EA026419B1 - Применение леводопы, карбидопы и энтакапона для лечения болезни паркинсона - Google Patents

Применение леводопы, карбидопы и энтакапона для лечения болезни паркинсона Download PDF

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Publication number
EA026419B1
EA026419B1 EA201290865A EA201290865A EA026419B1 EA 026419 B1 EA026419 B1 EA 026419B1 EA 201290865 A EA201290865 A EA 201290865A EA 201290865 A EA201290865 A EA 201290865A EA 026419 B1 EA026419 B1 EA 026419B1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbidopa
entacapone
levodopa
dosage form
amount
Prior art date
Application number
EA201290865A
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English (en)
Russian (ru)
Other versions
EA201290865A1 (ru
Inventor
Юха Роуру
Микко Куоппамяки
Юха Эллмен
Пекка Мяннисте
Original Assignee
Орион Корпорейшн
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Filing date
Publication date
Application filed by Орион Корпорейшн filed Critical Орион Корпорейшн
Publication of EA201290865A1 publication Critical patent/EA201290865A1/ru
Publication of EA026419B1 publication Critical patent/EA026419B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA201290865A 2010-03-04 2011-03-03 Применение леводопы, карбидопы и энтакапона для лечения болезни паркинсона EA026419B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31039810P 2010-03-04 2010-03-04
US41282110P 2010-11-12 2010-11-12
US201161438416P 2011-02-01 2011-02-01
PCT/FI2011/000013 WO2011107653A2 (en) 2010-03-04 2011-03-03 Method for treating parkinson's disease

Publications (2)

Publication Number Publication Date
EA201290865A1 EA201290865A1 (ru) 2013-02-28
EA026419B1 true EA026419B1 (ru) 2017-04-28

Family

ID=44065577

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290865A EA026419B1 (ru) 2010-03-04 2011-03-03 Применение леводопы, карбидопы и энтакапона для лечения болезни паркинсона

Country Status (14)

Country Link
US (4) US20130137729A1 (cg-RX-API-DMAC10.html)
EP (1) EP2542220B1 (cg-RX-API-DMAC10.html)
JP (2) JP5774610B2 (cg-RX-API-DMAC10.html)
KR (1) KR101868326B1 (cg-RX-API-DMAC10.html)
CN (1) CN102781424B (cg-RX-API-DMAC10.html)
AU (1) AU2011222856B2 (cg-RX-API-DMAC10.html)
BR (1) BR112012018256A8 (cg-RX-API-DMAC10.html)
CA (1) CA2784819C (cg-RX-API-DMAC10.html)
EA (1) EA026419B1 (cg-RX-API-DMAC10.html)
ES (1) ES2614179T3 (cg-RX-API-DMAC10.html)
IL (1) IL221744A (cg-RX-API-DMAC10.html)
MX (1) MX336187B (cg-RX-API-DMAC10.html)
WO (1) WO2011107653A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA201205836B (cg-RX-API-DMAC10.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ565460A (en) 2005-07-26 2011-06-30 Bial Portela & Ca Sa Nitrocatechol derivatives as COMT inhibitors
EP1845097A1 (en) 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
PL2481410T3 (pl) 2007-01-31 2017-03-31 Bial - Portela & Ca., S.A. Pochodne nitrokatecholu jako inhibitory COMT podawane w określonym schemacie dawkowania
JP2011514380A (ja) 2008-03-17 2011-05-06 バイアル−ポルテラ アンド シーエー，エス．エー． ５−［３−（２，５−ジクロロ−４，６−ジメチル−１−オキシ−ピリジン−３−イル）［１，２，４］オキサジアゾール−５−イル］−３−ニトロベンゼン−１，２−ジオールの結晶形
CN102448444B (zh) 2009-04-01 2016-05-25 巴尔-波特拉及康邦亚股份有限公司 包括硝基儿茶酚衍生物的药物制剂及其制备方法
AU2011222856B2 (en) * 2010-03-04 2015-10-15 Orion Corporation Use of levodopa, carbidopa and entacapone for treating Parkinson's disease
US20140045900A1 (en) * 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
WO2012147099A1 (en) * 2011-04-25 2012-11-01 Suven Nishtaa Pharma Pvt. Ltd. Pharmaceutical compositions of levodopa, carbidopa and entacapone
WO2013089573A1 (en) 2011-12-13 2013-06-20 BIAL - PORTELA & Cª., S.A. Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor
ES2955693T3 (es) * 2012-12-24 2023-12-05 Neurogastrx Inc Métodos para el tratamiento de trastornos del tracto GI
US9642810B2 (en) 2013-03-15 2017-05-09 Mylan Inc. Formulation containing carbidopa, levodopa, and entacapone
EP2799065A1 (en) * 2013-04-30 2014-11-05 Deva Holding Anonim Sirketi Levodopa carbidopa entacapone pharmaceutical formulations
US9844554B2 (en) 2014-06-24 2017-12-19 Neurogastrx, Inc. Prodrugs of metopimazine
JP2018500300A (ja) 2014-11-28 2018-01-11 ノヴィファーマ，エス．アー． パーキンソン病を遅延させるための医薬
SI3341380T1 (sl) * 2015-08-27 2020-02-28 Prexton Therapeutics Sa Možgansko-penetranten derivat kromon oksima za terapijo levodopa-inducirane diskinezije
ES3053690T3 (en) * 2018-03-23 2026-01-23 Lobsor Pharmaceuticals Ab Continuous administration of pharmaceutical composition for treatment of neurodegenerative disorders
US12251365B2 (en) 2018-11-15 2025-03-18 Abbvie Inc. Pharmaceutical formulations for subcutaneous administration
CN112741808B (zh) * 2019-10-29 2024-02-06 南京济群医药科技股份有限公司 一种提高含盐酸苄丝肼口服固体组合物稳定性的方法
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine
US20230181493A1 (en) * 2020-04-10 2023-06-15 Senda Biosciences, Inc. Biomarkers related to parkinson's disease and methods of using the same
EP4223288B1 (en) 2022-02-07 2024-03-06 Berlirem GmbH Novel kit of pharmaceutical preparations for the treatment of parkinson's disease
GB202212082D0 (en) * 2022-08-18 2022-10-05 Bial Portela & Ca Sa Treatment regimens for parkinson's disease
KR102903389B1 (ko) * 2022-11-30 2025-12-23 주식회사한국파마 신경퇴행성 질환 예방 또는 치료용 필름코팅정제

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017201A1 (en) * 1999-06-30 2003-01-23 Matti Virkki Pharmaceutical composition comprising entracapone, levodopa, and carbidopa
WO2010020970A1 (en) * 2008-08-22 2010-02-25 Wockhardt Research Centre Single unit oral dose pharmaceutical composition comprising levodopa, carbidopa and entacapone or salts thereof
WO2010020969A1 (en) * 2008-08-22 2010-02-25 Wockhardt Research Centre An extended release pharmaceutical composition of entacapone or salts thereof
WO2010027340A1 (en) * 2008-09-03 2010-03-11 Dr. F. Frik Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical compositions composing entakapon, levodopa and karbidoba

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3462536A (en) 1960-07-22 1969-08-19 Merck & Co Inc Method of inhibiting decarboxylase
DK175069B1 (da) 1986-03-11 2004-05-24 Hoffmann La Roche Pyrocatecholderivater
US5236952A (en) 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
JPH02138A (ja) 1987-09-18 1990-01-05 Banyu Pharmaceut Co Ltd Ｌ‐ドーパ誘導体
GB2238047B (en) 1989-11-03 1993-02-10 Orion Yhtymae Oy Stable polymorphic form of (e)-n,n-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
US5607969A (en) 1992-12-24 1997-03-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem L-DOPA ethyl ester to treat Parkinson's disease
GB2344819A (en) 1998-12-18 2000-06-21 Portela & Ca Sa 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones
US20040166159A1 (en) * 2002-05-29 2004-08-26 Chien-Hsuan Han Pharmaceutical dosage forms having immediate and controlled release properties that contain an aromatic amino acid decarboxylase inhibitor and levodopa
US20060013875A1 (en) * 2002-05-29 2006-01-19 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
AU2003293423A1 (en) 2002-12-06 2004-06-30 Xenoport, Inc. Carbidopa prodrugs and uses thereof
WO2005063696A2 (de) 2003-12-31 2005-07-14 Cilag Ag Neue kristalline formen von entacapone und deren herstellung
ES2390126T3 (es) 2004-06-04 2012-11-06 Xenoport, Inc. Derivados de levodopa, y composicones y usos de la misma
US20060241183A1 (en) * 2004-09-28 2006-10-26 Farouk Karoum Compositions and methods of using D-DOPA to treat Parkinson's disease
ES2311442T3 (es) * 2005-06-08 2010-01-07 Orion Corporation Un metood para la fabricacion de granulos que contienen entacapona para formas de dosificacion oral.
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
NZ565460A (en) 2005-07-26 2011-06-30 Bial Portela & Ca Sa Nitrocatechol derivatives as COMT inhibitors
TWI403493B (zh) 2005-12-05 2013-08-01 Xenoport Inc 左旋多巴前藥的甲磺酸鹽，其組成物，及其用途
WO2008053297A2 (en) 2006-10-30 2008-05-08 Wockhardt Research Centre Pharmaceutical compositions comprising entacapone, levodopa, and carbidopa
KR20100126452A (ko) 2008-02-28 2010-12-01 바이알 - 포르텔라 앤드 씨에이 에스에이 난용성 약물용 약학적 조성물
EP2233131A1 (en) 2009-03-23 2010-09-29 Laboratorios Lesvi, S.L. Pharmaceutical composition containing levodopa, entacapone and carbidopa
AU2011222856B2 (en) * 2010-03-04 2015-10-15 Orion Corporation Use of levodopa, carbidopa and entacapone for treating Parkinson's disease
JP5551001B2 (ja) 2010-06-22 2014-07-16 株式会社Ｐｆｕ 摩擦係数推定装置および摩擦係数推定方法
JP2015006373A (ja) * 2014-07-14 2015-01-15 株式会社大都技研 遊技台

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030017201A1 (en) * 1999-06-30 2003-01-23 Matti Virkki Pharmaceutical composition comprising entracapone, levodopa, and carbidopa
WO2010020970A1 (en) * 2008-08-22 2010-02-25 Wockhardt Research Centre Single unit oral dose pharmaceutical composition comprising levodopa, carbidopa and entacapone or salts thereof
WO2010020969A1 (en) * 2008-08-22 2010-02-25 Wockhardt Research Centre An extended release pharmaceutical composition of entacapone or salts thereof
WO2010027340A1 (en) * 2008-09-03 2010-03-11 Dr. F. Frik Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical compositions composing entakapon, levodopa and karbidoba

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KARLA EGGERT ; ÖRJAN SKOGAR ; KHALED AMAR ; LIISA LUOTONEN ; MIKKO KUOPPAMäKI ; MIKA LEINONEN ; HELENA NISSINEN ; WOLFGANG OERTE: "Direct switch from levodopa/benserazide or levodopa/carbidopa to levodopa/carbidopa/entacapone in Parkinson’s disease patients with wearing-off: efficacy, safety and feasibility—an open-label, 6-week study", JOURNAL OF NEURAL TRANSMISSION ; BASIC NEUROSCIENCES, GENETICS AND IMMUNOLOGY, PARKINSON'S DISEASE AND ALLIED CONDITIONS, ALZHEIMER'S DISEASE AND ADOLESCENT PSYCHIATRY RELATED DISORDERS, BIOLOGICAL PSYCHIATRY, BIOLOGICAL CHILD AND ADOLESCENT PSYCHIAT, vol. 117, no. 3, 15 December 2009 (2009-12-15), Vi, pages 333 - 342, XP019805095, ISSN: 1435-1463 *

Also Published As

Publication number Publication date
MX336187B (es) 2016-01-07
US12521363B2 (en) 2026-01-13
KR20130006638A (ko) 2013-01-17
ZA201205836B (en) 2014-01-29
WO2011107653A8 (en) 2012-08-02
US10857120B2 (en) 2020-12-08
CN102781424A (zh) 2012-11-14
BR112012018256A8 (pt) 2017-12-19
EA201290865A1 (ru) 2013-02-28
CN102781424B (zh) 2016-03-30
BR112012018256A2 (cg-RX-API-DMAC10.html) 2011-09-09
AU2011222856B2 (en) 2015-10-15
CA2784819A1 (en) 2011-09-09
CA2784819C (en) 2018-02-13
US20130137729A1 (en) 2013-05-30
US20240050394A1 (en) 2024-02-15
EP2542220B1 (en) 2016-11-02
KR101868326B1 (ko) 2018-06-19
IL221744A (en) 2016-11-30
HK1177896A1 (zh) 2013-08-30
US11771675B2 (en) 2023-10-03
US20210085635A1 (en) 2021-03-25
ES2614179T3 (es) 2017-05-30
MX2012010161A (es) 2012-10-03
JP2013521263A (ja) 2013-06-10
JP2015180644A (ja) 2015-10-15
JP5774610B2 (ja) 2015-09-09
US20150150839A1 (en) 2015-06-04
WO2011107653A2 (en) 2011-09-09
AU2011222856A1 (en) 2012-07-26
WO2011107653A3 (en) 2011-11-03
EP2542220A2 (en) 2013-01-09

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