PL2729470T3 - Krystaliczna (1R,4R)-6'-fluoro-N,N-dimetylo-4-fenylo-4',9'-dihydro-3'H-spiro[cykloheksano-1,1'-pirano[3,4,b]indolo]-4-amina - Google Patents

Krystaliczna (1R,4R)-6'-fluoro-N,N-dimetylo-4-fenylo-4',9'-dihydro-3'H-spiro[cykloheksano-1,1'-pirano[3,4,b]indolo]-4-amina

Info

Publication number
PL2729470T3
PL2729470T3 PL12748646T PL12748646T PL2729470T3 PL 2729470 T3 PL2729470 T3 PL 2729470T3 PL 12748646 T PL12748646 T PL 12748646T PL 12748646 T PL12748646 T PL 12748646T PL 2729470 T3 PL2729470 T3 PL 2729470T3
Authority
PL
Poland
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
PL12748646T
Other languages
English (en)
Polish (pl)
Inventor
Stefan Kluge
Stefan Prühs
Michael Gruss
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of PL2729470T3 publication Critical patent/PL2729470T3/pl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
PL12748646T 2011-07-08 2012-07-06 Krystaliczna (1R,4R)-6'-fluoro-N,N-dimetylo-4-fenylo-4',9'-dihydro-3'H-spiro[cykloheksano-1,1'-pirano[3,4,b]indolo]-4-amina PL2729470T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
EP12748646.2A EP2729470B1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (1)

Publication Number Publication Date
PL2729470T3 true PL2729470T3 (pl) 2017-11-30

Family

ID=46717800

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12748646T PL2729470T3 (pl) 2011-07-08 2012-07-06 Krystaliczna (1R,4R)-6'-fluoro-N,N-dimetylo-4-fenylo-4',9'-dihydro-3'H-spiro[cykloheksano-1,1'-pirano[3,4,b]indolo]-4-amina

Country Status (23)

Country Link
US (2) US8618156B2 (enExample)
EP (2) EP3235821B1 (enExample)
JP (2) JP6276689B2 (enExample)
CN (2) CN103649094B (enExample)
AR (1) AR087081A1 (enExample)
AU (2) AU2012283449B2 (enExample)
BR (1) BR112014000358A2 (enExample)
CA (1) CA2841032C (enExample)
CY (1) CY1120525T1 (enExample)
DK (2) DK2729470T3 (enExample)
EA (1) EA026750B1 (enExample)
ES (1) ES2641299T3 (enExample)
HR (1) HRP20170968T1 (enExample)
HU (1) HUE033043T2 (enExample)
IL (1) IL230331B (enExample)
LT (1) LT2729470T (enExample)
MX (1) MX2014000297A (enExample)
PL (1) PL2729470T3 (enExample)
PT (1) PT2729470T (enExample)
RS (1) RS56343B1 (enExample)
SI (1) SI2729470T1 (enExample)
TW (1) TWI585092B (enExample)
WO (1) WO2013007361A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2729470T3 (en) * 2011-07-08 2017-09-11 Gruenenthal Gmbh Crystalline (1r, 4r) -6'-fluoro-n, n-dimethyl-4-phenyl-4 ', 9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyran [3,4, b ] indole] -4-amine
US10022353B2 (en) * 2015-01-23 2018-07-17 Grünenthal GmbH Cebranopadol for treating pain in subjects with impaired hepatic and/or impaired renal function
ES2713960T3 (es) 2015-02-02 2019-05-24 Ratiopharm Gmbh Composición que comprende cebranopadol en forma disuelta
JP7373904B2 (ja) 2016-02-29 2023-11-06 パーク・セラピューティクス・インコーポレイテッド セブラノパドールの滴定
CN112313202A (zh) * 2019-05-21 2021-02-02 江苏众强药业有限公司 曲前列尼尔钠盐新晶型及制备方法
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
KR20250145673A (ko) 2023-02-15 2025-10-13 애드뉴리스 테라퓨틱스 인코포레이티드 통증 완화에 유용한 요법 및 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033109A1 (de) 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
AU2011287955B2 (en) * 2010-08-04 2015-07-09 Grünenthal GmbH Pharmaceutical dosage form comprising 6'-fluoro-(N-methyl- or N,N-dimethyl-)-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine for the treatment of neuropathic pain
DK2729470T3 (en) * 2011-07-08 2017-09-11 Gruenenthal Gmbh Crystalline (1r, 4r) -6'-fluoro-n, n-dimethyl-4-phenyl-4 ', 9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyran [3,4, b ] indole] -4-amine

Also Published As

Publication number Publication date
BR112014000358A2 (pt) 2017-01-10
AU2012283449A1 (en) 2014-02-20
AR087081A1 (es) 2014-02-12
EP2729470A1 (en) 2014-05-14
WO2013007361A1 (en) 2013-01-17
EA026750B1 (ru) 2017-05-31
PT2729470T (pt) 2017-10-02
TW201311694A (zh) 2013-03-16
AU2012283449B2 (en) 2017-04-06
EP3235821B1 (en) 2020-04-08
US8765800B2 (en) 2014-07-01
CA2841032C (en) 2020-12-15
AU2017204572B2 (en) 2018-05-24
EP3235821A1 (en) 2017-10-25
IL230331B (en) 2018-11-29
RS56343B1 (sr) 2017-12-29
JP2014518226A (ja) 2014-07-28
ES2641299T3 (es) 2017-11-08
CY1120525T1 (el) 2019-07-10
JP2017081981A (ja) 2017-05-18
SI2729470T1 (sl) 2017-10-30
EP2729470B1 (en) 2017-06-21
TWI585092B (zh) 2017-06-01
DK2729470T3 (en) 2017-09-11
WO2013007361A8 (en) 2013-04-04
JP6276689B2 (ja) 2018-02-07
CN106939005A (zh) 2017-07-11
MX2014000297A (es) 2014-01-31
US20130231381A1 (en) 2013-09-05
US20130012563A1 (en) 2013-01-10
EA201400120A1 (ru) 2014-06-30
JP6559165B2 (ja) 2019-08-14
CN103649094A (zh) 2014-03-19
AU2017204572A1 (en) 2017-07-27
CN103649094B (zh) 2017-05-24
US8618156B2 (en) 2013-12-31
WO2013007361A9 (en) 2013-12-27
DK3235821T3 (da) 2020-04-20
HRP20170968T1 (hr) 2017-09-22
CA2841032A1 (en) 2013-01-17
AU2012283449A8 (en) 2014-03-27
HUE033043T2 (hu) 2017-11-28
LT2729470T (lt) 2017-08-25

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