PL2576586T3 - C-28 amidy zmodyfikowanych pochodnych kwasu C-3 betulinowego jako inhibitory dojrzewania HIV - Google Patents

C-28 amidy zmodyfikowanych pochodnych kwasu C-3 betulinowego jako inhibitory dojrzewania HIV

Info

Publication number
PL2576586T3
PL2576586T3 PL11726564T PL11726564T PL2576586T3 PL 2576586 T3 PL2576586 T3 PL 2576586T3 PL 11726564 T PL11726564 T PL 11726564T PL 11726564 T PL11726564 T PL 11726564T PL 2576586 T3 PL2576586 T3 PL 2576586T3
Authority
PL
Poland
Prior art keywords
amides
modified
acid derivatives
betulinic acid
maturation inhibitors
Prior art date
Application number
PL11726564T
Other languages
English (en)
Polish (pl)
Inventor
Alicia Regueiro-Ren
Zheng Liu
Jacob Swidorski
Nicholas A Meanwell
Sing-Yuen Sit
Jie Chen
Yan Chen
Ny Sin
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PL2576586T3 publication Critical patent/PL2576586T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL11726564T 2010-06-04 2011-06-02 C-28 amidy zmodyfikowanych pochodnych kwasu C-3 betulinowego jako inhibitory dojrzewania HIV PL2576586T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35133210P 2010-06-04 2010-06-04
PCT/US2011/038884 WO2011153319A1 (en) 2010-06-04 2011-06-02 C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors
EP11726564.5A EP2576586B1 (en) 2010-06-04 2011-06-02 C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors

Publications (1)

Publication Number Publication Date
PL2576586T3 true PL2576586T3 (pl) 2016-01-29

Family

ID=44627254

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11726564T PL2576586T3 (pl) 2010-06-04 2011-06-02 C-28 amidy zmodyfikowanych pochodnych kwasu C-3 betulinowego jako inhibitory dojrzewania HIV

Country Status (20)

Country Link
US (1) US8802661B2 (cg-RX-API-DMAC7.html)
EP (1) EP2576586B1 (cg-RX-API-DMAC7.html)
JP (1) JP5755731B2 (cg-RX-API-DMAC7.html)
CN (1) CN102985438B (cg-RX-API-DMAC7.html)
AR (1) AR081638A1 (cg-RX-API-DMAC7.html)
BR (1) BR112012030810A2 (cg-RX-API-DMAC7.html)
CA (1) CA2801491C (cg-RX-API-DMAC7.html)
DK (1) DK2576586T3 (cg-RX-API-DMAC7.html)
EA (1) EA026140B1 (cg-RX-API-DMAC7.html)
ES (1) ES2548905T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20150977T1 (cg-RX-API-DMAC7.html)
HU (1) HUE026662T2 (cg-RX-API-DMAC7.html)
MX (1) MX2012013628A (cg-RX-API-DMAC7.html)
PL (1) PL2576586T3 (cg-RX-API-DMAC7.html)
PT (1) PT2576586E (cg-RX-API-DMAC7.html)
RS (1) RS54239B1 (cg-RX-API-DMAC7.html)
SI (1) SI2576586T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201500272B (cg-RX-API-DMAC7.html)
TW (1) TW201201792A (cg-RX-API-DMAC7.html)
WO (1) WO2011153319A1 (cg-RX-API-DMAC7.html)

