JP5778663B2 - ヒトの眼圧を低下させるための医薬組成物 - Google Patents

ヒトの眼圧を低下させるための医薬組成物 Download PDF

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Publication number
JP5778663B2
JP5778663B2 JP2012508764A JP2012508764A JP5778663B2 JP 5778663 B2 JP5778663 B2 JP 5778663B2 JP 2012508764 A JP2012508764 A JP 2012508764A JP 2012508764 A JP2012508764 A JP 2012508764A JP 5778663 B2 JP5778663 B2 JP 5778663B2
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pharmaceutical composition
compound
iop
composition according
eye
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Japanese (ja)
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JP2012525437A5 (enExample
JP2012525437A (ja
Inventor
バーマン、シーカ
エイ． バウムガートナー、ルドルフ
エイ． バウムガートナー、ルドルフ
Original Assignee
イノテック ファーマシューティカルズ コーポレイション
イノテック ファーマシューティカルズ コーポレイション
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
JP2012508764A 2009-05-01 2010-04-30 ヒトの眼圧を低下させるための医薬組成物 Expired - Fee Related JP5778663B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17465509P 2009-05-01 2009-05-01
US61/174,655 2009-05-01
US21999009P 2009-06-24 2009-06-24
US61/219,990 2009-06-24
PCT/US2010/033112 WO2010127210A1 (en) 2009-05-01 2010-04-30 Method of reducing intraocular pressure in humans

Publications (3)

Publication Number Publication Date
JP2012525437A JP2012525437A (ja) 2012-10-22
JP2012525437A5 JP2012525437A5 (enExample) 2013-06-20
JP5778663B2 true JP5778663B2 (ja) 2015-09-16

Family

ID=43030847

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012508764A Expired - Fee Related JP5778663B2 (ja) 2009-05-01 2010-04-30 ヒトの眼圧を低下させるための医薬組成物

Country Status (25)

Country Link
US (2) US8470800B2 (enExample)
EP (1) EP2424546B1 (enExample)
JP (1) JP5778663B2 (enExample)
KR (1) KR101757940B1 (enExample)
CN (1) CN102413832B (enExample)
AU (1) AU2010242943B2 (enExample)
BR (1) BRPI1009971A2 (enExample)
CA (1) CA2762064A1 (enExample)
CL (1) CL2011002675A1 (enExample)
DK (1) DK2424546T3 (enExample)
EA (1) EA024042B1 (enExample)
ES (1) ES2554684T3 (enExample)
HR (1) HRP20151200T1 (enExample)
HU (1) HUE028068T2 (enExample)
IL (1) IL216081A (enExample)
MX (1) MX2011011229A (enExample)
MY (1) MY159244A (enExample)
NZ (1) NZ596428A (enExample)
PL (1) PL2424546T3 (enExample)
PT (1) PT2424546E (enExample)
RS (1) RS54378B1 (enExample)
SG (1) SG175346A1 (enExample)
SI (1) SI2424546T1 (enExample)
SM (1) SMT201500295B (enExample)
WO (1) WO2010127210A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008062567A1 (de) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid-Prodrugs und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
CN102665730A (zh) * 2009-10-26 2012-09-12 伊诺泰克制药公司 眼用制剂及其制造方法
BR112012017106A2 (pt) * 2010-01-11 2018-05-29 Inotek Pharmaceuticals Corp combinação, kit e método de redução de pressão intraocular.
HUE031529T2 (en) * 2010-03-19 2017-07-28 Inotek Pharmaceuticals Corp Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure
JP2013522323A (ja) * 2010-03-19 2013-06-13 イノテック ファーマシューティカルズ コーポレイション 眼内圧を下げるためのアデノシンＡ１受容体アゴニストと非選択的β−アドレナリン受容体遮断薬との組合せ組成物
JP2013523739A (ja) 2010-03-26 2013-06-17 イノテック ファーマシューティカルズ コーポレイション Ｎ６−シクロペンチルアデノシン（ｃｐａ）、ｃｐａ誘導体またはそれらのプロドラッグを用いてヒトにおける眼内圧を低下させる方法
DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
US20120058983A1 (en) * 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
NZ627778A (en) * 2012-01-26 2017-01-27 Inotek Pharmaceuticals Corp Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
AU2014239222A1 (en) 2013-03-15 2015-10-01 Inotek Pharmaceuticals Corporation Ophthalmic formulations
JP2018501219A (ja) * 2014-12-03 2018-01-18 イノテック ファーマシューティカルズ コーポレイション 黄斑変性の予防、軽減または治療方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010085B (zh) * 2004-05-26 2012-12-26 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
PT1758596E (pt) * 2004-05-26 2010-06-23 Inotek Pharmaceuticals Corp Derivados de purina como agonistas do receptor de adenosina a1 e processos para a sua utilização
AU2006320578B2 (en) * 2005-11-30 2013-01-31 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof
CN102665730A (zh) * 2009-10-26 2012-09-12 伊诺泰克制药公司 眼用制剂及其制造方法
BR112012017106A2 (pt) * 2010-01-11 2018-05-29 Inotek Pharmaceuticals Corp combinação, kit e método de redução de pressão intraocular.
HUE031529T2 (en) * 2010-03-19 2017-07-28 Inotek Pharmaceuticals Corp Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure
JP2013522323A (ja) * 2010-03-19 2013-06-13 イノテック ファーマシューティカルズ コーポレイション 眼内圧を下げるためのアデノシンＡ１受容体アゴニストと非選択的β−アドレナリン受容体遮断薬との組合せ組成物

Also Published As

Publication number Publication date
DK2424546T3 (en) 2015-12-14
PT2424546E (pt) 2015-12-23
CA2762064A1 (en) 2010-11-04
PL2424546T3 (pl) 2016-04-29
NZ596428A (en) 2014-03-28
HK1167599A1 (en) 2012-12-07
SG175346A1 (en) 2011-11-28
AU2010242943A1 (en) 2011-12-01
IL216081A (en) 2015-11-30
IL216081A0 (en) 2012-01-31
SMT201500295B (it) 2016-01-08
WO2010127210A1 (en) 2010-11-04
SI2424546T1 (sl) 2016-02-29
JP2012525437A (ja) 2012-10-22
ES2554684T3 (es) 2015-12-22
KR20120017026A (ko) 2012-02-27
KR101757940B1 (ko) 2017-07-13
US20100279970A1 (en) 2010-11-04
EP2424546A4 (en) 2013-01-23
CN102413832B (zh) 2015-11-25
EP2424546A1 (en) 2012-03-07
CL2011002675A1 (es) 2012-06-01
EA024042B1 (ru) 2016-08-31
US20130217643A1 (en) 2013-08-22
MX2011011229A (es) 2011-11-18
RS54378B1 (sr) 2016-04-28
HUE028068T2 (en) 2016-11-28
US8470800B2 (en) 2013-06-25
MY159244A (en) 2016-12-30
HRP20151200T1 (hr) 2016-01-15
BRPI1009971A2 (pt) 2016-03-15
EA201171339A1 (ru) 2012-05-30
CN102413832A (zh) 2012-04-11
AU2010242943B2 (en) 2016-09-29
EP2424546B1 (en) 2015-10-28

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