EA024042B1 - Способ снижения внутриглазного давления у людей - Google Patents
Способ снижения внутриглазного давления у людей Download PDFInfo
- Publication number
- EA024042B1 EA024042B1 EA201171339A EA201171339A EA024042B1 EA 024042 B1 EA024042 B1 EA 024042B1 EA 201171339 A EA201171339 A EA 201171339A EA 201171339 A EA201171339 A EA 201171339A EA 024042 B1 EA024042 B1 EA 024042B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- iop
- eye
- hours
- treatment
- Prior art date
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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| PCT/US2010/033112 WO2010127210A1 (en) | 2009-05-01 | 2010-04-30 | Method of reducing intraocular pressure in humans |
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| EA201171339A1 EA201171339A1 (ru) | 2012-05-30 |
| EA024042B1 true EA024042B1 (ru) | 2016-08-31 |
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| EA201171339A EA024042B1 (ru) | 2009-05-01 | 2010-04-30 | Способ снижения внутриглазного давления у людей |
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| DE102008062567A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) * | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
| CN102665730A (zh) * | 2009-10-26 | 2012-09-12 | 伊诺泰克制药公司 | 眼用制剂及其制造方法 |
| BR112012017106A2 (pt) * | 2010-01-11 | 2018-05-29 | Inotek Pharmaceuticals Corp | combinação, kit e método de redução de pressão intraocular. |
| HUE031529T2 (en) * | 2010-03-19 | 2017-07-28 | Inotek Pharmaceuticals Corp | Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure |
| JP2013522323A (ja) * | 2010-03-19 | 2013-06-13 | イノテック ファーマシューティカルズ コーポレイション | 眼内圧を下げるためのアデノシンＡ１受容体アゴニストと非選択的β−アドレナリン受容体遮断薬との組合せ組成物 |
| JP2013523739A (ja) | 2010-03-26 | 2013-06-17 | イノテック ファーマシューティカルズ コーポレイション | Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法 |
| DE102010030688A1 (de) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dicyanopyridine und ihre Verwendung |
| US20120058983A1 (en) * | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
| NZ627778A (en) * | 2012-01-26 | 2017-01-27 | Inotek Pharmaceuticals Corp | Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof |
| AU2014239222A1 (en) | 2013-03-15 | 2015-10-01 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
| JP2018501219A (ja) * | 2014-12-03 | 2018-01-18 | イノテック ファーマシューティカルズ コーポレイション | 黄斑変性の予防、軽減または治療方法 |
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| WO2005117910A2 (en) * | 2004-05-26 | 2005-12-15 | Inotek Pharmaceuticals Corporation | Purine derivatives as adenosine a1 receptor agonists and methods of use thereof |
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| CN101010085B (zh) * | 2004-05-26 | 2012-12-26 | 伊诺泰克制药公司 | 嘌呤衍生物作为腺苷a1受体激动剂及其用法 |
| AU2006320578B2 (en) * | 2005-11-30 | 2013-01-31 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
| CN102665730A (zh) * | 2009-10-26 | 2012-09-12 | 伊诺泰克制药公司 | 眼用制剂及其制造方法 |
| BR112012017106A2 (pt) * | 2010-01-11 | 2018-05-29 | Inotek Pharmaceuticals Corp | combinação, kit e método de redução de pressão intraocular. |
| HUE031529T2 (en) * | 2010-03-19 | 2017-07-28 | Inotek Pharmaceuticals Corp | Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure |
| JP2013522323A (ja) * | 2010-03-19 | 2013-06-13 | イノテック ファーマシューティカルズ コーポレイション | 眼内圧を下げるためのアデノシンＡ１受容体アゴニストと非選択的β−アドレナリン受容体遮断薬との組合せ組成物 |
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| CROSSON C.E.: "Ocular Hypotensive Activity of the Adenosine Agonist (R)-Phenyhsopropyladenosine in Rabbits", Current Eye Research, 1992, vol. 11, no 5, pages 453-458. See in particular, abstract. See in particular, abstract, pg. 457, first column * |
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