 (ru)
EE (1) EE03336B1 (ru)
ES (1) ES2145425T3 (ru)
FI (1) FI119722B (ru)
GB (1) GB9501127D0 (ru)
GE (1) GEP20022752B (ru)
GR (1) GR3033677T3 (ru)
HK (1) HK1002851A1 (ru)
HU (1) HU226131B1 (ru)
IL (1) IL116830A (ru)
IN (1) IN181318B (ru)
MY (1) MY126346A (ru)
NO (1) NO311488B1 (ru)
NZ (1) NZ298846A (ru)
OA (1) OA10500A (ru)
PL (1) PL185307B1 (ru)
PT (1) PT806943E (ru)
RO (1) RO118175B1 (ru)
SK (1) SK282030B6 (ru)
TR (1) TR199700657T1 (ru)
UA (1) UA68325C2 (ru)
UY (2) UY25774A1 (ru)
WO (1) WO1996022082A1 (ru)
ZA (1) ZA96448B (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110279667A (zh) * 2019-07-30 2019-09-27 珠海润都制药股份有限公司 一种盐酸伐昔洛韦片及其制备方法

Families Citing this family (43)

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GB9501127D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Tablet
DE69726255T2 (de) * 1996-01-19 2004-08-26 Glaxo Group Ltd., Greenford Verwendung von valaciclovir zur herstellung eines arzneimittels zur behandlung von genitalherpes durch einmal tägliche verabreichung
AR017512A1 (es) 1997-08-22 2001-09-12 Smithkline Beecham Corp Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
AR016827A1 (es) 1997-08-22 2001-08-01 Smithkline Beecham Corp PROCEDIMIENTO PARA LA PREPARACIoN DE UNA TABLETA FARMACÉUTICA
SI20624A (sl) * 1998-12-18 2002-02-28 Abbott Laboratories Formulacija divalproeks natrija za kontrolirano sproščanje
GB0010446D0 (en) * 2000-04-28 2000-06-14 Glaxo Wellcome Kk Pharmaceutical formulation
PL366453A1 (en) * 2001-05-01 2005-02-07 Pfizer Products Inc. Method for manufacturing a low dose pharmaceutical composition having uniform drug distribution and potency
US7815936B2 (en) * 2001-10-30 2010-10-19 Evonik Degussa Gmbh Use of granular materials based on pyrogenically produced silicon dioxide in pharmaceutical compositions
US20040197396A1 (en) * 2001-11-05 2004-10-07 Fain Helen S Anhydrous crystal form of valaciclovir hydrochloride
PL371732A1 (en) * 2001-11-14 2005-06-27 Teva Pharmaceutical Industries Ltd. Synthesis and purification of valacyclovir
GB0203296D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel composition
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
AU2003240213A1 (en) * 2002-06-24 2004-01-06 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US20050051922A1 (en) * 2002-09-20 2005-03-10 Avinash Nangia Pharmaceutical composition with sodium lauryl sulfate as an extra-granular absorption/compression enhancer and the process to make the same
WO2004035583A1 (en) * 2002-10-16 2004-04-29 Teva Pharmaceutical Industries Ltd. Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
US20040109889A1 (en) * 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
EP1633753A1 (en) * 2003-05-30 2006-03-15 EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. Novel crystalline forms of valacyclovir hydrochloride
EP1638972A2 (en) * 2003-06-02 2006-03-29 Teva Pharmaceutical Industries Limited Novel crystalline forms of valacyclovir hydrochloride
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
PL3395338T3 (pl) 2003-09-12 2019-10-31 Amgen Inc Szybko rozpuszczająca się formulacja zawierająca cynakalcet HCl
DE10351448A1 (de) * 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
EP1541133B1 (en) * 2003-12-09 2005-08-10 Helm AG Pharmaceutical formulation of valaciclovir
US7344907B2 (en) * 2004-11-19 2008-03-18 International Business Machines Corporation Apparatus and methods for encapsulating microelectromechanical (MEM) devices on a wafer scale
KR101116747B1 (ko) 2004-12-06 2012-02-22 에스케이케미칼주식회사 안정성이 개선된 말레인산 암로디핀 약제 조성물
EP1868579B1 (en) 2005-03-07 2010-09-29 Bayer Schering Pharma Aktiengesellschaft Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer
US7846937B2 (en) * 2005-05-25 2010-12-07 Eli Lilly And Company Cyclopropanecarboxylate esters of acyclovir
EP1746098A1 (en) * 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
WO2007090595A1 (en) * 2006-02-06 2007-08-16 Fidia Pharmaceutici S.P.A. Solid formulations of valacyclovir hydrochloride
JP2009536165A (ja) * 2006-05-10 2009-10-08 エボニック デグサ ゲーエムベーハー 医薬組成物におけるロール圧縮された熱分解的に製造された二酸化ケイ素の使用
KR20090018843A (ko) * 2006-05-31 2009-02-23 버텍스 파마슈티칼스 인코포레이티드 인터류킨-1 베타 전환효소 억제제의 경구용 조절 방출 제제
WO2008006534A2 (en) * 2006-07-11 2008-01-17 Lek Pharmaceuticals D.D. Multiple unit tablets
US20080167325A1 (en) * 2006-12-27 2008-07-10 Bs Praveen Kumar Valacyclovir compositions
US20090076039A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched valacyclovir
ITRM20080027A1 (it) * 2008-01-18 2009-07-19 Maria Balestrieri Uso di aciclovir per il trattamento delle condilomatosi.
US20100124560A1 (en) * 2008-11-14 2010-05-20 Mcneil Ab Multi portion intra-oral dosage form and use thereof
EP2407166B1 (en) * 2009-03-13 2013-08-21 Toyama Chemical Co., Ltd. Tablet and granulated powder containing 6-fluoro-3-hydroxy-2-pyrazinecarboxamide
CH703348A1 (de) * 2010-06-29 2011-12-30 Mepha Gmbh Zusammensetzungen mit hohem Wirkstoffanteil an pharmazeutisch aktiven Substanzen.
GB2515486A (en) * 2013-06-24 2014-12-31 Kraft Foods R & D Inc Soluble Beverage Ingredients
KR101497508B1 (ko) * 2013-12-20 2015-03-03 한국유나이티드제약 주식회사 펠라고니움 시도이데스 추출물 및 규산 화합물을 포함하는 고형 제제 및 이의 제조 방법
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
WO2020049536A1 (en) * 2018-09-07 2020-03-12 Jubilant Generics Limited Pharmaceutical compositions of valacyclovir or its pharmaceutically acceptable salts thereof
CN116528853A (zh) * 2020-12-01 2023-08-01 株式会社Lg化学 包含1-(3-氰基-1-异丙基-吲哚-5-基)吡唑-4-甲酸的口服制剂及其制备方法