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KR101886467B1 (ko) * 2011-01-31 2018-08-07 비브 헬스케어 유케이 (넘버4) 리미티드 Hiv 성숙 억제 활성을 갖는 c-17 및 c-3 변형 트리테르페노이드
US8754069B2 (en) 2011-09-21 2014-06-17 Bristol-Myers Squibb Company Betulinic acid derivatives with antiviral activity
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) * 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
JP6186010B2 (ja) * 2013-02-06 2017-08-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｈｉｖ成熟阻害活性を有するｃ−１９修飾トリテルペノイド類
EA027861B1 (ru) * 2013-02-25 2017-09-29 Бристол-Майерс Сквибб Компани C-3 алкил- и алкенилмодифицированные производные бетулиновой кислоты или их фармацевтические соли, противовирусная фармацевтическая композиция и фармацевтическая композиция для лечения вич на их основе
SMT202000581T1 (it) 2014-04-11 2020-11-10 Viiv Healthcare Uk No 4 Ltd Triterpenoidi con attività di inibizione della maturazione di hiv, sostituiti in posizione 3 con un anello non aromatico portante un sostituente alogenoalchilico
US9920090B2 (en) 2014-06-19 2018-03-20 VIIV Healthcare UK (No.5) Limited Betulinic acid derivatives with HIV maturation inhibitory activity
WO2015198263A2 (en) * 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2016077569A1 (en) 2014-11-14 2016-05-19 Bristol-Myers Squibb Company C17-aryl substituted betulinic acid analogs
US9969767B2 (en) 2014-11-14 2018-05-15 VIIV Healthcare UK (No.5) Limited Oxolupene derivatives
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
EP3328876A1 (en) 2015-07-28 2018-06-06 Glaxosmithkline Intellectual Property (No. 2) Limited Betuin derivatives for preventing or treating hiv infections
CA2993758A1 (en) 2015-07-28 2017-02-02 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
JP2018528231A (ja) * 2015-09-24 2018-09-27 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ成熟阻害活性を有する化合物
CA3011616A1 (en) 2016-01-20 2017-07-27 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3478703A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
ES2970042T3 (es) 2018-04-24 2024-05-24 Viiv Healthcare Uk No 5 Ltd Compuestos con actividad inhibidora de la maduración del VIH
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie
US10343997B1 (en) 2018-12-04 2019-07-09 King Saud University Ursolic acid derivatives

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ATE348839T1 (de) * 1998-03-02 2007-01-15 Univ North Carolina Acylierte betulin- und dihydrobetulinderivate, ihre herstellung und verwendung
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TW200628161A (en) * 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
JP2009527563A (ja) * 2006-02-21 2009-07-30 アキリオン ファーマシューティカルズ，インコーポレーテッド ウイルス感染症を治療するのに有用な置換タラキサスタン
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WO2009114083A2 (en) 2008-03-03 2009-09-17 Panacos Pharmaceuticals, Inc. Determinants of antiviral response
JP5588966B2 (ja) * 2008-04-18 2014-09-10 リアタ ファーマシューティカルズ インコーポレイテッド 抗酸化炎症モジュレーター：ｃ−１７同族体化オレアノール酸誘導体
CN102883608A (zh) * 2010-02-11 2013-01-16 葛兰素史密丝克莱恩有限责任公司 白桦脂醇衍生物

Also Published As

Publication number Publication date
US20120142653A1 (en) 2012-06-07
JP2013527243A (ja) 2013-06-27
HUE026662T2 (en) 2016-06-28
JP5755731B2 (ja) 2015-07-29
WO2011153319A1 (en) 2011-12-08
SMT201500272B (it) 2016-01-08
CA2801491A1 (en) 2011-12-08
CA2801491C (en) 2018-01-23
ES2548905T3 (es) 2015-10-21
CN102985438B (zh) 2016-05-18
HRP20150977T1 (hr) 2015-10-09
PT2576586E (pt) 2015-10-23
EP2576586B1 (en) 2015-08-12
US8802661B2 (en) 2014-08-12
EA026140B1 (ru) 2017-03-31
CN102985438A (zh) 2013-03-20
EA201270800A1 (ru) 2013-04-30
DK2576586T3 (en) 2015-11-23
EP2576586A1 (en) 2013-04-10
MX2012013628A (es) 2012-12-17
SI2576586T1 (sl) 2015-11-30
TW201201792A (en) 2012-01-16
BR112012030810A2 (pt) 2019-09-24
RS54239B1 (sr) 2015-12-31
AR081638A1 (es) 2012-10-10

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