KR101757940B1 - 인간 안압을 감소시키는 방법 - Google Patents

인간 안압을 감소시키는 방법 Download PDF

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KR101757940B1
KR101757940B1 KR1020117025057A KR20117025057A KR101757940B1 KR 101757940 B1 KR101757940 B1 KR 101757940B1 KR 1020117025057 A KR1020117025057 A KR 1020117025057A KR 20117025057 A KR20117025057 A KR 20117025057A KR 101757940 B1 KR101757940 B1 KR 101757940B1
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KR20120017026A (ko
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시카 바먼
루돌프 에이 바움가르트너
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이노텍 파마슈티컬스 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
KR1020117025057A 2009-05-01 2010-04-30 인간 안압을 감소시키는 방법 Expired - Fee Related KR101757940B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17465509P 2009-05-01 2009-05-01
US61/174,655 2009-05-01
US21999009P 2009-06-24 2009-06-24
US61/219,990 2009-06-24
PCT/US2010/033112 WO2010127210A1 (en) 2009-05-01 2010-04-30 Method of reducing intraocular pressure in humans

Publications (2)

Publication Number Publication Date
KR20120017026A KR20120017026A (ko) 2012-02-27
KR101757940B1 true KR101757940B1 (ko) 2017-07-13

Family

ID=43030847

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117025057A Expired - Fee Related KR101757940B1 (ko) 2009-05-01 2010-04-30 인간 안압을 감소시키는 방법

Country Status (25)

Country Link
US (2) US8470800B2 (enExample)
EP (1) EP2424546B1 (enExample)
JP (1) JP5778663B2 (enExample)
KR (1) KR101757940B1 (enExample)
CN (1) CN102413832B (enExample)
AU (1) AU2010242943B2 (enExample)
BR (1) BRPI1009971A2 (enExample)
CA (1) CA2762064A1 (enExample)
CL (1) CL2011002675A1 (enExample)
DK (1) DK2424546T3 (enExample)
EA (1) EA024042B1 (enExample)
ES (1) ES2554684T3 (enExample)
HR (1) HRP20151200T1 (enExample)
HU (1) HUE028068T2 (enExample)
IL (1) IL216081A (enExample)
MX (1) MX2011011229A (enExample)
MY (1) MY159244A (enExample)
NZ (1) NZ596428A (enExample)
PL (1) PL2424546T3 (enExample)
PT (1) PT2424546E (enExample)
RS (1) RS54378B1 (enExample)
SG (1) SG175346A1 (enExample)
SI (1) SI2424546T1 (enExample)
SM (1) SMT201500295B (enExample)
WO (1) WO2010127210A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008062567A1 (de) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid-Prodrugs und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
JP2013508420A (ja) * 2009-10-26 2013-03-07 イノテック ファーマシューティカルズ コーポレイション 点眼製剤およびその製造方法
ME02608B (me) * 2010-01-11 2017-06-20 Inotek Pharmaceuticals Corp Kombinacija, komplet i postupak snižavanja intraokularnog pritiska
LT2555775T (lt) * 2010-03-19 2017-04-25 Inotek Pharmaceuticals Corporation Adenozino a1 agonistų ir karboanhidrazės inhibitorių derinio kompozicijos, skirtos akispūdžio mažinimui
CN102958526A (zh) * 2010-03-19 2013-03-06 伊诺泰克制药公司 用于降低眼内压的腺苷A1激动剂与非选择性β-肾上腺素能受体阻断剂的组合型组合物
CN102933593A (zh) * 2010-03-26 2013-02-13 伊诺泰克制药公司 使用n6-环戊基腺苷（cpa）、cpa衍生物或其前药降低人眼内压的方法
DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
US20120058983A1 (en) 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
US9278991B2 (en) * 2012-01-26 2016-03-08 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
BR112015021870A2 (pt) 2013-03-15 2017-07-18 Inotek Pharmaceuticals Corp formulações oftálmicas
US20160158267A1 (en) * 2014-12-03 2016-06-09 Inotek Pharmaceuticals Corporation Methods of preventing, reducing or treating macular degeneration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117910A2 (en) * 2004-05-26 2005-12-15 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
WO2007064795A2 (en) * 2005-11-30 2007-06-07 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010085B (zh) * 2004-05-26 2012-12-26 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
JP2013508420A (ja) * 2009-10-26 2013-03-07 イノテック ファーマシューティカルズ コーポレイション 点眼製剤およびその製造方法
ME02608B (me) * 2010-01-11 2017-06-20 Inotek Pharmaceuticals Corp Kombinacija, komplet i postupak snižavanja intraokularnog pritiska
LT2555775T (lt) * 2010-03-19 2017-04-25 Inotek Pharmaceuticals Corporation Adenozino a1 agonistų ir karboanhidrazės inhibitorių derinio kompozicijos, skirtos akispūdžio mažinimui
CN102958526A (zh) * 2010-03-19 2013-03-06 伊诺泰克制药公司 用于降低眼内压的腺苷A1激动剂与非选择性β-肾上腺素能受体阻断剂的组合型组合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117910A2 (en) * 2004-05-26 2005-12-15 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
WO2007064795A2 (en) * 2005-11-30 2007-06-07 Inotek Pharmaceuticals Corporation Purine derivatives and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Experimental Eye Research, 64(6), 979-989, 1997.

Also Published As

Publication number Publication date
MX2011011229A (es) 2011-11-18
JP5778663B2 (ja) 2015-09-16
IL216081A0 (en) 2012-01-31
JP2012525437A (ja) 2012-10-22
AU2010242943B2 (en) 2016-09-29
CN102413832B (zh) 2015-11-25
EP2424546B1 (en) 2015-10-28
MY159244A (en) 2016-12-30
HRP20151200T1 (hr) 2016-01-15
US20130217643A1 (en) 2013-08-22
RS54378B1 (sr) 2016-04-28
PT2424546E (pt) 2015-12-23
HK1167599A1 (en) 2012-12-07
AU2010242943A1 (en) 2011-12-01
IL216081A (en) 2015-11-30
EP2424546A1 (en) 2012-03-07
EA024042B1 (ru) 2016-08-31
PL2424546T3 (pl) 2016-04-29
NZ596428A (en) 2014-03-28
EA201171339A1 (ru) 2012-05-30
CA2762064A1 (en) 2010-11-04
SG175346A1 (en) 2011-11-28
DK2424546T3 (en) 2015-12-14
BRPI1009971A2 (pt) 2016-03-15
CN102413832A (zh) 2012-04-11
CL2011002675A1 (es) 2012-06-01
EP2424546A4 (en) 2013-01-23
ES2554684T3 (es) 2015-12-22
WO2010127210A1 (en) 2010-11-04
US8470800B2 (en) 2013-06-25
HUE028068T2 (en) 2016-11-28
SMT201500295B (it) 2016-01-08
KR20120017026A (ko) 2012-02-27
SI2424546T1 (sl) 2016-02-29
US20100279970A1 (en) 2010-11-04

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