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GB9501127D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Tablet

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110279667A (zh) * 2019-07-30 2019-09-27 珠海润都制药股份有限公司 一种盐酸伐昔洛韦片及其制备方法
CN110279667B (zh) * 2019-07-30 2023-02-10 珠海润都制药股份有限公司 一种盐酸伐昔洛韦片及其制备方法

Also Published As

Publication number Publication date
CN1179100A (zh) 1998-04-15
PT806943E (pt) 2000-08-31
AP9701057A0 (en) 1997-10-31
CA2210891A1 (en) 1996-07-25
CN1131026C (zh) 2003-12-17
IN181318B (ru) 1998-05-09
IL116830A (en) 2000-02-29
EE03336B1 (et) 2001-02-15
AP666A (en) 1998-08-24
RO118175B1 (ro) 2003-03-28
PL321361A1 (en) 1997-12-08
KR19980701524A (ko) 1998-05-15
FI973062A (fi) 1997-09-18
HU226131B1 (en) 2008-05-28
US5879706A (en) 1999-03-09
WO1996022082A1 (en) 1996-07-25
NO973327L (no) 1997-09-16
BG63187B1 (bg) 2001-06-29
ES2145425T3 (es) 2000-07-01
UY25774A1 (es) 2000-10-31
CN1313081C (zh) 2007-05-02
CY2182B1 (en) 2002-08-23
NO973327D0 (no) 1997-07-18
EA000276B1 (ru) 1999-02-25
OA10500A (en) 2002-04-10
CZ296514B6 (cs) 2006-03-15
JPH10512564A (ja) 1998-12-02
SK282030B6 (sk) 2001-10-08
FI973062A0 (fi) 1997-07-18
HUP9801872A3 (en) 2001-02-28
HK1002851A1 (en) 1998-09-25
ZA96448B (en) 1996-08-07
GEP20022752B (en) 2002-08-26
NZ298846A (en) 1998-06-26
KR100412298B1 (ko) 2004-04-21
CZ229297A3 (cs) 1998-02-18
PL185307B1 (pl) 2003-04-30
DE69607146D1 (de) 2000-04-20
SK96497A3 (en) 1998-01-14
MX9705459A (es) 1997-10-31
EP0806943B1 (en) 2000-03-15
CN1494898A (zh) 2004-05-12
AU4453496A (en) 1996-08-07
GR3033677T3 (en) 2000-10-31
IL116830A0 (en) 1996-05-14
MY126346A (en) 2006-09-29
UY25778A1 (es) 2000-08-21
TR199700657T1 (xx) 1998-02-21
FI119722B (fi) 2009-02-27
UA68325C2 (en) 2004-08-16
BR9606769A (pt) 1997-12-30
GB9501127D0 (en) 1995-03-08
DK0806943T3 (da) 2000-07-24
EP0806943A1 (en) 1997-11-19
JP3350055B2 (ja) 2002-11-25
HUP9801872A2 (hu) 1999-10-28
CA2210891C (en) 2009-05-19
BG101831A (en) 1998-04-30
DE69607146T2 (de) 2000-09-21
NO311488B1 (no) 2001-12-03
AU710823B2 (en) 1999-09-30
ATE190483T1 (de) 2000-04-15

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ BY KZ KG TJ TM RU