EA038422B1 - Конъюгат гиалуроновой кислоты и гемцитабина, способ его получения и применение для лечения рака - Google Patents

Конъюгат гиалуроновой кислоты и гемцитабина, способ его получения и применение для лечения рака Download PDF

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Publication number
EA038422B1
EA038422B1 EA201992518A EA201992518A EA038422B1 EA 038422 B1 EA038422 B1 EA 038422B1 EA 201992518 A EA201992518 A EA 201992518A EA 201992518 A EA201992518 A EA 201992518A EA 038422 B1 EA038422 B1 EA 038422B1
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EA
Eurasian Patent Office
Prior art keywords
cancer
conjugate
glycosaminoglycan
active compound
lymphoma
Prior art date
Application number
EA201992518A
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English (en)
Russian (ru)
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EA201992518A2 (ru
EA201992518A3 (ru
Inventor
Хуа-Ян Линь
Original Assignee
Хоули Стоун Баиотек Ко., Лтд.
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Application filed by Хоули Стоун Баиотек Ко., Лтд. filed Critical Хоули Стоун Баиотек Ко., Лтд.
Publication of EA201992518A2 publication Critical patent/EA201992518A2/ru
Publication of EA201992518A3 publication Critical patent/EA201992518A3/ru
Publication of EA038422B1 publication Critical patent/EA038422B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728Hyaluronic acid
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
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    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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  • Dermatology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201992518A 2013-08-29 2014-06-27 Конъюгат гиалуроновой кислоты и гемцитабина, способ его получения и применение для лечения рака EA038422B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361871352P 2013-08-29 2013-08-29
US14/308,972 US9572832B2 (en) 2013-08-29 2014-06-19 Compound of glycosaminoglycan and its fabrication method as well as application

Publications (3)

Publication Number Publication Date
EA201992518A2 EA201992518A2 (ru) 2020-03-31
EA201992518A3 EA201992518A3 (ru) 2020-05-31
EA038422B1 true EA038422B1 (ru) 2021-08-26

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Family Applications (4)

Application Number Title Priority Date Filing Date
EA201992518A EA038422B1 (ru) 2013-08-29 2014-06-27 Конъюгат гиалуроновой кислоты и гемцитабина, способ его получения и применение для лечения рака
EA201992517A EA038278B1 (ru) 2013-08-29 2014-06-27 Конъюгат гиалуроновой кислоты и леналидомида, способ его получения и применение для лечения рака
EA201690487A EA034600B1 (ru) 2013-08-29 2014-06-27 Конъюгаты гиалуроновой кислоты с антагонистами cox-2 и их применение для лечения рака
EA201501166A EA031285B1 (ru) 2013-08-29 2014-08-27 Конъюгат гиалуроновой кислоты и стероида, способ его получения и применение

Family Applications After (3)

Application Number Title Priority Date Filing Date
EA201992517A EA038278B1 (ru) 2013-08-29 2014-06-27 Конъюгат гиалуроновой кислоты и леналидомида, способ его получения и применение для лечения рака
EA201690487A EA034600B1 (ru) 2013-08-29 2014-06-27 Конъюгаты гиалуроновой кислоты с антагонистами cox-2 и их применение для лечения рака
EA201501166A EA031285B1 (ru) 2013-08-29 2014-08-27 Конъюгат гиалуроновой кислоты и стероида, способ его получения и применение

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US (7) US9572832B2 (enExample)
EP (2) EP3038656B1 (enExample)
JP (2) JP6404925B2 (enExample)
KR (2) KR102283978B1 (enExample)
CN (5) CN105579067A (enExample)
AU (6) AU2014314536B2 (enExample)
BR (2) BR112016004357B1 (enExample)
CA (3) CA3133853C (enExample)
DK (1) DK3038656T3 (enExample)
EA (4) EA038422B1 (enExample)
ES (2) ES2893329T3 (enExample)
HU (1) HUE056434T2 (enExample)
LT (1) LT3038656T (enExample)
MY (1) MY180502A (enExample)
PL (1) PL3038656T3 (enExample)
PT (1) PT3038656T (enExample)
TW (2) TWI526212B (enExample)
WO (2) WO2015028172A1 (enExample)

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US9572832B2 (en) * 2013-08-29 2017-02-21 Holy Stone Healthcare Co., Ltd. Compound of glycosaminoglycan and its fabrication method as well as application
EA027663B1 (ru) * 2016-05-20 2017-08-31 Тютор С.А.С.И.Ф.И.А. Способ получения твёрдой лекарственной формы для перорального применения и твёрдая лекарственная форма для перорального применения, полученная согласно указанному способу
US11524079B2 (en) 2019-06-03 2022-12-13 Aihol Corporation Hyaluronan conjugates and uses thereof
US11458204B2 (en) 2020-06-02 2022-10-04 Aihol Corporation Method for improving substitution rate and/or substitution efficiency of hyaluronan-drug conjugates
AU2021289350B2 (en) * 2020-06-08 2023-10-19 Aihol Corporation Uses of hyaluronan conjugate
BR112022021179A2 (pt) * 2020-07-15 2023-02-23 Coval Biopharma Shanghai Co Ltd Sistema de liberação de fármaco para a liberação local de agentes terapêuticos e usos do mesmo
AU2022291922B2 (en) * 2021-06-18 2024-07-25 Aihol Corporation Uses of hyaluronan conjugate
CN114377139B (zh) * 2022-03-11 2023-07-04 四川省医学科学院·四川省人民医院 载体、药物递送系统及其应用
WO2024031050A2 (en) * 2022-08-05 2024-02-08 Aihol Corporation Hyaluronan-nimesulide conjugate for treating locally advanced or metastatic tumors
PL442924A1 (pl) * 2022-11-23 2024-05-27 Politechnika Śląska Prolek - glikokoniugat pochodny gemcytabiny, jako związek o działaniu przeciwnowotworowym, sposób otrzymywania i zastosowanie
WO2025122826A1 (en) * 2023-12-07 2025-06-12 University Of Montana Hyaluronic acid-nonsteroidal anti-inflammatory drug conjugates for treating inflammation-mediated pathologies
CN118831067A (zh) * 2024-07-18 2024-10-25 广东药科大学 一种载药纳米粒及其制备方法和应用

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WO2008134528A1 (en) * 2007-04-25 2008-11-06 Board Of Regents, The University Of Texas System Anti-cancer agent-hyaluronic acid conjugate compositions and methods

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