EA026750B1 - КРИСТАЛЛИЧЕСКИЙ (1R,4R)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН - Google Patents

КРИСТАЛЛИЧЕСКИЙ (1R,4R)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН Download PDF

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Publication number
EA026750B1
EA026750B1 EA201400120A EA201400120A EA026750B1 EA 026750 B1 EA026750 B1 EA 026750B1 EA 201400120 A EA201400120 A EA 201400120A EA 201400120 A EA201400120 A EA 201400120A EA 026750 B1 EA026750 B1 EA 026750B1
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EA
Eurasian Patent Office
Prior art keywords
approximately
crystalline form
dimethyl
fluoro
pyrano
Prior art date
Application number
EA201400120A
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English (en)
Russian (ru)
Other versions
EA201400120A1 (ru
Inventor
Михаэль Грусс
Штефан Клуге
Штефан Прюс
Original Assignee
Грюненталь Гмбх
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Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201400120A1 publication Critical patent/EA201400120A1/ru
Publication of EA026750B1 publication Critical patent/EA026750B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
EA201400120A 2011-07-08 2012-07-06 КРИСТАЛЛИЧЕСКИЙ (1R,4R)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН EA026750B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
PCT/EP2012/002839 WO2013007361A1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (2)

Publication Number Publication Date
EA201400120A1 EA201400120A1 (ru) 2014-06-30
EA026750B1 true EA026750B1 (ru) 2017-05-31

Family

ID=46717800

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201400120A EA026750B1 (ru) 2011-07-08 2012-07-06 КРИСТАЛЛИЧЕСКИЙ (1R,4R)-6'-ФТОР-N,N-ДИМЕТИЛ-4-ФЕНИЛ-4',9'-ДИГИДРО-3'Н-СПИРО[ЦИКЛОГЕКСАН-1,1'-ПИРАНО[3,4,b]ИНДОЛ]-4-АМИН

Country Status (23)

Country Link
US (2) US8618156B2 (enExample)
EP (2) EP2729470B1 (enExample)
JP (2) JP6276689B2 (enExample)
CN (2) CN103649094B (enExample)
AR (1) AR087081A1 (enExample)
AU (2) AU2012283449B2 (enExample)
BR (1) BR112014000358A2 (enExample)
CA (1) CA2841032C (enExample)
CY (1) CY1120525T1 (enExample)
DK (2) DK3235821T3 (enExample)
EA (1) EA026750B1 (enExample)
ES (1) ES2641299T3 (enExample)
HR (1) HRP20170968T1 (enExample)
HU (1) HUE033043T2 (enExample)
IL (1) IL230331B (enExample)
LT (1) LT2729470T (enExample)
MX (1) MX2014000297A (enExample)
PL (1) PL2729470T3 (enExample)
PT (1) PT2729470T (enExample)
RS (1) RS56343B1 (enExample)
SI (1) SI2729470T1 (enExample)
TW (1) TWI585092B (enExample)
WO (1) WO2013007361A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3235821T3 (da) * 2011-07-08 2020-04-20 Gruenenthal Gmbh Krystallinsk (1r,4r)-6'-fluor-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexan-1,1'-pyran¬[3,4,b]indol]-4-amin
JP6673924B2 (ja) * 2015-01-23 2020-03-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 肝機能障害および／または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール
ES2713960T3 (es) 2015-02-02 2019-05-24 Ratiopharm Gmbh Composición que comprende cebranopadol en forma disuelta
WO2017148595A1 (en) 2016-02-29 2017-09-08 Grünenthal GmbH Titration of cebranopadol
US12435023B2 (en) * 2019-05-21 2025-10-07 Shanghai Forefront Pharmceutical Co., Ltd. Crystal form of Treprostinil sodium salt and preparation method therefor
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
KR20250145673A (ko) 2023-02-15 2025-10-13 애드뉴리스 테라퓨틱스 인코포레이티드 통증 완화에 유용한 요법 및 조성물
WO2026035694A1 (en) 2024-08-05 2026-02-12 Adneuris Therapeutics, Inc. Cebranopadol useful for preventing or reducing opioid induced respiratory depression

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004043967A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische cyclohexan-derivate
WO2006108565A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit
WO2008009415A2 (de) * 2006-07-18 2008-01-24 Grünenthal GmbH 4-heteroaryl-substituierte 1-aminocyclohexan-1- und cyclohexen-1-derivate mit wirkung auf das opiod rezeptor system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
HRP20180904T1 (hr) * 2010-08-04 2018-08-24 Grünenthal GmbH Farmaceutski oblik doziranja koji sadrži 6'-fluoro-(n-metil-ili n,n-dimetil-)-4-fenil-4',9'-dihidro-3'h-spiro[cikloheksan-1,1'-pirano[3,4,b]indol]-4-amin za liječenje neuropatske boli
DK3235821T3 (da) * 2011-07-08 2020-04-20 Gruenenthal Gmbh Krystallinsk (1r,4r)-6'-fluor-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexan-1,1'-pyran¬[3,4,b]indol]-4-amin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004043967A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische cyclohexan-derivate
WO2006108565A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spirocyclishe cyclohexanderivate zur behandlung von substanzabhängigkeit
WO2008009415A2 (de) * 2006-07-18 2008-01-24 Grünenthal GmbH 4-heteroaryl-substituierte 1-aminocyclohexan-1- und cyclohexen-1-derivate mit wirkung auf das opiod rezeptor system

Also Published As

Publication number Publication date
ES2641299T3 (es) 2017-11-08
AU2012283449B2 (en) 2017-04-06
TW201311694A (zh) 2013-03-16
DK2729470T3 (en) 2017-09-11
US8618156B2 (en) 2013-12-31
MX2014000297A (es) 2014-01-31
JP2017081981A (ja) 2017-05-18
PL2729470T3 (pl) 2017-11-30
AU2012283449A8 (en) 2014-03-27
US20130231381A1 (en) 2013-09-05
AU2017204572B2 (en) 2018-05-24
JP2014518226A (ja) 2014-07-28
PT2729470T (pt) 2017-10-02
JP6276689B2 (ja) 2018-02-07
CN103649094A (zh) 2014-03-19
EA201400120A1 (ru) 2014-06-30
WO2013007361A1 (en) 2013-01-17
AU2012283449A1 (en) 2014-02-20
TWI585092B (zh) 2017-06-01
CY1120525T1 (el) 2019-07-10
CN106939005A (zh) 2017-07-11
CN103649094B (zh) 2017-05-24
WO2013007361A9 (en) 2013-12-27
AU2017204572A1 (en) 2017-07-27
LT2729470T (lt) 2017-08-25
IL230331B (en) 2018-11-29
US20130012563A1 (en) 2013-01-10
DK3235821T3 (da) 2020-04-20
HUE033043T2 (hu) 2017-11-28
CA2841032A1 (en) 2013-01-17
EP2729470A1 (en) 2014-05-14
BR112014000358A2 (pt) 2017-01-10
AR087081A1 (es) 2014-02-12
EP2729470B1 (en) 2017-06-21
EP3235821A1 (en) 2017-10-25
WO2013007361A8 (en) 2013-04-04
JP6559165B2 (ja) 2019-08-14
US8765800B2 (en) 2014-07-01
CA2841032C (en) 2020-12-15
HRP20170968T1 (hr) 2017-09-22
EP3235821B1 (en) 2020-04-08
SI2729470T1 (sl) 2017-10-30
RS56343B1 (sr) 2017-12-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU