EA026140B1 - С-28 амиды модифицированных производных с-3 бетулиновой кислоты в качестве ингибиторов созревания вич - Google Patents

С-28 амиды модифицированных производных с-3 бетулиновой кислоты в качестве ингибиторов созревания вич Download PDF

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Publication number
EA026140B1
EA026140B1 EA201270800A EA201270800A EA026140B1 EA 026140 B1 EA026140 B1 EA 026140B1 EA 201270800 A EA201270800 A EA 201270800A EA 201270800 A EA201270800 A EA 201270800A EA 026140 B1 EA026140 B1 EA 026140B1
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EA
Eurasian Patent Office
Prior art keywords
group
alkyl
pentamethyl
substituted
prop
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EA201270800A
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English (en)
Russian (ru)
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EA201270800A1 (ru
Inventor
Алисия Регуейро-Рен
Чжэн Лю
Джейкоб Свидорски
Николас А. Минвелл
Синг-Юен Сит
Цзе Чэнь
Янь Чэнь
Ни Син
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Бристол-Майерс Сквибб Компани
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Publication of EA201270800A1 publication Critical patent/EA201270800A1/ru
Publication of EA026140B1 publication Critical patent/EA026140B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201270800A 2010-06-04 2011-06-02 С-28 амиды модифицированных производных с-3 бетулиновой кислоты в качестве ингибиторов созревания вич EA026140B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35133210P 2010-06-04 2010-06-04
PCT/US2011/038884 WO2011153319A1 (en) 2010-06-04 2011-06-02 C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors

Publications (2)

Publication Number Publication Date
EA201270800A1 EA201270800A1 (ru) 2013-04-30
EA026140B1 true EA026140B1 (ru) 2017-03-31

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EA201270800A EA026140B1 (ru) 2010-06-04 2011-06-02 С-28 амиды модифицированных производных с-3 бетулиновой кислоты в качестве ингибиторов созревания вич

Country Status (20)

Country Link
US (1) US8802661B2 (cg-RX-API-DMAC7.html)
EP (1) EP2576586B1 (cg-RX-API-DMAC7.html)
JP (1) JP5755731B2 (cg-RX-API-DMAC7.html)
CN (1) CN102985438B (cg-RX-API-DMAC7.html)
AR (1) AR081638A1 (cg-RX-API-DMAC7.html)
BR (1) BR112012030810A2 (cg-RX-API-DMAC7.html)
CA (1) CA2801491C (cg-RX-API-DMAC7.html)
DK (1) DK2576586T3 (cg-RX-API-DMAC7.html)
EA (1) EA026140B1 (cg-RX-API-DMAC7.html)
ES (1) ES2548905T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20150977T1 (cg-RX-API-DMAC7.html)
HU (1) HUE026662T2 (cg-RX-API-DMAC7.html)
MX (1) MX2012013628A (cg-RX-API-DMAC7.html)
PL (1) PL2576586T3 (cg-RX-API-DMAC7.html)
PT (1) PT2576586E (cg-RX-API-DMAC7.html)
RS (1) RS54239B1 (cg-RX-API-DMAC7.html)
SI (1) SI2576586T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201500272B (cg-RX-API-DMAC7.html)
TW (1) TW201201792A (cg-RX-API-DMAC7.html)
WO (1) WO2011153319A1 (cg-RX-API-DMAC7.html)

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US8889854B2 (en) * 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
JP6186010B2 (ja) * 2013-02-06 2017-08-23 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Hiv成熟阻害活性を有するc−19修飾トリテルペノイド類
EA027861B1 (ru) * 2013-02-25 2017-09-29 Бристол-Майерс Сквибб Компани C-3 алкил- и алкенилмодифицированные производные бетулиновой кислоты или их фармацевтические соли, противовирусная фармацевтическая композиция и фармацевтическая композиция для лечения вич на их основе
SMT202000581T1 (it) 2014-04-11 2020-11-10 Viiv Healthcare Uk No 4 Ltd Triterpenoidi con attività di inibizione della maturazione di hiv, sostituiti in posizione 3 con un anello non aromatico portante un sostituente alogenoalchilico
US9920090B2 (en) 2014-06-19 2018-03-20 VIIV Healthcare UK (No.5) Limited Betulinic acid derivatives with HIV maturation inhibitory activity
WO2015198263A2 (en) * 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2016077569A1 (en) 2014-11-14 2016-05-19 Bristol-Myers Squibb Company C17-aryl substituted betulinic acid analogs
US9969767B2 (en) 2014-11-14 2018-05-15 VIIV Healthcare UK (No.5) Limited Oxolupene derivatives
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
EP3328876A1 (en) 2015-07-28 2018-06-06 Glaxosmithkline Intellectual Property (No. 2) Limited Betuin derivatives for preventing or treating hiv infections
CA2993758A1 (en) 2015-07-28 2017-02-02 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
JP2018528231A (ja) * 2015-09-24 2018-09-27 グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited Hiv成熟阻害活性を有する化合物
CA3011616A1 (en) 2016-01-20 2017-07-27 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3478703A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
ES2970042T3 (es) 2018-04-24 2024-05-24 Viiv Healthcare Uk No 5 Ltd Compuestos con actividad inhibidora de la maduración del VIH
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
US10343997B1 (en) 2018-12-04 2019-07-09 King Saud University Ursolic acid derivatives

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Also Published As

Publication number Publication date
US20120142653A1 (en) 2012-06-07
JP2013527243A (ja) 2013-06-27
HUE026662T2 (en) 2016-06-28
JP5755731B2 (ja) 2015-07-29
WO2011153319A1 (en) 2011-12-08
SMT201500272B (it) 2016-01-08
CA2801491A1 (en) 2011-12-08
CA2801491C (en) 2018-01-23
ES2548905T3 (es) 2015-10-21
CN102985438B (zh) 2016-05-18
HRP20150977T1 (hr) 2015-10-09
PT2576586E (pt) 2015-10-23
EP2576586B1 (en) 2015-08-12
PL2576586T3 (pl) 2016-01-29
US8802661B2 (en) 2014-08-12
CN102985438A (zh) 2013-03-20
EA201270800A1 (ru) 2013-04-30
DK2576586T3 (en) 2015-11-23
EP2576586A1 (en) 2013-04-10
MX2012013628A (es) 2012-12-17
SI2576586T1 (sl) 2015-11-30
TW201201792A (en) 2012-01-16
BR112012030810A2 (pt) 2019-09-24
RS54239B1 (sr) 2015-12-31
AR081638A1 (es) 2012-10-10

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU