EA021554B9 - Органические соединения и их применение для лечения hcv инфекции - Google Patents

Органические соединения и их применение для лечения hcv инфекции

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Publication number
EA021554B9
EA021554B9 EA201101477A EA201101477A EA021554B9 EA 021554 B9 EA021554 B9 EA 021554B9 EA 201101477 A EA201101477 A EA 201101477A EA 201101477 A EA201101477 A EA 201101477A EA 021554 B9 EA021554 B9 EA 021554B9
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EA
Eurasian Patent Office
Prior art keywords
treatment
organic compounds
hcv infections
hcv
amelioration
Prior art date
Application number
EA201101477A
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English (en)
Other versions
EA021554B1 (ru
EA201101477A1 (ru
Inventor
Трикси Брандль
Пракаш Раман
Паскаль Риголлье
Мохиндра Сиперсауд
Оливер Зимик
Original Assignee
Новартис Аг
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42332382&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA021554(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201101477A1 publication Critical patent/EA201101477A1/ru
Publication of EA021554B1 publication Critical patent/EA021554B1/ru
Publication of EA021554B9 publication Critical patent/EA021554B9/ru

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    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07K5/10—Tetrapeptides
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Molecular Biology (AREA)
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  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В изобретении приведены описания органических соединений формул (I)-(IV) или их фармацевтически приемлемых солей, которые применимы для лечения, предупреждения и/или облегчения протекания заболеваний людей, в частности HCV инфекции.
EA201101477A 2009-04-10 2010-04-09 Органические соединения и их применение для лечения hcv инфекции EA021554B9 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16840809P 2009-04-10 2009-04-10
US18103809P 2009-05-26 2009-05-26
PCT/IB2010/000784 WO2010116248A1 (en) 2009-04-10 2010-04-09 Organic compounds and their uses

Publications (3)

Publication Number Publication Date
EA201101477A1 EA201101477A1 (ru) 2012-05-30
EA021554B1 EA021554B1 (ru) 2015-07-30
EA021554B9 true EA021554B9 (ru) 2018-06-29

Family

ID=42332382

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Application Number Title Priority Date Filing Date
EA201101477A EA021554B9 (ru) 2009-04-10 2010-04-09 Органические соединения и их применение для лечения hcv инфекции

Country Status (30)

Country Link
US (4) US8512690B2 (ru)
EP (1) EP2417108B1 (ru)
JP (1) JP5528537B2 (ru)
KR (2) KR20140048342A (ru)
CN (1) CN102388023B (ru)
AR (1) AR076236A1 (ru)
AU (1) AU2010233472B2 (ru)
BR (1) BRPI1015308A2 (ru)
CA (1) CA2758146C (ru)
CL (1) CL2011002494A1 (ru)
CO (1) CO6440597A2 (ru)
CR (1) CR20110505A (ru)
CU (1) CU24046B1 (ru)
EA (1) EA021554B9 (ru)
EC (1) ECSP11011389A (ru)
ES (1) ES2603744T3 (ru)
HN (1) HN2011002635A (ru)
IL (1) IL215310A (ru)
MA (1) MA33155B1 (ru)
MX (1) MX340733B (ru)
MY (1) MY153766A (ru)
NZ (1) NZ595458A (ru)
PE (1) PE20120557A1 (ru)
SG (1) SG174474A1 (ru)
TN (1) TN2011000482A1 (ru)
TW (2) TWI387591B (ru)
UA (1) UA106367C2 (ru)
UY (1) UY32551A (ru)
WO (1) WO2010116248A1 (ru)
ZA (1) ZA201106787B (ru)

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RU2463071C2 (ru) * 2006-10-12 2012-10-10 Новартис Аг Применение модифицированных циклоспоринов
EA201170441A1 (ru) * 2008-10-15 2012-05-30 Интермьюн, Инк. Терапевтические противовирусные пептиды
AR075584A1 (es) 2009-02-27 2011-04-20 Intermune Inc COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO.
US8512690B2 (en) * 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
KR20130120481A (ko) * 2010-10-08 2013-11-04 노파르티스 아게 술파미드 ｎｓ3 억제제의 비타민 ｅ 제제
US20130338061A1 (en) * 2010-10-08 2013-12-19 Lipa Shah Salts and Polymorphs of Sulfamide NS3 Inhibitors
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
KR20150074051A (ko) 2012-10-19 2015-07-01 브리스톨-마이어스 스큅 컴퍼니 C형 간염 바이러스 억제제
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014071007A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9409943B2 (en) 2012-11-05 2016-08-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014137869A1 (en) 2013-03-07 2014-09-12 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP3413915A1 (en) 2016-02-08 2018-12-19 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting her2 tumours and method for improving therapeutic index of antibody-conjugates
JP2019507741A (ja) 2016-02-08 2019-03-22 シンアフィックス ビー．ブイ． 治療において使用するためのスルファミドリンカーを含むバイオコンジュゲート
WO2017137423A1 (en) 2016-02-08 2017-08-17 Synaffix B.V. Improved sulfamide linkers for use in bioconjugates
EP3728266A1 (en) 2017-12-20 2020-10-28 Novartis AG Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals
CN114469952B (zh) * 2022-03-02 2023-09-19 中南大学湘雅三医院 特拉匹韦在制备malt1抑制剂、抗malt1依赖性肿瘤的药物中的应用及抗肿瘤药物

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