CN102413832B - 降低人眼内压的方法 - Google Patents

降低人眼内压的方法 Download PDF

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Publication number
CN102413832B
CN102413832B CN201080018539.XA CN201080018539A CN102413832B CN 102413832 B CN102413832 B CN 102413832B CN 201080018539 A CN201080018539 A CN 201080018539A CN 102413832 B CN102413832 B CN 102413832B
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China
Prior art keywords
iop
compound
affected eye
reduced
hours
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Expired - Fee Related
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CN201080018539.XA
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English (en)
Chinese (zh)
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CN102413832A (zh
Inventor
施哈·巴曼
鲁道夫·A·鲍姆加特内尔
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Rocket Pharmaceuticals Inc
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Inotek Pharmaceuticals Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
CN201080018539.XA 2009-05-01 2010-04-30 降低人眼内压的方法 Expired - Fee Related CN102413832B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17465509P 2009-05-01 2009-05-01
US61/174,655 2009-05-01
US21999009P 2009-06-24 2009-06-24
US61/219,990 2009-06-24
PCT/US2010/033112 WO2010127210A1 (en) 2009-05-01 2010-04-30 Method of reducing intraocular pressure in humans

Publications (2)

Publication Number Publication Date
CN102413832A CN102413832A (zh) 2012-04-11
CN102413832B true CN102413832B (zh) 2015-11-25

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ID=43030847

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080018539.XA Expired - Fee Related CN102413832B (zh) 2009-05-01 2010-04-30 降低人眼内压的方法

Country Status (25)

Country Link
US (2) US8470800B2 (enExample)
EP (1) EP2424546B1 (enExample)
JP (1) JP5778663B2 (enExample)
KR (1) KR101757940B1 (enExample)
CN (1) CN102413832B (enExample)
AU (1) AU2010242943B2 (enExample)
BR (1) BRPI1009971A2 (enExample)
CA (1) CA2762064A1 (enExample)
CL (1) CL2011002675A1 (enExample)
DK (1) DK2424546T3 (enExample)
EA (1) EA024042B1 (enExample)
ES (1) ES2554684T3 (enExample)
HR (1) HRP20151200T1 (enExample)
HU (1) HUE028068T2 (enExample)
IL (1) IL216081A (enExample)
MX (1) MX2011011229A (enExample)
MY (1) MY159244A (enExample)
NZ (1) NZ596428A (enExample)
PL (1) PL2424546T3 (enExample)
PT (1) PT2424546E (enExample)
RS (1) RS54378B1 (enExample)
SG (1) SG175346A1 (enExample)
SI (1) SI2424546T1 (enExample)
SM (1) SMT201500295B (enExample)
WO (1) WO2010127210A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008062567A1 (de) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid-Prodrugs und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
CA2774704A1 (en) * 2009-10-26 2011-05-05 Inotek Pharmaceuticals Corporation Ophthalmic formulation and method of manufacture thereof
EA025415B1 (ru) * 2010-01-11 2016-12-30 Инотек Фармасьютикалз Корпорейшн Комбинация, набор и способ снижения внутриглазного давления
PT2555775T (pt) * 2010-03-19 2017-02-01 Inotek Pharmaceuticals Corp Composições de combinação de agonistas de adenosina a1 e inibidores de anidrase carbónica para redução da pressão intra-ocular
LT2555776T (lt) * 2010-03-19 2017-04-25 Inotek Pharmaceuticals Corporation Adenozino a1 agonistų ir neselektyvių beta adrenerginių receptorių blokatorių derinio kompozicijos, skirtos akispūdžio mažinimui
EP2569325A4 (en) 2010-03-26 2013-10-09 Inotek Pharmaceuticals Corp METHOD FOR REDUCING INNER EYE PRESSURE IN HUMANS USING N6-CYCLOPENTYLADENOSINE (CPA), CPA DERIVATIVES OR PRODRUGS THEREOF
DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
US20120058983A1 (en) * 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
US9278991B2 (en) * 2012-01-26 2016-03-08 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
CA2903114A1 (en) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
EP3247715A1 (en) * 2014-12-03 2017-11-29 Inotek Pharmaceuticals Corporation Methods of preventing, reducing or treating macular degeneration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010085A (zh) * 2004-05-26 2007-08-01 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
CN101321460A (zh) * 2005-11-30 2008-12-10 伊诺泰克制药公司 嘌呤衍生物及其用法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005020286D1 (de) * 2004-05-26 2010-05-12 Inotek Pharmaceuticals Corp Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür
CA2774704A1 (en) * 2009-10-26 2011-05-05 Inotek Pharmaceuticals Corporation Ophthalmic formulation and method of manufacture thereof
EA025415B1 (ru) * 2010-01-11 2016-12-30 Инотек Фармасьютикалз Корпорейшн Комбинация, набор и способ снижения внутриглазного давления
PT2555775T (pt) * 2010-03-19 2017-02-01 Inotek Pharmaceuticals Corp Composições de combinação de agonistas de adenosina a1 e inibidores de anidrase carbónica para redução da pressão intra-ocular
LT2555776T (lt) * 2010-03-19 2017-04-25 Inotek Pharmaceuticals Corporation Adenozino a1 agonistų ir neselektyvių beta adrenerginių receptorių blokatorių derinio kompozicijos, skirtos akispūdžio mažinimui

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010085A (zh) * 2004-05-26 2007-08-01 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
CN101321460A (zh) * 2005-11-30 2008-12-10 伊诺泰克制药公司 嘌呤衍生物及其用法

Also Published As

Publication number Publication date
HK1167599A1 (en) 2012-12-07
ES2554684T3 (es) 2015-12-22
HRP20151200T1 (hr) 2016-01-15
CL2011002675A1 (es) 2012-06-01
KR101757940B1 (ko) 2017-07-13
KR20120017026A (ko) 2012-02-27
IL216081A (en) 2015-11-30
WO2010127210A1 (en) 2010-11-04
EA024042B1 (ru) 2016-08-31
US8470800B2 (en) 2013-06-25
EA201171339A1 (ru) 2012-05-30
EP2424546A4 (en) 2013-01-23
IL216081A0 (en) 2012-01-31
SMT201500295B (it) 2016-01-08
SI2424546T1 (sl) 2016-02-29
PL2424546T3 (pl) 2016-04-29
MX2011011229A (es) 2011-11-18
JP5778663B2 (ja) 2015-09-16
PT2424546E (pt) 2015-12-23
US20100279970A1 (en) 2010-11-04
EP2424546B1 (en) 2015-10-28
BRPI1009971A2 (pt) 2016-03-15
NZ596428A (en) 2014-03-28
US20130217643A1 (en) 2013-08-22
HUE028068T2 (en) 2016-11-28
EP2424546A1 (en) 2012-03-07
MY159244A (en) 2016-12-30
CN102413832A (zh) 2012-04-11
SG175346A1 (en) 2011-11-28
AU2010242943B2 (en) 2016-09-29
AU2010242943A1 (en) 2011-12-01
JP2012525437A (ja) 2012-10-22
RS54378B1 (sr) 2016-04-28
CA2762064A1 (en) 2010-11-04
DK2424546T3 (en) 2015-12-14

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GR01 Patent grant
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120411

Assignee: Eno Tech Co. Ltd.

Assignor: Inotek Pharmaceuticals Corporation

Contract record no.: 2017990000148

Denomination of invention: Method of reducing intraocular pressure in humans using n6-cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof

Granted publication date: 20151125

License type: Common License

Record date: 20170425

EE01 Entry into force of recordation of patent licensing contract
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Termination date: 20180430

CF01 Termination of patent right due to non-payment of annual fee